Physiology

Grants and Contracts

Grants and Contracts per year 1980 2000 2001 2003 2006 2008 2009 2010 2014 2016 2017 2020 2027

• 63 Active
• 542 Finished

Grants and Contracts per year

Search results

• Finished

  Synthetic HDL_ a Potential Sepsis Therapy

  Li, X. & Gong, M.

  National Institute of General Medical Sciences

  1/1/15 → 5/31/22

  Project: Research project

  • High Density Lipoprotein 100%
  • Sepsis 100%
  • Death 33%
  • Mouse 22%
  • Prognosis 11%

• NRSA Fellowship for Manning: Prevention of heart failure and remodeling through calcium channel modulation

  Satin, J., Andres, D. & Manning, J.

  National Heart Lung and Blood Institute

  12/1/14 → 11/30/15

  Project: Research project

  • Myocardial Infarction 100%
  • Heart Failure 50%
  • Heart 37%
  • Isotopes of Calcium 37%
  • Mouse 37%

• NRSA Fellowship for Manning: Prevention of heart failure and remodeling through calcium channel modulation

  Satin, J., Andres, D. & Manning, J.

  National Heart Lung and Blood Institute

  12/1/14 → 11/30/16

  Project: Research project

  • Myocardial Infarction 100%
  • Heart Failure 50%
  • Heart 37%
  • Isotopes of Calcium 37%
  • Mouse 37%

• Mineralocorticoid receptor and abdominal aortic aneurysm

  Gong, M. & Guo, Z.

  National Heart Lung and Blood Institute

  11/15/14 → 10/31/19

  Project: Research project

  • Aldosterone 100%
  • Sodium Chloride 94%
  • Aortic Aneurysm 75%
  • Smooth Muscle Cell 64%
  • Antagonist 30%

• Development and Dissemination of MuscleMiner: An Imaging Informatics Tool for Muscle

  Esser, K.

  9/8/14 → 7/31/15

  Project: Research project

  • Images 100%
  • Informatics 83%
  • Morphometrics 50%
  • Diagnosis 50%
  • Area 33%

• Fellowship for Lutshumba: Protection from Aortic Aneurysm by Bmal 1 deletion from Smooth Muscle Cells

  Gong, M. & Lutshumba, J.

  National Heart Lung and Blood Institute

  9/5/14 → 9/4/15

  Project: Research project

  • Aortic Aneurysm 100%
  • Tissues 61%
  • Matrix Metalloproteinase 22%
  • Sodium Chloride 22%
  • Smooth Muscle Cell 16%

• NRSA Fellowship for Lutshumba: Protection from Aortic Aneurysm by Bmal 1 deletion from Smooth Muscle Cells

  Gong, M. & Lutshumba, J.

  National Heart Lung and Blood Institute

  9/5/14 → 9/4/16

  Project: Research project

  • Aortic Aneurysm 100%
  • Tissues 61%
  • Matrix Metalloproteinase 22%
  • Sodium Chloride 22%
  • Smooth Muscle Cell 16%

• Ribosome specialization in adult skeletal muscle

  McCarthy, J.

  National Institute Arthritis Musculoskeletal & Skin

  9/1/14 → 8/31/17

  Project: Research project

  • Ribosome 100%
  • Muscle 100%
  • Ribosome Protein 60%
  • Ribosomal Proteins 60%
  • Skeletal Muscle 50%

• Stereocilia bundle stiffness and mechano-electrical transduction in the auditory hair cells

  Frolenkov, G.

  Office of the Director

  9/1/14 → 8/31/15

  Project: Research project

  • Stereocilium 100%
  • Actin Binding Protein 28%
  • Nonsyndromic Deafness 14%
  • Mechanotransduction 14%
  • Gene 14%

• Molecular clock and skeletal muscle weakness

  Esser, K. & Stumpf, E.

  National Institute Arthritis Musculoskeletal & Skin

  8/25/14 → 7/31/15

  Project: Research project

  • Skeletal Muscle 100%
  • Transcription Factors 37%
  • Gene 37%
  • Sarcomere 37%
  • Circadian Rhythm 12%

• Respiratory function and echocardiography validation study

  Esser, K. & Chung, C.

  8/14/14 → 7/30/15

  Project: Research project

• Odorant Receptor Pharmacology In Vivo

  McClintock, T.

  Firmenich

  7/14/14 → 7/1/15

  Project: Research project

• CXCR4 Signaling in Lung Epithelial Repair

  Waters, C.

  National Heart Lung and Blood Institute

  7/8/14 → 3/31/20

  Project: Research project

  • Apoptosis Signal Regulating Kinase 1 100%
  • Artificial Respiration 100%
  • Phosphotransferase 75%
  • Epithelial Cell 50%
  • Mortality 50%

• KSEF RDE: Long QT Gene to Function Screens that Clarify Variants of Uncertain Significance

  Delisle, B. & Farman, M.

  KY Science and Technology Co Inc

  7/1/14 → 12/31/16

  Project: Research project

  • Nested Gene 100%
  • Gene 100%
  • Mutation 87%
  • Functions 62%
  • Genetics 50%

• Genomic Editing to Elucidate CD33 Function

  Estus, G.

  BrightFocus Foundation

  7/1/14 → 6/30/16

  Project: Research project

  • CD33 100%
  • Exon 25%
  • Allele 16%
  • Sialic Acid 8%
  • Cytokine Production 8%

• Odorant Receptor Expression and Sensitivity to Odorants

  McClintock, T.

  National Institute on Deafness & Other Communications

  7/1/14 → 2/29/16

  Project: Research project

  • Eicosanoid Receptor 100%
  • Receptor Expression 40%
  • RNA-Seq 40%
  • Sensory Neuron 40%
  • Microarray 20%

• Usher proteins in the inner ear structure and function

  Frolenkov, G. & Velez Ortega, A. C.

  University of Maryland

  7/1/14 → 11/30/17

  Project: Research project

  • Protein 100%
  • Mutation 69%
  • Stereocilia 60%
  • Nested Gene 60%
  • Stereocilium 60%

• UK Professional Education Preparation Program

  McConnell, M. & Kennedy, T.

  7/1/14 → 6/30/16

  Project: Research project

  • Students 100%
  • Student 100%
  • Program 66%
  • Education 33%
  • Professional Personnel 33%

• UK Professional Education Preparation Program

  Snyder, C.

  7/1/14 → 6/30/15

  Project: Research project

  • Students 100%
  • Student 100%
  • Program 66%
  • Education 33%
  • Professional Personnel 33%

• Fellowship for Manning: Protection against myocardial infarction through the loss of Rad GTPase

  Satin, J., Andres, D. & Manning, J.

  American Heart Association Great Rivers Affiliate

  7/1/14 → 11/30/14

  Project: Research project

  • Myocardial Infarction 100%
  • Heart 55%
  • Contractile Function 33%
  • Myocyte 33%
  • Combination Therapy 22%

• Test Efficacy of Adynxx Compounds in a Preclinical Model of Mono-Arthritic Pain

  Taylor, B.

  6/17/14 → 12/31/14

  Project: Research project

• Translating CD33 Genetic Mechanism into a Novel Alzheimers Therapeutic

  Estus, G., Fardo, D., Nelson, P., Van Eldik, L. & Wilcock, D.

  National Institute on Aging

  4/15/14 → 11/30/18

  Project: Research project

  • CD33 100%
  • Genetics 16%
  • Single-Nucleotide Polymorphism 16%
  • Exon 16%
  • Sialic Acid 12%

• Impact of EOM specific myosin loss on extraocular muscle structure and function

  Andrade, F. & McCarthy, J.

  National Eye Institute

  4/1/14 → 3/31/17

  Project: Research project

  • Myosin 100%
  • Strabismus 22%
  • Surgery 22%
  • Absence 11%
  • Patient 11%

• Odorant Receptor Gene Regulation

  McClintock, T.

  National Institute on Deafness & Other Communications

  3/1/14 → 7/31/16

  Project: Research project

  • Receptor Gene 100%
  • Transcription Factors 50%
  • Chromatin 50%
  • Negative Feedback 16%
  • Gene Expression 16%

• Investigating the Therapeutic Potential for Selective Late INa Blockers in the Management of Type 2 Long QT Syndrome

  Delisle, B. & Burgess, D.

  Gilead Sciences Inc

  2/17/14 → 1/30/16

  Project: Research project

• Computer-assisted Optimization of Therapies for Heart Failure

  Wenk, J., Campbell, K. & Fornwalt, B.

  American Heart Association Great Rivers Affiliate

  1/1/14 → 12/31/16

  Project: Research project

  • Patient 100%
  • Combination Therapy 66%
  • Heart Failure 50%
  • Cell Level 50%
  • Measurement 33%

• Long QT Vulnerability in Sudden Infant Death Syndrome

  Delisle, B. & Burgess, D.

  Saving Tiny Hearts Society

  1/1/14 → 12/31/14

  Project: Research project

  • Sudden Infant Death Syndrome 100%
  • Long QT Syndrome 63%
  • Ventricle of Heart 54%
  • Gene 45%
  • Infant 36%

• Computer-assisted optimizationof therapies for heart failure

  Wenk, J., Campbell, K. & Fornwalt, B.

  American Heart Association Great Rivers Affiliate

  1/1/14 → 12/31/14

  Project: Research project

  • Patient 100%
  • Combination Therapy 66%
  • Heart Failure 50%
  • Cell Level 50%
  • Measurement 33%

• Effect of Satellite Cell Ablation on the Aging Diaphragm

  Dupont-Versteegden, E. & Andrade, F.

  National Institute on Aging

  9/30/13 → 6/30/17

  Project: Research project

  • Satellite Cell 100%
  • Diaphragm 93%
  • Age 66%
  • Aging 60%
  • Diaphragm Muscle 26%

• Statistical Genetics Methods for Mixed Pathologies

  Fardo, D., Estus, G., Kryscio, R., Nelson, P. & Schmitt, F.

  National Institute on Aging

  8/15/13 → 3/31/17

  Project: Research project

  • Genetics 100%
  • Diseases 50%
  • Research 35%
  • Pathology 28%
  • Ageing 28%

• STTR: Intelligent and Automatic Image Segmentation Software for High throughput Analysis

  Esser, K., Peterson, C. & Yang, L.

  8/1/13 → 6/30/14

  Project: Research project

• Therapeutic strategies to treat mdx mice

  Esser, K. & Stumpf, E.

  ARMGO Pharma Incorporated

  7/22/13 → 3/31/14

  Project: Research project

• NRSA Fellowship for Griggs: Methylglyoxal and TRPA1 contribution to neuropathic pain in type 2 diabetes

  Taylor, B. & Griggs, R.

  4/1/13 → 3/31/14

  Project: Research project

  • Pain 100%
  • Maturity Onset Diabetes of the Young 80%
  • Hypersensitivity 80%
  • Diabetes 80%
  • Glucose 60%

• NRSA Fellowship for Griggs: Methylglyoxal and TRPA1 contribution to neuropathic pain in type 2 diabetes

  Taylor, B. & Griggs, R.

  4/1/13 → 3/31/15

  Project: Research project

  • Pain 100%
  • Maturity Onset Diabetes of the Young 80%
  • Hypersensitivity 80%
  • Diabetes 80%
  • Glucose 60%

• Rad Modulation of Calcium Homeostatsis as a Putative Therapeutic for Diabetic Cardiomyopathy

  Satin, J.

  Washington University in St. Louis

  2/23/13 → 11/30/22

  Project: Research project

  • Diabetes Mellitus 100%
  • Heart Failure 60%
  • Diabetes 60%
  • Patient Population 40%
  • Heart 40%

• Translating Genetics into Biomarkers and Therapies: apoE/Ab and apoJ/Ab Complex Levels and Lipidation State as AD Biomarkers Modulated by VPA

  Estus, G.

  Alzheimers Drug Discovery Foundation

  2/1/13 → 3/31/14

  Project: Research project

  • Valproic Acid 100%
  • In Vitro 18%
  • In Vivo 18%
  • ELISA 18%
  • Clusterin 9%

• A Role For Cytokine Interleukin-6 In Post-Traumatic Epileptogenesis

  Boychuk, J. & Smith, B.

  1/1/13 → 12/31/13

  Project: Research project

  • Seizure 100%
  • Interleukin 6 100%
  • Brain 66%
  • Brain Injury 66%
  • Protein 33%

• Usher Proteins in the Inner Ear Structure and Function

  Frolenkov, G.

  Childrens Hospital Medical Center

  12/1/12 → 11/30/13

  Project: Research project

  • Protein 100%
  • Mutation 71%
  • Stereocilia 71%
  • Nested Gene 71%
  • Stereocilium 71%

• Usher proteins in the inner ear structure and function

  Frolenkov, G.

  Childrens Hospital Medical Center

  12/1/12 → 6/30/14

  Project: Research project

  • Protein 100%
  • Mutation 69%
  • Stereocilia 60%
  • Nested Gene 60%
  • Stereocilium 60%

• UK Professional Education Preparation Program

  Snyder, C.

  10/1/12 → 6/30/14

  Project: Research project

  • Students 100%
  • Student 100%
  • Program 66%
  • Education 33%
  • Professional Personnel 33%

• Supplement - Early detection and prevention of mild cognitive impairment due to cerebrovascular disease

  Moser, D., Bruckner, G., Estus, G., Jicha, G., Lennie, T. & Mudd, G.

  National Institute of Nursing Research

  9/23/12 → 6/30/16

  Project: Research project

  • Mild Cognitive Impairment 100%
  • Inpatient 50%
  • Cognitive Function 50%
  • Patient 37%
  • Parent 37%

• Skeletal muscle biologyin rheumatoid arthritis

  Reid, M., Andrade, F., Campbell, K., Esser, K., Moylan, J. & Crofford, L.

  National Institute Arthritis Musculoskeletal & Skin

  9/17/12 → 8/31/13

  Project: Research project

  • Rheumatoid Arthritis 100%
  • Inflammatory Arthritis 100%
  • Muscle 53%
  • Force 26%
  • Patient 20%

• Glutamate-evoked calcium signaling in spinal cord after nerve injury

  Doolen, S. & Taylor, B.

  9/1/12 → 8/31/14

  Project: Research project

  • Glutamic Acid 100%
  • Spinal Cord 44%
  • Behavior (Neuroscience) 33%
  • Calcium Channel 33%
  • Allodynia 22%

• Testing and Analysis Agreement

  Reid, M.

  8/30/12 → 8/29/13

  Project: Research project

• Testing and Analysis Agreement - Addendum

  Reid, M.

  8/30/12 → 8/29/13

  Project: Research project

• Exploratory Studies of AYX1 Efficacy

  Taylor, B.

  8/1/12 → 12/31/12

  Project: Research project

• BetaCatenin Regulation of Skeletal Muscle Hypertrophy

  McCarthy, J. & Esser, K.

  National Institute Arthritis Musculoskeletal & Skin

  7/1/12 → 6/30/16

  Project: Research project

  • Muscle Hypertrophy 100%
  • Catenin 87%
  • Skeletal Muscle 87%
  • Ribosome 62%
  • Ribosome Biogenesis 62%

• BetaCatenin Regulation of Skeletal Muscle Hypertrophy

  McCarthy, J. & Esser, K.

  National Institute Arthritis Musculoskeletal & Skin

  7/1/12 → 6/30/17

  Project: Research project

  • Muscle Hypertrophy 100%
  • Catenin 87%
  • Skeletal Muscle 87%
  • Ribosome 62%
  • Ribosome Biogenesis 62%

• Regulation of Blood Pressure Circadian Rhythm by Vascular Smooth Muscle BMAL1

  Gong, M., Guo, Z., Duncan, M. & Esser, K.

  National Heart Lung and Blood Institute

  5/15/12 → 4/30/18

  Project: Research project

  • Circadian Rhythm 100%
  • Blood Pressure 77%
  • Nested Gene 16%
  • Gene 16%
  • Tissue 11%

• Supplement - Regulation of Blood Pressure Circadian Rhythm by Vascular Smooth Muscle BMAL1

  Gong, M. & Guo, Z.

  National Heart Lung and Blood Institute

  5/15/12 → 4/30/17

  Project: Research project

  • Circadian Rhythm 100%
  • Vascular Smooth Muscle 66%
  • Estrogens 44%
  • Estrogen 44%
  • Diabetes 33%