Markey Cancer Center / Cancer Research Priority Initiative

Active

Targeting ABL1/2 And DDR1 Tyrosine Kinases for Treating NRAS-Mutant Melanoma

Plattner, R. (PI), Arays, R. (CoI), Liu, J. (CoI), Richards, D. (CoI) & Wang, C. (CoI)

V Foundation

6/1/25 → 6/1/29

Project: Research project

25-LUN-141-SZB-PMC(ZG006US001): A Phase 1 Dose Escalation Study of the Tolerability, Safety, Efficacy and Pharmacokinetics of ZG006 in Patients with Small Cell Lung Cancer

Hao, Z. (PI)

Courante Oncology LLC

5/23/25 → 5/23/27

Project: Research project

25-NHL-43-JJ-PMC (90014496LYM1001): A Phase 1b Multicenter, Open-label, Study of JNJ-90014496, an Autologous CD19/CD20 Bi-specific CAR-T Cell Therapy in Adult Participants with B-cell Non-Hodgkin Lymphoma

Iragavarapu, C. (PI)

Janssen Research and Development LLC

5/22/25 → 5/22/27

Project: Research project

What is the impact of communication quality on medical decision making and social isolation in long-term care facilities- OVPR Curate Program

Gordon, A. (PI)

University of Kentucky’s Office of the Vice President for Research

5/1/25 → 4/30/26

Project: Other project

Surveillance, Epidemiology, and End Results (SEER) Program

Durbin, E. B. (PI), Huang, B. (CoI), Shelton, B. (CoI), Ross, F. (Former CoI) & Tucker, T. (Former CoI)

National Cancer Institute

5/1/25 → 4/30/26

Project: Research project

25-NHL-44-HR(GO45434): A Phase II, Open-Label, Multicenter Study to Evaluate the Optimization of the Cytokine Release Syndrome Profile for Glofitamab in Combination With Gemcitabine Plus Oxaliplatin in Patients With Relapsed/Refractory Diffuse Large B-Cel

Iragavarapu, C. (PI)

Genentech Inc

4/28/25 → 4/28/27

Project: Research project

24-HEM-21-DP (DCC-3014-02-001): A Phase 2, Open-label, Multicenter Study to Evaluate the Safety, Tolerability, PK, and Efficacy of Vimseltinib in Adults With Active Chronic GVHD After Failure of Prior Systemic Therapy

Yalniz, F. (PI)

Deciphera Pharmaceuticals LLC

4/24/25 → 4/24/27

Project: Research project

24-LEUK-27-DS(AC220-168): Phase 3, Double-Blind, Randomized, Placebo-Controlled Trial Of Quizartinib Administered in Combination With Induction and Consolidation Chemotherapy and Administered as Maintenance Therapy in Adult Patients With Newly Diagnosed F

Qasrawi, A. (PI)

Daiichi Sankyo Incorporated

4/22/25 → 4/22/27

Project: Research project

25-GU-87-JJ (42756493BLC0013): Phase 1/2 Study of Erdafitinib Intravesical Delivery System (TAR-210) in Participants with Non-Muscle-Invasive or Muscle-Invasive Bladder Cancer

Hensley, P. (PI)

Janssen Research and Development LLC

4/21/25 → 4/21/27

Project: Research project

24-HN-42-BT(BCA101X301): A Multicenter, Randomized, Double-blind, Phase 2/3 Study of Ficerafusp Alfa (BCA101) or Placebo in Combination with Pembrolizumab for First-Line Treatment of PD-L1-positive, Recurrent or Metastatic Head and Neck Squamous Cell Carc

Arnold, S. (PI)

Bicara Therapeutics Incorporated

4/21/25 → 4/21/27

Project: Research project

Targeting MNK/GRP78 Pathway to Disrupt Proteostasis Rewiring in Castration-Resistant Prostate Cancer

Li, Z. (PI), Liu, J. (CoI) & Liu, X. (CoI)

Department of Defense

4/15/25 → 4/14/28

Project: Research project

Identification of NNMT as a New Target to Treat Triple-negative Breast Cancer

Zhou, B. (PI), Fan, W.-M. (CoI) & Wang, C. (CoI)

National Cancer Institute

4/7/25 → 3/31/30

Project: Research project

Pathways to Prevention: Exploring Social Determinants of Health in Early Onset Colorectal Cancer

Moore, J. (PI), Bhakta, A. (CoI), Burris, J. (CoI) & Chen, L. (CoI)

National Cancer Institute

4/1/25 → 3/31/27

Project: Research project

Experimental Manipulation of Sleep to Combat Epilepsy (RPA Pilot / Seed Project)

Sunderam, S. (PI) & Bauer, B. (CoI)

University of Kentucky Neuroscience Research Priority Area

3/15/25 → …

Project: Research project

Deoxysphingolipids as intermediates of taxane-induced peripheral neuropathy (RPA Pilot / Seed Projects)

Spassieva, S. (PI)

University of Kentucky Neuroscience Research Priority Area

3/14/25 → …

Project: Research project

24-GU-86-FP (ABLE-32): A Phase 3b, Randomised, Controlled Trial of Nadofaragene Firadenovec vs. Observation in Subjects with Intermediate Risk (IR) Non-Muscle Invasive Bladder Cancer (NMIBC)

Hensley, P. (PI)

Ferring Pharmaceuticals AS

3/4/25 → 3/4/27

Project: Research project

24-MULTI-65-TB-PMC (TORL123-001): A Phase 1, First in Human, Dose-Escalation Study of TORL-1-23 in Participants With Advanced Cancer

Villano, PhD, J. (PI)

Translational Research in Oncology

2/19/25 → 2/19/27

Project: Research project

24-MEL-14-RG (R3767-ONC-22122): A Phase 3 Study of Fixed Dose Combinations of Fianlimab and Cemiplimab Versus Relatlimab and Nivolumab in Participants With Unresectable or Metastatic Melanoma

Arays, R. (PI)

Regeneron Pharmaceuticals

2/7/25 → 2/7/27

Project: Research project

CCSG Pilot: The Cumulative Impact Of Air Pollution On Pediatric Brain Tumor In Kentucky

Lu, T. (PI), Christian, J. (CoI), Durbin, E. B. (CoI), Huang, B. (CoI), Liu, Y. (CoI) & Villano, PhD, J. (CoI)

National Cancer Institute

2/1/25 → 1/31/26

Project: Research project

The cumulative impact of air pollution on pediatric brain tumor in Kentucky (RPA Pilot / Seed Project)

Lu, T. (PI)

University of Kentucky UNITE Research Priority Area

2/1/25 → 1/31/26

Project: Research project

Targeting mitochondria in prostate cancer with novel a Gold (Au)-based therapeutic compound to improve radiation treatment (RPA Pilot / Seed Project)

Chaiswing, L. (PI)

University of Kentucky UNITE Research Priority Area

2/1/25 → 1/31/26

Project: Research project

FY25 Lung Cancer Screening Program Learning Collaborative C5546

Knight, J. (PI) & Mullett, T. (CoI)

KY Cabinet for Health and Family Services

1/28/25 → 6/30/26

Project: Research project

FY26 Lung Cancer Screening Program Learning Collaborative C5546

Knight, J. (PI) & Mullett, T. (CoI)

1/28/25 → 6/30/26

Project: Research project

24-NHL-40-AB (M22-128): A Phase 3, Multicenter, Randomized, Open-Label Study of Epcoritamab Plus Lenalidomide Compared to Rituximab Plus Gemcitabine and Oxaliplatin in Participants with Relapsed or Refractory Diffuse Large B-Cell Lymphoma

Iragavarapu, C. (PI)

AbbVie Incorporated

1/15/25 → 1/15/27

Project: Research project

Targeting PRX4 to sensitize prostate cancer to radiation (Radiation Medicine and Markey Cancer Center Collaborative Bench to Bedside pilot) (RPA Pilot / Seed Project)

Wei, Q. (PI)

University of Kentucky's Markey Cancer Center

1/1/25 → 12/31/25

Project: Research project

Optimizing the MLC-based Spatially Fractionated Radiotherapy (SFRT) Technique: Investigating the Radiobiological Response of Indirect Cell Kill Mechanisms in SFRT Treatment of Large and Bulky Tumors (Radiation Medicine and Markey Cancer Center Collaborative Bench to Bedside pilot) (RPA Pilot / Seed Project)

Pokhrel, D. (PI)

University of Kentucky Markey Cancer Center

1/1/25 → 12/31/25

Project: Research project

Determine How Collagen Lysyl Hydroxylase 2 Drives Metastasis

Guo, H. (PI), Chen, L. (CoI) & Wang, C. (CoI)

American Cancer Society

1/1/25 → 12/31/28

Project: Research project

FY25 Lung Cancer Screening Program Quality Project C5545

Knight, J. (PI), Mullett, T. (CoI) & Shelton, B. (CoI)

KY Cabinet for Health and Family Services

12/20/24 → 6/30/26

Project: Research project

Optimizing Treatment for Human Papillomavirus-Associated Oropharyngeal Cancer in Older Adults

McDowell, J. (PI)

Medical University of South Carolina

12/12/24 → 11/30/29

Project: Research project

24-HN-41-RMI (ASP-1929-381): A Phase 3 Multicenter, Randomized, Double-arm, Open-label Study of ASP-1929 Photoimmunotherapy in Combination With Pembrolizumab Versus Standard of Care in the First-line Treatment of Patients With

Valentino, J. (PI)

Rakuten Medical Incorporated

12/5/24 → 12/5/26

Project: Research project

24-GBM-16-NL (EF-41): A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of Optune (TTFields, 200 kHz) Concomitant with Maintenance Temozolomide and Pembrolizumab Versus Optune Concomitant with Maintenance Temozolomide and Placebo for the Tre

Villano, PhD, J. (PI)

Novocure GmbH

12/4/24 → 12/4/26

Project: Research project

24-LUN-138-BNT-PMC (BNT116-01): First-in-Human, Open label, Phase I Dose Confirmation Trial Evaluating The Safety, Tolerability, and Preliminary Efficacy of BNT116 Alone and in Combinations in Patients With Advanced Non-Small Cell Lung Cancer

Hao, Z. (PI)

BioNTech SE

11/25/24 → 11/25/26

Project: Research project

24-LUN-139-BNT (BNT327-01): A Phase II, Multi-site, Open-label, Parallel Group Trial of BNT327 in Combination with Chemotherapy for Participants with Untreated Extensive-Stage Small-Cell Lung Cancer and Participants with Previously Treated Small-Cell Lung

Hao, Z. (PI)

BioNTech SE

11/25/24 → 11/25/26

Project: Research project

HPV16 E6 Seropositivity and ctHPVDNA for Early Detection of Oropharyngeal Cancer

Kuhs, K. (PI), Bhakta, A. (CoI), Chen, L. (CoI) & Windon, M. (CoI)

Army Medical Research and Development Command

11/15/24 → 11/14/27

Project: Research project

24-LUN-140-DS-PMC (DS3201-330): A Multicenter, Randomized, Open-Label, Phase 1b/2 Trial of Valemetostat Tosylate Plus Pembrolizumab vs Pembrolizumab Alone in Participants with Advanced or Metastatic Non-Small Cell Lung Cancer Whose

Hao, Z. (PI)

Daiichi Sankyo Incorporated

11/12/24 → 11/12/26

Project: Research project

24-NHL-39-FTI-PMC(FT522-101): A Phase 1 Study of FT522 in Combination with Rituximab in Participants with Relapsed/Refractory B-Cell Lymphoma

Iragavarapu, C. (PI)

Fate Therapeutics Incorporated

10/28/24 → 10/28/26

Project: Research project

Developing Therapeutic Poly(caprolactone) Nanoparticles for Endometrial Drug Delivery Applications (Emerging Themes for Research: Nanomedicine and Bioelectronics Research Center) (RPA Pilot / Seed Project)

Givens Rassoolkhani, B. (PI)

University of Kentucky Markey Cancer Center

10/15/24 → 10/15/25

Project: Research project

Developing Therapeutic Poly(caprolactone) Nanoparticles for Endometrial Drug Delivery Applications (Emerging Themes for Research: Nanomedicine and Bioelectronics Research Center) (RPA Pilot / Seed Project)

Givens Rassoolkhani, B. (PI)

10/15/24 → 10/15/25

Project: Research project

SHE (Summer Healthcare Experience) in Oncology

Vanderford, N. (PI)

The University of Chicago

10/1/24 → 8/31/29

Project: Research project

24-GI-135-AZ (D7025C00001): A Phase III, Randomized, Double-Blind, Placebo-Controlled, Multicenter, Global Study of Rilvegostomig in Combination with Chemotherapy as Adjuvant Treatment After Resection of Biliary Tract Cancer with Curative Intent (ARTEMIDE

Patel, R. (PI)

AstraZeneca Pharmaceuticals LP (domestic)

9/26/24 → 9/26/26

Project: Research project

24-LEUK-26-OV (OV-AML-1231): A Multicenter, Open-label, Randomized, Phase 2 Study of Venetoclax and Azacitidine Plus Cusatuzumab Versus Venetoclax and Azacitidine Alone in Newly Diagnosed AML Patients Who Are Not Candidates for Intensive Therapy

Qasrawi, A. (PI)

OncoVerity Incorporated

9/4/24 → 9/4/26

Project: Research project

24-HN-40-MSD (007-00): A Phase 2/3, Adaptive, Randomized, Open-Label, Clinical Study to Evaluate Neoadjuvant and Adjuvant V940 (mRNA-4157) in Combination with Pembrolizumab (MK- 3475) Versus Standard of Care, and Pembrolizumab Monotherapy in Participants

Arnold, S. (PI)

Merck Sharp & Dohme Corporation

9/3/24 → 9/3/26

Project: Research project

Developing New Therapeutic Approaches for BRAFV600E Colorectal Cancer

Zaytseva, Y. (PI), Lee, E. (CoI) & Wang, C. (CoI)

Colorectal Cancer Alliance

9/1/24 → 8/31/26

Project: Research project

Statewide Capacity Building and Quality Implementation of Lung Cancer Screening Utilizing the QUILS System

Knight, J. (PI), Mullett, T. (CoI) & Shelton, B. (CoI)

Bristol Myers Squibb Foundation Incorporated

9/1/24 → 8/31/28

Project: Research project

Use of radioprotector in rectal cancer

Bernard, M. (PI)

University of Nebraska Omaha

9/1/24 → 1/31/27

Project: Research project

Research Triangle Center of Excellence in Regulatory Science and Innovation (CERSI)

Moga, D. (PI), Adatorwovor, R. (CoI), Freeman, P. (CoI), Lei, F. (CoI), Lofwall, M. (CoI) & Slavova, S. (CoI)

University of North Carolina Chapel Hill

9/1/24 → 8/31/25

Project: Research project

24-GI-136-AZ (D9802C0001): A Phase III Multi-center, Open-label, Sponsor-blinded, Randomized Study of AZD0901 Monotherapy Compared with Investigator s Choice of Therapy in Second- or Later-Line Adult Participants with Advanced/Metastatic Gastric or Gastr

Patel, R. (PI)

AstraZeneca Pharmaceuticals LP (domestic)

8/30/24 → 8/30/26

Project: Research project

NCI Collaboration

Burus, J. (PI)

National Cancer Institute

8/23/24 → 8/22/25

Project: Research project

Targeting Lung Fibrosis Using Epigenetic Therapy

Brainson, C. (PI), Allison, D. (CoI), Beswick, E. (CoI), Liu, J. (CoI), Sturgill, J. (CoI), Weiss, H. (CoI) & Waters, C. (Former CoI)

National Heart Lung and Blood Institute

8/15/24 → 7/31/28

Project: Research project

24-LEUK-25-KO-PMC (KO-MEN-007): Phase 1 Study of Venetoclax/Azacitidine or Venetoclax in Combination with Ziftomenib (KO-539) or Standard Induction Cytarabine/Daunorubicin (7+3) Chemotherapy in Combination with Ziftomenib for the Treatment of Patients wit

Qasrawi, A. (PI)

Kura Oncology Incorporated

8/14/24 → 8/14/26

Project: Research project

Markey Cancer Center / Cancer Research Priority Initiative

Grants and Contracts

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