Kentucky Tobacco Research and Development Center (KTRDC)

2025

Harnessing the spatial and transcriptional regulation of monoterpenoid indole alkaloid metabolism in Alstonia scholaris leads to the identification of broad geissoschizine cyclase activities

Méteignier, L. V., Szwarc, S., Barunava, P., Durand, M., Zamar, D. L., Birer Williams, C., Gautron, N., Dutilleul, C., Koudounas, K., Lezin, E., Perrot, T., Oudin, A., Pateyron, S., Delannoy, E., Brunaud, V., Lanoue, A., Abbasi, B. H., St-Pierre, B., Jensen, M. K. & Papon, N. & 6 others, Sun, C., Le Pogam, P., Yuan, L., Beniddir, M. A., Besseau, S. & Courdavault, V., Feb 2025, In: Plant Physiology and Biochemistry. 219, 109363.

Research output: Contribution to journal › Article › peer-review

Open Access

2024

A Cotyledon-based Virus-Induced Gene Silencing (Cotyledon-VIGS) approach to study specialized metabolism in medicinal plants

Liu, Y., Lyu, R., Singleton, J. J., Patra, B., Pattanaik, S. & Yuan, L., Dec 2024, In: Plant Methods. 20, 1, 26.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

A cytosine analogue 5-azacitidine improves the accumulation of licochalcone A in licorice Glycyrrhiza inflata

Ma, X., Jiang, N., Fu, J., Li, Y., Zhou, L., Yuan, L., Wang, Y. & Li, Y., Jan 2024, In: Journal of Plant Physiology. 292, 154145.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Improving digestibility of sorghum proteins by CRISPR/Cas9-based genome editing

Li, X., Liu, W., Wang, G., Sun, S. S. M., Yuan, L. & Wang, J., Jan 1 2024, In: Food and Energy Security. 13, 1, e506.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Integrated metabolomic and transcriptomic analysis provides insights into the flavonoid formation in different Glycyrrhiza species

Li, Y., Xie, Z., Huang, Y., Zeng, J., Yang, C., Yuan, L., Wang, Y. & Li, Y., Feb 2024, In: Industrial Crops and Products. 208, 117796.

Research output: Contribution to journal › Article › peer-review

4 Citations (SciVal)

2023

B-BOX-DOMAIN PROTEIN32 modulates seed oil biosynthesis in Arabidopsis by interacting with WRINKLED1

Lim, A. R. Q., Kong, Q., Noor, A., Song, Y. Q., Pattanaik, S., Yuan, L. & Ma, W., Jul 19 2023, (E-pub ahead of print) In: Plant Physiology.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Cellular dynamics of coenocytic endosperm development in Arabidopsis thaliana

Ali, M. F., Shin, J. M., Fatema, U., Kurihara, D., Berger, F., Yuan, L. & Kawashima, T., Feb 2023, In: Nature Plants. 9, 2, p. 330-342 13 p.

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Evaluation of the 1R6F certified reference cigarette for proficiency testing of mainstream smoke parameters

Slone, S., McNees, C. R., Craft, M., Ji, H., Shearer, A., Shelton, B., Yuan, L. & Chambers, O., Apr 2023, In: Accreditation and Quality Assurance. 28, 2, p. 69-76 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Genome-Wide Identification of SnRK1 Catalytic α Subunit and FLZ Proteins in Glycyrrhiza inflata Bat. Highlights Their Potential Roles in Licorice Growth and Abiotic Stress Responses

Yang, C., Shi, G., Li, Y., Luo, M., Wang, H., Wang, J., Yuan, L., Wang, Y. & Li, Y., Jan 2023, In: International Journal of Molecular Sciences. 24, 1, 121.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

Histone Deacetylase GiSRT2 Negatively Regulates Flavonoid Biosynthesis in Glycyrrhiza inflata

Zeng, J., Huang, Y., Zhou, L., Liang, X., Yang, C., Wang, H., Yuan, L., Wang, Y. & Li, Y., Jun 2023, In: Cells. 12, 11, 1501.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Integrated metabolic and transcriptional analysis reveals the role of carotenoid cleavage dioxygenase 4 (IbCCD4) in carotenoid accumulation in sweetpotato tuberous roots

Zhang, J., He, L., Dong, J., Zhao, C., Wang, Y., Tang, R., Wang, W., Ji, Z., Cao, Q., Xie, H., Wu, Z., Li, R., Yuan, L. & Jia, X., Dec 2023, In: Biotechnology for Biofuels and Bioproducts. 16, 1, 45.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

Multi-omics reveal key enzymes involved in the formation of phenylpropanoid glucosides in Artemisia annua

Yin, Q., Wu, T., Gao, R., Wu, L., Shi, Y., Wang, X., Wang, M., Xu, Z., Zhao, Y., Su, X., Su, Y., Han, X., Yuan, L., Xiang, L. & Chen, S., Aug 2023, In: Plant Physiology and Biochemistry. 201, 107795.

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

MYB30 and MYB14 form a repressor-activator module with WRKY8 that controls stilbene biosynthesis in grapevine

Mu, H., Li, Y., Yuan, L., Jiang, J., Wei, Y., Duan, W., Fan, P., Li, S., Liang, Z. & Wang, L., Jan 2023, In: Plant Cell. 35, 1, p. 552-573 22 p.

Research output: Contribution to journal › Article › peer-review

Open Access

26 Citations (SciVal)

Partial desensitization of MYC2 transcription factor alters the interaction with jasmonate signaling components and affects specialized metabolism

Hou, X., Singh, S. K., Werkman, J. R., Liu, Y., Yuan, Q., Wu, X., Patra, B., Sui, X., Lyu, R., Wang, B., Liu, X., Li, Y., Ma, W., Pattanaik, S. & Yuan, L., Dec 1 2023, In: International Journal of Biological Macromolecules. 252, 126472.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

Sweet potato ADP-glucose pyrophosphorylase small subunit affects vegetative growth, starch content and storage root yield

Fan, W., Wang, Y., Zhang, L., Fang, Y., Yan, M., Yuan, L., Yang, J. & Wang, H., Jul 2023, In: Plant Physiology and Biochemistry. 200, 107796.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

The class B heat shock factor HSFB1 regulates heat tolerance in grapevine

Chen, H., Liu, X., Li, S., Yuan, L., Mu, H., Wang, Y., Li, Y., Duan, W., Fan, P., Liang, Z. & Wang, L., Mar 1 2023, In: Horticulture Research. 10, 3, uhad001.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

The transcription factor GhTCP7 suppresses petal expansion by interacting with the WIP-type zinc finger protein GhWIP2 in Gerbera hybrida

Ren, G., Li, L., Patra, B., Li, N., Zhou, Y., Zhong, C., Wang, Y., Yuan, L. & Wang, X., Aug 3 2023, In: Journal of Experimental Botany. 74, 14, p. 4093-4109 17 p.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Transcription factor bZIP52 modulates Arabidopsis seed oil biosynthesis through interaction with WRINKLED1

Yang, Y., Kong, Q., Tee, W. T., Li, Y., Low, P. M., Patra, B., Guo, L., Yuan, L. & Ma, W., Aug 3 2023, In: Plant Physiology. 192, 4, p. 2628-2639 12 p.

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

VvBBX44 and VvMYBA1 form a regulatory feedback loop to balance anthocyanin biosynthesis in grape

Liu, W., Mu, H., Yuan, L., Li, Y., Li, Y., Li, S., Ren, C., Duan, W., Fan, P., Dai, Z., Zhou, Y., Liang, Z., Li, S. & Wang, L., Oct 1 2023, In: Horticulture Research. 10, 10, uhad176.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

2022

Allele-aware chromosome-level genome assembly of Artemisia annua reveals the correlation between ADS expansion and artemisinin yield

Liao, B., Shen, X., Xiang, L., Guo, S., Chen, S., Meng, Y., Liang, Y., Ding, D., Bai, J., Zhang, D., Czechowski, T., Li, Y., Yao, H., Ma, T., Howard, C., Sun, C., Liu, H., Liu, J., Pei, J. & Gao, J. & 10 others, Wang, J., Qiu, X., Huang, Z., Li, H., Yuan, L., Wei, J., Graham, I., Xu, J., Zhang, B. & Chen, S., Aug 1 2022, In: Molecular Plant. 15, 8, p. 1310-1328 19 p.

Research output: Contribution to journal › Article › peer-review

Open Access

57 Scopus citations

Functional Antagonism of WRI1 and TCP20 Modulates GH3.3 Expression to Maintain Auxin Homeostasis in Roots

Kong, Q., Low, P. M., Lim, A. R. Q., Yang, Y., Yuan, L. & Ma, W., Feb 1 2022, In: Plants. 11, 3, 454.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

Identification and Characterization of Transcription Factors Regulating Terpenoid Indole Alkaloid Biosynthesis in Catharanthus roseus

Singh, S. K., Patra, B., Singleton, J. J., Liu, Y., Paul, P., Sui, X., Suttipanta, N., Pattanaik, S. & Yuan, L., 2022, In: Methods in Molecular Biology. 2505, p. 203-221 19 p.

Research output: Contribution to journal › Article › peer-review

Metabolic engineering to enhance the accumulation of bioactive flavonoids licochalcone A and echinatin in Glycyrrhiza inflata (Licorice) hairy roots

Wu, Z., Singh, S. K., Lyu, R., Pattanaik, S., Wang, Y., Li, Y., Yuan, L. & Liu, Y., 2022, In: Frontiers in Plant Science. 13, p. 932594

Research output: Contribution to journal › Article › peer-review

Metabolic engineering to enhance the accumulation of bioactive flavonoids licochalcone A and echinatin in Glycyrrhiza inflata (Licorice) hairy roots

Wu, Z., Singh, S. K., Lyu, R., Pattanaik, S., Wang, Y., Li, Y., Yuan, L. & Liu, Y., Aug 18 2022, In: Frontiers in Plant Science. 13, 932594.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

Sunflower WRINKLED1 Plays a Key Role in Transcriptional Regulation of Oil Biosynthesis

Lim, A. R. Q., Kong, Q., Singh, S. K., Guo, L., Yuan, L. & Ma, W., Mar 1 2022, In: International Journal of Molecular Sciences. 23, 6, 3054.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

Virus-Induced Gene Silencing as a Tool to Study Regulation of Alkaloid Biosynthesis in Medicinal Plants

Patra, B., Liu, Y., Singleton, J. J., Singh, S. K., Pattanaik, S. & Yuan, L., 2022, In: Methods in Molecular Biology. 2469, p. 155-164 10 p.

Research output: Contribution to journal › Article › peer-review

2021

A transcriptional hub integrating gibberellin-brassinosteroid signals to promote seed germination in Arabidopsis

Zhong, C., Patra, B., Tang, Y., Li, X., Yuan, L. & Wang, X., Jun 22 2021, In: Journal of Experimental Botany. 72, 13, p. 4708-4720 13 p.

Research output: Contribution to journal › Article › peer-review

A transcriptional hub integrating gibberellin-brassinosteroid signals to promote seed germination in Arabidopsis

Zhong, C., Patra, B., Tang, Y., Li, X., Yuan, L. & Wang, X., Jun 22 2021, In: Journal of Experimental Botany. 72, 13, p. 4708-4720 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

25 Scopus citations

BHLH IRIDOID SYNTHESIS 3 Is a Member of a bHLH Gene Cluster Regulating Terpenoid Indole Alkaloid Biosynthesis in Catharanthus roseus

Singh, S. K., Patra, B., Paul, P., Liu, Y., Pattanaik, S. & Yuan, L., Jan 25 2021, In: Plant Direct. 5, 1, p. e00305 e00305.

Research output: Contribution to journal › Article › peer-review

Open Access

File

32 Scopus citations

Dynamic network biomarker analysis discovers IbNAC083 in the initiation and regulation of sweet potato root tuberization

He, S., Wang, H., Hao, X., Wu, Y., Bian, X., Yin, M., Zhang, Y., Fan, W., Dai, H., Yuan, L., Zhang, P. & Chen, L., Nov 2021, In: Plant Journal. 108, 3, p. 793-813 21 p.

Research output: Contribution to journal › Article › peer-review

Open Access

32 Scopus citations

Genome-Wide Analysis of Light-Regulated Alternative Splicing in Artemisia annua L.

Ma, T., Gao, H., Zhang, D., Sun, W., Yin, Q., Wu, L., Zhang, T., Xu, Z., Wei, J., Su, Y., Shi, Y., Ding, D., Yuan, L., Dong, G., Leng, L., Xiang, L. & Chen, S., Sep 29 2021, In: Frontiers in Plant Science. 12, 733505.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

NIC1 cloning and gene editing generates low-nicotine tobacco plants

Qin, Q., Humphry, M., Gilles, T., Fisher, A., Patra, B., Singh, S. K., Li, D. & Yang, S., Nov 2021, In: Plant Biotechnology Journal. 19, 11, p. 2150-2152 3 p.

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Protein phosphatase NtPP2C2b and MAP kinase NtMPK4 act in concert to modulate nicotine biosynthesis

Liu, X., Singh, S. K., Patra, B., Liu, Y., Wang, B., Wang, J., Pattanaik, S. & Yuan, L., Feb 27 2021, In: Journal of Experimental Botany. 72, 5, p. 1661-1676 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

Protein phosphatase NtPP2C2b and MAP kinase NtMPK4 act in concert to modulate nicotine biosynthesis

Liu, X., Singh, S. K., Patra, B., Liu, Y., Wang, B., Wang, J., Pattanaik, S. & Yuan, L., Feb 27 2021, In: Journal of Experimental Botany. 72, 5, p. 1661-1676 16 p.

Research output: Contribution to journal › Article › peer-review

Spatio-temporal selection of reference genes in the two congeneric species of Glycyrrhiza

Li, Y., Liang, X., Zhou, X., An, Y., Li, M., Yuan, L., Li, Y. & Wang, Y., Dec 2021, In: Scientific Reports. 11, 1, 1122.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

The H⁺-pyrophosphatase IbVP1 regulates carbon flux to influence the starch metabolism and yield of sweet potato

Fan, W., Zhang, Y., Wu, Y., Zhou, W., Yang, J., Yuan, L., Zhang, P. & Wang, H., Dec 2021, In: Horticulture Research. 8, 1, 20.

Research output: Contribution to journal › Article › peer-review

Open Access

24 Scopus citations

The Pumilio RNA-binding protein APUM24 regulates seed maturation by fine-tuning the BPM-WRI1 module in Arabidopsis

Huang, R., Liu, M., Gong, G., Wu, P., Patra, B., Yuan, L., Qin, H., Wang, X., Wang, G., Liao, H., Gao, L., Yang, C., Li, H. & Zhang, S., Jul 2021, In: Journal of Integrative Plant Biology. 63, 7, p. 1240-1259 20 p.

Research output: Contribution to journal › Article › peer-review

The Pumilio RNA-binding protein APUM24 regulates seed maturation by fine-tuning the BPM-WRI1 module in Arabidopsis

Huang, R., Liu, M., Gong, G., Wu, P., Patra, B., Yuan, L., Qin, H., Wang, X., Wang, G., Liao, H., Gao, L., Yang, C., Li, H. & Zhang, S., Jul 2021, In: Journal of Integrative Plant Biology. 63, 7, p. 1240-1259 20 p.

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

2020

Genome-wide analysis of glycerol-3-phosphate O-acyltransferase gene family and functional characterization of two cutin group GPATs in Brassica napus

Wang, J., Singh, S. K., Geng, S., Zhang, S. & Yuan, L., Apr 1 2020, In: Planta. 251, 4, 93.

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Maleic hydrazide elicits global transcriptomic changes in chemically topped tobacco to influence shoot bud development

Singh, S. K., Richmond, M. D., Pearce, R. C., Bailey, W. A., Hou, X., Pattanaik, S. & Yuan, L., Sep 24 2020, In: Planta. 252, 4, p. 64

Research output: Contribution to journal › Article › peer-review

Maleic hydrazide elicits global transcriptomic changes in chemically topped tobacco to influence shoot bud development

Singh, S. K., Richmond, M. D., Pearce, R. C., Bailey, W. A., Hou, X., Pattanaik, S. & Yuan, L., Oct 1 2020, In: Planta. 252, 4, 64.

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Mutually Regulated AP2/ERF Gene Clusters Modulate Biosynthesis of Specialized Metabolites in Plants

Paul, P., Singh, S. K., Patra, B., Liu, X., Pattanaik, S. & Yuan, L., Feb 2020, In: Plant Physiology. 182, 2, p. 840-856 17 p.

Research output: Contribution to journal › Article › peer-review

Mutually regulated AP2/ERF gene clusters modulate biosynthesis of specialized metabolites in PlantS^1[open]

Paul, P., Singh, S. K., Patra, B., Liu, X., Pattanaik, S. & Yuan, L., Feb 2020, In: Plant Physiology. 182, 2, p. 840-856 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

61 Scopus citations

Reference gene selection for transcriptional profiling in Cryptocercus punctulatus, an evolutionary link between Isoptera and Blattodea

Li, Z., Li, X., Zhang, Q., Yuan, L. & Zhou, X., Dec 2020, In: Scientific Reports. 10, 1, 22169.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Revisiting the ORCA gene cluster that regulates terpenoid indole alkaloid biosynthesis in Catharanthus roseus

Singh, S. K., Patra, B., Paul, P., Liu, Y., Pattanaik, S. & Yuan, L., Apr 2020, In: Plant Science. 293, p. 110408

Research output: Contribution to journal › Article › peer-review

Revisiting the ORCA gene cluster that regulates terpenoid indole alkaloid biosynthesis in Catharanthus roseus

Singh, S. K., Patra, B., Paul, P., Liu, Y., Pattanaik, S. & Yuan, L., Apr 2020, In: Plant Science. 293, 110408.

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Selection of reference genes for qrt-pcr analysis in medicinal plant glycyrrhiza under abiotic stresses and hormonal treatments

Li, Y., Liang, X., Zhou, X., Wu, Z., Yuan, L., Wang, Y. & Li, Y., Nov 2020, In: Plants. 9, 11, p. 1-20 20 p., 1441.

Research output: Contribution to journal › Article › peer-review

Open Access

24 Scopus citations

TEOSINTE BRANCHED1/CYCLOIDEA/PROLIFERATING CELL FACTOR4 Interacts with WRINKLED1 to Mediate Seed Oil Biosynthesis

Kong, Q., Singh, S. K., Mantyla, J. J., Pattanaik, S., Guo, L., Yuan, L., Benning, C. & Ma, W., Oct 2020, In: Plant Physiology. 184, 2, p. 658-665 8 p.

Research output: Contribution to journal › Article › peer-review

Teosinte branched1/cycloidea/ proliferating cell factor4 interacts with wrinkled1 to mediate seed oil biosynthesis

Kong, Q., Singh, S. K., Mantyla, J. J., Pattanaik, S., Guo, L., Yuan, L., Benning, C. & Ma, W., Oct 2020, In: Plant Physiology. 184, 2, p. 658-665 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

31 Scopus citations

The function of the WRI1-TCP4 regulatory module in lipid biosynthesis

Kong, Q., Yang, Y., Low, P. M., Guo, L., Yuan, L. & Ma, W., Nov 1 2020, In: Plant Signaling and Behavior. 15, 11, 1812878.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

Kentucky Tobacco Research and Development Center (KTRDC)

Research output

Search results