Markey Cancer Center / Cancer Research Priority Initiative

National Center for Advancing Translational Sciences

7/1/24 → 7/1/24

Project: Research project

KL2 Scholar Scope - Characterizing the Pan-Cancer Endogenous Retroviruses Landscapes at Single-Cell Resolution

Liu, J. (PI) & Kelly, T. (CoI)

2/1/24 → 6/30/24

Project: Research project

Mechanistic and structural insights into a new pro-metastatic collagen glucosyltransferase

Guo, H. (PI), Brainson, C. (CoI) & Chen, L. (CoI)

1/16/24 → 12/31/24

Project: Research project

ICOSL Reverse Signaling Orchestrates Macrophage Programming in Pancreatic Adenocarcinoma

Barry-Hundeyin, M. (PI) & Weiss, H. (CoI)

Elsa U Pardee Foundation

1/1/24 → 12/31/24

Project: Research project

FY24 Early Adult Onset Colorectal Cancer Study C4597

Tucker, T. (PI), Huang, B. (CoI) & McDowell, J. (CoI)

11/1/23 → 6/30/24

Project: Research project

CCSG Pilot: Circulating Neutrophils-Tailored Cancer Biomarker Discovery and Therapy

Liu, X. (PI), Hao, Z. (CoI) & Liu, J. (CoI)

National Institute on Drug Abuse

10/1/23 → 9/30/24

Project: Research project

Appalachian Tobacco Regulatory Science Team (AppalTRuST): Community & Participant Engagement (COPE)

Hull, P. (PI), Haynes, E. (CoI), Kingsolver, A. (CoI) & Himelhoch, S. (Former CoI)

9/30/23 → 8/31/24

Project: Research project

Appalachian Tobacco Regulatory Science Team (AppalTRuST): Biostatistics and Informatics Core (BIC)

Rayens, M. K. (PI), Jeong, J. C. (CoI), Thaxton Wiggins, A. (CoI) & Himelhoch, S. (Former CoI)

National Institute on Drug Abuse

9/30/23 → 8/31/24

Project: Research project

Extending the Capabilities and Reach of EMERSE in Support of Cancer Research

Jeong, J. C. (PI), Durbin, E. B. (CoI), Harris, D. (CoI) & Talbert, J. (CoI)

University of Michigan

9/15/23 → 8/31/24

Project: Research project

CCSG Pilot: Determining Mechanisms of Immunotherapy Resistance in KEAP1 and LKB1 Mutant Lung Cancers

Brainson, C. (PI), Durbin, E. B. (CoI), Hao, Z. (CoI), Jeong, J. C. (CoI) & Liu, J. (CoI)

9/1/23 → 12/31/24

Project: Research project

CCSG Pilot: Improving Anti-PD1 Therapy in Triple-Negative Breast Cancer

Liu, X. (PI), Liu, J. (CoI) & Marcinkowski, E. (CoI)

National Institute on Drug Abuse

9/1/23 → 6/30/24

Project: Research project

The University of Kentucky Racial Equity Initiative Coordinating Center

Stevens-Watkins, D. (PI), Adatorwovor, R. (CoI), Canedo, J. (CoI), Francis, D. (CoI), Hargons, C. (CoI), Knudsen, H. (CoI), Oser, C. (CoI), Stoops, W. (CoI), Vickers-Smith, R. (CoI) & Wolf, B. G. (CoI)

8/15/23 → 6/30/24

Project: Research project

FY24 Spatial Transcriptomic Characterization of Pediatric Brain Tumors in Kentucky

Wang, C. (PI), Durbin, E. B. (CoI), Harrison, D. (CoI), Jeong, J. C. (CoI), Liu, J. (CoI), Neltner, J. (CoI), Tucker, T. (CoI), Villano, PhD, J. (CoI) & Zhang, S. (CoI)

American Lung Association

7/1/23 → 6/30/24

Project: Research project

Targeting Lung Fibrosis with Epigenetic Therapy

Brainson, C. (PI), Bachert, S. (CoI) & Liu, J. (CoI)

7/1/23 → 8/14/24

Project: Research project

Evaluating Coverage and Cost of Care Links (C4299): FY24 Evaluating CC Links

Edward, J. (PI), D'Orazio, J. (CoI), Northrip, K. (CoI) & Shelton, B. (CoI)

7/1/23 → 6/30/24

Project: Research project

Summer Health Experience (SHE) in Oncology Program

Vanderford, N. (PI)

Anthem Health Plans of Kentucky Inc

7/1/23 → 12/31/23

Project: Research project

Kentucky Lung Cancer Education Awareness Detection Survivorship (LEADS) Prevention and Early Detection and QUILS (Quality Implementation of Lung Cancer Screening)

Knight, J. (PI) & Mullett, T. (CoI)

6/30/23 → 12/31/24

Project: Research project

Health Equity in Fertility Specialty Care Among Cancer Survivors (00015476)

Buchanan, A. (PI) & Durbin, E. B. (CoI)

MD Anderson Cancer Center

6/28/23 → 12/31/24

Project: Research project

Center for Appalachian Research in Environmental Sciences: Administrative Core

Haynes, E. (PI), Arnett, D. (CoI), Bauer, J. (CoI), Cassis, L. (CoI), Christian, J. (CoI), Cox, N. (CoI), Curry, T. (CoI), DiPaola, R. (CoI), Dignan, M. (CoI), Evers, B. M. (CoI), Fan, W.-M. (CoI), Hoover, A. (CoI), Kern, P. (CoI), May, B. (CoI), Miller, J. (CoI), Pearson, K. (CoI), Pennell, K. (CoI), Richardson, K. (CoI), Sanderson, W. (CoI), Schoenberg, N. (CoI), Stanifer, S. (CoI), Stratton, T. (CoI), Swanson, H. (CoI), Talbert, J. (CoI), Unrine, J. (CoI), Hahn, E. (Former PI), Heath, E. (Former CoI), Stanley, S. (Former CoI) & Stromberg, A. (Former CoI)

National Institute of Environmental Health Sciences

6/3/23 → 4/30/24

Project: Research project

Surveillance, Epidemiology, and End Results (SEER) Program

Durbin, E. B. (PI), Huang, B. (CoI), Shelton, B. (CoI), Tucker, T. (CoI) & Ross, F. (Former CoI)

National Institute on Aging

5/1/23 → 4/30/24

Project: Research project

Role of P4HA1 in Endocrine Resistance of Breast Cancer

Xiong, G. (PI) & Wang, C. (CoI)

3/1/23 → 9/17/23

Project: Research project

22-MULTI-56-IB-PMC (IDE397) An Open Label, Phase 1, Treatment Study to Evaluate the Safety, Pharmacokinetics and Pharmacodynamics of IDE397 (MAT2A Inhibitor) In Adult Participants with Advanced Solid Tumors

Villano, PhD, J. (PI)

IDEAYA Biosciences

2/8/23 → 1/8/25

Project: Research project

Reducing Lung Cancer Risk among Appalachian Women Using Community-Engaged Intervention Research

Thompson, J. (PI), Hull, P. (CoI), Mullett, T. (CoI), Schoenberg, N. (CoI) & Hahn, E. (Former CoI)

2/1/23 → 4/30/24

Project: Research project

Reducing Lung Cancer Risk among Appalachian Women Using Community-Engaged Intervention Research

Thompson, J. (PI), Hull, P. (CoI), Mullett, T. (CoI), Schoenberg, N. (CoI), Waters, T. (CoI) & Hahn, E. (Former CoI)

Kinnate Biopharma Incorporated

2/1/23 → 1/31/24

Project: Research project

22-MULTI-53-KB-PMC : A Phase 1/1b Open-label, Multicenter Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Antitumor Activity of KIN-2787 in Participants with BRAF and/or NRAS Mutation-positive Solid Tumors, KN-8701

Arnold, S. (PI)

1/9/23 → 11/30/24

Project: Research project

Exploring and Planning Dissemination of the Quality Implementation of Lung Cancer Screening (QUILS) # System from the Kentucky LEADS Collaborative

Knight, J. (PI) & Mullett, T. (CoI)

Bristol Myers Squibb Foundation Incorporated

1/1/23 → 11/30/24

Project: Research project

Gold Complexes that Regulate Metabolism and Microbiome to Accelerate Mucosal Healing in IBD

Barrett, T. (PI), Alam, M. (CoI), Awuah, S. (CoI), Chaiswing, L. (CoI), Kapur, N. (CoI), Sullivan, P. (CoI) & Wang, C. (CoI)

Crohns and Colitis Foundation of America

1/1/23 → 12/31/24

Project: Research project

Pilot: Center for Appalachian Research in Environmental Sciences: Evaluation of Health and Safety Information Dissemination with Vulnerable Patients and Providers Post-Flooding

Stanifer, S. (PI), Curry, T. (CoI), Hahn, E. (CoI), Hull, P. (CoI), Roper, K. (CoI) & Wurth, M. (CoI)

National Institute of Environmental Health Sciences

1/1/23 → 3/31/23

Project: Research project

Pilot: Role Of Succinate In Regulating Cancer Cell Plasticity And Stemness

Xu, R. (PI)

1/1/23 → 12/31/23

Project: Research project

Pilot: Targeting De Novo and Salvage Nucleotide Synthesis with FASN/ATR Inhibition to Enhance Radiation Therapy Reponses

Rychahou, P. (PI), Weiss, H. (CoI) & Zaytseva, Y. (CoI)

1/1/23 → 12/31/23

Project: Research project

Key-Opinion-Led Best Practices in Diagnosis and Management of Breast, Lung, and Ovarian Cancers

Mullett, T. (PI), Arays, R. (CoI) & Fredericks, T. (CoI)

OncoLens

1/1/23 → 12/31/23

Project: Research project

Pilot: CDK9-RNF20-LSD1 Axis in Breast Cancer Metabolic Reprogramming

Wu, Y. (PI)

1/1/23 → 12/31/23

Project: Research project

Patterns of Care Study: Diagnosis Year 2022 (Breast Cancer and Colorectal Cancer)

Durbin, E. B. (PI)

National Science Foundation

12/23/22 → 12/22/23

Project: Research project

22-MULTI-51-IT-PMC (TIG-006): A Multicenter, Open-Label, Phase I/II Study of EOS884448 In Combination With Standard Of Care And/Or Investigational Therapies In Participants With Advanced Solid Tumors

Villano, PhD, J. (PI)

iTeos Belgium SA

12/20/22 → 11/2/24

Project: Research project

Testing the Capacity of Novel SIK Inhibitors to Promote Pigmentation of the Skin

D'Orazio, J. (PI)

Soltego Incorporated

9/15/22 → 9/15/23

Project: Research project

Robust and Reliable Mathematical Models for Biomolecular Data via Differential Geometry and Graph Theory

Nagel, U. (PI), Ellingson, S. (CoI) & Nguyen, D. (Former PI)

9/15/22 → 6/30/24

Project: Research project

EPScOR: Robust and Reliable Mathematical Models for Biomolecular Data via Differential Geometry and Graph Theory

Nagel, U. (PI), Ellingson, S. (CoI) & Nguyen, D. (Former PI)

National Science Foundation

9/15/22 → 6/30/24

Project: Research project

22-GI-127-RP: Phase 2 Single-Arm Study of Nanoliposomal Irinotecan with Fluorouracil and Leucovorin in Refractory Advanced High-Grade Neuroendocrine Cancer of GI, Unknown, or Pancreatic Origi

Chauhan, A. (PI)

9/7/22 → 9/7/22

Project: Research project

University of Kentucky SuRE Resource Center

Spear, B. (PI), D'Orazio, S. (CoI), Dupont-Versteegden, E. (CoI), Fardo, D. (CoI), Loria Kinsey, A. (CoI), Murphy, M. (CoI), Nickell, M. (CoI), Rice, B. (CoI), Smalls, B. (CoI), Stevens-Watkins, D. (CoI), Stratton, T. (CoI) & Wolf, B. G. (CoI)

KY Council on Postsecondary Education

9/5/22 → 8/31/24

Project: Research project

UKRF Healthcare Workforce Collaborative Scope: Kentucky Workforce INitiative for our State (KY-WINS)

White, S. (PI), Bradley, L. (CoI), Cardarelli, K. (CoI), D'Orazio, S. (CoI), DiPaola, R. (CoI), Jackson, W. (CoI) & O'Connor, K. (CoI)

9/1/22 → 8/31/23

Project: Research project

Pilot: Development and Pilot Testing of a Facebook HPV Vaccination Intervention for Young Black Adults

Adegboyega, A. (PI), Dignan, M. (CoI), Francis, D. (CoI), Hull, P. (CoI) & Ickes, M. (CoI)

9/1/22 → 9/30/22

Project: Research project

Pilot: Development and Pilot Testing of a Facebook HPV Vaccination Intervention for Young Black Adults

Adegboyega, A. (PI), Dignan, M. (CoI), Francis, D. (CoI), Hull, P. (CoI) & Ickes, M. (CoI)

9/1/22 → 12/15/23

Project: Research project

Alterations in DNA Damage following Major Surgery and Hyperthermic Intraperitoneal Chemotherapy

Kim, J. (PI), Gao, M. (CoI), Goellner, E. (CoI) & Weiss, H. (CoI)

AstraZeneca Pharmaceuticals LP (domestic)

8/5/22 → 7/31/24

Project: Research project

22-MULTI-48-AZ-PMC: D9950C00001 A Phase 1 First-in-human Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics and Efficacy of AZD8701 Administered Intravenously as Monotherapy and in Combination with Durvalumab (MEDI4736)

Arnold, S. (PI)

7/13/22 → 6/28/23

Project: Research project

FY24 Artesunate as Treatment for Childhood Acute Myeloid Leukemia

Kolesar, J. (PI), Badgett, J. (CoI), Hill, K. (CoI), Ji, H. (CoI) & Yuan, L. (CoI)

7/1/22 → 6/30/24

Project: Research project

CCSG Pilot: Targeting L-Tryptophan-5-Hydroxylase 1 (TPH1) in Small Cell Lung Cancer

Wei, Q. (PI), Chen, L. (CoI) & Hao, Z. (CoI)

7/1/22 → 6/30/23

Project: Research project

Summer Health Experience (SHE) in Oncology Program

Vanderford, N. (PI)

7/1/22 → 12/31/22

Project: Research project

FY23 Accelerate

Durbin, E. B. (PI), Jeong, J. C. (CoI), Villano, PhD, J. (CoI) & Wang, C. (CoI)

7/1/22 → 6/30/23

Project: Research project

FY23 Breast Cancer Screening and/or Cervical Cancer Community

Hull, P. (PI)