Pharmaceutical Sciences

Active

COBRE in Pharmaceutical Research and Innovation

Thorson, J. (PI), Helmy, Y. A. (CoI), Jaramillo, A. (CoI), She, Q.-B. (CoI), Adams, V. (Former CoI), Alam, M. (Former CoI), Awuah, S. (Former CoI), Bardo, M. (Former CoI), Bauer, B. (Former CoI), Burgess, D. (Former CoI), Czuba, L. (Former CoI), Daugherty, A. (Former CoI), Dwoskin, L. (Former CoI), Feola, D. (Former CoI), Garneau-Tsodikova, S. (Former CoI), Gensel, J. (Former CoI), Glazer, E. (Former CoI), Grady, M. (Former CoI), Graf, G. (Former CoI), Kapur, N. (Former CoI), Kolesar, J. (Former CoI), Korotkov, K. (Former CoI), Korotkova, N. (Former CoI), Leggas, M. (Former CoI), Mahmoud, K. A. (Former CoI), McLaurin, K. (Former CoI), Messaoudi Powers, I. (Former CoI), Nikolajczyk, B. (Former CoI), Ortinski, P. (Former CoI), Pack, D. (Former CoI), Park, J. (Former CoI), Prisinzano, T. (Former CoI), Richards, C. (Former CoI), Rohr, J. (Former CoI), Sen, P. (Former CoI), Shaffer, C. (Former CoI), Stevenson, B. (Former CoI), Sturgill, J. (Former CoI), Sviripa, V. (Former CoI), Tidgewell, K. (Former CoI), Tiruvannamalai Annam, R. (Former CoI), Turner, J. (Former CoI), Van Lanen, S. (Former CoI), Venditto, V. (Former CoI), Watt, D. (Former CoI), Webb, N. (Former CoI) & Zhan, C.-G. (Former CoI)

National Institute of General Medical Sciences

3/1/20 → 1/31/26

Project: Research project

Translational Core Scope: COBRE in Pharmaceutical Research and Innovation

Thorson, J. (PI)

National Institute of General Medical Sciences

3/1/20 → 1/31/26

Project: Research project

Computational Core Scope: COBRE in Pharmaceutical Research and Innovation

Thorson, J. (PI)

National Institute of General Medical Sciences

3/1/20 → 1/31/26

Project: Research project

Caroline Geisler Ignite Scholar Scope: COBRE in Pharmaceutical Research and Innovation

Geisler, C. (PI) & Thorson, J. (CoI)

National Institute of General Medical Sciences

3/1/20 → 1/31/26

Project: Research project

Kristen McLaurin Scope: COBRE in Pharmaceutical Research and Innovation

McLaurin, K. (PI) & Thorson, J. (CoI)

National Institute of General Medical Sciences

3/1/20 → 1/31/26

Project: Research project

Mohammad Alam Scope: COBRE in Pharmaceutical Research and Innovation

Alam, M. (PI) & Thorson, J. (CoI)

National Institute of General Medical Sciences

3/1/20 → 1/31/26

Project: Research project

Kevin Tidgewell Scope: COBRE in Pharmaceutical Research and Innovation

Tidgewell, K. (PI) & Thorson, J. (CoI)

National Institute of General Medical Sciences

3/1/20 → 1/31/26

Project: Research project

Kentucky Network for Innovation & Commercialization (KYNETIC)

Dwoskin, L. (PI), McClure, I. (CoI), Prisinzano, T. (CoI), Thorson, J. (CoI) & Hall, E. (Former CoI)

National Heart Lung and Blood Institute

9/23/19 → 8/31/25

Project: Research project

University of Kentucky Center for Cancer Metabolism (Admin Core)

Zhou, B. (PI), Brainson, C. (CoI), Chaiswing, L. (CoI), D'Orazio, J. (CoI), Duncan, E. (CoI), Fan, W.-M. (CoI), Fong, K. W. (CoI), Hao, Z. (CoI), Higashi, R. (CoI), Jia, J. (CoI), Lane, A. (CoI), Liu, J. (CoI), Liu, X. (CoI), Moseley, H. (CoI), Myint, Z. (CoI), Rellinger, E. (CoI), Thorson, J. (CoI), Van Eldik, L. (CoI), Vanderford, N. (CoI), Wang, C. (CoI), Weiss, H. (CoI) & Yalniz, F. (CoI)

National Institute of General Medical Sciences

3/1/17 → 12/31/26

Project: Research project

Finished

SBIR: Synthesis of Q-N-Oxide Subcontract

Prisinzano, T. (PI)

Naprogenix

4/1/25 → 6/4/25

Project: Research project

CCSG Pilot: Targeting Merkel Cell Carcinoma by Natural Product-Based Degraders of MCV Small T Antigen

She, Q.-B. (PI), Thorson, J. (CoI) & Wang, C. (CoI)

National Cancer Institute

7/1/24 → 6/30/25

Project: Research project

Molecular Mechanisms: Dysregulation of Monoamine Transporters by HIV-1 Tat and Cocaine

Zhan, C.-G. (PI)

University of South Carolina

7/1/24 → 4/30/25

Project: Research project

ADORE Biobank Equipment

Nikolajczyk, B. (PI)

University of Kentucky Diabetes and Obesity Research Priority Area

5/1/24 → 4/30/25

Project: Research project

Exploiting Emerging Supramolecules as In Vivo Sequestrants to Induce Drug Reversal

Prisinzano, T. (PI), Alilain, W. (CoI) & Bardo, M. (CoI)

Reversal Therapeutics Incorporated

3/5/24 → 12/31/24

Project: Research project

NRSA Fellowship Emily Prantzalos: Role of Neuregulin 3-ErbB4 Signaling in a Murine Model of Co-Morbid Nicotine Dependence and Schizophrenia

Turner, J. (PI)

National Institute on Drug Abuse

1/12/24 → 1/11/25

Project: Research project

Examining the effect of estradiol and sex on gene expression in the subfornical organ

Santollo, J. (PI) & Turner, J. (PI)

University of Kentucky Neuroscience Research Priority Area

11/15/23 → 5/31/25

Project: Research project

Fellowship-Emily Prantzalos:Role of Neuregulin 3-ErbB4 Signaling in a Murine Model of Co-Morbid Nicotine Dependence and Schizophrenia

Turner, J. (PI)

American Foundation for Pharmaceutical Education

9/1/23 → 5/31/25

Project: Research project

Long-Acting Aldicarb Hydrolase as a Medical Countermeasure for Aldicarb Poisoning

Zheng, F. (PI) & Zhan, C.-G. (CoPI)

National Institute of Neurological Disorders & Stroke

9/1/23 → 8/31/24

Project: Research project

Fellowship Jack Keady: Investigation Into The Sex And Cell Specific Impacts Of Nicotine Withdrawal In The Murine Hippocampus

Turner, J. (PI)

American Foundation for Pharmaceutical Education

9/1/23 → 8/31/24

Project: Research project

DMS/NIGMS 1: Data-driven Ricci Curvatures and Spectral Graph for Machine Learning and Adaptive Virtual Screening

Nagel, U. (PI), Zhan, C.-G. (CoI) & Nguyen, D. (Former PI)

National Science Foundation

8/1/23 → 6/30/24

Project: Research project

DMS/NIGMS 1: Data-driven Ricci Curvatures and Spectral Graph for Machine Learning and Adaptive Virtual Screening

Zhan, C.-G. (PI), Nagel, U. (CoI) & Nguyen, D. (Former CoI)

National Science Foundation

8/1/23 → 6/30/24

Project: Research project

Center of Biomedical Research Excellence in CNS Metabolism - Administrative Core

Sullivan, P. (PI), Bachstetter, A. (CoI), Bauer, B. (CoI), Dutch, R. (CoI), Hubbard, W. (CoI), Johnson, L. (CoI), Nikolajczyk, B. (CoI), Norris, C. (CoI), Patel, S. (CoI), Schmitt, F. (CoI), Selenica, M.-L. (CoI), Slevin, J. (CoI), Wilcock, D. (CoI) & Yamasaki, T. (CoI)

National Institute of General Medical Sciences

5/15/23 → 2/29/24

Project: Research project

Center of Biomedical Research Excellence in CNS Metabolism - Administrative Core

Sullivan, P. (PI), Bachstetter, A. (CoI), Bauer, B. (CoI), Dutch, R. (CoI), Hubbard, W. (CoI), Johnson, L. (CoI), Nikolajczyk, B. (CoI), Norris, C. (CoI), Patel, S. (CoI), Schmitt, F. (CoI), Selenica, M.-L. (CoI), Slevin, J. (CoI), Wilcock, D. (CoI) & Yamasaki, T. (CoI)

National Institute of General Medical Sciences

5/15/23 → 2/28/25

Project: Research project

Development of Alginate Biosynthesis Inhibitors and Identification of their Targets

Garneau-Tsodikova, S. (PI)

University of Maryland at College Park

5/1/23 → 4/30/25

Project: Research project

Effects of HIV-1 Tat Protein and Methamphetamine on VMAT2-mediated Dopamine Transmission in the Context of NeuroHIV and Drug Abuse

Zhan, C.-G. (PI)

University of South Carolina

4/1/23 → 1/31/25

Project: Research project

Single Cell Resolution of Transcriptomic Changes in the Hippocampus During Nicotine Withdrawal

Turner, J. (PI)

University of Kentucky Substance Use Priority Research Area

2/1/23 → 12/31/24

Project: Research project

Jill Kolesar Scope: State Matching: Kentucky Network for Innovation & Commercialization (#KYNETIC#) Yr 4

Kolesar, J. (PI), Dwoskin, L. (CoI) & Richards, C. (CoI)

KY Economic Development Cab

1/1/23 → 12/31/23

Project: Research project

Mark Fritz Scope: State Matching: Kentucky Network for Innovation & Commercialization (#KYNETIC#) Yr 4

Fritz, M. (PI), Dwoskin, L. (CoI) & Zhang, G. (CoI)

KY Economic Development Cab

1/1/23 → 12/31/23

Project: Research project

Alpha2 Noradrenergic Antagonist as a Fentanyl Counter Measure

Bardo, M. (PI), Prisinzano, T. (PI) & Alilain, W. (CoI)

University of Kentucky Neuroscience Research Priority Area

1/1/23 → 12/31/23

Project: Research project

Rodney Guy Scope: State Matching: Kentucky Network for Innovation & Commercialization (#KYNETIC#) Yr 4

Guy, R. K. (PI), Bardo, M. (CoI) & Dwoskin, L. (CoI)

KY Economic Development Cab

1/1/23 → 6/30/23

Project: Research project

Mark Lovell Scope: State Matching: Kentucky Network for Innovation & Commercialization (#KYNETIC#) Yr 5

Lovell, M. (PI), Dwoskin, L. (CoI) & Prisinzano, T. (CoI)

KY Economic Development Cab

7/1/22 → 6/30/24

Project: Research project

Jill Kolesar Scope: State Matching: Kentucky Network for Innovation & Commercialization (#KYNETIC#) Yr 5

Kolesar, J. (PI), Arnold, S. M. (CoI), Bondada, S. (CoI), Dwoskin, L. (CoI), Gedaly, R. (CoI), Richards, C. (CoI) & Ueland, F. (CoI)

KY Economic Development Cab

7/1/22 → 6/30/24

Project: Research project

PTPRD Phosphatase Inhibitors for Stimulant Use Disorders

Prisinzano, T. (PI)

University of Maryland at Baltimore

7/1/22 → 6/30/23

Project: Research project

State Matching: Kentucky Network for Innovation & Commercialization (#KYNETIC#) Yr 4

Dwoskin, L. (PI), Fritz, M. (CoI), Kolesar, J. (CoI) & Guy, R. (Former CoI)

KY Economic Development Cab

7/1/22 → 12/31/23

Project: Research project

Ghrelin Deacylase as a Treatment for Opioid Polysubstance Abuse

Zhan, C.-G. (PI) & Zheng, F. (CoPI)

National Institute on Drug Abuse

7/1/22 → 6/30/25

Project: Research project

Vincent Venditto Scope: State Matching: Kentucky Network for Innovation & Commercialization (#KYNETIC#) Yr 5

Venditto, V. (PI) & Dwoskin, L. (CoI)

KY Economic Development Cab

7/1/22 → 6/30/24

Project: Research project

State Matching: Kentucky Network for Innovation & Commercialization (#KYNETIC#) Yr 5

Dwoskin, L. (PI), Arnold, S. M. (CoI), Bondada, S. (CoI), Lovell, M. (CoI), Prisinzano, T. (CoI), Richards, C. (CoI), Ueland, F. (CoI) & Venditto, V. (CoI)

KY Economic Development Cab

7/1/22 → 6/30/24

Project: Research project

Development of Chemical Inhibitors of Pseudomonas Aeruginosa Alginate Production

Garneau-Tsodikova, S. (PI)

University of Maryland at College Park

5/1/22 → 4/30/23

Project: Research project

In Vitro Evaluation of TNX-1300

Zhan, C.-G. (PI)

Tonix Pharmaceuticals Incorporated

3/14/22 → 6/30/22

Project: Research project

Production of CocH3-Fc(M3) Protein

Zheng, F. (PI)

Enzyme Therapy Incorporated

3/1/22 → 1/31/24

Project: Research project

Safety and Biodistribution of a Novel Enzyme-Antibody Fusion in a Canine Model

Gerhardt, G. (PI), Grondin, R. (CoI), Pauly, J. (CoI), Zhang, Z. (CoI) & Gentry, M. (Former CoI)

Citizens United for Research in Epilepsy

3/1/22 → 11/30/24

Project: Research project

Development of UKY-21, a Novel VMAT2 Inhibitor for the Treatment of Methamphetamine Use Disorder

Guy, R. K. (PI)

University of Kentucky Substance Use Priority Research Area

1/1/22 → 6/30/23

Project: Research project

Elucidating Molecular Mechanisms Linking Fructose to Cholesterol Metabolism

Helsley, R. (PI), Graf, G. (CoI), Lane, A. (CoI) & Softic, S. (CoI)

National Institute Diabetes & Digestive & Kidney

1/1/22 → 12/31/23

Project: Research project

Acetate as a Platform for Carbon-Negative Production of Renewable Fuels and Chemicals

Chappell, J. (PI) & Zhan, C.-G. (CoI)

University of Wisconsin

10/1/21 → 9/30/24

Project: Research project

Development of Agents for Synthetic Opioid Overdose

Prisinzano, T. (PI), Alilain, W. (CoI), Bardo, M. (CoI) & Turner, J. (CoI)

National Institute on Drug Abuse

9/1/21 → 7/31/23

Project: Research project

Development of Agents for Synthetic Opioid Overdose

Prisinzano, T. (PI), Alilain, W. (CoI), Bardo, M. (CoI) & Turner, J. (CoI)

National Institute on Drug Abuse

9/1/21 → 7/31/22

Project: Research project

Development of Agents for Synthetic Opioid Overdose

Prisinzano, T. (PI), Alilain, W. (CoI), Bardo, M. (CoI) & Turner, J. (CoI)

National Institute on Drug Abuse

9/1/21 → 7/31/24

Project: Research project

Neuropeptide-Dependent Parabrachial Control of the BNST During Alcohol Abstinence-Induced Negative Affect

Jaramillo, A. (PI)

National Institute on Alcohol Abuse and Alcoholism

8/6/21 → 5/31/25

Project: Research project

Non-invasive nanotherapeutics to modulate neuroinflammation after spinal cord injury

Park, J. (PI) & Gensel, J. (CoI)

University of Kentucky Neuroscience Research Priority Area

8/1/21 → 7/31/22

Project: Research project

Immunoproteasome Inhibitors for the Treatment of Alzheimer's Disease

Kim, K. (PI), Bae, Y. (CoI) & Van Eldik, L. (CoI)

National Institute on Aging

8/1/21 → 1/31/23

Project: Research project

Pharmaceutical Sciences

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