Markey Cancer Center / Cancer Research Priority Initiative

Active

A Randomized, Parallel Group Study to Evaluate the Safety, Pharmacokinetics, and Dose Response of Paltusotine Treatment in Subjects with Carcinoid Syndrome.

Anthony, L. & Chauhan, A.

Crinetics Pharmaceuticals

4/6/22 → 3/8/24

Project: Research project

An Open-label, Randomized, Phase 3 Clinical Trial of IO102-IO103 in Combination With Pembrolizumab Versus Pembrolizumab Alone in Patients With Previously Untreated, Unresectable, or Metastatic (Advanced) Melanoma (IO102-IO103-013 / MK3475-D

Villano, J. & Wang, P.

IO Biotech ApS

4/5/22 → 2/19/24

Project: Research project

Phase 1-2 Study Investigating Safety, Tolerability, Pharmacokinetics and Preliminary Antitumor Activity of Anti-TIM-3 Monoclonal Antibody BGB-A425 in Combination with Anti-PD-1 Monoclonal Antibody Tislelizumab in Patient

Hao, Z.

BeiGene Switzerland GmbH

4/4/22 → 1/29/24

Project: Research project

Methods and Tools for Integrating Pathomics Data into Cancer Registries

Durbin, E. B., Bachert, S., Bocklage, T. & Qasem, S.

Research Foundation of State University of New York

4/1/22 → 3/31/24

Project: Research project

A multicenter, Randomized, Open-label, Blinded Endpoint Evaluation, Phase 3 Study Comparing the Effect of Abelacimab Relative to Apixaban on Venous Thromboembolism (VTE) Recurrence and Bleeding in Patients with Cancer Associated VTE

Villano, J.

Anthos Therapeutics Incorporated

3/23/22 → 2/14/24

Project: Research project

A Phase 3 Randomized Study Comparing Bortezomib, Lenalidomide and Dexamethasone (VRd) Followed by Ciltacabtagene Autoleucel, a Chimeric Antigen Receptor T Cell (CAR-T) Therapy Directed Against BCMA Versus Bortezomib, Lenalidomide, and D

Monohan, G.

Janssen Research and Development LLC

3/15/22 → 1/29/24

Project: Research project

Erythrocyte-Derived Particles for Near Infrared Phototherapy of Port Wine Stains

D'Orazio, J.

Regents of the University of California Riverside

3/1/22 → 2/28/24

Project: Research project

A Phase III, Randomized, Open-label, Multicenter Study Evaluating the Efficacy and Safety of Adjuvant Giredestrant Compared with Physician's Choice of Adjuvant Endocrine Monotherapy in Patients with Estrogen Receptor-Positive, HER2-Negat

Chambers, M.

NSABP Foundation

2/4/22 → 11/30/23

Project: Research project

A Phase III Multi-center, Randomized, Open-label Study to Evaluate the Efficacy and Safety of Lutathera in Patients With Grade 2 and Grade 3 Advanced GEP-NET (CAAA601A22301)

Anthony, L. & Chauhan, A.

Advanced Accelerator Applications SA

1/7/22 → 11/2/24

Project: Research project

Phase 3 Randomized Trial of DFP-10917 vs Non-Intensive Reinduction (LoDAC, Azacitidine, Decitabine, Venetoclax Combination Regimens) or Intensive Reinduction (High & Intermediate Dose Cytarabine Regimens) for Acute Myelogenous Leukemia Pat

Qasrawi, A. & Hildebrandt, G.

Delta Fly Pharma Incorporated

12/23/21 → 8/21/24

Project: Research project

A Randomized, Open-Label, Phase 3 Trial of Epcoritamab vs Investigator s Choice Chemotherapy in Relapsed/Refractory Diffuse Large B-cell Lymphoma

Iragavarapu, C. & Hildebrandt, G.

Genmab US Incorporated

12/15/21 → 7/31/24

Project: Research project

Phase II Clinical Trial Evaluating Cabozantinib and Pembrolizumab in Second-Line Therapy for Metastatic Pancreatic Adenocarcinoma

Kim, J., Fan, W., Gao, M., Higashi, R., Rueckert, J. & Qasem, S.

Exelixis Inc.

12/15/21 → 6/7/24

Project: Research project

A Randomized, Multi-Center, Open-Label, Active-Controlled Phase 3 Trial to Assess the Efficacy and Safety of Octreotide Subcutaneous Depot (CAM2029) versus Octreotide LAR or Lanreotide ATG in Patients with Gastroenteropancreatic

Anthony, L.

Fortrea Incorporated

12/2/21 → 8/21/24

Project: Research project

A Phase 1b/2 Study to Evaluate the Efficacy and Safety of Pembrolizumab in Combination With Investigational Agents for the Treatment of Participants With PD-1/L1-refractory Extensive-Stage Small Cell Lung Cancer in Need of Second-Line

Arnold, S.

Merck Sharp & Dohme Corporation

11/16/21 → 9/13/24

Project: Research project

A Phase 1/2 Dose Escalation and Dose Expansion Study of BA3021 Alone and In Combination With Nivolumab In Patients With Advanced Solid Tumors

Arnold, S.

Fortrea Incorporated

11/5/21 → 10/4/24

Project: Research project

A Multicenter, Open-Label, Phase I Study Evaluating the Safety and Tolerability of HMPL-306 in Subjects With Advanced or Metastatic Solid Tumors With IDH Mutations

Villano, J.

Syneos Health LLC

10/8/21 → 8/21/24

Project: Research project

Scope - Subject Injury: A Phase 1b Study Evaluating the Safety and Efficacy of AMG 757 in Combination with AMG 404 in Subjects with Small Cell Lung Cancer (SCLC)

Hao, Z. & Chauhan, A.

AMGen

10/4/21 → 8/29/24

Project: Research project

A Phase 1b Study Evaluating the Safety and Efficacy of AMG 757 in Combination with AMG 404 in Subjects with Small Cell Lung Cancer (SCLC)

Hao, Z. & Chauhan, A.

AMGen

10/4/21 → 8/29/24

Project: Research project

A Phase 3 Open-Label, Randomized Study of LOXO-305 versus Investigator Choice of BTK Inhibitor in Patients with Previously Treated BTK Inhibitor Naive Mantle Cell Lymphoma (BRUIN MCL-321)

Munker, R.

IQVIA RDS Incorporated

9/29/21 → 6/28/24

Project: Research project

A Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled Trial Comparing the Efficacy and Safety of Tafasitamab Plus Lenalidomide in Addition to R-CHOP Versus RCHOP in Previously Untreated, High-intermediate

Iragavarapu, C.

MorphoSys AG

9/29/21 → 8/21/24

Project: Research project

A Multicenter, Open-Label Study with a Randomized Control Arm of the Efficacy, Safety, and Pharmacokinetics of Intravenously Infused Berubicin in Adult Patients with Recurrent Glioblastoma Multiforme (WHO Grade IV)

Villano, J.

CNS Pharmaceuticals Incorporated

9/29/21 → 7/18/24

Project: Research project

Phase III, Multi-Center, Open-Label, Randomized Study Of Oral Asciminib Versus Investigator Selected TKI in Patients With Newly Diagnosed Philadelphia Chromosome Positive Chronic Myelogenous Leukemia In Chronic Phase

Munker, R.

Novartis (domestic)

8/17/21 → 10/30/24

Project: Research project

SPLASH: Study Evaluating Metastatic Castrate Resistant Prostate Cancer Treatment Using 177Lu-PNT2002 PSMA Therapy After Second-line Hormonal Treatment

Myint, Z.

POINT Biopharma Incorporated

8/5/21 → 6/15/24

Project: Research project

Gold-derived Therapeutic Compounds for Disease Application

Awuah, S., O'Connor, K. & Weiss, H.

National Cancer Institute

8/4/21 → 7/31/26

Project: Research project

An Open Label, Multi-Center Phase IIIb Study of Asciminib (ABL001) Monotherapy in Previously Treated Patients with Chronic Myeloid Leukemia in Chronic Phase (CML-CP) With and Without T315I Mutation

Munker, R.

Novartis (domestic)

7/15/21 → 12/31/23

Project: Research project

A Phase 1, Open-label Study of ASP9801, an Oncolytic Virus, Administered by Intratumoral Injection in Patients with Advanced/Metastatic Solid Tumors

Villano, J. & Chauhan, A.

Astellas Pharma Global Development Incorporated

7/5/21 → 7/13/24

Project: Research project

Statistical Methods for Cancer Progression Delineation and Subtype Identification

Wang, C., Arnold, S. & Liu, C.

National Cancer Institute

7/1/21 → 6/30/24

Project: Research project

Natural Language Processing Platform for Cancer Surveillance

Durbin, E. B., Jeong, J. C. & Kavuluru, R.

Boston Childrens Hospital

7/1/21 → 6/30/24

Project: Research project

A Phase Ib/II, Open-Label, Multicenter, Randomized Umbrella Study Evaluating the Efficacy and Safety of Multiple Immunotherapy-Based Treatments and Combinations in Patients With Urothelial Carcinoma (MORPHEUS-UC)

Myint, Z. & Wang, P.

Genentech Inc

6/14/21 → 6/12/24

Project: Research project

A Randomized, Double-Blind, Placebo-Controlled Phase 3 Study of Enzastaurin Added to Temozolomide During and Following Radiation Therapy in Newly Diagnosed Glioblastoma Patients Who Possess the Novel Genomic Biomarker DGM1

Villano, J.

Pharmaceutical Research Associates

5/27/21 → 6/7/24

Project: Research project

Phase II Clinical Trial Evaluating Cabozantinib and Pembrolizumab in Metastatic Pancreatic Cancer

Kim, J.

Exelixis Inc.

4/29/21 → 6/7/24

Project: Research project

Expanded Access Protocol (EAP) For Subjects Receiving Idecabtagene Vicleucel That Is Nonconforming For Commercial Release

Iragavarapu, C.

Celgene

4/6/21 → 3/15/24

Project: Research project

Understanding Mechanisms and Consequences of T Cell Co-Receptor Regulated RNA Maturation

Lane, A., Fan, W. & Higashi, R.

Health Research Incorporated

4/5/21 → 3/31/24

Project: Research project

Targeting Lipid Metabolism in Colorectal Cancer

Zaytseva, Y., Evers, B. M., Lee, E., Moseley, H., Nikolova-Karakashian, M., Rychahou, P. & Weiss, H.

National Cancer Institute

4/1/21 → 3/31/26

Project: Research project

Defining the Critical Function and Regulation of NNMT in Breast Cancer Progression and Metastasis

Zhou, B., Lane, A., St Clair, D., Wang, C. & Zhu, H.

National Cancer Institute

4/1/21 → 3/31/26

Project: Research project

The Role of Crypt Fissioning in IBD Ulcer Healing

Barrett, T., Beyer, R., Chaiswing, L., Flomenhoft, D., Gao, T., Goretsky, T., Harrison, D., Kapur, N., Lohr, K., Sullivan, P., Grigorian, A., Holt, E., Liu, J. & Stromberg, A.

National Institute Diabetes & Digestive & Kidney

2/24/21 → 1/31/25

Project: Research project

Modulation of Asparagine Bioavailability and Stress Response Signaling to Enhance T Cell Robustness and Maximize Immunotherapy

Fan, W.

Research Institute at Nationwide Childrens Hospital

2/15/21 → 1/31/24

Project: Research project

HPV16 E6 Antibody Detection as an Early Marker for Oropharyngeal Cancer Among Men Living with HIV

Kuhs, K. & Chen, L.

National Institute of Dental and Craniofacial Research

2/5/21 → 4/30/25

Project: Research project

Expanded Access Protocol (EAP) For Patients Receiving Lisocabtagene Maraleucel That Is Nonconforming For Commercial Release

Iragavarapu, C. & Hildebrandt, G.

Celgene

1/29/21 → 9/18/24

Project: Research project

A Phase 1/2 Multiple Expansion Cohort Trial of MRTX849 in Patients with Advanced Solid Tumors with KRAS G12C Mutation

Zinner, R.

Mirati Therapeutics Incorporated

11/20/20 → 8/16/24

Project: Research project

Multi-35 Sub-Study C: A Phase 1b/2 Substudy of ASP-1929 Photoimmunotherapy in Combination with Anti-PD1 Therapy in Patients with Locally Advanced or Metastatic Cutaneous Squamous Cell Carcinoma Who Have Progressed on Anti-PD1 Therapy

Valentino, J.

Rakuten Medical Incorporated

11/10/20 → 5/15/24

Project: Research project

Multi-35 Sub-Study A: Phase 1b/2 Subprotocol of ASP-1929 Photoimmunotherapy in Combination with anti-PD1 Therapy in Patients with Head and Neck Squamous Cell Carcinoma

Valentino, J.

Rakuten Medical Incorporated

11/10/20 → 5/15/24

Project: Research project

Multi-35 Sub-Study B: Phase 1b/2 Subprotocol of ASP-1929 Photoimmunotherapy in Combination with anti-PD1 Therapy in Patients with Locally Advanced or Metastatic Cutaneous Squamous Cell Carcinoma

Valentino, J.

Rakuten Medical Incorporated

11/10/20 → 5/15/24

Project: Research project

Implementation of School-Entry Policies for Human Papillomavirus Vaccination

Hull, P.

Universidad de Puerto Rico

11/4/20 → 11/30/23

Project: Research project

A Phase II, Open-Label, Multi-Center Study of PDS0101 (ImmunoMAPK -RDOTAP/HPV-16 E6 & E7 Peptides) and Pembrolizumab (KEYTRUDA) Combination Immunotherapy as a First Line Treatment in Subjects with Recurrent

Zinner, R. & Kejner, A.

PDS Biotechnology

11/2/20 → 7/26/24

Project: Research project

T-DXd vs. T-DM1 in high risk HER2-positive patients with residual invasive breast cancer following neoadjuvant therapy (DESTINY-Breast05)

Chambers, M.

NSABP Foundation

11/1/20 → 12/3/23

Project: Research project

Master Protocol to Assess the Safety and Recommended Phase 2 Dose of Next Generations of Autologous Enhanced NY-ESO-1/ LAGE-1a TCR Engineered Tcells, alone or in combination with other agents, in Participants with Advanced Tumors

Patel, R.

PPD Investigator Services LLC

10/29/20 → 10/12/24

Project: Research project

Covid 19: Evaluation of SARS-CoV-2 Positivity, Genetic Risk Factors & Outcomes in Patients Enrolled in TCC

Kolesar, J., Durbin, E. B., McLouth, L. & Wang, C.

M2Gen Corporation

10/27/20 → 7/1/24

Project: Research project

Mechanisms of UV-Mediated Melanoma Development

D'Orazio, J.

Ohio State University

9/4/20 → 5/31/25

Project: Research project

IIBR Informatics: Comprehensive Metabolism Phenotype Characterization and Interpretation

Moseley, H. & Flight, R.

National Science Foundation

8/15/20 → 7/31/24

Project: Research project

Markey Cancer Center / Cancer Research Priority Initiative

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