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  • 2017

    Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

    Sims, R., Van Der Lee, S. J., Naj, A. C., Bellenguez, C., Badarinarayan, N., Jakobsdottir, J., Kunkle, B. W., Boland, A., Raybould, R., Bis, J. C., Martin, E. R., Grenier-Boley, B., Heilmann-Heimbach, S., Chouraki, V., Kuzma, A. B., Sleegers, K., Vronskaya, M., Ruiz, A., Graham, R. R., Olaso, R., & 426 othersHoffmann, P., Grove, M. L., Vardarajan, B. N., Hiltunen, M., Nöthen, M. M., White, C. C., Hamilton-Nelson, K. L., Epelbaum, J., Maier, W., Choi, S. H., Beecham, G. W., Dulary, C., Herms, S., Smith, A. V., Funk, C. C., Derbois, C., Forstner, A. J., Ahmad, S., Li, H., Bacq, D., Harold, D., Satizabal, C. L., Valladares, O., Squassina, A., Thomas, R., Brody, J. A., Qu, L., Sánchez-Juan, P., Morgan, T., Wolters, F. J., Zhao, Y., Garcia, F. S., Denning, N., Fornage, M., Malamon, J., Naranjo, M. C. D., Majounie, E., Mosley, T. H., Dombroski, B., Wallon, D., Lupton, M. K., Dupuis, J., Whitehead, P., Fratiglioni, L., Medway, C., Jian, X., Mukherjee, S., Keller, L., Brown, K., Lin, H., Cantwell, L. B., Panza, F., McGuinness, B., Moreno-Grau, S., Burgess, J. D., Solfrizzi, V., Proitsi, P., Adams, H. H., Allen, M., Seripa, D., Pastor, P., Cupples, L. A., Price, N. D., Hannequin, D., Frank-García, A., Levy, D., Chakrabarty, P., Caffarra, P., Giegling, I., Beiser, A. S., Giedraitis, V., Hampel, H., Garcia, M. E., Wang, X., Lannfelt, L., Mecocci, P., Eiriksdottir, G., Crane, P. K., Pasquier, F., Boccardi, V., Henández, I., Barber, R. C., Scherer, M., Tarraga, L., Adams, P. M., Leber, M., Chen, Y., Albert, M. S., Riedel-Heller, S., Emilsson, V., Beekly, D., Braae, A., Schmidt, R., Blacker, D., Masullo, C., Schmidt, H., Doody, R. S., Spalletta, G., Longstreth, W. T., Fairchild, T. J., Bossù, P., Lopez, O. L., Frosch, M. P., Sacchinelli, E., Ghetti, B., Yang, Q., Huebinger, R. M., Jessen, F., Li, S., Kamboh, M. I., Morris, J. C., Sotolongo-Grau, O., Katz, M. J., Corcoran, C., Dunstan, M., Braddel, A., Thomas, C., Meggy, A., Marshall, R., Gerrish, A., Chapman, J., Aguilar, M., Taylor, S., Hill, M., Fairén, M. D., Hodges, A., Vellas, B., Soininen, H., Kloszewska, I., Daniilidou, M., Uphill, J., Patel, Y., Hughes, J. T., Lord, J., Turton, J., Hartmann, A. M., Cecchetti, R., Fenoglio, C., Serpente, M., Arcaro, M., Caltagirone, C., Orfei, M. D., Ciaramella, A., Pichler, S., Mayhaus, M., Gu, W., Lleó, A., Fortea, J., Blesa, R., Barber, I. S., Brookes, K., Cupidi, C., Maletta, R. G., Carrell, D., Sorbi, S., Moebus, S., Urbano, M., Pilotto, A., Kornhuber, J., Bosco, P., Todd, S., Craig, D., Johnston, J., Gill, M., Lawlor, B., Lynch, A., Fox, N. C., Hardy, J., Albin, R. L., Apostolova, L. G., Arnold, S. E., Asthana, S., Atwood, C. S., Baldwin, C. T., Barnes, L. L., Barral, S., Beach, T. G., Becker, J. T., Bigio, E. H., Bird, T. D., Boeve, B. F., Bowen, J. D., Boxer, A., Burke, J. R., Burns, J. M., Buxbaum, J. D., Cairns, N. J., Cao, C., Carlson, C. S., Carlsson, C. M., Carney, R. M., Carrasquillo, M. M., Carroll, S. L., Diaz, C. C., Chui, H. C., Clark, D. G., Cribbs, D. H., Crocco, E. A., Decarli, C., Dick, M., Duara, R., Evans, D. A., Faber, K. M., Fallon, K. B., Fardo, D. W., Farlow, M. R., Ferris, S., Foroud, T. M., Galasko, D. R., Gearing, M., Geschwind, D. H., Gilbert, J. R., Graff-Radford, N. R., Green, R. C., Growdon, J. H., Hamilton, R. L., Harrell, L. E., Honig, L. S., Huentelman, M. J., Hulette, C. M., Hyman, B. T., Jarvik, G. P., Abner, E., Jin, L. W., Jun, G., Karydas, A., Kaye, J. A., Kim, R., Kowall, N. W., Kramer, J. H., Laferla, F. M., Lah, J. J., Leverenz, J. B., Levey, A. I., Li, G., Lieberman, A. P., Lunetta, K. L., Lyketsos, C. G., Marson, D. C., Martiniuk, F., Mash, D. C., Masliah, E., McCormick, W. C., McCurry, S. M., McDavid, A. N., McKee, A. C., Mesulam, M., Miller, B. L., Miller, C. A., Miller, J. W., Murrell, J. R., Myers, A. J., O'Bryant, S., Olichney, J. M., Pankratz, V. S., Parisi, J. E., Paulson, H. L., Perry, W., Peskind, E., Pierce, A., Poon, W. W., Potter, H., Quinn, J. F., Raj, A., Raskind, M., Reisberg, B., Reitz, C., Ringman, J. M., Roberson, E. D., Rogaeva, E., Rosen, H. J., Rosenberg, R. N., Sager, M. A., Saykin, A. J., Schneider, J. A., Schneider, L. S., Seeley, W. W., Smith, A. G., Sonnen, J. A., Spina, S., Stern, R. A., Swerdlow, R. H., Tanzi, R. E., Thornton-Wells, T. A., Trojanowski, J. Q., Troncoso, J. C., Van Deerlin, V. M., Van Eldik, L. J., Vinters, H. V., Vonsattel, J. P., Weintraub, S., Welsh-Bohmer, K. A., Wilhelmsen, K. C., Williamson, J., Wingo, T. S., Woltjer, R. L., Wright, C. B., Yu, C. E., Yu, L., Garzia, F., Golamaully, F., Septier, G., Engelborghs, S., Vandenberghe, R., De Deyn, P. P., Fernadez, C. M., Benito, Y. A., Thonberg, H., Forsell, C., Lilius, L., Kinhult-Stählbom, A., Kilander, L., Brundin, R., Concari, L., Helisalmi, S., Koivisto, A. M., Haapasalo, A., Dermecourt, V., Fievet, N., Hanon, O., Dufouil, C., Brice, A., Ritchie, K., Dubois, B., Himali, J. J., Keene, C. D., Tschanz, J., Fitzpatrick, A. L., Kukull, W. A., Norton, M., Aspelund, T., Larson, E. B., Munger, R., Rotter, J. I., Lipton, R. B., Bullido, M. J., Hofman, A., Montine, T. J., Coto, E., Boerwinkle, E., Petersen, R. C., Alvarez, V., Rivadeneira, F., Reiman, E. M., Gallo, M., O'Donnell, C. J., Reisch, J. S., Bruni, A. C., Royall, D. R., Dichgans, M., Sano, M., Galimberti, D., St George-Hyslop, P., Scarpini, E., Tsuang, D. W., Mancuso, M., Bonuccelli, U., Winslow, A. R., Daniele, A., Wu, C. K., Peters, O., Nacmias, B., Riemenschneider, M., Heun, R., Brayne, C., Rubinsztein, D. C., Bras, J., Guerreiro, R., Al-Chalabi, A., Shaw, C. E., Collinge, J., Mann, D., Clarimón, J., Sussams, R., Lovestone, S., O'Donovan, M. C., Owen, M. J., Behrens, T. W., Mead, S., Uitterlinden, A. G., Holmes, C., Cruchaga, C., Ingelsson, M., Bennett, D. A., Powell, J., Golde, T. E., Graff, C., De Jager, P. L., Morgan, K., Ertekin-Taner, N., Combarros, O., Psaty, B. M., Passmore, P., Younkin, S. G., Berr, C., Gudnason, V., Rujescu, D., Dickson, D. W., Dartigues, J. F., Destefano, A. L., Ortega-Cubero, S., Hakonarson, H., Campion, D., Boada, M., Kauwe, J. K., Farrer, L. A., Van Broeckhoven, C., Ikram, M. A., Jones, L., Haines, J. L., Tzourio, C., Launer, L. J., Escott-Price, V., Mayeux, R., Deleuze, J. F., Amin, N., Goate, A. M., Pericak-Vance, M. A., Holmans, P. A., Van Duijn, C. M., Ramirez, A., Wang, L. S., Lambert, J. C., Seshadri, S., Williams, J. & Schellenberg, G. D., Sep 1 2017, In: Nature Genetics. 49, 9, p. 1373-1384 12 p.

    Research output: Contribution to journalArticlepeer-review

    513 Scopus citations
  • Retention of normal glia function by an isoform-selective protein kinase inhibitor drug candidate that modulates cytokine production and cognitive outcomes

    Zhou, Z., Bachstetter, A. D., Späni, C. B., Roy, S. M., Watterson, D. M. & Van Eldik, L. J., Apr 5 2017, In: Journal of Neuroinflammation. 14, 1, 75.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    14 Scopus citations
  • Risk factors and global cognitive status related to brain arteriolosclerosis in elderly individuals

    Ighodaro, E. T., Abner, E. L., Fardo, D. W., Lin, A. L., Katsumata, Y., Schmitt, F. A., Kryscio, R. J., Jicha, G. A., Neltner, J. H., Monsell, S. E., Kukull, W. A., Moser, D. K., Appiah, F., Bachstetter, A. D., Van Eldik, L. J. & Nelson, P. T., Jan 1 2017, In: Journal of Cerebral Blood Flow and Metabolism. 37, 1, p. 201-216 16 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    52 Scopus citations
  • Risk of incident clinical diagnosis of Alzheimer's disease–type dementia attributable to pathology-confirmed vascular disease

    Jun 2017, In: Alzheimer's and Dementia. 13, 6, p. 613-623 11 p.

    Research output: Contribution to journalArticlepeer-review

    23 Scopus citations
  • Rod-shaped microglia morphology is associated with aging in 2 human autopsy series

    Bachstetter, A. D., Ighodaro, E. T., Hassoun, Y., Aldeiri, D., Neltner, J. H., Patel, E., Abner, E. L. & Nelson, P. T., Apr 1 2017, In: Neurobiology of Aging. 52, p. 98-105 8 p.

    Research output: Contribution to journalArticlepeer-review

    41 Scopus citations
  • Screw-type device diameter and orthodontic loading influence adjacent bone remodeling

    Francis, J. C., Oz, U., Cunningham, L. L., Huja, P. E., Kryscio, R. J. & Huja, S. S., May 2017, In: Angle Orthodontist. 87, 3, p. 466-472 7 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    6 Scopus citations
  • Single-Base Resolution Mapping of 5-Hydroxymethylcytosine Modifications in Hippocampus of Alzheimer’s Disease Subjects

    Ellison, E. M., Bradley-Whitman, M. A. & Lovell, M. A., Oct 1 2017, In: Journal of Molecular Neuroscience. 63, 2, p. 185-197 13 p.

    Research output: Contribution to journalArticlepeer-review

    21 Scopus citations
  • Symptoms Relevant to Surveillance for Ovarian Cancer

    Ore, R. M., Baldwin, L., Woolum, D., Elliott, E., Wijers, C., Chen, C. Y., Miller, R. W., Desimone, C. P., Ueland, F. R., Kryscio, R. J., van Nagell, J. R. & Pavlik, E. J., Mar 2017, In: Diagnostics. 7, 1, 18.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    4 Scopus citations
  • The Effectiveness of Small-group Community-based Information Sessions on Clinical Trial Recruitment for Secondary Prevention of Alzheimer's Disease

    Tarrant, S. D., Bardach, S. H., Bates, K., Nichols, H., Towner, J., Tamatha, C., Caban-Holt, A., Van-Eldik, L. J., Murphy, R. R., Sperling, R. & Jicha, G. A., May 1 2017, In: Alzheimer Disease and Associated Disorders. 31, 2, p. 141-145 5 p.

    Research output: Contribution to journalArticlepeer-review

    8 Scopus citations
  • Time-course of glial changes in the hyperhomocysteinemia model of vascular cognitive impairment and dementia (VCID)

    Sudduth, T. L., Weekman, E. M., Price, B. R., Gooch, J. L., Woolums, A., Norris, C. M. & Wilcock, D. M., Jan 26 2017, In: Neuroscience. 341, p. 42-51 10 p.

    Research output: Contribution to journalArticlepeer-review

    38 Scopus citations
  • Tolerability of ORM-12741 and effects on episodic memory in patients with Alzheimer's disease

    Rinne, J. O., Wesnes, K., Cummings, J. L., Hakulinen, P., Hallikainen, M., Hänninen, J., Murphy, M., Riordan, H., Scheinin, M., Soininen, H. & Rouru, J., Jan 1 2017, In: Alzheimer's and Dementia: Translational Research and Clinical Interventions. 3, 1, p. 1-9 9 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    16 Scopus citations
  • Transethnic genome-wide scan identifies novel Alzheimer's disease loci

    Jul 2017, In: Alzheimer's and Dementia. 13, 7, p. 727-738 12 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    95 Scopus citations
  • Using multivariate base rates to interpret low scores on an abbreviated battery of the delis-kaplan executive function system

    Karr, J. E., Garcia-Barrera, M. A., Holdnack, J. A. & Iverson, G. L., May 2017, In: Archives of Clinical Neuropsychology. 32, 3, p. 297-305 9 p.

    Research output: Contribution to journalArticlepeer-review

    24 Scopus citations
  • White Matter Hyperintensity Associations with Cerebral Blood Flow in Elderly Subjects Stratified by Cerebrovascular Risk

    Bahrani, A. A., Powell, D. K., Yu, G., Johnson, E. S., Jicha, G. A. & Smith, C. D., Apr 1 2017, In: Journal of Stroke and Cerebrovascular Diseases. 26, 4, p. 779-786 8 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    36 Scopus citations
  • Widespread tau seeding activity at early Braak stages

    Furman, J. L., Vaquer-Alicea, J., White, C. L., Cairns, N. J., Nelson, P. T. & Diamond, M. I., Jan 1 2017, In: Acta Neuropathologica. 133, 1, p. 91-100 10 p.

    Research output: Contribution to journalArticlepeer-review

    77 Scopus citations
  • 2016

    1H-MRS metabolites in adults with Down syndrome: Effects of dementia

    Lin, A. L., Powell, D., Caban-Holt, A., Jicha, G., Robertson, W., Gold, B. T., Davis, R., Abner, E., Wilcock, D. M., Schmitt, F. A. & Head, E., 2016, In: NeuroImage: Clinical. 11, p. 728-735 8 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    27 Scopus citations
  • 5-Hydroxymethylation-associated epigenetic modifiers of Alzheimer's disease modulate Tau-induced neurotoxicity

    Bernstein, A. I., Lin, Y., Street, R. C., Lin, L., Dai, Q., Yu, L., Bao, H., Gearing, M., Lah, J. J., Nelson, P. T., He, C., Levey, A. I., Mullé, J. G., Duan, R. & Jin, P., Jun 15 2016, In: Human Molecular Genetics. 25, 12, p. 2437-2450 14 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    46 Scopus citations
  • A comprehensive behavioral test battery to assess learning and memory in 129S6/ Tg2576 mice

    Wolf, A., Bauer, B., Abner, E. L., Ashkenazy-Frolinger, T. & Hartz, A. M. S., Jan 1 2016, In: PLoS ONE. 11, 1, e0147733.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    149 Scopus citations
  • Aging in down syndrome and the development of Alzheimer’s disease neuropathology

    Head, E., Lott, I. T., Wilcock, D. M. & Lemere, C. A., Jan 1 2016, In: Current Alzheimer Research. 13, 1, p. 18-29 12 p.

    Research output: Contribution to journalArticlepeer-review

    156 Scopus citations
  • Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy

    Kovacs, G. G., Ferrer, I., Grinberg, L. T., Alafuzoff, I., Attems, J., Budka, H., Cairns, N. J., Crary, J. F., Duyckaerts, C., Ghetti, B., Halliday, G. M., Ironside, J. W., Love, S., Mackenzie, I. R., Munoz, D. G., Murray, M. E., Nelson, P. T., Takahashi, H., Trojanowski, J. Q., Ansorge, O., & 52 othersArzberger, T., Baborie, A., Beach, T. G., Bieniek, K. F., Bigio, E. H., Bodi, I., Dugger, B. N., Feany, M., Gelpi, E., Gentleman, S. M., Giaccone, G., Hatanpaa, K. J., Heale, R., Hof, P. R., Hofer, M., Hortobágyi, T., Jellinger, K., Jicha, G. A., Ince, P., Kofler, J., Kövari, E., Kril, J. J., Mann, D. M., Matej, R., McKee, A. C., McLean, C., Milenkovic, I., Montine, T. J., Murayama, S., Lee, E. B., Rahimi, J., Rodriguez, R. D., Rozemüller, A., Schneider, J. A., Schultz, C., Seeley, W., Seilhean, D., Smith, C., Tagliavini, F., Takao, M., Thal, D. R., Toledo, J. B., Tolnay, M., Troncoso, J. C., Vinters, H. V., Weis, S., Wharton, S. B., White, C. L., Wisniewski, T., Woulfe, J. M., Yamada, M. & Dickson, D. W., Jan 1 2016, In: Acta Neuropathologica. 131, 1, p. 87-102 16 p.

    Research output: Contribution to journalArticlepeer-review

    293 Scopus citations
  • Alzheimer's biomarkers are correlated with brain connectivity in older adults differentially during resting and task states

    Jiang, Y., Huang, H., Abner, E., Broster, L. S., Jicha, G. A., Schmitt, F. A., Kryscio, R., Andersen, A., Powell, D., Van Eldik, L., Gold, B. T., Nelson, P. T., Smith, C. & Ding, M., 2016, In: Frontiers in Aging Neuroscience. 8, FEB, 15.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    21 Scopus citations
  • Alzheimer's disease risk polymorphisms regulate gene expression in the ZCWPW1 and the CELF1 loci

    Feb 2016, In: PLoS ONE. 11, 2, e0148717.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    66 Scopus citations
  • A novel Alzheimer disease locus located near the gene encoding tau protein

    Jun, G., Ibrahim-Verbaas, C. A., Vronskaya, M., Lambert, J. C., Chung, J., Naj, A. C., Kunkle, B. W., Wang, L. S., Bis, J. C., Bellenguez, C., Harold, D., Lunetta, K. L., Destefano, A. L., Grenier-Boley, B., Sims, R., Beecham, G. W., Smith, A. V., Chouraki, V., Hamilton-Nelson, K. L., Ikram, M. A., & 332 othersFievet, N., Denning, N., Martin, E. R., Schmidt, H., Kamatani, Y., Dunstan, M. L., Valladares, O., Laza, A. R., Zelenika, D., Ramirez, A., Foroud, T. M., Choi, S. H., Boland, A., Becker, T., Kukull, W. A., Van Der Lee, S. J., Pasquier, F., Cruchaga, C., Beekly, D., Fitzpatrick, A. L., Hanon, O., Gill, M., Barber, R., Gudnason, V., Campion, D., Love, S., Bennett, D. A., Amin, N., Berr, C., Tsolaki, M., Buxbaum, J. D., Lopez, O. L., Deramecourt, V., Fox, N. C., Cantwell, L. B., Tárraga, L., Dufouil, C., Hardy, J., Crane, P. K., Eiriksdottir, G., Hannequin, D., Clarke, R., Evans, D., Mosley, T. H., Letenneur, L., Brayne, C., Maier, W., De Jager, P., Emilsson, V., Dartigues, J. F., Hampel, H., Kamboh, M. I., De Bruijn, R. F. A. G., Tzourio, C., Pastor, P., Larson, E. B., Rotter, J. I., O'Donovan, M. C., Montine, T. J., Nalls, M. A., Mead, S., Reiman, E. M., Jonsson, P. V., Holmes, C., St George-Hyslop, P. H., Boada, M., Passmore, P., Wendland, J. R., Schmidt, R., Morgan, K., Winslow, A. R., Powell, J. F., Carasquillo, M., Younkin, S. G., Jakobsdóttir, J., Kauwe, J. S. K., Wilhelmsen, K. C., Rujescu, D., Nöthen, M. M., Hofman, A., Jones, L., Haines, J. L., Psaty, B. M., Van Broeckhoven, C., Holmans, P., Launer, L. J., Mayeux, R., Lathrop, M., Goate, A. M., Escott-Price, V., Seshadri, S., Pericak-Vance, M. A., Amouyel, P., Williams, J., Van Duijn, C. M., Schellenberg, G. D., Farrer, L. A., Adams, P. M., Albert, M. S., Albin, R. L., Apostolova, L. G., Arnold, S. E., Asthana, S., Atwood, C. S., Baldwin, C. T., Barmada, M. M., Barnes, L. L., Beach, T. G., Bigio, E. H., Bird, T. D., Blacker, D., Boeve, B. F., Bowen, J. D., Boxer, A., Burke, J. R., Cairns, N. J., Cao, C., Carlson, C. S., Carlsson, C. M., Carney, R. M., Carrasquillo, M. M., Carroll, S. L., Chui, H. C., Clark, D. G., Corneveaux, J., Cribbs, D. H., Crocco, E. A., DeCarli, C., DeKosky, S. T., Yesim Demirci, F., Dick, M., Dickson, D. W., Doody, R. S., Duara, R., Ertekin-Taner, N., Faber, K. M., Fairchild, T. J., Fallon, K. B., Farlow, M. R., Ferris, S., Frosch, M. P., Galasko, D. R., Gearing, M., Geschwind, D. H., Ghetti, B., Gilbert, J. R., Glass, J. D., Graff-Radford, N. R., Green, R. C., Growdon, J. H., Hakonarson, H., Hamilton, R. L., Harrell, L. E., Head, E., Honig, L. S., Huebinger, R. M., Huentelman, M. J., Hulette, C. M., Hyman, B. T., Jarvik, G. P., Jicha, G. A., Jin, L. W., Karydas, A., Kaye, J. A., Kim, R., Koo, E. H., Kowall, N. W., Kramer, J. H., LaFerla, F. M., Lah, J. J., Leverenz, J. B., Levey, A. I., Li, G., Lieberman, A. P., Lin, C. F., Lyketsos, C. G., Mack, W. J., Marson, D. C., Martiniuk, F., Mash, D. C., Masliah, E., McCormick, W. C., McCurry, S. M., McDavid, A. N., McKee, A. C., Mesulam, M., Miller, B. L., Miller, C. A., Miller, J. W., Morris, J. C., Mukherjee, S., Murrell, J. R., Myers, A. J., O'Bryant, S., Olichney, J. M., Pankratz, V. S., Parisi, J. E., Partch, A., Paulson, H. L., Perry, W., Peskind, E., Petersen, R. C., Pierce, A., Poon, W. W., Potter, H., Quinn, J. F., Raj, A., Raskind, M., Reisberg, B., Reisch, J. S., Reitz, C., Ringman, J. M., Roberson, E. D., Rogaeva, E., Rosen, H. J., Rosenberg, R. N., Royall, D. R., Sager, M. A., Sano, M., Saykin, A. J., Schneider, J. A., Schneider, L. S., Seeley, W. W., Smith, A. G., Sonnen, J. A., Spina, S., Stern, R. A., Tanzi, R. E., Thornton-Wells, T. A., Trojanowski, J. Q., Troncoso, J. C., Tsuang, D. W., Van Deerlin, V. M., Van Eldik, L. J., Vardarajan, B. N., Vinters, H. V., Vonsattel, J. P., Weintraub, S., Welsh-Bohmer, K. A., Williamson, J., Wishnek, S., Woltjer, R. L., Wright, C. B., Wu, C. K., Yu, C. E., Yu, L., Thomas, C., Gerrish, A., Chapman, J., Stretton, A., Morgan, A., Oldham, H., Owen, M. J., Kehoe, P. G., Medway, C., Brown, K., Lord, J., Turton, J., Hooper, N. M., Vardy, E., Warren, J. D., Schott, J. M., Uphill, J., Hollingworth, P., Ryan, N., Rossor, M., Collinge, J., Ben-Shlomo, Y., Makrina, D., Gkatzima, O., Lupton, M., Koutroumani, M., Avramidou, D., Germanou, A., Jessen, F., Riedel-Heller, S., Dichgans, M., Heun, R., Kölsch, H., Schürmann, B., Herold, C., Lacour, A., Drichel, D., Hoffmann, P., Kornhuber, J., Gu, W., Feulner, T., Mayhaus, M., Pichler, S., Riemenschneider, M., van den Bussche, H., Lawlor, B., Lynch, A., Mann, D., Smith, A. D., Warden, D., Wilcock, G., Heuser, I., Wiltfang, J., Frölich, L., Hüll, M., Mayo, K., Livingston, G., Bass, N. J., Gurling, H., McQuillin, A., Gwilliam, R., Deloukas, P., Al-Chalabi, A., Shaw, C. E., Singleton, A. B., Guerreiro, R., Russo, G., Jöckel, K. H., Moebus, S., Klopp, N., Wichmann, H. E., Ma, L., Bisceglio, G., Fisher, E., Warner, N., Pickering-Brown, S., Craig, D., Johnston, J. A., McGuinness, B., Todd, S., Rubinsztein, D. C., Lovestone, S., Bayer, A., Gallacher, J., Proitsi, P. & Ortega-Cubero, S., Jan 1 2016, In: Molecular Psychiatry. 21, 1, p. 108-117 10 p.

    Research output: Contribution to journalArticlepeer-review

    160 Scopus citations
  • A Novel Small Molecule Modulator of Amyloid Pathology

    Lovell, M. A., Lynn, B. C., Fister, S., Bradley-Whitman, M., Murphy, M. P., Beckett, T. L. & Norris, C. M., Jun 22 2016, In: Journal of Alzheimer's Disease. 53, 1, p. 273-287 15 p., JAD151160.

    Research output: Contribution to journalArticlepeer-review

    3 Scopus citations
  • Assessment of the genetic variance of late-onset Alzheimer's disease

    May 1 2016, In: Neurobiology of Aging. 41, p. 200.e13-200.e20

    Research output: Contribution to journalArticlepeer-review

    Open Access
    46 Scopus citations
  • Association between anticholinergic medication use and cognition, brain metabolism, and brain atrophy in cognitively normal older adults

    Jun 2016, In: JAMA Neurology. 73, 6, p. 721-732 12 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    187 Scopus citations
  • Blockade of astrocytic calcineurin/NFAT signaling helps to normalize hippocampal synaptic function and plasticity in a rat model of traumatic brain injury

    Furman, J. L., Sompol, P., Kraner, S. D., Pleiss, M. M., Putman, E. J., Dunkerson, J., Abdul, H. M., Roberts, K. N., Scheff, S. W. & Norris, C. M., Feb 3 2016, In: Journal of Neuroscience. 36, 5, p. 1502-1515 14 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    54 Scopus citations
  • Brain pathologies in extreme old age

    Neltner, J. H., Abner, E. L., Jicha, G. A., Schmitt, F. A., Patel, E., Poon, L. W., Marla, G., Green, R. C., Davey, A., Johnson, M. A., Jazwinski, S. M., Kim, S., Davis, D., Woodard, J. L., Kryscio, R. J., Van Eldik, L. J. & Nelson, P. T., Jan 1 2016, In: Neurobiology of Aging. 37, p. 1-11 11 p.

    Research output: Contribution to journalArticlepeer-review

    63 Scopus citations
  • Calcineurin proteolysis in astrocytes: Implications for impaired synaptic function

    Pleiss, M. M., Sompol, P., Kraner, S. D., Abdul, H. M., Furman, J. L., Guttmann, R. P., Wilcock, D. M., Nelson, P. T. & Norris, C. M., Sep 1 2016, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1862, 9, p. 1521-1532 12 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    20 Scopus citations
  • Cerebrovascular contributions to aging and Alzheimer's disease in Down syndrome

    Wilcock, D. M., Schmitt, F. A. & Head, E., May 1 2016, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1862, 5, p. 909-914 6 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    29 Scopus citations
  • Comparing performance of non-tree-based and tree-based association mapping methods

    Thompson, K. L. & Fardo, D. W., 2016, In: BMC Proceedings. 10, 43.

    Research output: Contribution to journalArticlepeer-review

    Open Access
  • Crowdsourced estimation of cognitive decline and resilience in Alzheimer's disease

    Allen, G. I., Amoroso, N., Anghel, C., Balagurusamy, V., Bare, C. J., Beaton, D., Bellotti, R., Bennett, D. A., Boehme, K. L., Boutros, P. C., Caberlotto, L., Caloian, C., Campbell, F., Chaibub Neto, E., Chang, Y. C., Chen, B., Chen, C. Y., Chien, T. Y., Clark, T., Das, S., & 81 othersDavatzikos, C., Deng, J., Dillenberger, D., Dobson, R. J. B., Dong, Q., Doshi, J., Duma, D., Errico, R., Erus, G., Everett, E., Fardo, D. W., Friend, S. H., Fröhlich, H., Gan, J., St George-Hyslop, P., Ghosh, S. S., Glaab, E., Green, R. C., Guan, Y., Hong, M. Y., Huang, C., Hwang, J., Ibrahim, J., Inglese, P., Iyappan, A., Jiang, Q., Katsumata, Y., Kauwe, J. S. K., Klein, A., Kong, D., Krause, R., Lalonde, E., Lauria, M., Lee, E., Lin, X., Liu, Z., Livingstone, J., Logsdon, B. A., Lovestone, S., Ma, T. W., Malhotra, A., Mangravite, L. M., Maxwell, T. J., Merrill, E., Nagorski, J., Namasivayam, A., Narayan, M., Naz, M., Newhouse, S. J., Norman, T. C., Nurtdinov, R. N., Oyang, Y. J., Pawitan, Y., Peng, S., Peters, M. A., Piccolo, S. R., Praveen, P., Priami, C., Sabelnykova, V. Y., Senger, P., Shen, X., Simmons, A., Sotiras, A., Stolovitzky, G., Tangaro, S., Tateo, A., Tung, Y. A., Tustison, N. J., Varol, E., Vradenburg, G., Weiner, M. W., Xiao, G., Xie, L., Xie, Y., Xu, J., Yang, H., Zhan, X., Zhou, Y., Zhu, F., Zhu, H. & Zhu, S., Jun 1 2016, In: Alzheimer's and Dementia. 12, 6, p. 645-653 9 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    57 Scopus citations
  • Decreased synaptic proteins in neuronal exosomes of frontotemporal dementia and Alzheimer's disease

    Goetzl, E. J., Kapogiannis, D., Schwartz, J. B., Lobach, I. V., Goetzl, L., Abner, E. L., Jicha, G. A., Karydas, A. M., Boxer, A. & Miller, B. L., Dec 2016, In: FASEB Journal. 30, 12, p. 4141-4148 8 p.

    Research output: Contribution to journalArticlepeer-review

    218 Scopus citations
  • Diabetes is associated with cerebrovascular but not Alzheimer's disease neuropathology

    Abner, E. L., Nelson, P. T., Kryscio, R. J., Schmitt, F. A., Fardo, D. W., Woltjer, R. L., Cairns, N. J., Yu, L., Dodge, H. H., Xiong, C., Masaki, K., Tyas, S. L., Bennett, D. A., Schneider, J. A. & Arvanitakis, Z., Aug 1 2016, In: Alzheimer's and Dementia. 12, 8, p. 882-889 8 p.

    Research output: Contribution to journalArticlepeer-review

    147 Scopus citations
  • Diffuse traumatic brain injury induces prolonged immune dysregulation and potentiates hyperalgesia following a peripheral immune challenge

    Rowe, R. K., Ellis, G. I., Harrison, J. L., Bachstetter, A. D., Corder, G. F., Van Eldik, L. J., Taylor, B. K., Marti, F. & Lifshitz, J., May 10 2016, In: Molecular Pain. 12

    Research output: Contribution to journalArticlepeer-review

    Open Access
    29 Scopus citations
  • Early role of vascular dysregulation on late-onset Alzheimer's disease based on multifactorial data-driven analysis

    Jun 21 2016, In: Nature Communications. 7, 11934.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    596 Scopus citations
  • Endogenous cortisol exposure and declarative verbal memory: A longitudinal study of healthy older adults

    Segerstrom, S. C., Geiger, P. J., Boggero, I. A., Schmitt, F. A. & Sephton, S. E., 2016, In: Psychosomatic Medicine. 78, 2, p. 182-191 10 p.

    Research output: Contribution to journalArticlepeer-review

    13 Scopus citations
  • Examining the Quality of 21st Century Community Learning Center After-school Programs: Current Practices and Their Relationship to Outcomes

    Paluta, L. M., Lower, L., Anderson-Butcher, D., Gibson, A. & Iachini, A. L., Jan 1 2016, In: Children and Schools. 38, 1, p. 49-56 8 p.

    Research output: Contribution to journalArticlepeer-review

    5 Scopus citations
  • Extracellular vesicle-associated aβ mediates trans-neuronal bioenergetic and ca2+-handling deficits in alzheimer’s disease models

    Eitan, E., Hutchison, E. R., Marosi, K., Comotto, J., Mustapic, M., Nigam, S. M., Suire, C., Maharana, C., Jicha, G. A., Liu, D., Machairaki, V., Witwer, K. W., Kapogiannis, D. & Mattson, M. P., 2016, In: npj Aging and Mechanisms of Disease. 2, 1, 16019.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    77 Scopus citations
  • Gait dyspraxia as a clinical marker of cognitive decline in Down syndrome: A review of theory and proposed mechanisms

    Anderson-Mooney, A. J., Schmitt, F. A., Head, E., Lott, I. T. & Heilman, K. M., Apr 1 2016, In: Brain and Cognition. 104, p. 48-57 10 p.

    Research output: Contribution to journalArticlepeer-review

    21 Scopus citations
  • Genomics and CSF analyses implicate thyroid hormone in hippocampal sclerosis of aging

    Nelson, P. T., Katsumata, Y., Nho, K., Artiushin, S. C., Jicha, G. A., Wang, W. X., Abner, E. L., Saykin, A. J., Kukull, W. A., Alzheimer’s Disease Neuroimaging Initiative (ADNI), D. N. I. & Fardo, D. W., Dec 1 2016, In: Acta Neuropathologica. 132, 6, p. 841-858 18 p.

    Research output: Contribution to journalArticlepeer-review

    24 Scopus citations
  • Hippocampal sclerosis but not normal aging or Alzheimer disease is associated with TDP-43 pathology in the basal forebrain of aged persons

    Cykowski, M. D., Takei, H., Van Eldik, L. J., Schmitt, F. A., Jicha, G. A., Powell, S. Z. & Nelson, P. T., May 1 2016, In: Journal of Neuropathology and Experimental Neurology. 75, 5, p. 397-407 11 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    32 Scopus citations
  • Hippocampal Sclerosis of Aging, a Common Alzheimer's Disease 'Mimic': Risk Genotypes are Associated with Brain Atrophy Outside the Temporal Lobe

    Nho, K., Saykin, A. J. & Nelson, P. T., Apr 26 2016, In: Journal of Alzheimer's Disease. 52, 1, p. 373-383 11 p.

    Research output: Contribution to journalArticlepeer-review

    20 Scopus citations
  • Homocysteine, hyperhomocysteinemia and vascular contributions to cognitive impairment and dementia (VCID)

    Hainsworth, A. H., Yeo, N. E., Weekman, E. M. & Wilcock, D. M., May 1 2016, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1862, 5, p. 1008-1017 10 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    85 Scopus citations
  • Impact of time-varying treatment exposures on the risk of venous thromboembolism in multiple myeloma

    Brown, J. D., Adams, V. R. & Moga, D. C., Dec 2016, In: Healthcare (Switzerland). 4, 4, 93.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    5 Scopus citations
  • MiR-27a and miR-27b regulate autophagic clearance of damaged mitochondria by targeting PTEN-induced putative kinase 1 (PINK1)

    Kim, J., Fiesel, F. C., Belmonte, K. C., Hudec, R., Wang, W. X., Kim, C., Nelson, P. T., Springer, W. & Kim, J., Jul 26 2016, In: Molecular Neurodegeneration. 11, 1, 55.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    81 Scopus citations
  • Multisite assessment of NIA-AA guidelines for the neuropathologic evaluation of Alzheimer's disease

    Montine, T. J., Monsell, S. E., Beach, T. G., Bigio, E. H., Bu, Y., Cairns, N. J., Frosch, M., Henriksen, J., Kofler, J., Kukull, W. A., Lee, E. B., Nelson, P. T., Schantz, A. M., Schneider, J. A., Sonnen, J. A., Trojanowski, J. Q., Vinters, H. V., Zhou, X. H. & Hyman, B. T., Feb 1 2016, In: Alzheimer's and Dementia. 12, 2, p. 164-169 6 p.

    Research output: Contribution to journalArticlepeer-review

    65 Scopus citations
  • MW151 Inhibited IL-1β Levels after Traumatic Brain Injury with No Effect on Microglia Physiological Responses

    Bachstetter, A. D., Zhou, Z., Rowe, R. K., Xing, B., Goulding, D. S., Conley, A. N., Sompol, P., Meier, S., Abisambra, J. F., Lifshitz, J., Watterson, D. M. & Van Eldik, L. J., Feb 2016, In: PLoS ONE. 11, 2, e0149451.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    15 Scopus citations
  • National trends in off-label use of atypical antipsychotics in children and adolescents in the United States

    Sohn, M., Moga, D. C., Blumenschein, K. & Talbert, J., 2016, In: Medicine (United States). 95, 23, e3784.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    63 Scopus citations
  • NEDD4-mediated HSF1 degradation underlies α-synucleinopathy

    Kim, E., Wang, B., Sastry, N., Masliah, E., Nelson, P. T., Cai, H. & Liao, F. F., Jan 15 2016, In: Human Molecular Genetics. 25, 2, p. 211-222 12 p.

    Research output: Contribution to journalArticlepeer-review

    46 Scopus citations