Markey Cancer Center / Cancer Research Priority Initiative

National Institute on Drug Abuse

9/1/23 → 8/31/28

Project: Research project

The University of Kentucky Racial Equity Initiative Coordinating Center

Stevens-Watkins, D., Adatorwovor, R., Canedo, J., Francis, D., Hargons, C., Knudsen, H., Oser, C., Stoops, W., Vickers-Smith, R. & Wolf, B. G.

8/15/23 → 6/30/28

Project: Research project

23-BRE-56-AZ (D8531C00002): A Phase III, Open-Label, Randomised Study to Assess the Efficacy and Safety of Extended Therapy With Camizestrant Versus Standard Endocrine Therapy (Aromatase Inhibitor or Tamoxifen) in Patients With ER+/HER2- Early Breast Can

Moss, J.

NSABP Foundation

8/4/23 → 8/4/25

Project: Research project

Pathways, a Hope-Based Intervention to Support Personal Goal Pursuit, Mental Health, and Quality of Life during Advanced Lung Cancer Treatment

McLouth, L., Arnold, S., Burris, J., McFarlin, J., Shelton, B. & Stapleton, J.

Lisata Therapeutics Incorporated

7/25/23 → 6/30/28

Project: Research project

23-NHL-30-OP (ONO-4059-09): An Open-label Phase II Study to Investigate the Efficacy, Safety, and Pharmacokinetics of Tirabrutinib in Patients with Primary Central Nervous System Lymphoma (PCNSL)

Munker, R.

Ono Pharmaceutical

7/24/23 → 7/24/25

Project: Research project

23-MULTI-59-LTI(LTSA1-P02): A Phase 2a, Double-blind, Placebo-controlled, Multi-center, Randomized Study Evaluating LSTA1 When Added to Standard of Care (SoC) Versus Standard of Care Alone in Subjects with Advanced Solid Tumors (BOLSTER)

Arnold, S.

7/18/23 → 7/18/25

Project: Research project

23-LUN-132-RBI-PMC: Phase 1b Single Arm, Open-Label Trial of RYZ101 in Combination with Carboplatin + Etoposide + Atezolizumab in Subjects with Somatostatin Receptor Expressing (SSTR+) Extensive Stage Small Cell Lung Cancer (ES-SCLC)

Hao, Z.

RayzeBio Incorporated

7/18/23 → 7/18/25

Project: Research project

Empathic Communication Skills Training to Reduce Lung Cancer Stigma

Mullett, T. & Burris, J.

Memorial Sloan Kettering Cancer Center

7/14/23 → 7/14/28

Project: Research project

23-LUN-133-LB-PMC: LB2102-1001, A First in Human Dose Escalation and Cohort Expansion Study of DLL3-directed Chimeric Antigen Receptor T-cells in Subjects With Extensive Stage Small Cell Lung Cancer

Hao, Z.

Legend Biotech USA Incorporated

7/10/23 → 7/10/25

Project: Research project

Evaluating Coverage and Cost of Care Links (C4299): FY24 Evaluating CC Links

Edward, J., D'Orazio, J., Northrip, K. & Shelton, B.

KY Cabinet for Health and Family Services

7/1/23 → 6/30/25

Project: Research project

Summer Health Experience (SHE) in Oncology Program

Vanderford, N.

American Lung Association

7/1/23 → 12/31/23

Project: Research project

Targeting Lung Fibrosis with Epigenetic Therapy

Brainson, C., Bachert, S. & Liu, J.

7/1/23 → 6/30/25

Project: Research project

FY24 Spatial Transcriptomic Characterization of Pediatric Brain Tumors in Kentucky

Wang, C., Durbin, E. B., Harrison, D., Jeong, J. C., Liu, J., Neltner, J., Tucker, T., Villano, J. & Zhang, S.

KY Cabinet for Health and Family Services

7/1/23 → 6/30/24

Project: Research project

Targeting the Plk1/Pdcd4/mTORC2 Signaling to Treat Castration-Resistant Prostate Cancer

Liu, X., Allison, D., Chen, L. & Yang, H.

7/1/23 → 6/30/28

Project: Research project

Targeting the Plk1/Pdcd4/mTORC2 Signaling to Treat Castration-Resistant Prostate Cancer

Yang, H., Allison, D., Chen, L. & Liu, X.

7/1/23 → 6/30/28

Project: Research project

Roles of mRNA Transfer in Cancer Cell-Platelet Communication

Xu, R., Liu, X. & Trinkle, C.

Markey Cancer Center Foundation

7/1/23 → 6/30/28

Project: Research project

Overcoming Therapeutic Resistance in Lung Cancer Using Novel Combination Therapies

Brainson, C. & Liu, J.

7/1/23 → 7/31/24

Project: Research project

Developing New Therapies for Metatsic Melanoma

Plattner, R., Goellner, E., Liu, J. & Richards, D.

Markey Cancer Center Foundation

7/1/23 → 7/31/24

Project: Research project

Health Equity in Fertility Specialty Care Among Cancer Survivors (00015476)

Saltzman, A. & Durbin, E. B.

MD Anderson Cancer Center

6/28/23 → 12/31/27

Project: Research project

23-LEUK-22-GS: GS-US-546-5857, Enhance-2_A Phase 3, Randomized, Open-Label Study Evaluating the Safety and Efficacy of Magrolimab in Combination with Azacitidine versus Physician s Choice of Venetoclax in Combination with Azacitidine or Intensive Chemothe

Qasrawi, A.

Gilead Sciences Inc

6/27/23 → 6/27/25

Project: Research project

23-NHL-29-DO: MK2140-003, A Phase 2/3 Multicenter, Open-label, Randomized, Active-Control Study of Zilovertamab Vedotin (MK-2140) in Combination With Standard of Care in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma (waveLINE-003)

Iragavarapu, C.

Viewpoint Molecular Targeting Incorporated

6/26/23 → 6/26/25

Project: Research project

23-NET-01-VMT-PMC(VMT-alpha-NET-T101): A Phase I/IIa First-in-Human Study of [212Pb]VMT-alpha-NET Targeted Alpha-Particle Therapy for Advanced SSTR2 Positive Neuroendocrine Tumors

Anthony, L.

6/22/23 → 6/22/25

Project: Research project

Center for Appalachian Research in Environmental Sciences: Administrative Core

Hahn, E., Arnett, D., Bauer, J., Cassis, L., Christian, J., Cox, N., Curry, T., DiPaola, R., Dignan, M., Evers, B. M., Fan, W., Haynes, E., Hoover, A., Kern, P., May, B., Miller, J., Pearson, K., Pennell, K., Richardson, K., Sanderson, W., Schoenberg, N., Stanifer, S., Stanley, S., Stratton, T., Stromberg, A., Swanson, H., Talbert, J., Unrine, J. & Heath, E.

National Institute of Environmental Health Sciences

6/3/23 → 4/30/28

Project: Research project

Study Of PTPRF-Mediated Regulation Of Wnt Signaling

Gao, T., Barrett, T. & Wang, C.

6/1/23 → 3/31/27

Project: Research project

22-HN-37-MSD (689-07): A Phase III, Randomized, Open-label Study to Evaluate Pembrolizumab as Neoadjuvant Therapy and in Combination With Standard of Care as Adjuvant Therapy for Stage III-IVA Resectable Locoregionally Advanced Head and Neck Squamous Cell

Arnold, S.

5/11/23 → 5/10/25

Project: Research project

Surveillance, Epidemiology, and End Results (SEER) Program

Durbin, E. B., Huang, B., Shelton, B., Tucker, T. & Ross, F.

National Institute on Aging

5/1/23 → 4/30/24

Project: Research project

22-GI-130-BG-PMC (LAG-3): A Phase 1b/2, Randomized, Open-Label Study Investigating the Efficacy and Safety of LBL-007 Plus Tislelizumab in Combination With Bevacizumab Plus Capecitabine Versus Bevacizumab Plus Capecitabine as Maintenance Therapy in Patien

Nutalapati, S.

BeiGene USA Incorporated

4/26/23 → 4/25/25

Project: Research project

22-GI-129-EI: XL092-303, A Randomized Open-Label Phase 3 Study of XL092 + Atezolizumab vs Regorafenib in Subjects with Metastatic Colorectal Cancer

Patel, R.

Exelixis Inc.

3/29/23 → 3/28/25

Project: Research project

Risk Stratified Survivorship Care Pathways For Early-Onset Colorectal Cancer

Huang, B. & Durbin, E. B.

University of Michigan

3/21/23 → 2/29/28

Project: Research project

22-NHL-28-KP-PMC: A Phase 3 Randomized, Open-Label, Multicenter Study Evaluating the Efficacy of Axicabtagene Ciloleucel Versus Standard of Care Therapy in Subjects with Relapsed/Refractory Follicular Lymphoma, ZUMA-22

Iragavarapu, C.

Kite Pharma Incorporated

3/6/23 → 12/5/23

Project: Research project

Role of P4HA1 in Endocrine Resistance of Breast Cancer

Xiong, G. & Wang, C.

3/1/23 → 2/28/25

Project: Research project

22-MULTI-56-IB-PMC (IDE397) An Open Label, Phase 1, Treatment Study to Evaluate the Safety, Pharmacokinetics and Pharmacodynamics of IDE397 (MAT2A Inhibitor) In Adult Participants with Advanced Solid Tumors

Villano, J.

IDEAYA Biosciences

2/8/23 → 1/8/24

Project: Research project

22-BRE-55-CI A Phase 3, Open-Label, Randomized, Two-Part Study Comparing Gedatolisib in Combination with Palbociclib and Fulvestrant to Standard-of-Care Therapies in Patients with HR-Positive, HER2-Negative Advanced Breast Cancer Previously Treated with

Chambers, M.

Celcuity Incorporated

2/7/23 → 11/2/23

Project: Research project

22-LEUK-21-NP (CABL001AUS08): A Phase II Multicenter, Open-Label, Single-Arm Dose Escalation Study of Asciminib Monotherapy in 2nd Line Chronic Phase-Chronic Myelogenous Leukemia (ASC2ESCALATE)

Munker, R.

Novartis (domestic)

2/3/23 → 12/13/23

Project: Research project

Reducing Lung Cancer Risk among Appalachian Women Using Community-Engaged Intervention Research

Thompson, J., Hahn, E., Hull, P., Mullett, T., Schoenberg, N. & Waters, T.

Bristol Myers Squibb Company

2/1/23 → 1/31/25

Project: Research project

MCC-23-LUN-131-BMS: Phase II Study of Induction Platinum Doublet in Combination with Nivolumab Followed by Surgery or Concurrent Chemoradiation in Unresectable Stage IIIA-C Non-Small Cell Lung Cancer (NSCLC)

Zinner, R.

1/23/23 → 1/23/25

Project: Research project

22-HEM-19-MSD: A Phase 3 Randomized Clinical Study of MK-4280A (Coformulated Favezelimab [MK-4280] plus Pembrolizumab [MK-3475]) Versus Physician's Choice Chemotherapy in PD-(L)1-Refractory, Relapsed or Refractory Classical Hodgkin Lymphoma

Munker, R.

1/23/23 → 11/2/23

Project: Research project

22-LUN-130-MSD (MK-7339 -013-03): A Randomized, Double-blind, Placebo-controlled Phase 3 Study of Pembrolizumab (MK-3475) in Combination with Concurrent Chemoradiation Therapy Followed by Pembrolizumab with or without Olaparib (MK-7339), Compared to Conc

Zinner, R.

Kinnate Biopharma Incorporated

1/13/23 → 10/25/23

Project: Research project

22-MULTI-53-KB-PMC : A Phase 1/1b Open-label, Multicenter Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Antitumor Activity of KIN-2787 in Participants with BRAF and/or NRAS Mutation-positive Solid Tumors, KN-8701

Arnold, S.

1/9/23 → 11/30/23

Project: Research project

Key-Opinion-Led Best Practices in Diagnosis and Management of Breast, Lung, and Ovarian Cancers

Mullett, T.

OncoLens

1/1/23 → 12/31/23

Project: Research project

Gold Complexes that Regulate Metabolism and Microbiome to Accelerate Mucosal Healing in IBD

Barrett, T., Alam, M., Awuah, S., Chaiswing, L., Kapur, N., Sullivan, P. & Wang, C.

Crohns and Colitis Foundation of America

1/1/23 → 12/31/23

Project: Research project

Diversity in Cancer Research Supplement: University of Kentucky

O'Connor, K., Adegboyega, A., Awuah, S., Blackburn, J., Brainson, C., Gao, T., Hahn, E., Hull, P., Lee, Y. & Williams, L.

1/1/23 → 12/31/25

Project: Research project

Pilot: CDK9-RNF20-LSD1 Axis in Breast Cancer Metabolic Reprogramming

Wu, Y.

1/1/23 → 12/31/23

Project: Research project

Pilot: Targeting De Novo and Salvage Nucleotide Synthesis with FASN/ATR Inhibition to Enhance Radiation Therapy Reponses

Rychahou, P., Weiss, H. & Zaytseva, Y.

Bristol Myers Squibb Foundation Incorporated

1/1/23 → 12/31/23

Project: Research project

Exploring and Planning Dissemination of the Quality Implementation of Lung Cancer Screening (QUILS) # System from the Kentucky LEADS Collaborative

Knight, J. & Mullett, T.

1/1/23 → 12/31/23

Project: Research project

Institutional Research Grant

O'Connor, K.

1/1/23 → 12/31/25

Project: Research project

Markey STRONG Post-baccalaureate Program

O'Connor, K., Adegboyega, A., Awuah, S., Blackburn, J., Brainson, C., Gao, T. & Williams, L.

1/1/23 → 12/31/25

Project: Research project

Pilot: Role Of Succinate In Regulating Cancer Cell Plasticity And Stemness

Xu, R.