Diabetes & Obesity Research Priority Area

Grants and Contracts

Grants and Contracts per year 1996 2013 2014 2015 2016 2017 2018 2019 2025

• 46 Active
• 389 Finished

Grants and Contracts per year

Search results

• Overcoming Resistance to Enzalutamide with first-in-field TGF-beta Inhibition

  Kyprianou, N.

  6/1/15 → 5/31/19

  Project: Research project

  • Mesenchymal-Epithelial Transition 100%
  • Transforming Growth Factor Beta 66%
  • Androgen Receptor 44%
  • TGF Beta Signaling 44%
  • Prostate Cancer 44%

• Phibro Study of Probiotic Blends for Group-Fed Nursery Pigs

  Lindemann, M.

  Phibro Animal Health Corporation

  5/8/19 → 3/1/20

  Project: Research project

• Pioglitazone Protects Dopamine Neurons After Traumatic Brain Injury

  Bing, G. & Sullivan, P.

  KY Spinal Cord and Head Injury Research Trust

  1/15/18 → 1/14/22

  Project: Research project

  • Traumatic Brain Injury 100%
  • Pioglitazone 71%
  • Substantia nigra 21%
  • Dopaminergic 21%
  • Oxidative Stress 14%

• Plate It Up! Kentucky Proud: Recipe Development and Evaluation Based on 2015-2020 Dietary Guidelines for Americans

  Stephenson, T. & Vail, A.

  KY Department of Agriculture

  3/1/17 → 9/30/19

  Project: Research project

  • Recipes 100%
  • Specialty Crops 66%
  • Americans 66%
  • Dietary Guideline for Americans 66%
  • Lifestyle 33%

• Plate It Up! Kentucky Proud Mobile Kitchen Project

  Norman-Burgdolf, H., Brewer, D., Hunter, J. & Stephenson, T.

  KY Department of Agriculture

  12/1/18 → 9/29/21

  Project: Research project

  • Kitchens 100%
  • Specialty Crops 89%
  • Extension Agents 50%
  • Recipes 50%
  • Carts 30%

• Pluristem - A Phase 2, Randomized, Double-Blind, Multicenter, Multinational, Placebo-Controlled, Parallel-Group Study to Evaluate the Safety and Efficacy of Intramuscular Injections of Allogeneic PLX-PAD Cells for the Treatment of Subjects with Intermitte

  Saha, S., Ferraris, V., Minion, D., Sorial, E. & Xenos, E.

  Pluristem Therapeutics Incorporated

  11/1/12 → 3/31/15

  Project: Research project

• Postdoctoral Fellowship for Kraemer: Regulation and Function of Lipoprotein Associated Bioactive Lysophospholipid Mediators of Atherosclerosis

  Kraemer, M., Morris, A. & Smyth, S.

  7/1/18 → 6/30/20

  Project: Research project

  • Lysophosphatidic Acid 100%
  • Low-Density Lipoprotein 42%
  • Diet 42%
  • Atherosclerosis 42%
  • Low Density Lipoprotein 42%

• PostDoctoral Fellowship for Reynolds: Perinatal tobacco exposure and mechanisms of offspring obesity and insulin resistance

  Pearson, K. & Reynolds, L.

  American Heart Association Great Rivers Affiliate

  7/1/15 → 6/30/17

  Project: Research project

  • Smoke 100%
  • Child 75%
  • Obesity 62%
  • Tobacco Smoke 50%
  • Nicotine 37%

• PPAR Inhibition of Spinal Pain Transmission

  Taylor, B., Albuquerque, R. & Smith, B.

  12/18/08 → 3/31/18

  Project: Research project

  • Diabetic Neuropathy 100%
  • Methylglyoxal 100%
  • Pain 50%
  • Maturity Onset Diabetes of the Young 33%
  • Non Insulin Dependent Diabetes Mellitus 33%

• Prebiotics Intervention to Reduce Alzheimer's Disease Risk via Brain-Gut Axis in an APOE4 Mouse Model

  Lin, A. L., Abner, E., Hartz, A., Morganti, J. & Yu, G.

  National Institute on Aging

  5/1/19 → 8/1/21

  Project: Research project

  • Brain 100%
  • Inulin 50%
  • Gut Microbiome 42%
  • Apolipoprotein 42%
  • Blood Brain Barrier 35%

• Preclinical evaluation of IGF1 therapy for traumatic brain injury

  Saatman, K., Chen, L. & Kizhakke Madathil, S.

  National Institute of Neurological Disorders & Stroke

  7/15/11 → 6/30/17

  Project: Research project

  • Traumatic Brain Injury 100%
  • Neurogenesis 50%
  • Growth Factor 50%
  • Insulin 50%
  • Angiogenesis 50%

• Preclinical Evaluation of Tacrolimus in a Canine Model of Alzheimer's Disease

  Head, E., Abner, E., Lin, A. L., Powell, D. & Norris, C.

  National Institute on Aging

  9/15/17 → 1/31/19

  Project: Research project

  • Calcineurin 100%
  • Alzheimer Disease 88%
  • Tacrolimus 66%
  • Beagle 44%
  • Human 22%

• Preclinical Evaluation of Tacrolimus in a Canine Model of Alzheimer's Disease

  Norris, C., Powell, D. & Lin, A. L.

  University of California Irvine

  8/1/19 → 5/31/22

  Project: Research project

  • Calcineurin 100%
  • Alzheimer Disease 88%
  • Tacrolimus 66%
  • Beagle 44%
  • Human 22%

• Predictive Neurophysiological Biomarkers for Risk of Alzheimer's Disease (AD) and Related Dementia (ADRD) Induced Cognitive Impairment in Sino-US Cohorts

  Jiang, Y., Abner, E., Jicha, G., Kryscio, R. & Caban-Holt, A.

  National Institute on Aging

  9/15/18 → 8/31/22

  Project: Research project

  • Dementia 100%
  • Mild Cognitive Impairment 84%
  • Biological Marker 46%
  • Memory 30%
  • Brain 30%

• Prenatal Tobacco Exposure and Mechanisms of Offspring Obesity

  Pearson, K., Pauly, J. & Ashford, K.

  National Institute of Environmental Health Sciences

  9/30/17 → 8/31/19

  Project: Research project

  • Child 100%
  • Progeny 89%
  • Obesity 80%
  • Smoke 60%
  • Smoking 60%

• Preventing hyperphagia in Prader Willi syndrome using an oligonucleotide

  Stamm, S.

  National Institute of Child Health and Human Develop

  9/23/14 → 8/31/17

  Project: Research project

  • Overeating 100%
  • Oligonucleotide 66%
  • Prader Willi Syndrome 66%
  • Eicosanoid Receptor 66%
  • Arcuate Nucleus 33%

• Q134R in a Canine Model of Aging and Alzheimer Disease

  Norris, C., Abner, E., Powell, D., Head, E. & Lin, A. L.

  Aperus Pharma Incorporated

  5/1/18 → 5/30/22

  Project: Research project

• Quantifying Grocery Tax Impacts on Health Utilizing Multiple State Tax Changes in the United States

  Zheng, Y.

  Economic Research Service

  6/18/18 → 6/30/20

  Project: Research project

  • Tax 100%
  • Taxation 100%
  • State 80%
  • Health 60%
  • Difference 40%

• Reaching Rural Veterans: Engaging Faith-Based Food Pantries in Serving Low-Income, Homeless, and At-Risk Veterans in Rural Areas

  Ashurst, K.

  Purdue University

  5/26/15 → 8/25/16

  Project: Research project

  • Food 100%
  • Service Industries 75%
  • Communities 75%
  • Project 50%
  • Homeless 50%

• Reducing diabetes risk for Rural Appalachian Grandparent Headed Households

  Hatcher, J., Rayens, M. K., Schoenberg, N. & Scott, L.

  National Institute Diabetes & Digestive & Kidney

  7/1/14 → 11/30/17

  Project: Research project

  • Diabetes 100%
  • Household 66%
  • Grandparent 66%
  • Family 66%
  • Grandparent-Headed Household 66%

• Regulation, Signaling, and Dynamics of Glucan Phosphatases

  Gentry, M., Vander Kooi, C. & Zhu, H.

  7/1/10 → 4/30/20

  Project: Research project

  • Glucan 100%
  • Protein 85%
  • Ubiquitination 71%
  • Phosphatase 71%
  • Dynamics 57%

• Regulation of Blood Pressure Circadian Rhythm by Vascular Smooth Muscle BMAL1

  Gong, M., Guo, Z., Duncan, M. & Esser, K.

  National Heart Lung and Blood Institute

  5/15/12 → 4/30/18

  Project: Research project

  • Circadian Rhythm 100%
  • Blood Pressure 77%
  • Nested Gene 16%
  • Gene 16%
  • Tissue 11%

• Regulation of Cilia by Ceramide

  Bieberich, E., Spassieva, S. & Wang, G.

  National Institute of Neurological Disorders & Stroke

  9/30/16 → 6/30/21

  Project: Research project

  • Cilium 100%
  • Ceramide 87%
  • Ependymal Cell 50%
  • Protein 37%
  • Astrocyte 37%

• Regulation of Mitochondrial Oxidative Metabolism by Lipin 1

  Ren, H.

  7/1/12 → 6/30/15

  Project: Research project

  • Mitochondrion 100%
  • Aerobic Metabolism 62%
  • Lipid Composition 37%
  • Triglyceride 37%
  • Surface Property 37%

• Regulation of Mitochondrial Oxidative Metabolism by Lipin 1 2015-2016 Yr 4

  Ren, H. & Morris, A.

  7/1/12 → 2/29/16

  Project: Research project

  • Mitochondrion 100%
  • Aerobic Metabolism 62%
  • Lipid Composition 37%
  • Triglyceride 37%
  • Surface Property 37%

• Rel B Mediated-Redox Regulation of Radiation Therapy

  St Clair, D., Shelton, B., St Clair, W., Strup, S. & Crispen, P.

  National Cancer Institute

  1/1/11 → 12/31/16

  Project: Research project

  • Prostate Cancer 100%
  • Interleukin 8 57%
  • Radiation Therapy 42%
  • Androgen 42%
  • Cancer Cell 28%

• Research on Equine Endocrine Disorders of Pituitary Pars Intermedia (#PPI#), Equine Metabolic Syndrome/obesity/laminitis and Geriatric Horse Healthcare/nutritional Management.

  Adams, A.

  Mars Horsecare UK Limited

  9/20/16 → 1/1/22

  Project: Research project

• Resource Center for Stable Isotope-Resolved Metabolomics

  Higashi, R., Fan, W., Lane, A. & Moseley, H.

  National Institute Diabetes & Digestive & Kidney

  9/11/13 → 8/31/17

  Project: Research project

  • Metabolomics 100%
  • Motivation 36%
  • Sample 36%
  • Processing 27%
  • Stable Isotope 18%

• Resource Center for Stable Isotope-Resolved Metabolomics

  Higashi, R., Deshpande, R., Flight, R., Scott, T., Zhang, Y., Fan, W., Lane, A., Moseley, H., Somashekar, B. & Tripathi, P.

  National Institute Diabetes & Digestive & Kidney

  9/11/13 → 8/31/15

  Project: Research project

  • Metabolomics 100%
  • Motivation 36%
  • Sample 36%
  • Processing 27%
  • Stable Isotope 18%

• Resource Center for Stable Isotope-Resolved Metabolomics

  Higashi, R., Fan, W., Lane, A. & Moseley, H.

  National Institute Diabetes & Digestive & Kidney

  9/11/13 → 8/31/16

  Project: Research project

  • Metabolomics 100%
  • Motivation 36%
  • Sample 36%
  • Processing 27%
  • Stable Isotope 18%

• Resource Center for Stable Isotope-Resolved Metabolomics

  Higashi, R., Fan, W., Lane, A. & Moseley, H.

  National Institute Diabetes & Digestive & Kidney

  9/11/13 → 2/28/21

  Project: Research project

  • Metabolomics 100%
  • Motivation 36%
  • Sample 36%
  • Processing 27%
  • Stable Isotope 18%

• Role for RitGTPAses Signaling in Forebrain Neurogenesis Following Traumatic Brain Injury

  Andres, D. & Saatman, K.

  KY Spinal Cord and Head Injury Research Trust

  1/15/13 → 1/15/17

  Project: Research project

  • Neurogenesis 100%
  • Neuron 88%
  • Brain Injury 33%
  • In Vitro 33%
  • Nerve Cell Differentiation 22%

• Role of Hydrogen Sulfide in Mitochondrial Remodeling and Myocardial Energetics

  Veeranki, S.

  7/1/18 → 6/30/20

  Project: Research project

  • Density 100%
  • Aerobic Exercise 75%
  • Energy Transfer 75%
  • Crista 75%
  • Regulatory Mechanism 75%

• Role of Hydrogen Sulfide in Mitochondrial Remodeling and Myocardial Energetics

  Veeranki, S.

  7/1/18 → 6/30/19

  Project: Research project

  • Density 100%
  • Aerobic Exercise 75%
  • Energy Transfer 75%
  • Crista 75%
  • Regulatory Mechanism 75%

• Role of IKKB in obesity and atherosclerosis

  Zhou, C., Charnigo, R. & Kern, P.

  National Heart Lung and Blood Institute

  4/1/16 → 7/31/19

  Project: Research project

  • Atherosclerosis 100%
  • Adipocyte 75%
  • Water-Electrolyte Imbalance 50%
  • Obesity 50%
  • Overnutrition 37%

• Role of oligomeric amylin in impairing cardiac energy substrate metabolism

  Despa, F.

  American Heart Association

  7/1/13 → 11/30/15

  Project: Research project

  • Amylin 100%
  • Heart 50%
  • Rat 31%
  • Sarcolemma 25%
  • CD36 18%

• Role of Oligomerized Amylin in Vascular Injury and Alzheimer's Disease

  Despa, F. & Nelson, P.

  Alzheimers Association

  10/1/15 → 3/31/19

  Project: Research project

  • Amylin 100%
  • Brain 36%
  • Diabetes 31%
  • Alzheimer's Disease 21%
  • Brain Blood Vessel 21%

• Role of RFT1 in Dolichol-linked Oligosaccharide Assembly in Human Fibroblasts

  Rush, J.

  4/1/15 → 3/31/17

  Project: Research project

  • Dolichol 100%
  • Oligosaccharide 95%
  • Synthesis 33%
  • Mannose 23%
  • Glycosylation 19%

• Role of Systemic Amylin Dyshomeostasis in Alzheimer's Disease

  Despa, F., Despa, S. & Nelson, P.

  National Institute on Aging

  9/15/16 → 11/30/22

  Project: Research project

  • Amylin 100%
  • Brain 23%
  • Amyloid 17%
  • Rat 17%
  • Rodent 17%

• Roles for Lymphocyte RANKL in Periodontal Complications of type 2 Diabetes

  Nikolajczyk, B.

  National Institute of Dental Research

  7/1/16 → 6/30/19

  Project: Research project

  • Maturity Onset Diabetes of the Young 100%
  • Periodontitis 61%
  • Osteoclast Differentiation Factor 33%
  • RANKL 33%
  • B Cell 28%

• Roles for Lymphocyte RANKL in Periodontal Complications of Type 2 Diabetes

  Nikolajczyk, B.

  National Institute of Dental Research

  7/1/16 → 6/30/20

  Project: Research project

  • Maturity Onset Diabetes of the Young 100%
  • Periodontitis 61%
  • Osteoclast Differentiation Factor 33%
  • RANKL 33%
  • B Cell 28%

• Ryan White Part C: Outpatient Early Intervention Services to HIV Positive Persons 2015-2017

  Thornton, A., Cary, L., Forster, D., Huaman Joo, M., Karki Maskey, M., Leedy, N., Murphy, B., Myint, T., Romanelli, F., Schaninger, T., Hoellein, A. & Mullen, N.

  Health Resources and Services Administration

  4/1/15 → 3/31/16

  Project: Research project

  • Patient 100%
  • Hospital 64%
  • Person 30%
  • Human Immunodeficiency Virus 20%
  • Outpatient 10%

• Ryan White Part C: Outpatient Early Intervention Services to HIV Positive Persons 2015-2017

  Thornton, A., Fanucchi, L., Forster, D., Holleman, D., Karki Maskey, M., Leedy, N., Murphy, B., Myint, T., Romanelli, F. & Schaninger, T.

  Health Resources and Services Administration

  9/30/01 → 3/31/18

  Project: Research project

  • Patient 100%
  • Hospital 64%
  • Person 30%
  • Human Immunodeficiency Virus 20%
  • Outpatient 10%

• Ryan White Part C: Outpatient Early Intervention Services to HIV Positive Persons 2015-2017

  Thornton, A., Forster, D., Karki Maskey, M., Leedy, N., Murphy, B., Myint, T., Romanelli, F., Schaninger, T., Cary, L., Hoellein, A., Huaman Joo, M., Mullen, N. & Relyea Ashley, H.

  Health Resources and Services Administration

  9/30/01 → 3/31/17

  Project: Research project

  • Patient 100%
  • Hospital 64%
  • Person 30%
  • Human Immunodeficiency Virus 20%
  • Outpatient 10%

• Saxagliptin to prevent coronary artery stiffness with HFpEF

  Fleenor, B.

  8/4/15 → 7/30/16

  Project: Research project

• SBIR: Dose-Ranging Safety and Efficacy Studies to Advance Novel Mechanism-of-Action Drug Candidates to Reverse Age-Related Muscle Degeneration

  Fry, C.

  Ridgeline Therapeutics

  7/1/19 → 3/31/21

  Project: Research project

• SBIR: System for Automated Noninvasive Monitoring of Mouse Sleep and Behavior

  Sunderam, S.

  Signal Solutions LLC

  8/1/15 → 4/30/18

  Project: Research project

• SBIR Phase 1: Novel flavonoids as anti-inflammatory agents in alcoholism

  Littleton, J.

  9/5/14 → 6/30/16

  Project: Research project

• SBIR Phase II: Selection-Driven Plant Metabolites for Treatment of CNS Diseases

  Gerhardt, G.

  Naprogenix

  9/10/13 → 6/30/16

  Project: Research project

• SCH: INT: Collaborative Research: "RehabBuddy" Extending Individualized Physical Rehabilitation Beyond the Clinic Using Wearable Technology to Empower Patients

  Uhl, T.

  National Science Foundation

  8/15/19 → 7/31/22

  Project: Research project

  • Patient 100%
  • Exercise 57%
  • Feedback System 28%
  • Rehabilitation Engineering 21%
  • Time 14%