Neuroscience Research Priority Area

National Institute of Neurological Disorders & Stroke

8/1/20 → 4/30/25

Project: Research project

Novel Therapeutic Strategies to Resolve Neurovascular Inflammation and Repair Blood-Brain Barrier Dysfunction in Epilepsy

Bauer, B., Hartz, A., Kryscio, R., Pauly, J., Sunderam, S., Lin, A. L. & Smith, B.

6/15/20 → 3/31/26

Project: Research project

Embolise:Embolization of the Middle Meningeal Artery with ONYX# Liquid Embolic System In the Treatment of Subacute and Chronic Subdural HEmatoma

Fraser, J.

Covidien

5/26/20 → 11/27/24

Project: Research project

Anticoagulation in ICH Survivors for Prevention and Recovery (ASPIRE)

Gangadhara, S. & Pettigrew, L.

University of Cincinnati

4/30/20 → 4/30/24

Project: Research project

The A3 Study: Ante-Amyloid Prevention of Alzheimer's Disease

National Institute of Child Health and Human Develop

4/30/20 → 4/30/24

Project: Research project

Noninvasive Noncontact High-Density Optical Imaging of Neonatal Intraventricular Hemorrhage

Yu, G., Abu Jawdeh, E., Bada, H., Chen, L., Chen, L., Cheng, Q., Huang, C., Powell, D., Huang, C. & Miller, B.

4/10/20 → 3/31/25

Project: Research project

SBIR: Novel Modulators of the Dopamine Transporter for Alcohol and Nicotine Use Disorders

Gerhardt, G., Bardo, M., Littleton, J., Lynn, B. & Barron, S.

Naprogenix

4/5/20 → 3/31/24

Project: Research project

Long-term Effects of Wildtype Huntingtin Lowering in the Primate Corticostriatal Tract and Thalamus

Grondin, R., Gerhardt, G. & Zhang, Z.

National Institute of Neurological Disorders & Stroke

4/1/20 → 3/31/24

Project: Research project

The Amylin Dyshomeostasis Hypothesis of Vascular Contributions to Cognitive Impairment and Dementia (VCID)

Despa, F., Abner, E., Despa, S., Goldstein, L., Jicha, G. & Wilcock, D.

National Institute of Neurological Disorders & Stroke

4/1/20 → 3/31/25

Project: Research project

Mitochondrial Uncoupling Prodrug as a Translational Therapy for TBI.

Sullivan, P., Hubbard, W. & Whiteheart, S.

National Institute of Neurological Disorders & Stroke

3/15/20 → 1/31/26

Project: Research project

Regulation of Microglial Activation State by a Lipid Transporter

Bieberich, E., Bachstetter, A., Estus, G., McClintock, T., Wang, G. & Stromberg, A.

3/1/20 → 12/31/24

Project: Research project

Task Order 1: Platform Level Site Support for Platform Trial for the Treatment of Amyotrophic Lateral Sclerosis

KY Spinal Cord and Head Injury Research Trust

2/4/20 → 2/22/24

Project: Research project

Preclinical Development of Intranasal IGF-1 Therapy for TBI

Saatman, K. & Chen, L.

2/1/20 → 2/1/24

Project: Research project

Task Order 3: Regimen-Specific Appendix (RSA) B to Mast Protocol Verdiperstat: Double-Blind Phase

1/30/20 → 2/2/24

Project: Research project

Task Order 2: Regimen-Specific Appendix (RSA) A to Master Protocol Zilucoplan: Double-Blind Phase

1/30/20 → 2/2/24

Project: Research project

Task Order 4: Regimen-Specific Appendix (RSA) C to Master Protocol CNM-Au8: Double-Blind Phase

1/27/20 → 2/2/24

Project: Research project

HEALEY ALS Platform Trial: Start-Up

1/17/20 → 2/2/24

Project: Research project

AHEAD 3-45 Study: A Placebo-Controlled, Double-Blind, Parallel Treatment Arm, 216 Week Study to Evaluate Efficacy and Safety of Treatment With BAN2401 in Subjects With Preclinical Alzheimer's Disease and Elevated Amyloid (A45 Trial) and (A3 Trial)

1/1/20 → 12/31/23

Project: Research project

ATLAS: Safety and Effectiveness of the Treatment of Wide Neck, Saccular Intracranial Aneurysms with the Neuroform Atlas Stent System

Fraser, J.

Stryker Corporation

9/4/19 → 9/7/24

Project: Research project

A Placebo-Controlled, Double-Blind, Parallel-Group, 18-Month Study With an Open-Label Extension Phase to Confirm Safety and Efficacy of BAN2401 in Subjects With Early Alzheimer's Disease

Eisai Incorporated

8/20/19 → 2/6/24

Project: Research project

Pre-Clinical Efficacy of a Selective p38MAPK Inhibitor in a Model of Comorbid Alzheimer/Vascular Pathology

Van Eldik, L., Fardo, D., Morganti, J., Norris, C. & Lin, A. L.

8/15/19 → 3/31/24

Project: Research project

ARCADIA-CSI: Cognition and Silent Infarcts

Das, S. & Pettigrew, L.

University of Cincinnati

7/1/19 → 1/8/24

Project: Research project

Evaluation of Retinal Amyloid Imaging Sensitivity and Specificity Alone and in Combination with Blood-based Biomarkers to Amyloid Status as Determined by PET and/or CSF in Normal, MCI and Early AD Patients

NeuroVision Imaging Incorporated

4/11/19 → 3/21/24

Project: Research project

Changing the Energy Substrate Balance: Does APOE2 Promote Glucose Usage to Protect from Alzheimers Disease?

Johnson, L., Brandon, J., Kern, P., Morris, A. & Sun, R.

National Institute of Neurological Disorders & Stroke

4/1/19 → 3/31/24

Project: Research project

Cell-Specific Actions of IL-1 / IL-1R1 Signaling Following Traumatic Brain Injury

Bachstetter, A., Morganti, J. & Norris, C.

12/15/18 → 11/30/24

Project: Research project

A Novel Strategy to Overcome the P-gp/BCRP Drug Efflux System at the Blood-Brain Barrier to Improve Brain Uptake of CNS Therapeutics

Bauer, B., Hartz, A., Kryscio, R. & Lin, A. L.

National Institute of Neurological Disorders & Stroke

8/15/18 → 7/31/24

Project: Research project

Neural Mechanisms of Cannabinoid-Impaired Decision-Making in Emerging Adults

Wesley, M., Hays, L., Lile, J. & Sawaki Adams, L.

National Institute on Drug Abuse

7/15/18 → 6/30/24

Project: Research project

Global Alzheimer's Platform Trial-Ready Cohort for Preclinical/Prodromal Alzheimer's Disease

National Institute on Drug Abuse

5/15/18 → 4/30/24

Project: Research project

Dynamic Signaling of NRG3-ErbB4 in the Hippocampus Mediates Nicotine Withdrawal Phenotypes

Turner, J. & Ortinski, P.

4/1/18 → 1/31/24

Project: Research project

Molecular mechanisms: Dysregulation of monoamine transporters by HIV-1 Tat and cocaine

Zhan, C.

University of South Carolina

4/1/18 → 1/31/24

Project: Research project

Addressing Neuromuscular Deficits for Improved Outcomes in Ankle Sprain Rehabilitation

Gribble, P., Heebner, N., Johnson, N., Kosik, K., Powell, D. & Abt, J.

Army Medical Research and Materiel Command

3/15/18 → 3/14/24

Project: Research project

RIT1-Mediated Protection Following Traumatic Brain Injury

Andres, D., Black, P., Norris, C., Saatman, K., Wang, C. & Mir, S.

National Institute of Neurological Disorders & Stroke

2/15/18 → 1/31/24

Project: Research project

Comprehensive Analysis of Periocular Mesenchyme Composition, Specification and Function During Anterior Segment Formation

Famulski, J. & Smith, J.

National Eye Institute

2/1/18 → 1/31/24

Project: Research project

Programing Amylin Secretion to Slow Brain Aging - An Animal Model

Despa, F.

9/15/17 → 4/30/24

Project: Research project

Longitudinal Evaluation of Amyloid Risk and Neurodegeneration - the LEARN Study year 2

Jicha, G., Oates, M. E., Bardach, S., Caban-Holt, A., Murphy, R. & Smith, C.

Vanderbilt University Medical Center

11/1/15 → 4/30/24

Project: Research project

RNS System Long-term Treatment Clinical Investigation in epilepsy(NP10005)

Bensalem Owen, M.

NeuroPace Incorporated

5/6/15 → 1/25/24

Project: Research project

FEAT: Framing Eighteen coils in cerebral Aneurysms Trial

Fraser, J.

7/12/13 → 1/16/24

Project: Research project

A Placebo-controlled, Double-blind, Parallel-group, Bayesian Adaptive Randomization Design and Dose Regimen-finding Study to Evaluate Safety, Tolerability and Efficacy of BAN2401 in Subjects With Early Alzheimer#s Disease

Jicha, G., Caban-Holt, A. & Smith, C.

Eisai Incorporated

6/10/13 → 2/27/24

Project: Research project

SCoBIRC Support

Gensel, J., Geddes, J. & Springer, J.

KY Spinal Cord and Head Injury Research Trust

1/15/13 → 12/31/23

Project: Research project

Role of Impaired Cognitive States & Risk Factors in Conversion to Mixed Dementias

Kryscio, R., Fardo, D., Moga, D., Nelson, P., Schmitt, F. & Abner, E.

9/1/11 → 1/31/24

Project: Research project

Self-Regulation and Brain and Cognitive Health in Older Adults

Gold, B., Johnson, N., Karr, J., Lutz, C., McGavran, M., Schmitt, F., Westgate, P., Segerstrom, S. & Berry, D.

7/15/06 → 3/31/24

Project: Research project

Ceramide and Acute Phase Proteins Elevation During Aging

Nikolova-Karakashian, M., Bieberich, E., McClintock, T. & Wang, C.