Markey Cancer Center / Cancer Research Priority Initiative

Plattner, R. (PI), Arays, R. (CoI), Gandhapudi, S. (CoI), Liu, J. (CoI), Richards, D. (CoI), Wang, C. (CoI), Yan, D. (CoI), Zhang, S. (CoI), Kolesar, J. (CoPI), COHEN, D. (Former CoI) & Wang, P. (Former CoI)

National Cancer Institute

5/23/22 → 4/30/27

Project: Research project

22-LUN-127-AZ: A Phase III, Double-blind, Randomised, Placebo-Controlled, International Study to Assess the Efficacy and Safety of Adjuvant Osimertinib Versus Placebo in Participants With EGFR Mutation-positive Stage IA2-IA3 Non-small Cell Lung Cancer, Fo

Villano, PhD, J. (PI) & Zinner, R. (Former PI)

AstraZeneca Pharmaceuticals LP (domestic)

5/12/22 → 2/6/25

Project: Research project

A Phase 1/2 Study of ASP1570 as Monotherapy and in Combination with Pembrolizumab in Participants with Locally Advanced or Metastatic Solid Tumors

Villano, PhD, J. (PI) & Chauhan, A. (Former PI)

Astellas Pharma Global Development Incorporated

4/8/22 → 1/30/26

Project: Research project

A Randomized, Parallel Group Study to Evaluate the Safety, Pharmacokinetics, and Dose Response of Paltusotine Treatment in Subjects with Carcinoid Syndrome.

Anthony, L. (PI) & Chauhan, A. (Former PI)

Crinetics Pharmaceuticals

4/6/22 → 3/8/25

Project: Research project

Phase 1-2 Study Investigating Safety, Tolerability, Pharmacokinetics and Preliminary Antitumor Activity of Anti-TIM-3 Monoclonal Antibody BGB-A425 in Combination with Anti-PD-1 Monoclonal Antibody Tislelizumab in Patient

Hao, Z. (PI)

BeiGene Switzerland GmbH

4/4/22 → 1/29/25

Project: Research project

A multicenter, Randomized, Open-label, Blinded Endpoint Evaluation, Phase 3 Study Comparing the Effect of Abelacimab Relative to Apixaban on Venous Thromboembolism (VTE) Recurrence and Bleeding in Patients with Cancer Associated VTE

Villano, PhD, J. (PI)

Anthos Therapeutics Incorporated

3/23/22 → 2/14/25

Project: Research project

A Phase III, Randomized, Open-label, Multicenter Study Evaluating the Efficacy and Safety of Adjuvant Giredestrant Compared with Physician's Choice of Adjuvant Endocrine Monotherapy in Patients with Estrogen Receptor-Positive, HER2-Negat

Chambers, M. (PI)

NSABP Foundation

2/4/22 → 11/30/25

Project: Research project

A Phase III Multi-center, Randomized, Open-label Study to Evaluate the Efficacy and Safety of Lutathera in Patients With Grade 2 and Grade 3 Advanced GEP-NET (CAAA601A22301)

Anthony, L. (PI) & Chauhan, A. (Former PI)

Advanced Accelerator Applications SA

1/7/22 → 11/2/25

Project: Research project

Phase 3 Randomized Trial of DFP-10917 vs Non-Intensive Reinduction (LoDAC, Azacitidine, Decitabine, Venetoclax Combination Regimens) or Intensive Reinduction (High & Intermediate Dose Cytarabine Regimens) for Acute Myelogenous Leukemia Pat

Qasrawi, A. (PI) & Hildebrandt, G. (Former PI)

Delta Fly Pharma Incorporated

12/23/21 → 8/21/25

Project: Research project

Phase II Clinical Trial Evaluating Cabozantinib and Pembrolizumab in Second-Line Therapy for Metastatic Pancreatic Adenocarcinoma

Kim, J. (PI), Fan, W.-M. (CoI), Gao, M. (CoI), Higashi, R. (CoI), Rueckert, J. (CoI) & Qasem, S. (Former CoI)

Exelixis Inc.

12/15/21 → 6/7/25

Project: Research project

A Multicenter, Open-Label, Phase I Study Evaluating the Safety and Tolerability of HMPL-306 in Subjects With Advanced or Metastatic Solid Tumors With IDH Mutations

Villano, PhD, J. (PI)

Syneos Health LLC

10/8/21 → 8/21/25

Project: Research project

Scope - Subject Injury: A Phase 1b Study Evaluating the Safety and Efficacy of AMG 757 in Combination with AMG 404 in Subjects with Small Cell Lung Cancer (SCLC)

Hao, Z. (PI) & Chauhan, A. (Former PI)

AMGen

10/4/21 → 8/29/25

Project: Research project

A Phase 1b Study Evaluating the Safety and Efficacy of AMG 757 in Combination with AMG 404 in Subjects with Small Cell Lung Cancer (SCLC)

Hao, Z. (PI) & Chauhan, A. (Former PI)

AMGen

10/4/21 → 8/29/25

Project: Research project

A Phase 3 Open-Label, Randomized Study of LOXO-305 versus Investigator Choice of BTK Inhibitor in Patients with Previously Treated BTK Inhibitor Naive Mantle Cell Lymphoma (BRUIN MCL-321)

Munker, R. (PI)

IQVIA RDS Incorporated

9/29/21 → 6/28/25

Project: Research project

A Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled Trial Comparing the Efficacy and Safety of Tafasitamab Plus Lenalidomide in Addition to R-CHOP Versus RCHOP in Previously Untreated, High-intermediate

Iragavarapu, C. (PI)

MorphoSys AG

9/29/21 → 8/21/25

Project: Research project

A Multicenter, Open-Label Study with a Randomized Control Arm of the Efficacy, Safety, and Pharmacokinetics of Intravenously Infused Berubicin in Adult Patients with Recurrent Glioblastoma Multiforme (WHO Grade IV)

Villano, PhD, J. (PI)

CNS Pharmaceuticals Incorporated

9/29/21 → 7/18/25

Project: Research project

Phase III, Multi-Center, Open-Label, Randomized Study Of Oral Asciminib Versus Investigator Selected TKI in Patients With Newly Diagnosed Philadelphia Chromosome Positive Chronic Myelogenous Leukemia In Chronic Phase

Munker, R. (PI)

Novartis (domestic)

8/17/21 → 10/30/25

Project: Research project

SPLASH: Study Evaluating Metastatic Castrate Resistant Prostate Cancer Treatment Using 177Lu-PNT2002 PSMA Therapy After Second-line Hormonal Treatment

Myint, Z. (PI)

POINT Biopharma Incorporated

8/5/21 → 6/15/25

Project: Research project

Gold-derived Therapeutic Compounds for Disease Application

Awuah, S. (PI), O'Connor, K. (CoI) & Weiss, H. (CoI)

National Cancer Institute

8/4/21 → 7/31/26

Project: Research project

An Open Label, Multi-Center Phase IIIb Study of Asciminib (ABL001) Monotherapy in Previously Treated Patients with Chronic Myeloid Leukemia in Chronic Phase (CML-CP) With and Without T315I Mutation

Munker, R. (PI)

Novartis (domestic)

7/15/21 → 2/28/25

Project: Research project

Supplement: GMaP Supplement: University of Kentucky Markey Cancer Center - Cancer Support Grant

Evers, B. M. (PI), Cromo, M. (CoI) & Dignan, M. (CoI)

National Cancer Institute

7/1/21 → 6/30/25

Project: Research project

A Phase Ib/II, Open-Label, Multicenter, Randomized Umbrella Study Evaluating the Efficacy and Safety of Multiple Immunotherapy-Based Treatments and Combinations in Patients With Urothelial Carcinoma (MORPHEUS-UC)

Myint, Z. (PI) & Wang, P. (Former PI)

Genentech Inc

6/14/21 → 6/12/25

Project: Research project

A Randomized, Double-Blind, Placebo-Controlled Phase 3 Study of Enzastaurin Added to Temozolomide During and Following Radiation Therapy in Newly Diagnosed Glioblastoma Patients Who Possess the Novel Genomic Biomarker DGM1

Villano, PhD, J. (PI)

Pharmaceutical Research Associates

5/27/21 → 6/7/25

Project: Research project

Phase II Clinical Trial Evaluating Cabozantinib and Pembrolizumab in Metastatic Pancreatic Cancer

Kim, J. (PI)

Exelixis Inc.

4/29/21 → 6/7/25

Project: Research project

Expanded Access Protocol (EAP) For Subjects Receiving Idecabtagene Vicleucel That Is Nonconforming For Commercial Release

Iragavarapu, C. (PI)

Celgene

4/6/21 → 3/15/25

Project: Research project

Understanding Mechanisms and Consequences of T Cell Co-Receptor Regulated RNA Maturation

Lane, A. (PI), Fan, W.-M. (CoI) & Higashi, R. (CoI)

Health Research Incorporated

4/5/21 → 3/31/25

Project: Research project

Improving Uptake of Cervical Cancer Prevention Services - Diversity Supplement Canedo

Dignan, M. (PI) & Canedo, J. (CoI)

Ohio State University

4/1/21 → 3/31/25

Project: Research project

Effectiveness and Implementation of a Health System Intervention to Improve Quality of Cancer Care for Rural, Underserved Patients

Mullett, T. (PI)

University of Iowa

4/1/21 → 3/31/26

Project: Research project

Targeting Lipid Metabolism in Colorectal Cancer

Zaytseva, Y. (PI), Evers, B. M. (CoI), Lee, E. (CoI), Moseley, H. (CoI), Nikolova-Karakashian, M. (CoI), Rychahou, P. (CoI) & Weiss, H. (CoI)

National Cancer Institute

4/1/21 → 3/31/26

Project: Research project

Defining the Critical Function and Regulation of NNMT in Breast Cancer Progression and Metastasis

Zhou, B. (PI), Lane, A. (CoI), St Clair, D. (CoI), Wang, C. (CoI) & Zhu, H. (Former CoI)

National Cancer Institute

4/1/21 → 3/31/26

Project: Research project

The Role of Crypt Fissioning in IBD Ulcer Healing

Barrett, T. (PI), Beyer, R. (CoI), Chaiswing, L. (CoI), Flomenhoft, D. (CoI), Gao, T. (CoI), Goretsky, T. (CoI), Harrison, D. (CoI), Kapur, N. (CoI), Lohr, K. (CoI), Sullivan, P. (CoI), Grigorian, A. (Former CoI), Holt, E. (Former CoI), Liu, J. (Former CoI) & Stromberg, A. (Former CoI)