Markey Cancer Center / Cancer Research Priority Initiative

Active

GOG-3091: A Two-Arm Randomized, Double-Blind, Placebo-Controlled Phase 2 Selection Trial to Evaluate the Efficacy and Safety of VB10.16 Alone or in Combination with Atezolizumab in Patients with HPV16-Positive, PD-L1-positive, Recurrent or Metastatic Cerv

Miller, R. (PI)

Gynecological Oncology Group Foundation Incorporated

5/14/24 → 5/14/26

Project: Research project

23-GI-132-GI (GO44479): A Phase II, Open-Label, Mulitcenter, Randomized Study of The Efficacy and Safety of Adjuvant Autogene Cevumeranplus Atezolizumab and mFOLFIRINOX Vs mFOLFIRINOX Alone in Patients with Resected Pancreatic Ductal Adenocarcinoma

Kim, J. (PI)

Genentech Inc

5/14/24 → 5/14/26

Project: Research project

23-LUN-135-EL (J3M-MC-JZQB): A Global Pivotal Study in Participants with KRAS G12C-Mutant, Locally Advanced or Metastatic Non-Small Cell Lung Cancer Comparing First- Line Treatment of LY3537982 and Pembrolizumab vs Placebo and Pembrolizumab in Those with

Arnold, S. (PI)

Eli Lilly and Company

5/6/24 → 5/6/26

Project: Research project

NCI Patterns of Care Study: Diagnosis Year 2021 (Prostate Cancer and Ovarian Cancer)

Durbin, E. B. (PI)

National Cancer Institute

5/1/24 → 4/30/25

Project: Research project

TNBC (Triple Negative Breast Cancer Specific) Ligand-displaying Exosomes Using RNA Nanotechnology for Targeted Cytosol Delivery of RNAi without Endosome Entrapment

Xu, R. (PI)

Ohio State University

5/1/24 → 4/30/25

Project: Research project

Surveillance, Epidemiology, and End Results (SEER) Program

Durbin, E. B. (PI), Huang, B. (CoI), Shelton, B. (CoI), Tucker, T. (CoI) & Ross, F. (Former CoI)

National Cancer Institute

5/1/24 → 4/30/25

Project: Research project

24-GU-84-MSD (003-00):A Phase 3 Randomized, Open-label Study of MK-5684 Versus Alternative Abiraterone Acetate or Enzalutamide in Participants With Metastatic Castration-Resistant Prostate Cancer (mCRPC) Previously Treated With Next-Generation Hormonal Ag

Myint, Z. (PI)

Merck Sharp & Dohme Corporation

4/29/24 → 4/29/26

Project: Research project

24-GU-85-MSD (004-00): A Phase 3, Randomized, Open-Label Study of MK-5684 Versus Alternative Abiraterone Acetate or Enzalutamide in Participants with Metastatic Castration-Resistant Prostate Cancer (mCRPC) That Progressed On or After Prior Treatment with

Myint, Z. (PI)

Merck Sharp & Dohme Corporation

4/28/24 → 4/28/26

Project: Research project

23-GU-82-SI-PMC (SGN22E-004): A Study Of Intravesical Enfortumab Vedotin For Treatment Of Patients With Non-Muscle Invasive Bladder Cancer (NMIBC)

Hensley, P. (PI)

Seagen Incorporated

4/22/24 → 4/22/26

Project: Research project

23-HEM-20-SA (EFC17757): A Randomized, Double-blind, Multicenter,Phase 3 Study to Evaluate Efficacy and Safety of Belumosudil in Combination With Corticosteroids Versus Placebo in Combination with Corticosteroids in Participants at Least 12 Years of Age W

Qasrawi, A. (PI) & Ramlal, R. (Former PI)

Sanofi Aventis US Inc

4/1/24 → 4/1/26

Project: Research project

Integrative Targeted Therapy for Melanoma

Yang, J. (PI), Evers, B. M. (CoI), Ren, X. (CoI) & Yan, D. (CoI)

National Cancer Institute

4/1/24 → 3/31/29

Project: Research project

AFT-58 (SOLTI-2101): A Phase III, Multicenter, Open-Label Study of Ribociclib vs. Palbociclib in Patients with Advanced Hormone Receptor-Positive/HER2-negative/HER2-Enriched Breast Cancer, Harmonia TrialAFT-58 (SOLTI-2101): A Phase III, Multicenter, Open-

Arays, R. (PI)

Alliance Foundation Trials LLC

3/20/24 → 3/20/26

Project: Research project

23-MULTI-64-GUI-PMC (GCT1042-01): A First-in-Human, Open-label, Dose-escalation Trial With Expansion Cohorts to Evaluate Safety and Anti-tumor Activity of GEN1042 in Subjects With Malignant Solid Tumors

Arnold, S. (PI)

Genmab US Incorporated

3/6/24 → 3/6/26

Project: Research project

Summer Health Experience (SHE) in Oncology Program

Vanderford, N. (PI)

American Cancer Society

3/1/24 → 2/28/25

Project: Research project

Novel Strategy to Augmenting Immunotherapy Against Melanoma

Yang, J. (PI), Ren, X. (CoI) & Yan, D. (CoI)

National Cancer Institute

3/1/24 → 2/28/26

Project: Research project

Personnel Costs: The Experimental Therapeutics Clinical Trials Network

Arnold, S. (PI), Gabriel, G. (CoI), Myint, Z. (CoI), Chauhan, A. (Former CoI), Kolesar, J. (Former CoI) & Kunos, C. (Former CoI)

Ohio State University

3/1/24 → 2/28/26

Project: Research project

Fatty Acid Synthase as a Novel Molecular Target for Colon Cancer Treatment

Gao, T. (PI), Lee, E. (CoI), Messaoudi Powers, I. (CoI), St Clair, D. (CoI), Wang, C. (CoI), Zaytseva, Y. (CoI) & Evers, B. M. (CoPI)

National Cancer Institute

3/1/24 → 2/28/29

Project: Research project

23-MULTI-62-BI-PMC (1438-0005): An Open-label, Multi-center Phase II Dose Selection Trial of Intravenous BI 764532, a DLL3-targeting T Cell Engager, in Patients With Relapsed/Refractory Extensive-stage Small Cell Lung Cancer and in Patients With Other Rel

Anthony, L. (PI)

Boehringer-Ingelheim

2/26/24 → 2/26/26

Project: Research project

23-MULTI-63-FFP (FF10832-PEM-201): A Phase 2a Study with Safety Run-in to Evaluate the Safety, Tolerability, and Preliminary Efficacy of FF-10832 Monotherapy or in Combination with Pembrolizumab in Patients with Advanced

Villano, PhD, J. (PI)

Fujifilm Pharmaceuticals USA Incorporated

2/15/24 → 2/15/26

Project: Research project

KL2 Scholar Scope - Characterizing the Pan-Cancer Endogenous Retroviruses Landscapes at Single-Cell Resolution

Liu, J. (PI) & Kelly, T. (CoI)

National Center for Advancing Translational Sciences

2/1/24 → 6/30/25

Project: Research project

23-LEUK-24-BF-PMC(COVALENT-103): A Phase 1, Open-label, Dose-escalation, and Dose-expansion Study of BMF-500, an Oral Covalent FLT3 Inhibitor, in Adults With Acute Leukemia

Qasrawi, A. (PI)

Biomea Fusion Incorporated

1/31/24 → 1/31/26

Project: Research project

23-BRE-57-GS (GS-US-595-6184): A Randomized, Open-label, Phase 3 Study of Adjuvant Sacituzumab Govitecan and Pembrolizumab Versus Treatment of Physician s Choice in Patients with Triple Negative Breast Cancer Who Have Residual Invasive Disease After Surge

Moss, J. (PI)

Alliance Foundation Trials LLC

1/30/24 → 1/30/26

Project: Research project

23-NHL-33-RG (R1979-ONC-2075): A Phase 3, Open-Label, Randomized Study to Compare the Safety and Efficacy of Odronextamab (REGN1979), An Anti-CD20 X Anti-CD3 Bispecific Antibody, Combined with Chemotherapy Versus Rituximab Combined with Chemotherapy In Pr

Iragavarapu, C. (PI)

Regeneron Pharmaceuticals

1/30/24 → 1/30/26

Project: Research project

23-NHL-34-JJ-PMC (90009530): A Phase 1b Multicenter, Open-label, Study of JNJ-90009530, an Autologous Anti-CD20 CAR-T Cell Therapy in Adult Participants with Relapse

Iragavarapu, C. (PI)

Janssen Research and Development LLC

1/19/24 → 10/29/27

Project: Research project

23-MYEL-20-CB-PMC: A Phase 1, Multicenter, Open-Label Study of CB-011, a CRISPR-Edited Allogeneic Anti-BCMA CAR-T Cell Therapy in Patients With Relapsed/Refractory Multiple Myeloma (CaMMouflage Trial)

Monohan, G. (PI)

Caribou Biosciences Incorporated

1/17/24 → 1/17/26

Project: Research project

Mechanistic and structural insights into a new pro-metastatic collagen glucosyltransferase

Guo, H. (PI), Brainson, C. (CoI) & Chen, L. (CoI)

National Cancer Institute

1/16/24 → 12/31/28

Project: Research project

23-LUN-134-OC4(Preserve-003): Phase 3, Two-stage, Randomized Study of ONC-392 Versus Docetaxel in Metastatic Non-Small Cell Lung Cancers that Progressed on PD-1/PD-L1 Inhibitors

Hao, Z. (PI)

OncoC4 Incorporated

1/8/24 → 1/8/26

Project: Research project

ICOSL Reverse Signaling Orchestrates Macrophage Programming in Pancreatic Adenocarcinoma

Barry-Hundeyin, M. (PI) & Weiss, H. (CoI)

Elsa U Pardee Foundation

1/1/24 → 12/31/24

Project: Research project

HPV16 E6 Seropositivity and ctHPVDNA for Early Detection of Oropharyngeal Cancer

Kuhs, K. (PI), Chen, L. (CoI), Douthitt, K. (CoI), Kale, N. (CoI) & Yeoh, M. (CoI)

American Cancer Society

1/1/24 → 12/31/28

Project: Research project

Pilot: Development of a k-mer based Bioinformatics Method for Characterizing the Pan- Cancer Endogenous Retroviruses

Liu, J. (PI)

American Cancer Society

1/1/24 → 6/30/25

Project: Research project

GOG-3068-HOTT: A Phase III Randomized Trial of Hyperthermic Intraperitoneal Chemotherapy (HIPEC) with Cisplatin Versus no HIPEC at the Time of Interval Cytoreductive Surgery Followed by Niraparib Maintenance in Patients with Newly Diagnosed Stage III and

Dietrich, C. (PI)

Gynecological Oncology Group Foundation Incorporated

12/6/23 → 12/6/25

Project: Research project

23-LEUK-23-CC: ACE-536-MF-002, A Phase 3, Double-blind, Randomized Study to Compare the Efficacy and Safety of Luspatercept (ACE-536) Versus Placebo in Subjects With Myeloproliferative Neoplasm-Associated Myelofibrosis on Concomitant JAK Inhibitor Therapy

Yalniz, F. (PI)

Celgene

11/27/23 → 11/27/25

Project: Research project

23-NHL-32-CT-PMC: CNTY-101-111-01, The ELiPSE-1 Study: A Phase 1, Multicenter, Open-Label Study of CNTY-101 in Subjects With Relapsed or Refractory CD19-Positive B-Cell Malignancies

Iragavarapu, C. (PI)

Century Therapeutics Incorporated

11/2/23 → 11/2/25

Project: Research project

23-HN-38-BG(BGB-HNSCC-201):A Phase 2, Randomized, Open-label, multi-arm Study of Tislelizumab in Combination with Investigational Agents as First Line Treatment in Patients with Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma

Arnold, S. (PI)

BeiGene USA Incorporated

10/26/23 → 10/26/25

Project: Research project

Aberrant Fucosylation is a Critical Feature of Neuroblastoma Immune Evasion

Rellinger, E. (PI), Allison, D. (CoI) & Wang, C. (CoI)

V Foundation

10/15/23 → 10/15/26

Project: Research project

23-MULTI-60-BT-PMC (BCA101X1101): First-in-Human, Phase 1/1b, Open-label, Multicenter Study of Bifunctional EGFR/TGFbeta; Fusion Protein BCA101 Monotherapy and in Combination Therapy in Patients with EGFR-Driven Advanced Solid Tumors

Arnold, S. (PI)

Bicara Therapeutics Incorporated

10/3/23 → 10/3/25

Project: Research project

CCSG Pilot: Addressing An Unmet Need: Anxiety And Quality Of Life In Caregivers Of Youth Affected By Inherited Cancer Syndromes

D'Orazio, J. (PI), Harrington, A. (CoI), Marsac, M. (CoI) & Shelton, B. (CoI)

National Cancer Institute

10/1/23 → 6/30/25

Project: Research project

Appalachian Tobacco Regulatory Science Team (AppalTRuST): Community & Participant Engagement (COPE)

Hull, P. (PI), Dutch, R. (CoI), Haynes, E. (CoI) & Kingsolver, A. (CoI)

National Institute on Drug Abuse

9/30/23 → 8/31/28

Project: Research project

Appalachian Tobacco Regulatory Science Team (AppalTRuST): Biostatistics and Informatics Core (BIC)

Rayens, M. K. (PI), Dutch, R. (CoI), Jeong, J. C. (CoI), Rzeszutek, M. (CoI) & Thaxton Wiggins, A. (CoI)

National Institute on Drug Abuse

9/30/23 → 8/31/28

Project: Research project

STTR: Development of a Wearable Fluorescence Imaging Device for Intraoperative Identification of Brain Tumors

Yu, G. (PI), Chen, L. (CoI), Chen, J. (CoI), Neltner, J. (CoI) & Pittman, T. (CoI)

Bioptics Technology LLC

9/25/23 → 8/31/25

Project: Research project

23-MEL-13-VMT-PMC (VMT01-T101): A Phase I/IIa, First-In-Human, Multi-Center Dose Escalation and Dose Expansion Study of [203/212Pb]VMT01 Receptor-Targeted, Image-Guided Alpha-Particle Therapy in Patients With Previously Treated Unresectable or Metastatic

Arays, R. (PI)

Viewpoint Molecular Targeting Incorporated

9/21/23 → 9/21/25

Project: Research project

Pdcd4-Rictor Interaction in Suppression of Lung Tumorigenesis

Yang, H.-S. (PI), Chen, L. (CoI), Fan, W.-M. (CoI), Hao, Z. (CoI), Lee, E. (CoI), Liu, X. (CoI) & Zhan, C.-G. (CoI)

National Cancer Institute

9/20/23 → 8/31/28

Project: Research project

Impact Of Dysbiotic And Symbiotic Catabolism Of Luminal Amino Acids On Intestinal Epithelial Barrier Function And Inflammation

Alam, M. (PI), Barrett, T. (CoI), Evers, B. M. (CoI), Fields, K. (CoI), Gao, T. (CoI), Goretsky, T. (CoI) & Thorson, J. (CoI)

National Institute Diabetes & Digestive & Kidney

9/20/23 → 8/31/25

Project: Research project

SEER - Linked Virtual Tissue Repository (VTR) Program

Tucker, T. (PI)

National Cancer Institute

9/15/23 → 9/14/25

Project: Research project

Extending the Capabilities and Reach of EMERSE in Support of Cancer Research

Jeong, J. C. (PI), Durbin, E. B. (CoI), Harris, D. (CoI) & Talbert, J. (CoI)

University of Michigan

9/15/23 → 2/28/25

Project: Research project

23-NHL-31-CB-PMC: CB-10A, A Phase 1, Multicenter, Open-Label Study of CB-010, a CRISPR-Edited Allogeneic Anti-CD19 CAR-T Cell Therapy in Patients with Relapsed/Refractory B Cell Non-Hodgkin Lymphoma (ANTLER)

Yalniz, F. (PI)

Caribou Biosciences Incorporated

9/8/23 → 9/8/25

Project: Research project

Targeting RSK-TRIM28-E2F1 Axis Overcomes CDK4/6 Inhibitor Resistance in Lethal RB1 Deficient Prostate Cancer

Fong, K. W. (PI), Allison, D. (CoI), Liu, J. (CoI) & Liu, X. (CoI)

V Foundation

9/1/23 → 9/1/26

Project: Research project

The PLOD2/Succinate Axis in Cancer Cell Plasticity and Stemness

Xu, R. (PI), Bocklage, T. (CoI), Chen, L. (CoI) & Guo, H. (CoI)

National Cancer Institute

9/1/23 → 8/31/28

Project: Research project

Targeting the Immunosuppressive Tumor Microenvironment for Colorectal Cancer Treatment

Wang, Q. (PI), Bondada, S. (CoI), Higashi, R. (CoI), Lee, E. (CoI), Wang, C. (CoI), Weiss, H. (CoI) & Evers, B. M. (CoPI)

National Cancer Institute

9/1/23 → 8/31/28

Project: Research project

Targeting NNMT to Inhibit Obesity-Associated Breast Cancer Development and Progression

Zhou, B. (PI), Lane, A. (CoI), St Clair, D. (CoI) & Wang, C. (CoI)

Department of Defense

9/1/23 → 8/31/26

Project: Research project

Markey Cancer Center / Cancer Research Priority Initiative

Grants and Contracts

Search results