Markey Cancer Center / Cancer Research Priority Initiative

Phone859-257-4500
Websitehttp://markey.uky.edu

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800 Rose Street
40536 Lexington
United States

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297 Active
1707 Finished

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Long-Term Follow-Up Protocol for Subjects Treated with Gene-Modified T Cells
Iragavarapu, C. (PI) & Hildebrandt, G. (Former PI)
Celgene
8/12/20 → 3/12/25
Project: Research project
A Phase 3 Study of Pembrolizumab (MK-3475) in Combination with Concurrent Chemoradiation Therapy Followed by Pembrolizumab with or without Olaparib vs Concurrent Chemoradiation Therapy Followed by Durvalumab in Participants
Hao, Z. (PI) & Zinner, R. (Former PI)
Merck Sharp & Dohme Corporation
8/10/20 → 1/30/26
Project: Research project
Mechanistic and Pharmacologic Studies of Selective Mithramycin Analogues Targeting EWS-FLI1 in Ewing Sarcoma
Tsodikov, O. (PI), Badgett, J. (CoI), Rohr, J. (CoPI), Leggas, M. (Former PI), Wang, C. (Former CoI) & Weiss, H. (Former CoI)
National Cancer Institute
6/1/20 → 5/31/25
Project: Research project
Randomized Trial of a Social Media-Delivered Intervention Targeting Indoor Tanning Users
Stapleton, J. (PI) & Shelton, B. (CoI)
National Cancer Institute
6/1/20 → 5/31/25
Project: Research project
An Open-Label, Multi-Center, Rollover Study to Provide Continued Treatment Access for Participants Enrolled in Studies of BXQ-350
Villano, PhD, J. (PI)
CTI Clinical Trial and Consulting Services
5/27/20 → 3/12/25
Project: Research project
A Phase 3, Multicenter, Randomized, Double-blind, Placebo-Controlled Study of AG-881 in Subjects With Residual or Recurrent Grade 2 Glioma With an IDH1 or IDH2 Mutation (AG881-C-004)
Villano, PhD, J. (PI)
Servier Pharmaceuticals LLC
5/12/20 → 5/2/25
Project: Research project
Patient Care Costs: The Experimental Therapeutics Clinical Trials Network
Arnold, S. (PI), DiPaola, R. (CoI), Gabriel, G. (CoI), Chauhan, A. (Former CoI) & Kolesar, J. (Former CoI)
Ohio State University
5/5/20 → 2/28/26
Project: Research project
Bridge Scholars Program - Bridging Disease Prevention Through Nutrition Focused Education In Community Clinics
Plasencia, J. (PI), Brewer, D. (CoI), Ceballos Osorio, J. (CoI), Grubbs, A. (CoI), Miller, C. (CoI) & Norman-Burgdolf, H. (CoI)
National Institute of Food and Agriculture
5/1/20 → 4/30/25
Project: Research project
Mechanisms and Functions of Shoc2-Transduced Cellular Signals
Galperin, E. (PI) & Morris, A. (CoI)
National Institute of General Medical Sciences
5/1/20 → 4/30/25
Project: Research project
Noninvasive Noncontact High-Density Optical Imaging of Neonatal Intraventricular Hemorrhage
Yu, G. (PI), Abu Jawdeh, E. (CoI), Bada, H. (CoI), Chen, L. (CoI), Chen, L. (CoI), Cheng, Q. (CoI), Huang, C. (CoI), Powell, D. (CoI), Huang, C. (Former CoI) & Miller, B. (Former CoI)
National Institute of Child Health and Human Develop
4/10/20 → 3/31/25
Project: Research project
Defining Genetic and Metabolic Requirements of Aggressive Breast Cancer (KY SOW)
Lane, A. (PI) & Fan, W.-M. (CoI)
University of Cincinnati
4/1/20 → 3/31/25
Project: Research project
An Open-Label, Randomised, Multicentre, Phase III Study of Irinotecan Liposome Injection, Oxaliplatin, 5-fluorouracil/Leucovorin Versus Nab-paclitaxel Plus Gemcitabine in Subjects Who Have Not Previously Received Chemotherapy for Metastatica
Patel, R. (PI)
Medpace Inc
3/24/20 → 1/11/25
Project: Research project
COBRE in Pharmaceutical Research and Innovation
Thorson, J. (PI), Helmy, Y. A. (CoI), Jaramillo, A. (CoI), She, Q.-B. (CoI), Adams, V. (Former CoI), Alam, M. (Former CoI), Awuah, S. (Former CoI), Bardo, M. (Former CoI), Bauer, B. (Former CoI), Burgess, D. (Former CoI), Czuba, L. (Former CoI), Daugherty, A. (Former CoI), Dwoskin, L. (Former CoI), Feola, D. (Former CoI), Garneau-Tsodikova, S. (Former CoI), Gensel, J. (Former CoI), Glazer, E. (Former CoI), Grady, M. (Former CoI), Graf, G. (Former CoI), Kapur, N. (Former CoI), Kolesar, J. (Former CoI), Korotkov, K. (Former CoI), Korotkova, N. (Former CoI), Leggas, M. (Former CoI), Mahmoud, K. A. (Former CoI), McLaurin, K. (Former CoI), Messaoudi Powers, I. (Former CoI), Nikolajczyk, B. (Former CoI), Ortinski, P. (Former CoI), Pack, D. (Former CoI), Park, J. (Former CoI), Prisinzano, T. (Former CoI), Richards, C. (Former CoI), Rohr, J. (Former CoI), Sen, P. (Former CoI), Shaffer, C. (Former CoI), Stevenson, B. (Former CoI), Sturgill, J. (Former CoI), Sviripa, V. (Former CoI), Tidgewell, K. (Former CoI), Tiruvannamalai Annam, R. (Former CoI), Turner, J. (Former CoI), Van Lanen, S. (Former CoI), Venditto, V. (Former CoI), Watt, D. (Former CoI), Webb, N. (Former CoI) & Zhan, C.-G. (Former CoI)
National Institute of General Medical Sciences
3/1/20 → 1/31/25
Project: Research project
A Randomized Phase 3, Double-Blind Study of Chemotherapy With or Without Pembrolizumab Followed by Maintenance With Olaparib or Placebo for the First-Line Treatment of BRCA Non-Mutated Advanced Epithelial Ovarian Cancer (EOC)
Miller, R. (PI)
Gynecological Oncology Group Foundation Incorporated
2/27/20 → 8/24/25
Project: Research project
PrE0905: Randomized Trial of Gilteritinib vs Midostaurin in FLT3 Mutated Acute Myeloid Leukemia (AML)
Qasrawi, A. (PI) & Hildebrandt, G. (Former PI)
Alpha Oncology Incorporated
2/27/20 → 10/30/25
Project: Research project
Substudy 2: A Phase 2, Umbrella Study with Rolling Arms of Investigational Agents in Combination with Pembrolizumab in Treatment Naïve Patients with PD-L1 Positive Advanced Non-small Cell Lung Cancer (NSCLC)
Arnold, S. (PI)
Merck Sharp & Dohme Corporation
2/4/20 → 6/2/25
Project: Research project
Substudy 1: A Phase 2, Umbrella Study with Rolling Arms of Investigational Agents with Pembrolizumab in Combination with Chemotherapy in Treatment-Naive Patients with Advanced Non-small Cell Lung Cancer (NSCLC)
Arnold, S. (PI)
Merck Sharp & Dohme Corporation
2/4/20 → 6/2/25
Project: Research project
Substudy 3: A Phase 2, Umbrella Study with Rolling Arms of Investigational Agents in Combination with Pembrolizumab in Patients with Advanced Non-small Cell Lung Cancer (NSCLC) Previously Treated with anti-PD-(L)1 Therapy
Arnold, S. (PI)
Merck Sharp & Dohme Corporation
2/4/20 → 6/2/25
Project: Research project
Master: A Phase 2, Umbrella Study with Rolling Arms of Investigational Agents with either Pembrolizumab in Combination with Chemotherapy or with Pembrolizumab Alone in Patients with Advanced Non-small Cell Lung Cancer (NSCLC)
Arnold, S. (PI)
Merck Sharp & Dohme Corporation
2/4/20 → 6/2/25
Project: Research project
Program Income: Cigar Reference Products Program
Chambers, O. (PI), Fisher, A. (CoI), Fisher, C. (CoI), Ji, H. (CoI), McNees, C. (CoI), Shelton, B. (CoI) & Yuan, L. (CoI)
Food and Drug Administration
2/1/20 → 1/31/25
Project: Research project
Brent Shelton Scope: Cigar Reference Products Program
Shelton, B. (PI)
Food and Drug Administration
2/1/20 → 1/31/25
Project: Research project
Cigar Reference Products Program
Chambers, O. (PI), Fisher, A. (CoI), Fisher, C. (CoI), Ji, H. (CoI), McNees, C. (CoI), Shelton, B. (CoI) & Yuan, L. (CoI)
Food and Drug Administration
2/1/20 → 1/31/25
Project: Research project
A Phase 3, Randomized, Double-Arm, Open-Label, Controlled Trial of ASP-1929 Photoimmunotherapy Versus Physician's Choice Standard of Care for the Treatment of Locoregional, Recurrent Head and Neck Squamous Cell Carcinoma
Valentino, J. (PI)
Rakuten Medical Incorporated
12/11/19 → 1/3/26
Project: Research project
A Phase 3, Randomized, Placebo-Controlled Clinical Study to Evaluate the Safety and Efficacy of Stereotactic Body Radiotherapy (SBRT) with or without Pembrolizumab (MK-3475) in Participants with Medically Inoperable Stages I or IIA NSCLC
Arnold, S. (PI)
Merck Sharp & Dohme Corporation
11/27/19 → 11/7/25
Project: Research project
Comparison of Operative to Monitoring and Endocrine Therapy (COMET) Trial For Low Risk DCIS: A Phase III Prospective Randomized Trial
Chambers, M. (PI) & Marcinkowski, E. (Former PI)
Alliance Foundation Trials LLC
11/25/19 → 2/14/25
Project: Research project
A Phase 3, Randomized, Double-Blind, Multicenter Study of Dostarlimab (TSR-042) Plus Carboplatin-Paclitaxel Versus Placebo Plus Carboplatin-Paclitaxel in Patients with Recurrent or Primary Advanced Endometrial Cancer (RUBY)
Miller, R. (PI)
Gynecological Oncology Group Foundation Incorporated
11/15/19 → 1/16/25
Project: Research project
Hedgehog Signaling in the Brain Contributes to Alzheimer's Disease in a Drosophila Model
Jia, J. (PI)
National Institute of General Medical Sciences
9/1/19 → 8/31/25
Project: Research project
Hedgehog Signaling in Development and Metabolism
Jia, J. (PI), Wang, C. (CoI), Vander Kooi, C. (Former CoI) & Zhu, H. (Former CoI)
National Institute of General Medical Sciences
9/1/19 → 8/31/25
Project: Research project
A Phase 1b Dose Escalation Study of Cabozantinib (XL184) Administered in Combination with Atezolizumab to Subjects with Locally Advanced or Metastatic Solid Tumors
Arnold, S. (PI)
Exelixis Inc.
8/13/19 → 1/2/25
Project: Research project
A Phase III, Randomized, Double-blind, Placebo-controlled, Multi-centre, International Study of Durvalumab or Durvalumab and Tremelimumab as Consolidation Treatment for Patients with Stage I/III Limited Disease Small-Cell Lung
Arnold, S. (PI)
AstraZeneca Pharmaceuticals AB
7/26/19 → 6/14/25
Project: Research project
Chemical Biology of the Control of Neddylation by DCN1
Guy, R. K. (PI)
National Cancer Institute
7/1/19 → 6/30/25
Project: Research project
Targeting Epigenetic Heterogeneity to Improve Lung Cancer Immunotherapy Response
Brainson, C. (PI), Liu, J. (CoI) & Wang, C. (CoI)
National Cancer Institute
7/1/19 → 6/30/25
Project: Research project
MCC-18-LUN-107-CLO: Phase II Study of Combination Rucaparib with Nivolumab in Platinum Sensitive Small Cell Lung Carcinoma Patients as Maintenance After Induction Therapy with Platinum Doublet
Hao, Z. (PI) & Chauhan, A. (Former PI)
Bristol Myers Squibb Company
6/27/19 → 1/17/25
Project: Research project
A Phase 2 Trial for Patients with Newly Diagnosed High Grade Glioma Treated with Concurrent Radiation Therapy, Temozolomide, and BMX-001
Villano, PhD, J. (PI)
BioMimetix JV LLC
4/29/19 → 12/31/24
Project: Research project
Admin Core: Improving Uptake of Cervical Cancer Prevention Services in Appalachia:
Dignan, M. (PI), Burris, J. (CoI) & Vanderpool, R. (Former CoI)
Ohio State University
4/11/19 → 3/31/25
Project: Research project
Project 2: Improving Uptake of Cervical Cancer Prevention Services in Appalachia: Testing Multi-level Intervention to Improve HPV Vaccination
Dignan, M. (PI), Adegboyega, A. (CoI), Burris, J. (CoI), Williams, L. (CoI) & Vanderpool, R. (Former CoI)
Ohio State University
4/11/19 → 3/31/25
Project: Research project
Core 3: Improving Uptake of Cervical Cancer Prevention Services in Appalachia: Biostatistics and Evaluation Core
Dignan, M. (PI), Burris, J. (CoI) & Vanderpool, R. (Former CoI)
Ohio State University
4/11/19 → 3/31/25
Project: Research project
Core 1: Improving Uptake of Cervical Cancer Prevention Services in Appalachia: Intervention Consortium Core
Dignan, M. (PI), Burris, J. (CoI) & Vanderpool, R. (Former CoI)
Ohio State University
4/11/19 → 3/31/25
Project: Research project
Project 3: Improving Uptake of Cervical Cancer Prevention Services in Appalachia: A Multi-level HPV Self-testing Intervention to Increase Cervical Cancer Screening among
Dignan, M. (PI), Adegboyega, A. (CoI), Burris, J. (CoI), Canedo, J. (CoI), Williams, L. (CoI) & Vanderpool, R. (Former CoI)
Ohio State University
4/11/19 → 3/31/25
Project: Research project
Project 1: Improving Uptake of Cervical Cancer Prevention Services in Appalachia: Break Free: Effectiveness of a Multi-level Smoking Cessation Program Adapted for High-risk Women in Rural Communities
Dignan, M. (PI), Burris, J. (CoI) & Vanderpool, R. (Former CoI)
Ohio State University
4/11/19 → 3/31/25
Project: Research project
Functional Analysis of Programmed Genome Rearrangement
Smith, J. (PI)
National Institute of General Medical Sciences
2/1/19 → 1/31/25
Project: Research project
Integrin alpha6beta4 Regulation of Cancer Epigenetics
O'Connor, K. (PI), Chen, M. (CoI), Liu, J. (CoI), Wang, C. (CoI), Fondufe-Mittendorf, Y. (Former CoI) & Hodges, K. (Former CoI)
National Cancer Institute
1/1/19 → 12/31/24
Project: Research project
GOG-3020/CO-338-087: ATHENA (A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase 3 Study in Ovarian Cancer Patients Evaluating Rucaparib and Nivolumab as Maintenance Treatment Following Response to Front-Line Platinum-Based Chemotherapy)
Ueland, F. (PI)
Gynecological Oncology Group Foundation Incorporated
11/30/18 → 12/18/25
Project: Research project
A Phase 2 Study Evaluating a Proprietary Amino Acid Based Medical Food (enterade®) in Patients with Quality of Life Limiting Diarrhea due to Carcinoid Syndrome and Other Neuroendocrine Tumors
Anthony, L. (PI)
Entrinsic Health Solutions Incorporated
11/5/18 → 2/27/25
Project: Research project
Increasing Access to Hepatitis C Treatment in Opioid Endemic Rural Areas: the Kentucky Viral Hepatitis Treatment (KeY Treat) Study
Havens, J. (PI), Fardo, D. (CoI), Hoven, A. (CoI), Lofwall, M. (CoI), Rosenau, J. (CoI), Staton, C. (CoI), Walsh, S. (CoI) & Young, A. (CoI)
National Institute on Drug Abuse
9/30/18 → 7/31/25
Project: Research project
(ACCSIS) Accelerating Colorectal Cancer Screening through Implementation Science in Appalachia
Dignan, M. (PI), Carman, A. (CoI), Huang, B. (CoI) & Kruse-Diehr, A. (CoI)
National Cancer Institute
9/19/18 → 8/31/25
Project: Research project
Restricted Carryforward Scope: (ACCSIS) Accelerating Colorectal Cancer Screening through Implementation Science in Appalachia
Dignan, M. (PI), Carman, A. (CoI), Huang, B. (CoI) & Kruse-Diehr, A. (CoI)
National Cancer Institute
9/19/18 → 8/31/25
Project: Research project
Appalachian Career Training in Oncology (ACTION) Program
Vanderford, N. (PI) & Evers, B. M. (CoI)
National Cancer Institute
9/18/18 → 8/31/28
Project: Research project
Characterize the Role of EBF1 in Breast Cancer Progression
Wu, Y. (PI), Fan, W.-M. (CoI), Chen, L. (Former CoI), Shi, Q. (Former CoI) & Wang, C. (Former CoI)
National Cancer Institute
9/1/18 → 8/31/25
Project: Research project
18-LUN-106-BMS (CA209816) Randomized, Open-Label, Phase 3 Trial of Nivolumab plus Ipilimumab or Nivolumab plus Platinum-Doublet Chemotherapy versus Platinum-Doublet Chemotherapy in Early Stage NSCLC
Villano, PhD, J. (PI)
Bristol Myers Squibb Company
8/16/18 → 8/24/25
Project: Research project