Neurosurgery

Active

STRIDE: Pivotal Study to Evaluate the Safety and Effectiveness of the CereVasc eShunt System in the Treatment of Normal Pressure Hydrocephalus

Fraser, J. (PI)

CereVasc Incorporated

3/20/25 → 3/20/27

Project: Research project

Resolving the full MAPT H2 inverted haplotype using optical genome mapping and ultra-long-read nanopore sequencing (RPA Pilot / Seed Project)

Ebbert, M. T. W. (PI), Fardo, D. (CoI) & Nelson, P. (CoI)

University of Kentucky Neuroscience Research Priority Area

3/15/25 → …

Project: Research project

Functional and Biological Predictors of Degenerative Cervical Myelopathy Spinal Cord Injury

Gensel, J. (PI) & Farhadi, F. (CoPI)

KY Spinal Cord and Head Injury Research Trust

2/1/25 → 1/31/28

Project: Research project

Study to Assess the Effects of NTS Compound on Stroke Pathology

Roberts, J. (PI)

NeuroTrauma Sciences LLC

11/18/24 → 7/31/25

Project: Research project

SBIR: Novel Product Formulation to Modulate Alpha7 Nicotinic Receptors for Therapy in Stroke

Stowe, A. (PI) & Roberts, J. (CoI)

Epigen Biosciences Incorporated

7/29/24 → 5/31/26

Project: Research project

Evaluation of catabolic response in neurologically injured patients with augmented renal clearance (RPA Pilot/ Seed Project)

Cook, A. (PI), Flannery, A. (CoI), Duprey, M. (CoI), Magnuson, B. (CoI) & Dornbos, D. (CoI)

University of Kentucky Neuroscience Research Priority Area NEURO

7/1/24 → …

Project: Research project

Phase I Cell Therapy for Maintaining Cholinergic Circuits in the Spectrum of Alzheimer's Disease

Gerhardt, G. (PI), Ali, S. (CoI), Jicha, G. (CoI), McQuerry, K. (CoI), Quintero, J. (CoI), Schmitt, F. (CoI), Slevin, J. (CoI), van Horne, C. (CoI) & Kryscio, R. (Former CoI)

National Institute on Aging

6/15/24 → 5/31/29

Project: Research project

Impact of Quantitative Perfusion Deficits on Endothelial Dysfunction During Endovascular Thrombectomy in Large Vessel Ischemic Stroke

Dornbos, D. (PI), Fraser, J. (CoI), McLouth, C. (CoI) & Pennypacker, K. (CoI)

SNIS Foundation

2/15/24 → 7/31/25

Project: Research project

Safety and Tolerability of GTX-104 Compared with Oral Nimodipine in Patients with aSAH

Hatton, K. (PI), Cook, A. (CoI) & Dornbos, D. (CoI)

WuXi Clinical Development Incorporated

1/8/24 → 1/8/26

Project: Research project

LVO-ICH-VISION: A Multicenter Registry of Pre-Post Intervention of Automated Detection and Care Coordination for Suspected LVO or ICH Using Artificial Intelligence and Computer Vision

Fraser, J. (PI)

Viz.ai Incorporated

12/7/23 → 12/7/25

Project: Research project

Cannabidiol (CBD) as a Potential Therapeutic for Experimental Subarachnoid Hemorrhage

Roberts, J. (PI), Bauer, B. (CoI), Fraser, J. (CoI), McLouth, C. (CoI) & Sompol, P. (CoI)

National Institute of Neurological Disorders & Stroke

12/5/23 → 11/30/25

Project: Research project

CLIN-0016: Pilot Study To Evaluate The Safety And Effectiveness Of The Cerevasc? Eshunt? System In The Treatment Of Normal Pressure Hydrocephalus

Fraser, J. (PI)

CereVasc Incorporated

11/6/23 → 11/5/25

Project: Research project

Large Scale Human Schwann Cell Manufacturing and Quality Control

Monje, P. (PI)

AxoSim Incoporated

10/19/23 → 10/19/26

Project: Research project

STTR: Development of a Wearable Fluorescence Imaging Device for Intraoperative Identification of Brain Tumors

Yu, G. (PI), Chen, L. (CoI), Neltner, J. (CoI), Pittman, T. (CoI) & Chen, J. (Former CoI)

Bioptics Technology LLC

9/25/23 → 8/31/25

Project: Research project

Contribution of Vitamin D Deficiency to Pathological Progression in Models of Cerebral Hypoperfusion

Roberts, J. (PI)

National Center for Advancing Translational Sciences

9/1/23 → 8/31/25

Project: Research project

Biomarkers to Track Effective Interventions That Delay Dementia Onset In Participants of the "Risk Reduction for Alzheimer's Disease (rrAD)" Trial

Stowe, A. (PI), Trout, A. (CoI) & Wilcock, D. (CoI)

National Institute on Aging

9/1/23 → 8/31/26

Project: Research project

Predictors and Biomarkers for VCID versus Cognitive Recovery after Stroke Thrombectomy in Rural Appalachia

Harp, J. (PI), Fraser, J. (CoI), McLouth, C. (CoI), Pennypacker, K. (CoI), Schmitt, F. (CoI) & Wilcock, D. (Former CoI)

National Institute of Neurological Disorders & Stroke

4/15/23 → 3/31/28

Project: Research project

WEB-PAS: Post Market Surveillance Study to Evaluate the Long Term Safety and Effectiveness of the WEB Device

Dornbos, D. (PI)

MicroVention Incorporated

3/10/23 → 10/13/25

Project: Research project

Acute Alterations in CT Perfusion Imaging Following Thrombectomy for Acute Ischemic Stroke

Dornbos, D. (PI)

Siemens Medical Systems Inc

10/4/22 → 9/30/26

Project: Research project

Platelet Metabolism in Diabetes Mellitus

Wang, Q. (PI), Fraser, J. (CoI), Roberts, J. (CoI), Wang, C. (CoI), Whiteheart, S. (CoI), Gentry, M. (Former CoI) & Tannock, L. (Former CoI)

National Heart Lung and Blood Institute

9/20/22 → 6/30/26

Project: Research project

KL2 Scholar Scope - ProBDNF/BDNF EV Expression to Predict Cognitive Decline with VCID

Trout, A. (PI) & Kelly, T. (CoI)

National Center for Advancing Translational Sciences

7/1/22 → 6/30/25

Project: Research project

Prospective Evaluation of Mechanomyography Versus Triggered Electromyography for Intraoperative Assessment of Cortical Breaches During Instrumented Lumbar Spine Surgery

Farhadi, F. (PI)

Medical Device Business Services Incorporated

5/9/22 → 1/16/26

Project: Research project

The Citadel Embolization Device Study

Fraser, J. (PI)

Stryker Corporation

2/28/22 → 8/29/25

Project: Research project

BEACH: Biomarker and Edema Attenuation in IntraCerebral Hemorrhage Phase 2a Trial

Hatton, K. (PI), Dornbos, D. (CoI) & Lee, J. (CoI)

Johns Hopkins University

12/1/21 → 11/30/25

Project: Research project

ELEVATE: Evaluate Endovascular Treatment of Acutely Ruptured Shallow Intradural Aneurysms with the Pipeline Flex Embolization Device with Shield Technology

Dornbos, D. (PI) & Fraser, J. (Former PI)

Medtronics Inc

11/12/21 → 7/10/26

Project: Research project

BioHOBIT: The Biomarkers In The Hyperbaric Oxygen Brain Injury Treatment Trial

Dornbos, D. (PI)

University of Michigan

9/1/21 → 8/31/25

Project: Research project

Sleep Dysfunction as a Predictor of Plasma Biomarkers and Cognitive Dysfunction in Parkinson’s Disease (RPA Pilot / Seed Project)

Harp, J. (PI), Whitehurst, L. (CoI), Yamasaki, T. (CoI), Schmitt, F. (CoI) & Lee, D. (CoI)

University of Kentucky Neuroscience Research Priority Area

8/1/21 → …

Project: Research project

Inflammatory Contributions of Astrocytic RelA in Comorbid VCID/AD

Morganti, J. (PI), Norris, C. (CoI), Roberts, J. (CoI), Liu, J. (Former CoI) & Wilcock, D. (Former CoI)

National Institute of Neurological Disorders & Stroke

9/15/20 → 8/31/25

Project: Research project

Embolise:Embolization of the Middle Meningeal Artery with ONYX# Liquid Embolic System In the Treatment of Subacute and Chronic Subdural HEmatoma

Fraser, J. (PI)

Covidien

5/26/20 → 11/27/25

Project: Research project

HOBIT: Hyperbaric Oxygen Brain Injury Treatment Trial

Dornbos, D. (PI)

University of Michigan

9/30/17 → 6/30/25

Project: Research project

Kentucky Center for Clinical and Translational Science - Institutional Career Development Core

Kelly, T. (PI), Barry-Hundeyin, M. (CoI), Curry, T. (CoI), DiPaola, R. (CoI), Evers, B. M. (CoI), Giannone, P. (CoI), Guy, R. K. (CoI), Helmy, Y. A. (CoI), Jicha, G. (CoI), Kern, P. (CoI), King, V. (CoI), Lephart, S. (CoI), Liu, J. (CoI), Talbert, J. (CoI), Trout, A. (CoI), Williams, L. (CoI), Bush, M. (CoPI), Arnett, D. (Former CoI), Duncan, M. (Former CoI), Heath, E. (Former CoI), Lacy Leigh, M. (Former CoI), McLouth, L. (Former CoI), Roberts, J. (Former CoI), Samaan, M. (Former CoI) & Supinski, G. (Former CoI)

National Center for Advancing Translational Sciences

8/15/16 → 6/30/26

Project: Research project

Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial (CREST-2) Protocol

Lee, J. (PI), Endean, E. (CoI), Fraser, J. (CoI) & Pettigrew, L. (Former PI)

Mayo Clinic

3/15/14 → 8/31/25

Project: Research project

Finished

Pilot: Exploring Neuroprotective Role of Leukemia Inhibitory Factor (LIF) on Brain Metabolomics and Mitochondrial Bioenergetics Following Ischemic Stroke

Pandya, C. (PI), Fraser, J. (CoI), McLouth, C. (CoI) & Pennypacker, K. (CoI)

National Institute of General Medical Sciences

6/1/24 → 2/28/25

Project: Research project

Optimizing FINDERS workflow and refining EEG-fMRI post-processing (RPA Pilot / Seed Project)

Bae, J. (PI), Mirza, F. (CoPI), Koupparis, A. (CoPI), Raslau, F. (CoI), Clay, J. L. (CoI) & Ainger, T. (CoI)

University of Kentucky Neuroscience Research Priority Area

9/26/23 → 12/31/24

Project: Research project

Translational Evaluation of Complement Component 5a Receptor 1 (C5aR1) as a Novel Mediator in Post Stroke Depression (RPA Pilot/ Seed Project)

Pandya, C. (PI), Fraser, J. (CoPI), Pennypacker, K. (CoPI) & McLouth, C. (CoI)

University of Kentucky Neuroscience Research Priority Area

9/26/23 → 5/31/25

Project: Research project

Evaluation of Postictal Electroencephalogram (EEG) Slowing and Development of a Postictal EEG Source Imaging Technique to Localize Seizure Onset in Epilepsy (RPA Pilot / Seed Project)

Bae, J. (PI), Clay, J. L. (CoI), Raslau, F. (CoI) & Sunderam, S. (CoI)

University of Kentucky Neuroscience Research Priority Area

6/1/23 → 6/30/24

Project: Research project

Neurovascular EV Biomarkers to Predict Cognitive and Cerebrovascular Changes in rrAD

Trout, A. (PI), Fraser, J. (CoI), Stowe, A. (CoI) & Wilcock, D. (CoI)

American Heart Association

4/1/23 → 3/31/24

Project: Research project

Neurovascular EV Biomarkers to Predict Cognitive and Cerebrovascular Changes in rrAD

Trout, A. (PI), Fraser, J. (CoI), Stowe, A. (CoI) & Wilcock, D. (CoI)

American Heart Association

4/1/23 → 3/31/25

Project: Research project

Therapeutic targeting of B cell-mediated adaptive immune responses to traumatic brain injury (TBI) (RPA Pilot / Seed Project)

Saatman, K. (PI) & Stowe, A. (CoI)

University of Kentucky Neuroscience Research Priority Area

2/1/23 → 9/30/24

Project: Research project

Preclinical Development of Human Peripheral Nerve-Derived Therapeutic Products

Monje, P. (PI)

Indiana University

8/1/22 → 6/30/23

Project: Research project

ProBDNF/BDNF EV Expression to Predict Cognitive Decline with VCID

Trout, A. (PI) & Kelly, T. (CoI)

National Center for Advancing Translational Sciences

7/1/22 → 6/30/23

Project: Research project

KL2 Scholar Scope - ProBDNF/BDNF EV Expression to Predict Cognitive Decline with VCID

Trout, A. (PI) & Kelly, T. (CoI)

National Center for Advancing Translational Sciences

7/1/22 → 6/30/24

Project: Research project

CATSS Collaborative Group (RPA Pilot / Seed Project)

Pennypacker, K. (PI)

University of Kentucky Neuroscience Research Priority Area

7/1/22 → 3/31/24

Project: Research project

Pediatric Molecular Tumor Board C3358: FY 23

Villano, PhD, J. (PI), Badgett, J. (CoI), Durbin, E. B. (CoI), Kolesar, J. (CoI), Lightner, D. (CoI), Lukins, D. (CoI), Mirza, F. (CoI), Morgan, R. (CoI) & Shelton, B. (CoI)

KY Cabinet for Health and Family Services

7/1/22 → 6/30/23

Project: Research project

Using Extracellular Vesicles Isolated from Intracranial Blood to Understand the Local Ischemic Environment and Predict Outcome in Patients Undergoing Mechanical Thrombectomy.

Trout, A. (PI) & Fraser, J. (CoI)

SNIS Foundation

6/13/22 → 6/30/23

Project: Research project

Prospective Follow-up of Patients Undergoing Instrumented Thoracic and Lumbar Arthrodesis Supplemented by the Implanet Jazz System™

Farhadi, F. (PI)

Implanet America Incorporated

1/1/22 → 11/10/24

Project: Research project

Optimization and Translational Validation of a Novel Mouse Surgical Model of Moyamoya Syndrome

Roberts, J. (PI)

National Center for Advancing Translational Sciences

7/30/21 → 6/30/22

Project: Research project

MT-3921: A Phase 2a, Randomized, Double-blind, Placebo-controlled Study to Assess the Efficacy and Safety of MT-3921 in Subjects with Acute Traumatic Cervical Spinal Cord Injury

Motiei-Langroudi, R. (PI)

Mitsubishi Tanabe Pharma America Incorporated

6/30/21 → 7/10/24

Project: Research project

Cannabidiol (CBD) Therapy to Reduce Vasospasm and Inflammation Following Subarachnoid Hemorrhage (RPA Pilot / Seed Project)

Roberts, J. (PI), Chappell, J. (CoI) & Fraser, J. (CoI)

University of Kentucky Neuroscience Research Priority Area

2/1/21 → 1/31/22

Project: Research project

Inflammatory Contributions of Astrocytic RelA in Comorbid VCID/AD

Morganti, J. (PI), Norris, C. (CoI), Roberts, J. (CoI), Liu, J. (Former CoI) & Wilcock, D. (Former CoI)

National Institute of Neurological Disorders & Stroke

9/15/20 → 8/31/24

Project: Research project

Neurosurgery

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