Sanders-Brown Center on Aging (SBCoA)

106 Active
723 Finished

1 - 50 out of 829 results

Active

ALN-APP-002: A Phase 2, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy, Safety, Tolerability, and Pharmacodynamics of Intrathecally Administered ALN-APP in Patients with Cerebral Amyloid Angiopathy (CAA)
Jicha, G. (PI)
Alnylam Pharmaceuticals Incorporated
10/3/24 → 10/3/26
Project: Research project
Comprehensive Gene-Environment Interactions on Alzheimer's Disease
Wu, X. (PI), Abner, E. (CoI), Fardo, D. (CoI), Katsumata, Y. (CoI) & Nelson, P. (CoI)
8/1/24 → 7/31/26
Project: Research project
Relationship Between Astrocyte p38 MAPK, Neuroinflammation, and Alzheimer Pathology
Van Eldik, L. (PI) & Braun, D. (CoI)
BrightFocus Foundation
7/1/24 → 6/30/27
Project: Research project
Extracellular Vesicle-Mediated Nrf2 Protein Secretion and its Therapeutic Application in Cardiogenic Dementia
Tian, C. (PI) & Sompol, P. (CoI)
American Heart Association
7/1/24 → 6/30/27
Project: Research project
Phase I Cell Therapy for Maintaining Cholinergic Circuits in the Spectrum of Alzheimer's Disease
Gerhardt, G. (PI), Ali, S. (CoI), Jicha, G. (CoI), Kryscio, R. (CoI), Quintero, J. (CoI), Schmitt, F. (CoI), Slevin, J. (CoI) & van Horne, C. (CoI)
National Institute on Aging
6/15/24 → 5/31/29
Project: Research project
Year 3: Scholar Elizabeth Elliott (Mentor Robin Cooper): Beckman Scholars Program: Scholars United by Chemistry: Cultivating Excellence through Science Stewardship (SUCCESS)
Cooper, R. (PI), Risko, C. (CoI), Miller, A.-F. (Former CoI) & Van Eldik, L. (Former CoI)
Arnold and Mabel Beckman Foundation
5/15/24 → 8/13/25
Project: Research project
Year 3: Mentor Robin Cooper (Scholar Elizabeth Elliott): Beckman Scholars Program: Scholars United by Chemistry: Cultivating Excellence through Science Stewardship (SUCCESS)
Cooper, R. (PI), Risko, C. (CoI), Miller, A.-F. (Former CoI) & Van Eldik, L. (Former CoI)
Arnold and Mabel Beckman Foundation
5/15/24 → 8/13/25
Project: Research project
Year 3: Mentor: Chad Risko (Scholar Shasanka Lamichhane): Beckman Scholars Program: Scholars United by Chemistry: Cultivating Excellence through Science Stewardship (SUCCESS)
Risko, C. (PI), Cooper, R. (Former CoI), Miller, A.-F. (Former CoI) & Van Eldik, L. (Former CoI)
Arnold and Mabel Beckman Foundation
5/15/24 → 8/13/25
Project: Research project
Year 3: Scholar Shasanka Lamichhane (Mentor Chad Risko): Beckman Scholars Program: Scholars United by Chemistry: Cultivating Excellence through Science Stewardship (SUCCESS)
Risko, C. (PI), Cooper, R. (Former CoI), Miller, A.-F. (Former CoI) & Van Eldik, L. (Former CoI)
Arnold and Mabel Beckman Foundation
5/15/24 → 8/13/25
Project: Research project
Changes in Protein Glycosylation Due to Translation of Mannosidases Encoded by Circular RNAs
Stamm, S. (PI) & Nelson, P. (CoI)
National Institute on Aging
5/1/24 → 4/30/26
Project: Research project
PTI-125-10: An Open-Label, Long-Term Extension Study to Evaluate the Safety and Tolerability of Simufilam 100mg Tablets in Participants with Mild to Moderate Alzheimer#s Disease
Jicha, G. (PI)
Premier Research International LLC
2/19/24 → 2/19/26
Project: Research project
Emerging role of PAD4 mediated TDP-43 citrullination in the neuropathology of LATE and Alzheimer’s Disease Related Dementias
Selenica, M.-L. (PI), Abner, E. (CoI), Lee, D. (CoI), Nelson, P. (CoI) & Norris, C. (CoI)
National Institute on Aging
2/15/24 → 1/31/29
Project: Research project
KSCHIRT: A miRNA-Based Liposome Nanoparticle Intervention to Treat Secondary Injury Following Traumatic Brain Injury in Mice
Wang, W. (PI), Bachstetter, A. (CoI) & Prajapati, P. (CoI)
KY Spinal Cord and Head Injury Research Trust
2/1/24 → 1/31/27
Project: Research project
Gabapentin Prescription and Health-Related Outcomes in Older Adults
Oh, G. Y. (PI), Abner, E. (CoI), Chen, J. (CoI), Freeman, P. (CoI), Moga, D. (CoI) & Talbert, J. (CoI)
National Institute on Aging
12/15/23 → 11/30/25
Project: Research project
Cannabidiol (CBD) as a Potential Therapeutic for Experimental Subarachnoid Hemorrhage
Roberts, J. (PI), Bauer, B. (CoI), Fraser, J. (CoI), McLouth, C. (CoI) & Sompol, P. (CoI)
National Institute of Neurological Disorders & Stroke
12/5/23 → 11/30/25
Project: Research project
AHEAD Plasma Extension (APEX) - SCON 6064
Jicha, G. (PI)
University of Southern California
12/1/23 → 11/30/25
Project: Research project
Johns Hopkins University Trial Innovation Center
Van Eldik, L. (PI)
Johns Hopkins University
11/1/23 → 4/30/28
Project: Research project
Federated Digital Pathology Platform for AD/ADRD Research and Diagnostics
Nelson, P. (PI), Cheung, S.-C. (CoI), Fardo, D. (CoI) & Bumgardner, V. (CoPI)
National Institute of Neurological Disorders & Stroke
9/20/23 → 8/31/25
Project: Research project
Alzheimer’s Clinical Trials Consortium (ACTC): Committee
Jicha, G. (PI)
University of Southern California
9/15/23 → 8/31/28
Project: Research project
Bisphenol-Induced Blood-Brain Barrier Dysfunction in Alzheimer’s Disease
Hartz, A. (PI), Bauer, B. (CoI), Gold, B. (CoI), Hennig, B. (CoI), Kryscio, R. (CoI) & Pearson, K. (CoI)
National Institute of Neurological Disorders & Stroke
9/15/23 → 7/31/28
Project: Research project
Longitudinal Follow-up of Clinical Trial Participants For Brain Donation (U24)
Jicha, G. (PI)
University of Southern California
9/15/23 → 8/31/25
Project: Research project
Alzheimer’s Clinical Trials Consortium (ACTC): Infrastructure
Jicha, G. (PI) & Coskun, E. (CoI)
University of Southern California
9/15/23 → 8/31/28
Project: Research project
A Randomized, Double-blind, Placebo-controlled, Dose-finding Study to Evaluate the Safety, Efficacy, Pharmacokinetics, and Pharmacodynamics of ABBV-552 in Participants with Mild Alzheimer's Disease
Jicha, G. (PI)
AbbVie Incorporated
9/6/23 → 9/6/25
Project: Research project
The Alzheimer's Biomarker Consortium - Down Syndrome (ABC-DS) - Gait Supplement
Glueck, A. (PI) & Schmitt, F. (CoI)
University of Pittsburgh
9/1/23 → 8/31/25
Project: Research project
Citrullinated Tau as a Therapeutic Target in Tauopathies
Lee, D. (PI)
BrightFocus Foundation
7/1/23 → 6/30/26
Project: Research project
Diverse Clinical Trial Participation Using Data-Driven and Evidence-Based Participant Recruitment and Retention Science
Rhodus, E. (PI)
University of Southern California
7/1/23 → 3/31/26
Project: Research project
Cognitive Aging Trajectories in Survivors of Trauma
Lawrence, K. (PI), Fardo, D. (CoI), Schmitt, F. (CoI) & Segerstrom, S. (CoI)
National Institute on Aging
5/15/23 → 1/31/28
Project: Research project
Center of Biomedical Research Excellence in CNS Metabolism - Administrative Core
Sullivan, P. (PI), Bachstetter, A. (CoI), Bauer, B. (CoI), Dutch, R. (CoI), Hubbard, W. (CoI), Johnson, L. (CoI), Nikolajczyk, B. (CoI), Norris, C. (CoI), Patel, S. (CoI), Schmitt, F. (CoI), Selenica, M.-L. (CoI), Slevin, J. (CoI), Wilcock, D. (CoI) & Yamasaki, T. (CoI)
National Institute of General Medical Sciences
5/15/23 → 2/29/28
Project: Research project
Administrative Supplement: Feasibility of Implementing Time-Restricted Eating in Women with Mild Cognitive Impairment
Pendergast, J. (PI), Bumgardner, V. (CoI), Fry, J. (CoI), Jicha, G. (CoI), Katsumata, Y. (CoI) & Kern, P. (CoI)
National Institute on Aging
5/1/23 → 1/31/26
Project: Research project
Predictors and Biomarkers for VCID versus Cognitive Recovery after Stroke Thrombectomy in Rural Appalachia
Harp, J. (PI), Fraser, J. (CoI), McLouth, C. (CoI), Pennypacker, K. (CoI), Schmitt, F. (CoI) & Wilcock, D. (Former CoI)
National Institute of Neurological Disorders & Stroke
4/15/23 → 3/31/28
Project: Research project
Genetic Architecture of Aging-Related TDP-43 and Mixed Pathology Dementia
Fardo, D. (PI), Ebbert, M. T. W. (CoI), Katsumata, Y. (CoI) & Nelson, P. (CoPI)
National Institute on Aging
4/15/23 → 3/31/26
Project: Research project
MicroRNA Lipid-Nanoparticle Based Therapy Targets Neuroinflammation and ApoE Dysregulation in Alzheimer's Disease
Wang, W. (PI), Bachstetter, A. (CoI), Nelson, P. (CoI) & Van Eldik, L. (CoI)
National Institute on Aging
4/15/23 → 12/31/27
Project: Research project
Mechanism and Therapeutic Potential of CBD to Repair Blood-Brain Barrier Dysfunction in Epilepsy
Bauer, B. (PI), Abner, E. (CoI), Hartz, A. (CoI), Sunderam, S. (CoI) & Pauly, J. (Former CoI)
National Institute of Neurological Disorders & Stroke
4/1/23 → 3/31/25
Project: Research project
APOE Allele Switching as a Therapeutic Approach for Alzheimer's Disease
Johnson, L. (PI), Gordon, S. (CoI), Morganti, J. (CoPI) & Sun, R. (Former CoI)
National Institute on Aging
12/1/22 → 11/30/27
Project: Research project
A Randomized, Double-blind, Placebo-controlled, Phase 2, 6-month Study to Evaluate the Safety, Tolerability and Exploratory Efficacy of CT1812 in Subjects with Mild to Moderate Dementia with Lewy Bodies
Jicha, G. (PI)
Cognition Therapeutics Incorporated
10/17/22 → 8/23/25
Project: Research project
APOE Allelic Switching to Delay or Prevent Alzheimer's Disease
Johnson, L. (PI), Gordon, S. (CoI), Morganti, J. (CoI) & Sun, R. (Former CoI)
Alzheimers Association
10/1/22 → 9/30/25
Project: Research project
Replacement of Peripheral APOE4 with APOE2: Effects on AD Pathogenesis.
Johnson, L. (PI) & Morganti, J. (CoI)
Alzheimers Association
10/1/22 → 9/30/25
Project: Research project
A Novel Therapeutic Approach For Targeting Tdp-43 In ALS
Selenica, M.-L. (PI)
Gismo Therapeutics Incorporated
10/1/22 → 6/14/25
Project: Research project
A Seamless Phase 2A-B Randomized Double-Blind Placebo-Controlled Trial to Evaluate the Efficacy and Safety of an Investigational New Drug in Patients with Early Alzheimers Disease (AD)
Jicha, G. (PI)
University of California San Diego Health
10/1/22 → 2/28/25
Project: Research project
Strategies for Targeting Astrocyte Reactivity in Alzheimer's Disease and Related Dementias: Core D - Data Management and Statistics Core
Katsumata, Y. (PI), Bahrani, A. (CoI) & Norris, C. (CoI)
National Institute on Aging
9/1/22 → 6/30/27
Project: Research project
Strategies for Targeting Astrocyte Reactivity in Alzheimer's Disease and Related Dementias: Core C - Human Consultation-Biosamples-Biomarkers Core
Nelson, P. (PI), Bahrani, A. (CoI), Jiang, Y. (CoI), Jicha, G. (CoI), Norris, C. (CoI), Powell, D. (CoI) & Wilcock, D. (Former CoI)
National Institute on Aging
9/1/22 → 6/30/27
Project: Research project
Strategies for Targeting Astrocyte Reactivity in Alzheimer's Disease and Related Dementias: Project 1 - Astrocytic End-Feet and VCI
Norris, C. (PI), Weekman, E. (CoI) & Wilcock, D. (Former PI)
National Institute on Aging
9/1/22 → 6/30/27
Project: Research project
Strategies for Targeting Astrocyte Reactivity in Alzheimer's Disease and Related Dementias: Project 2 - Astrocytic Insulin Signaling and AD
Thibault, O. (PI) & Norris, C. (CoI)
National Institute on Aging
9/1/22 → 6/30/27
Project: Research project
Supplement: Improving Person-Environment Fit of Community-Residing Older Adults with Dementia Through Assessment and Individualized Intervention
Rhodus, E. (PI)
National Institute on Aging
9/1/22 → 6/30/27
Project: Research project
Improving Person-Environment Fit of Community-Residing Older Adults with Dementia Through Assessment and Individualized Intervention
Rhodus, E. (PI), Abner, E. (CoI), Gibson, A. (CoI), Jicha, G. (CoI), Schmitt, F. (CoI), Schoenberg, N. (CoI), Koehl, L. (Former CoI), Segerstrom, S. (Former CoI) & Wilcock, D. (Former CoI)
National Institute on Aging
9/1/22 → 6/30/27
Project: Research project
Strategies for Targeting Astrocyte Reactivity in Alzheimer's Disease and Related Dementias: Project 3 - Astrocytic Glutamate Dysregulation in AD and VCID
Norris, C. (PI), Gerhardt, G. (CoI) & Sompol, P. (CoI)
National Institute on Aging
9/1/22 → 6/30/27
Project: Research project
Strategies for Targeting Astrocyte Reactivity in Alzheimer's Disease and Related Dementias: Core B- Animal Vascular-Metabolic-Neural Network Core
Sompol, P. (PI), Bahrani, A. (CoI), Norris, C. (CoI), Powell, D. (CoI) & Thibault, O. (CoI)
National Institute on Aging
9/1/22 → 6/30/27
Project: Research project
Strategies for Targeting Astrocyte Reactivity in Alzheimer's Disease and Related Dementias: Core A - Administrative Core
Norris, C. (PI), Bahrani, A. (CoI), Bieberich, E. (CoI), Gerhardt, G. (CoI), Goldstein, L. (CoI), Jiang, Y. (CoI), Jicha, G. (CoI), Katsumata, Y. (CoI), Nelson, P. (CoI), Niedowicz, D. (CoI), Powell, D. (CoI), Selenica, M.-L. (CoI), Sompol, P. (CoI), Thibault, O. (CoI), Van Eldik, L. (CoI), Wang, W. (CoI), Weekman, E. (CoI), Gentry, M. (Former CoI) & Wilcock, D. (Former CoI)
National Institute on Aging
9/1/22 → 6/30/27
Project: Research project
Strategies for Targeting Astrocyte Reactivity in Alzheimer's Disease and Related Dementias: Project 4 - Astrocytic KATP Channels in LATE+HS
Nelson, P. (PI), Niedowicz, D. (CoI), Norris, C. (CoI), Selenica, M.-L. (CoI) & Wang, W. (CoI)
National Institute on Aging
9/1/22 → 6/30/27
Project: Research project
Administrative Supplement: Strategies for Targeting Astrocyte Reactivity in Alzheimer's Disease and Related Dementias
Norris, C. (PI)
National Institute on Aging
9/1/22 → 6/30/27
Project: Research project