Markey Cancer Center / Cancer Research Priority Initiative

9/1/23 → 12/31/24

Project: Research project

IMGN853-0421/GOG-3078: Randomized, Multicenter, Open-label, Phase 3 study of Mirvetuximab Soravtansine in Combination with Bevacizumab Versus Bevacizumab Alone as Maintenance Therapy for Patients with FRa-positive Recurrent Platinum-sensitive Epithelial o

Miller, R. (PI)

ImmunoGen Inc

8/30/23 → 8/30/25

Project: Research project

23-BRE-56-AZ (D8531C00002): A Phase III, Open-Label, Randomised Study to Assess the Efficacy and Safety of Extended Therapy With Camizestrant Versus Standard Endocrine Therapy (Aromatase Inhibitor or Tamoxifen) in Patients With ER+/HER2- Early Breast Can

Moss, J. (PI)

NSABP Foundation

8/4/23 → 8/4/25

Project: Research project

STTR: Time-Resolved Laser Speckle Contrast Imaging Of Resting-State Functional Connectivity In Neonatal Brain

Yu, G. (PI), Chen, L. (CoI), Chen, L. (CoI), Chen, J. (CoI) & Powell, D. (CoI)

Bioptics Technology LLC

8/1/23 → 7/31/25

Project: Research project

Pathways, a Hope-Based Intervention to Support Personal Goal Pursuit, Mental Health, and Quality of Life during Advanced Lung Cancer Treatment

McLouth, L. (PI), Arnold, S. (CoI), Burris, J. (CoI), McFarlin, J. (CoI), Shelton, B. (CoI) & Stapleton, J. (CoI)

Lisata Therapeutics Incorporated

7/25/23 → 6/30/28

Project: Research project

23-NHL-30-OP (ONO-4059-09): An Open-label Phase II Study to Investigate the Efficacy, Safety, and Pharmacokinetics of Tirabrutinib in Patients with Primary Central Nervous System Lymphoma (PCNSL)

Munker, R. (PI)

Ono Pharmaceutical

7/24/23 → 7/24/25

Project: Research project

23-LUN-132-RBI-PMC: Phase 1b Single Arm, Open-Label Trial of RYZ101 in Combination with Carboplatin + Etoposide + Atezolizumab in Subjects with Somatostatin Receptor Expressing (SSTR+) Extensive Stage Small Cell Lung Cancer (ES-SCLC)

Hao, Z. (PI)

RayzeBio Incorporated

7/18/23 → 7/18/25

Project: Research project

23-MULTI-59-LTI(LTSA1-P02): A Phase 2a, Double-blind, Placebo-controlled, Multi-center, Randomized Study Evaluating LSTA1 When Added to Standard of Care (SoC) Versus Standard of Care Alone in Subjects with Advanced Solid Tumors (BOLSTER)

Arnold, S. (PI)

7/18/23 → 7/18/25

Project: Research project

23-LUN-133-LB-PMC: LB2102-1001, A First in Human Dose Escalation and Cohort Expansion Study of DLL3-directed Chimeric Antigen Receptor T-cells in Subjects With Extensive Stage Small Cell Lung Cancer

Hao, Z. (PI)

Legend Biotech USA Incorporated

7/10/23 → 7/10/25

Project: Research project

Targeting the Plk1/Pdcd4/mTORC2 Signaling to Treat Castration-Resistant Prostate Cancer

Yang, H.-S. (PI), Allison, D. (CoI), Chen, L. (CoI) & Liu, X. (CoPI)

7/1/23 → 6/30/28

Project: Research project

Targeting the Plk1/Pdcd4/mTORC2 Signaling to Treat Castration-Resistant Prostate Cancer

Liu, X. (PI), Allison, D. (CoI), Chen, L. (CoI) & Yang, H.-S. (CoPI)

Markey Cancer Center Foundation

7/1/23 → 6/30/28

Project: Research project

Overcoming Therapeutic Resistance in Lung Cancer Using Novel Combination Therapies

Brainson, C. (PI) & Liu, J. (CoI)

7/1/23 → 7/31/25

Project: Research project

Roles of mRNA Transfer in Cancer Cell-Platelet Communication

Xu, R. (PI), Liu, X. (CoI) & Trinkle, C. (CoI)

KY Cabinet for Health and Family Services

7/1/23 → 6/30/28

Project: Research project

Evaluating Coverage and Cost of Care Links C4643: FY25 Evaluating CC Links

Edward, J. (PI), D'Orazio, J. (CoI), Northrip, K. (CoI) & Shelton, B. (CoI)

7/1/23 → 6/30/25

Project: Research project

Developing New Therapies for Metatsic Melanoma

Plattner, R. (PI), Goellner, E. (CoI), Liu, J. (CoI) & Richards, D. (CoI)

Markey Cancer Center Foundation

7/1/23 → 7/31/25

Project: Research project

Kentucky Lung Cancer Education Awareness Detection Survivorship (LEADS) Prevention and Early Detection and QUILS (Quality Implementation of Lung Cancer Screening)

Knight, J. (PI) & Mullett, T. (CoI)

Anthem Health Plans of Kentucky Inc

6/30/23 → 12/31/24

Project: Research project

Health Equity in Fertility Specialty Care Among Cancer Survivors (00015476)

Buchanan, A. (PI) & Durbin, E. B. (CoI)

MD Anderson Cancer Center

6/28/23 → 12/31/27

Project: Research project

23-LEUK-22-GS: GS-US-546-5857, Enhance-2_A Phase 3, Randomized, Open-Label Study Evaluating the Safety and Efficacy of Magrolimab in Combination with Azacitidine versus Physician s Choice of Venetoclax in Combination with Azacitidine or Intensive Chemothe

Qasrawi, A. (PI)

Gilead Sciences Inc

6/27/23 → 6/27/25

Project: Research project

23-NHL-29-DO: MK2140-003, A Phase 2/3 Multicenter, Open-label, Randomized, Active-Control Study of Zilovertamab Vedotin (MK-2140) in Combination With Standard of Care in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma (waveLINE-003)

Iragavarapu, C. (PI)

Viewpoint Molecular Targeting Incorporated

6/26/23 → 6/26/25

Project: Research project

23-NET-01-VMT-PMC(VMT-alpha-NET-T101): A Phase I/IIa First-in-Human Study of [212Pb]VMT-alpha-NET Targeted Alpha-Particle Therapy for Advanced SSTR2 Positive Neuroendocrine Tumors

Anthony, L. (PI)

6/22/23 → 6/22/25

Project: Research project

Lu Tianjun Scope: UK Cares Career Development Award: Advancing Environmental Health Sciences: Enhancing Air Quality Exposure Assessment, Cancer Impact Research, and Community Engagement

Lu, T. (PI), Haynes, E. (CoI), Hoover, A. (CoI) & Tucker, T. (CoI)

National Institute of Environmental Health Sciences

6/3/23 → 4/30/28

Project: Research project

Study Of PTPRF-Mediated Regulation Of Wnt Signaling

Gao, T. (PI), Barrett, T. (CoI) & Wang, C. (CoI)

6/1/23 → 3/31/27

Project: Research project

Diversity Supplement for Haley Stanczyk

Gao, T. (PI)

6/1/23 → 3/31/27

Project: Research project

Study of PTPRF-Mediated Regulation of Wnt Signaling- Supplement

Gao, T. (PI)

6/1/23 → 3/31/27

Project: Research project

22-HN-37-MSD (689-07): A Phase III, Randomized, Open-label Study to Evaluate Pembrolizumab as Neoadjuvant Therapy and in Combination With Standard of Care as Adjuvant Therapy for Stage III-IVA Resectable Locoregionally Advanced Head and Neck Squamous Cell

Arnold, S. (PI)

Bristol Myers Squibb Company

5/11/23 → 5/10/25

Project: Research project

22-GI-130-BG-PMC (LAG-3): A Phase 1b/2, Randomized, Open-Label Study Investigating the Efficacy and Safety of LBL-007 Plus Tislelizumab in Combination With Bevacizumab Plus Capecitabine Versus Bevacizumab Plus Capecitabine as Maintenance Therapy in Patien

Nutalapati, S. (PI)

BeiGene USA Incorporated

4/26/23 → 4/25/25

Project: Research project

22-GI-129-EI: XL092-303, A Randomized Open-Label Phase 3 Study of XL092 + Atezolizumab vs Regorafenib in Subjects with Metastatic Colorectal Cancer

Patel, R. (PI)

Exelixis Inc.

3/29/23 → 3/28/25

Project: Research project

Risk Stratified Survivorship Care Pathways For Early-Onset Colorectal Cancer

Huang, B. (PI) & Durbin, E. B. (CoI)

University of Michigan

3/21/23 → 2/29/28

Project: Research project

22-NHL-28-KP-PMC: A Phase 3 Randomized, Open-Label, Multicenter Study Evaluating the Efficacy of Axicabtagene Ciloleucel Versus Standard of Care Therapy in Subjects with Relapsed/Refractory Follicular Lymphoma, ZUMA-22

Iragavarapu, C. (PI)

Kite Pharma Incorporated

3/6/23 → 12/5/25

Project: Research project

22-MULTI-56-IB-PMC (IDE397) An Open Label, Phase 1, Treatment Study to Evaluate the Safety, Pharmacokinetics and Pharmacodynamics of IDE397 (MAT2A Inhibitor) In Adult Participants with Advanced Solid Tumors

Villano, PhD, J. (PI)

IDEAYA Biosciences

2/8/23 → 1/8/25

Project: Research project

22-BRE-55-CI A Phase 3, Open-Label, Randomized, Two-Part Study Comparing Gedatolisib in Combination with Palbociclib and Fulvestrant to Standard-of-Care Therapies in Patients with HR-Positive, HER2-Negative Advanced Breast Cancer Previously Treated with

Chambers, M. (PI)

Celcuity Incorporated

2/7/23 → 11/2/25

Project: Research project

22-LEUK-21-NP (CABL001AUS08): A Phase II Multicenter, Open-Label, Single-Arm Dose Escalation Study of Asciminib Monotherapy in 2nd Line Chronic Phase-Chronic Myelogenous Leukemia (ASC2ESCALATE)

Munker, R. (PI)

Novartis (domestic)

2/3/23 → 12/31/28

Project: Research project

MCC-23-LUN-131-BMS: Phase II Study of Induction Platinum Doublet in Combination with Nivolumab Followed by Surgery or Concurrent Chemoradiation in Unresectable Stage IIIA-C Non-Small Cell Lung Cancer (NSCLC)

Zinner, R. (PI)

1/23/23 → 1/23/26

Project: Research project

22-HEM-19-MSD: A Phase 3 Randomized Clinical Study of MK-4280A (Coformulated Favezelimab [MK-4280] plus Pembrolizumab [MK-3475]) Versus Physician's Choice Chemotherapy in PD-(L)1-Refractory, Relapsed or Refractory Classical Hodgkin Lymphoma

Munker, R. (PI)

1/23/23 → 11/2/25

Project: Research project

22-LUN-130-MSD (MK-7339 -013-03): A Randomized, Double-blind, Placebo-controlled Phase 3 Study of Pembrolizumab (MK-3475) in Combination with Concurrent Chemoradiation Therapy Followed by Pembrolizumab with or without Olaparib (MK-7339), Compared to Conc

Hao, Z. (PI) & Zinner, R. (Former PI)

Crohns and Colitis Foundation of America

1/13/23 → 10/25/25

Project: Research project

Markey STRONG Post-baccalaureate Program

O'Connor, K. (PI), Adegboyega, A. (CoI), Awuah, S. (CoI), Blackburn, J. (CoI), Brainson, C. (CoI), Gao, T. (CoI) & Williams, L. (CoI)

American Cancer Society

1/1/23 → 12/31/25

Project: Research project

Diversity in Cancer Research Supplement: University of Kentucky

O'Connor, K. (PI), Adegboyega, A. (CoI), Awuah, S. (CoI), Blackburn, J. (CoI), Brainson, C. (CoI), Gao, T. (CoI), Hull, P. (CoI), Lee, Y.-S. (CoI), Williams, L. (CoI) & Hahn, E. (Former CoI)

American Cancer Society

1/1/23 → 12/31/25

Project: Research project

Gold Complexes that Regulate Metabolism and Microbiome to Accelerate Mucosal Healing in IBD

Barrett, T. (PI), Alam, M. (CoI), Awuah, S. (CoI), Chaiswing, L. (CoI), Kapur, N. (CoI), Sullivan, P. (CoI) & Wang, C. (CoI)

1/1/23 → 12/31/24

Project: Research project

Institutional Research Grant

O'Connor, K. (PI)

American Cancer Society

1/1/23 → 12/31/25

Project: Research project

22-MULTI-55-FP-PMC (FPI-2059-101): A Phase 1 Study of [225AC]-FPI-2059 In Adult Participants with NTSR1-Expressing Advanced, Metastatic and/or Recurrent Solid Tumours

St Clair, W. (PI) & Kunos, C. (Former PI)

Medpace Inc

12/20/22 → 10/4/25

Project: Research project

22-MULTI-52-EP-PMC: A Modular, Open-label, Phase I/II Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Efficacy of EP0031 in Patients with Advanced RET-altered Malignancies

Arnold, S. (PI)

Ellipses Pharma Limited

11/11/22 → 8/29/25

Project: Research project

22-GI-128-RBI-PMC: Phase 1b/3 Global, Randomized, Controlled, Open-Label Trial Comparing Treatment With Actinium Ac 225 Dotatate (RYZ101) to Standard of Care (SoC) Therapy In Subjects With Inoperable, Advanced, Somatostatin Receptor Expressing (SSTR+)

Anthony, L. (PI)

RayzeBio Incorporated

10/25/22 → 7/26/25

Project: Research project

22-NEURO-13-NL: METIS, Pivotal, Open-label, Randomized Study of Radiosurgery with or Without Tumor Treating Fields (TTFields) for 1-10 Brain Metastases from Non-small Cell Lung Cancer (NSCLC)

Villano, PhD, J. (PI)

Novocure GmbH

10/24/22 → 8/3/25

Project: Research project

22-GI-126-BE-PMC: BXQ-350.AG, A Phase 1b/2 Placebo Controlled, Double Blinded Study on the Efficacy and Safety of BXQ-350 in Combination with mFOLFOX7 and Bevacizumab in Newly Diagnosed Metastatic Colorectal Carcinoma

Patel, R. (PI)

Clinical Trial Services

10/18/22 → 6/7/25

Project: Research project

MCC-22-GU-80: Phase II Study of Pembrolizumab in Combination with Radiation with or without Olaparib in Localized High-risk Prostate Cancer

Myint, Z. (PI)

National Heart Lung and Blood Institute

10/12/22 → 9/18/25

Project: Research project

Platelet Metabolism in Diabetes Mellitus

Wang, Q. (PI), Fraser, J. (CoI), Roberts, J. (CoI), Wang, C. (CoI), Whiteheart, S. (CoI), Gentry, M. (Former CoI) & Tannock, L. (Former CoI)

9/20/22 → 6/30/26

Project: Research project

22-MULTI-49-OM-PMC: OM-GRPR1-02, A Phase 1 Open-Label Dose Escalation and Expansion Study to Determine the Safety, Tolerability, Dosimetry, and Preliminary Efficacy of ???Pb-DOTAM-GRPR1 in Adult Subjects With Recurrent or Metastatic GRPR-expressing Tumors

Yang, E. (PI) & Kunos, C. (Former PI)

Medpace Inc

9/15/22 → 7/10/25

Project: Research project

University of Kentucky SuRE Resource Center

Spear, B. (PI), D'Orazio, S. (CoI), Dupont-Versteegden, E. (CoI), Fardo, D. (CoI), Loria Kinsey, A. (CoI), Murphy, M. (CoI), Nickell, M. (CoI), Rice, B. (CoI), Smalls, B. (CoI), Stevens-Watkins, D. (CoI), Stratton, T. (CoI) & Wolf, B. G. (CoI)