Cardiovascular Research Priority Area

Active

Development of a Minimally Invasive Single Cannulation, Compact Single Port Pulsatile Ventricular Assist Device (sppVAD) for Total LV Support

Ballard Croft, C. (PI)

10/1/24 → 6/30/26

Project: Research project

Extracellular vesicle-mediated Nrf2 protein secretion and its therapeutic application in cardiogenic dementia

Tian, C. (PI)

7/1/24 → 6/30/27

Project: Research project

Development of a Percutaneous Double Lumen Cannula- Based Cavopulmonary Assist System Toward Clinical Application

Ballard Croft, C. (PI)

2/1/24 → 1/31/28

Project: Research project

CorMatrix Cor TRICUSPID ECM Valve Replacement Safety and Early Feasibility Study

Sekela, M. (PI)

CorMatrix Cardiovascular Incorporated

5/7/20 → 1/11/26

Project: Research project

Mechanisms of Cardiac Remodeling Triggered by Gestational Diabetes

Despa, S. (PI) & Despa, F. (CoI)

National Heart Lung and Blood Institute

5/1/20 → 4/30/25

Project: Research project

Statins Use in Intracerebral Hemorrhage Patients (SATURN)

O'Connor, K. (PI) & Pettigrew, L. (Former PI)

University of Cincinnati

4/30/20 → 7/26/25

Project: Research project

Anticoagulation in ICH Survivors for Prevention and Recovery (ASPIRE)

Gangadhara, S. (PI) & Pettigrew, L. (Former PI)

University of Cincinnati

4/30/20 → 4/30/25

Project: Research project

The Amylin Dyshomeostasis Hypothesis of Vascular Contributions to Cognitive Impairment and Dementia (VCID)

Despa, F. (PI), Abner, E. (CoI), Despa, S. (CoI), Goldstein, L. (CoI), Jicha, G. (CoI) & Wilcock, D. (Former CoI)

National Institute of Neurological Disorders & Stroke

4/1/20 → 3/31/26

Project: Research project

BIO-LIBRA: Analysis of Both Sex and Device Specific Factors on Outcomes in Patients with Non-Ischemic Cardiomyopathy

Ellison, K. (PI) & Hesselson, A. (Former PI)

Biotronik Incorporated

11/22/19 → 7/4/25

Project: Research project

A Randomized, Double Blinded Controlled Parallel Group Non-inferiority, Phase III Study to Evaluate the Efficacy and Safety of the INTERCEPT Blood System for Red Blood Cells in Patients undergoing Complex Cardiac Surgery Procedures (ReCePI)

Sekela, M. (PI)

Cerus Corporation

5/24/19 → 8/3/25

Project: Research project

Therapeutic Targeting of Metabolic microRNAs as a New Treatment Paradigm for NASH

Temel, R. (PI)

Aalborg University

1/1/19 → 12/31/25

Project: Research project

PFO PAS: AMPLATZER PFO Occluder Post Approval Study

Gurley, J. (PI)

St Jude Business Services Incorporated

5/25/18 → 7/10/25

Project: Research project

AMPLATZER Amulet Left Atrial Appendage Occluder

Gurley, J. (PI)

St Jude Medical Incorporated

3/28/17 → 8/11/25

Project: Research project

SPYRAL HTN ON MEDS

Kotter, J. (PI) & Ziada, K. (Former PI)

Medtronics Inc

6/22/15 → 7/7/25

Project: Research project

Epidemiologic and Biostatistical Support to AlphaNet

Choate, R. (PI), Browning, S. (Former PI), Mannino, D. (Former PI) & Gan, W. (Former CoI)

AlphaNet Incorporated

1/1/15 → 6/30/25

Project: Research project

Not started

Development of a Percutaneous Double Lumen Cannula- Based Cavopulmonary Assist System Toward Clinical Application

Ballard Croft, C. (PI)

Project: Research project

Finished

Targeting aberrant glycogen metabolism in CLN3 disease

Wang, Q. (PI) & Gentry, M. (CoI)

4/1/22 → 3/31/23

Project: Research project

Developing a novel therapy for CLN3 disease-related neurological deficits

Wang, Q. (PI), Norris, C. (CoI), O'Hara, B. (CoI), Sunderam, S. (CoI) & McLouth, C. (CoI)

12/1/21 → 11/30/22

Project: Research project

Developing a novel therapy for CLN3 disease-associated neurological deficits

Wang, Q. (PI), Norris, C. (CoI), O'Hara, B. (CoI) & Sunderam, S. (CoI)

2/1/21 → 1/31/22

Project: Research project

A Randomized, Double-Blind, Placebo-Controlled Proof-of-Concept Study to Assess the Safety and Efficacy of Elezanumab in Acute Ischemic Stroke

Hatton, K. (PI), Lee, J. (CoI) & Swafford, K. (CoI)

AbbVie Incorporated

6/24/20 → 3/14/22

Project: Research project

Fellowship for Peng: Cardiomyocyte phenotype drives enhanced AMI recovery in spiny mice

Abdel-Latif, A. (PI), Satin, J. (CoI), Seifert, A. (CoI) & Smyth, S. (CoI)

National Heart Lung and Blood Institute

6/1/20 → 8/31/20

Project: Research project

Implementing a Novel, Multimodal Technique for Monitoring Cerebrovascular Hemodynamics in Mice as a Diagnostic and Prognostic Tool for Single and Repeated Mild TBI

Saatman, K. (PI), Chen, L. (CoI), Gentry, M. (CoI), Huang, C. (CoI), Yu, G. (CoI), Huang, C. (Former CoI) & Sun, R. (Former CoI)

National Institute of Neurological Disorders & Stroke

6/1/20 → 5/31/23

Project: Research project

Diabetes, Glucose Metabolism, and Neuroplasticity in the Vagal Complex

Smith, B. (PI) & Gerhardt, G. (CoI)

National Institute Diabetes & Digestive & Kidney

4/15/20 → 7/31/21

Project: Research project

Rethinking Repair: Long-Term Adaptive Immunity Supports Functional Recovery for Stroke Patients

Stowe, A. (PI), Fraser, J. (CoI), Nelson, P. (CoI) & Pennypacker, K. (CoI)

American Heart Association

4/1/20 → 3/31/21

Project: Research project

Platelet Exocytosis and Endocytosis in Thrombosis and Immunity

Whiteheart, S. (PI) & Garvy, B. (CoI)

National Heart Lung and Blood Institute

4/1/20 → 3/31/21

Project: Research project

COBRE in Pharmaceutical Research and Innovation

Thorson, J. (PI), Adams, V. (CoI), Awuah, S. (CoI), Burgess, D. (CoI), Dwoskin, L. (CoI), Feola, D. (CoI), Garneau-Tsodikova, S. (CoI), Glazer, E. (CoI), Grady, M. (CoI), Kolesar, J. (CoI), Korotkov, K. (CoI), Korotkova, N. (CoI), Leggas, M. (CoI), Mahmoud, K. A. (CoI), Pack, D. (CoI), Prisinzano, T. (CoI), Richards, C. (CoI), Rohr, J. (CoI), Shaffer, C. (CoI), Stevenson, B. (CoI), Tiruvannamalai Annam, R. (CoI), Van Lanen, S. (CoI), Venditto, V. (CoI), Zhan, C.-G. (CoI), Daugherty, A. (Former CoI), Graf, G. (Former CoI), Sviripa, V. (Former CoI), Watt, D. (Former CoI) & Webb, N. (Former CoI)

National Institute of General Medical Sciences

3/1/20 → 1/31/21

Project: Research project

LT3001-201: A Phase IIa, Double-Blind, Single Dose, Randomized, Placebo-Controlled Study to Evaluate the Safety, Tolerability, and Potential Efficacy of LT3001 Drug Product in Subjects with Acute Ischemic Stroke (AIS)

Pettigrew, L. (PI)

1/22/20 → 10/6/21

Project: Research project

The Atherosclerosis Risk in Communities (ARIC) Study

Kucharska-Newton, A. (PI)

11/15/19 → 11/14/20

Project: Research project

Influence of Dietary Nitrogen on Hind Limb Ischemia

Suckow, M. (PI)

10/31/19 → 2/1/23

Project: Research project

A Prospective, Multi-Center, Single Arm Study to Obtain "Real World" Clinical Data and Characterize the Acute and Long-Term Performance of the Micrusframe and Galaxy Coils for the Endovascular Treatment of Intracranial Aneurysms

Fraser, J. (PI)

Cerenovus Incorporated

10/18/19 → 3/2/21

Project: Research project

Assessment of the CARILLON Mitral Contour System in Treating Functional Mitral Regurgitation Associated with Heart Failure

Gurley, J. (PI)

Cardiac Dimensions Incorporated

10/16/19 → 12/15/22

Project: Research project

Fat Nerve Recording in Mice

Loria Kinsey, A. (PI)

American Physiological Society

10/1/19 → 10/31/21

Project: Research project

Healthy Kentucky Research Building Fit-up for Vascular Research

Cassis, L. (PI), Daugherty, A. (CoI), Miller, G. (CoI), Van Eldik, L. (CoI) & Zhang, G. (CoI)

Office of the Director

9/23/19 → 10/31/21

Project: Research project

Understanding the role of anti-apolipoprotein A-I antibodies in atherosclerotic cardiovascular disease

Venditto, V. (PI), Daugherty, A. (CoI), Temel, R. (CoI) & Charnigo, R. (Former CoI)

National Heart Lung and Blood Institute

9/20/19 → 6/30/20

Project: Research project

A Novel Mechanism of Immunosuppression in Sepsis: Depletion of Monocytes and Macrophages

Li, Z. (PI), Morris, P. (CoI), Wei, Y. (CoPI) & Li, X. (Former CoI)

National Institute of General Medical Sciences

9/20/19 → 11/30/21

Project: Research project

NSF/FDA/SIR: Evaluating Cellular Integrity as a Function of Bioprinter Nozzle Geometry

Berron, B. (PI)

National Science Foundation

9/1/19 → 8/31/21

Project: Research project

Detecting, Understanding, and Reducing Diabetes Belt Preventive Care Disparities

Sohn, M.-W. (PI)

University of Virginia

9/1/19 → 1/31/23

Project: Research project

STTR: Southeast XLerator Network

McClure, I. (PI), Cassis, L. (CoI), Kern, P. (CoI) & Phillips, T. (CoI)

XLerate Health LLC

9/1/19 → 8/31/20

Project: Research project

Force Validated Heart Valve Surgical Planning Tool

Wenk, J. (PI)

University of Arkansas

9/1/19 → 7/31/23

Project: Research project

NRSA Fellowship for Chen: Mechanisms of Renin Angiotensin Modulation in Thoracic Aortic Aneurysms

Daugherty, A. (PI) & Chen, Z. (CoI)

National Heart Lung and Blood Institute

9/1/19 → 8/31/20

Project: Research project

Pre-Clinical Efficacy of a Selective p38MAPK Inhibitor in a Model of Comorbid Alzheimer/Vascular Pathology

Van Eldik, L. (PI), Fardo, D. (CoI), Morganti, J. (CoI), Norris, C. (CoI) & Lin, A. L. (Former CoI)

National Institute on Aging

8/15/19 → 8/31/24

Project: Research project

A Prospectice, Multicenter, Randomized Study Evaluating the Use of Jetstream Atherectomy (JS) Followed by DCB in Comparison to the Use of Plain Old Balloon Angioplasty (POBA) Followed by DCB Alone in the Treatment of Complex Lesions

Tyagi, S. (PI) & Rockich, A. (CoI)

Midwest Cardiovascular Research Foundation

7/2/19 → 2/4/20

Project: Research project

Thick-Filament Regulation In Human Heart Failure

Campbell, K. (PI)

Washington State University

7/1/19 → 6/30/22

Project: Research project

Cardiovascular Consequences of Gestational Diabetes; Role of Amylin

Despa, S. (PI) & Despa, F. (CoI)

American Heart Association

7/1/19 → 6/30/20

Project: Research project

A Novel Role for IKKbeta in Epicardial Adipose Tissue Formation

Zhou, C. (PI), Abdel-Latif, A. (CoI) & Kern, P. (CoI)

American Heart Association

7/1/19 → 7/31/19

Project: Research project

Association of baseline and time-varying serum magnesium levels with cardiovascular disease events in SPRINT participants with and without chronic kidney disease

Neyra Lozano, J. (PI)

7/1/19 → 6/30/21

Project: Research project

ARCADIA-CSI: Cognition and Silent Infarcts

Das, S. (PI) & Pettigrew, L. (Former PI)

7/1/19 → 1/8/24

Project: Research project

Macrophage Migration Inhibitory Factor and Urinary Pain

Daugherty, A. (PI)

Lexington Biomedical Research Institute

7/1/19 → 12/31/23

Project: Research project

High Density Lipoprotein Targeting Protease Inhibitors for Preservation of Lung Function

Gordon, S. (PI)

Alpha One Foundation Incorporated

7/1/19 → 12/31/20

Project: Research project

Pharmacological Induction of Mitochondrial Biogenesis for the Treatment of Spinal Cord Injury

Rabchevsky, A. (PI)

University of Arizona

6/1/19 → 5/31/22

Project: Research project

Cardiovascular Research Priority Area

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