Toxicology and Cancer Biology

10/23/23 → 2/29/24

Project: Research project

CCSG Pilot: Circulating Neutrophils-Tailored Cancer Biomarker Discovery and Therapy

Liu, X. (PI), Hao, Z. (CoI) & Liu, J. (CoI)

10/1/23 → 9/30/24

Project: Research project

CCSG Pilot: Improving Anti-PD1 Therapy in Triple-Negative Breast Cancer

Liu, X. (PI), Liu, J. (CoI) & Marcinkowski, E. (CoI)

American Lung Association

9/1/23 → 6/30/24

Project: Research project

Targeting Lung Fibrosis with Epigenetic Therapy

Brainson, C. (PI), Bachert, S. (CoI) & Liu, J. (CoI)

7/1/23 → 8/14/24

Project: Research project

Center for Appalachian Research in Environmental Sciences: Pilot Project Program

Curry, T. (PI), Fan, W.-M. (CoI), Haynes, E. (CoI), Richardson, K. (CoI), Swanson, H. (CoI) & Hahn, E. (Former CoI)

National Institute of Environmental Health Sciences

6/3/23 → 4/30/24

Project: Research project

Center for Appalachian Research in Environmental Sciences: Administrative Core

Haynes, E. (PI), Arnett, D. (CoI), Bauer, J. (CoI), Cassis, L. (CoI), Christian, J. (CoI), Cox, N. (CoI), Curry, T. (CoI), DiPaola, R. (CoI), Dignan, M. (CoI), Evers, B. M. (CoI), Fan, W.-M. (CoI), Hoover, A. (CoI), Kern, P. (CoI), May, B. (CoI), Miller, J. (CoI), Pearson, K. (CoI), Pennell, K. (CoI), Richardson, K. (CoI), Sanderson, W. (CoI), Schoenberg, N. (CoI), Stanifer, S. (CoI), Stratton, T. (CoI), Swanson, H. (CoI), Talbert, J. (CoI), Unrine, J. (CoI), Hahn, E. (Former PI), Heath, E. (Former CoI), Stanley, S. (Former CoI) & Stromberg, A. (Former CoI)

National Institute of Environmental Health Sciences

6/3/23 → 4/30/24

Project: Research project

Pilot: Targeting De Novo and Salvage Nucleotide Synthesis with FASN/ATR Inhibition to Enhance Radiation Therapy Reponses

Rychahou, P. (PI), Weiss, H. (CoI) & Zaytseva, Y. (CoI)

1/1/23 → 12/31/23

Project: Research project

Pilot: Inhibiting CK1a increases the Efficacy of Enzalutamide in Castration-resistant

Liu, J. (PI)

12/1/22 → 11/30/23

Project: Research project

Pilot: Determining the Role of AR-Repressed Gene, CCDC83 in Conferring Anti-Androgen Resistance in Prostate Cancer

Fong, K. W. (PI)

12/1/22 → 11/30/23

Project: Research project

Alterations in DNA Damage following Major Surgery and Hyperthermic Intraperitoneal Chemotherapy

Kim, J. (PI), Gao, M. (CoI), Goellner, E. (CoI) & Weiss, H. (CoI)

8/5/22 → 7/31/24

Project: Research project

SARRP with Cone Beam CT and bioluminescence imaging guidance

Cheek, D. (PI), Chen, Q. (CoI) & Izumi, T. (CoI)

Office of the Director

8/1/22 → 7/31/24

Project: Research project

CCSG Pilot: Targeting L-Tryptophan-5-Hydroxylase 1 (TPH1) in Small Cell Lung Cancer

Wei, Q. (PI), Chen, L. (CoI) & Hao, Z. (CoI)

7/1/22 → 6/30/23

Project: Research project

CCSG Pilot: Integrating AI-based Protein 3D Structure Prediction and In-silico Ligand Screening to Discover FDA approved Drugs Overcoming Therapy Resistance of Uncommon EGFR-mutant Lung Cancers

Ellingson, S. (PI), Brainson, C. (CoI), Liu, X. (CoI), Shao, Q. (CoI) & Zinner, R. (CoI)

7/1/22 → 6/30/23

Project: Research project

Aberrant Glycogen in Lung Adenocarcinoma Tumorigenesis

Sun, R. (PI), Allison, D. (CoI), Brainson, C. (CoI), Wang, C. (CoI), Gentry, M. (CoPI) & Vander Kooi, C. (Former CoI)

7/1/22 → 10/31/22

Project: Research project

CCSG Pilot: Point-of-care phase-gradient microscope for non-destructive metabolic imaging on live tumor slices

Zhu, C. (PI), Fan, W.-M. (CoI) & Wang, X. (CoI)

7/1/22 → 6/30/23

Project: Research project

Pilot: Novel Role of the Metabolic Hormone Neurotensin on Liver Lipid Metabolism and Pathophysiology

Evers, B. M. (PI), Fan, W.-M. (CoI), Moseley, H. (CoI) & Weiss, H. (CoI)

6/15/22 → 12/31/22

Project: Research project

Pilot: Lipid Metabolism Reprograming upon Spermine Synthase Inhibition in Colorectal Cancer

She, Q.-B. (PI), Fan, W.-M. (CoI) & Wang, C. (CoI)

6/15/22 → 12/31/22

Project: Research project

Pilot: Plk1 in Serine Metabolism of Prostate Cancer

Liu, X. (PI), Allison, D. (CoI), Higashi, R. (CoI), Moseley, H. (CoI) & Wang, C. (CoI)

6/15/22 → 12/31/22

Project: Research project

Pilot: Validation of Peripheral Blood Exosome Lipid Biomarkers in Lung Cancer and IBD

Barrett, T. (PI), Arnold, S. (CoI), Higashi, R. (CoI), Khosravi, M. (CoI) & Wang, C. (CoI)

6/15/22 → 12/31/22

Project: Research project

SUPPLEMENT: Diversity in Cancer Research Supplement: University of Kentucky

O'Connor, K. (PI), Awuah, S. (CoI), Bocklage, T. (CoI), Cavnar, M. (CoI), Chambers, M. (CoI), Gao, T. (CoI), Gentry, M. (CoI), Goellner, E. (CoI), Kuhs, K. (CoI), Miller, R. (CoI), Wang, X. (CoI) & Williams, L. (CoI)

National Institute Diabetes & Digestive & Kidney

1/1/22 → 12/31/22

Project: Research project

Elucidating Molecular Mechanisms Linking Fructose to Cholesterol Metabolism

Helsley, R. (PI), Graf, G. (CoI), Lane, A. (CoI) & Softic, S. (CoI)

1/1/22 → 12/31/23

Project: Research project

Covid 19: Mechanism of the Short- and Long-Term Effects of COVID-19-Induced Alarmins on Hematopoietic Stem and Progenitor Cells

Liang, Y. (PI)

9/1/21 → 6/30/23

Project: Research project

Novel DNA Mismatch Repair Interacting Proteins in Colon and Endometrial Cancers

Goellner, E. (PI)

Phi Beta Psi Sorority

8/15/21 → 8/14/22

Project: Research project

TRIM28 fuels prostate cancer growth through SETDB1-mediated epigenetic silencing of androgen metabolic genes UGT2B15 and UGT2B17 (Project #3)

Fong, K. W. (PI), Moseley, H. (CoI) & Weiss, H. (CoI)

8/13/21 → 12/31/21

Project: Research project

E2F Family Transcription Factors are Directly Regulated by TRIM28 to Promote Castration-Resistance in Prostate Cancer

Fong, K. W. (PI), Liu, X. (CoI) & Wang, C. (CoI)

7/5/21 → 6/30/24

Project: Research project

Fatty Acid Synthase in Regulation of UDP-GlcNAc Synthesis in Colorectal Cancer

Zaytseva, Y. (PI) & Wang, C. (CoI)

Army Medical Research and Materiel Command

7/1/21 → 6/30/23

Project: Research project

A Novel Peptide Suppresses Invasion and Metastasis in Rictor-amplified Lung Cancer

Yang, H.-S. (PI), Chen, M. (CoI) & Chen, L. (CoI)

7/1/21 → 6/30/23

Project: Research project

CCSG Supplement: Childhood Cancer Survivors

Evers, B. M. (PI), Borders, T. (CoI), D'Orazio, J. (CoI), Durbin, E. B. (CoI), Stapleton, J. (CoI) & Vanderford, N. (CoI)

7/1/21 → 6/30/23

Project: Research project

CCSG Pilot: Elucidating How a Truncating ATR Mutation Leads to Genomic Instability

D'Orazio, J. (PI), Evers, B. M. (CoI), Shelton, B. (CoI) & Zaytseva, Y. (CoI)

7/1/21 → 6/30/23

Project: Research project

Diversity in Cancer Research (DICR) Markey STRONG Scholars Program

O'Connor, K. (PI), Awuah, S. (CoI), Bocklage, T. (CoI), Cavnar, M. (CoI), Chambers, M. (CoI), Gao, T. (CoI), Goellner, E. (CoI), Kuhs, K. (CoI), Miller, R. (CoI), Vanderford, N. (CoI), Wang, X. (CoI), Williams, L. (CoI) & Fondufe-Mittendorf, Y. (Former CoI)

National Institute of Environmental Health Sciences

5/5/21 → 5/4/22

Project: Research project

Pilot: Center for Appalachian Research in Environmental Sciences: Metabolism-Linked Epigenetic Mechanism in Arsenic Carcinogenesis

Higashi, R. (PI), Curry, T. (CoI), Hahn, E. (CoI) & Lane, A. (CoI)

4/1/21 → 3/31/22

Project: Research project

Epigenetic Regulation of Anti-Cancer Efficacy of Selenium Agents in Lung Cancer

Fan, W.-M. (PI), Higashi, R. (CoI), St Clair, D. (CoI) & Wang, C. (CoI)

American Institute for Cancer Research

1/1/21 → 12/31/21

Project: Research project

How Dietary Methionine Influences Lung Cancer Initiation and Chemosensitivity

Brainson, C. (PI) & Deng, P. (Former CoI)

1/1/21 → 12/31/23

Project: Research project

Targeting Prometastatic Neutrophils to Inhibit Breast Cancer Metastasis

Liu, X. (PI) & Zhou, B. (CoI)

Susan G Komen Foundation

12/16/20 → 9/11/22

Project: Research project

(LTW) Peripheral Blood Exosome Lipid Compositions as IBD Biomarkers

Barrett, T. (PI), Alam, M. (CoI), Fan, W.-M. (CoI), Higashi, R. (CoI), Lane, A. (CoI) & Wang, C. (CoI)

Crohns and Colitis Foundation of America

12/15/20 → 11/30/21

Project: Research project

PILOT: Development of Individualized Anti-metastatic Strategies by Targeting Circulating Tumor Cell Clusters

Liu, X. (PI)

National Institute of Environmental Health Sciences

12/1/20 → 6/30/22

Project: Research project

Career Development Award: Mismatch Repair and Environmental DNA Damage

Goellner, E. (PI), D'Orazio, J. (CoI), Gao, T. (CoI), Hahn, E. (CoI), Liu, X. (CoI) & St Clair, D. (CoI)

9/1/20 → 3/31/21

Project: Research project

PILOT: Plk1 in the Efficacy of Immune Therapy

Li, Z. (PI) & Liu, X. (CoI)

National Institute of Environmental Health Sciences

9/1/20 → 7/31/22

Project: Research project

Career Development Award: Center for Appalachian Research in Environmental Sciences: Mismatch Repair and Environmental DNA Damage

Goellner, E. (PI), D'Orazio, J. (CoI), Gao, T. (CoI), Hahn, E. (CoI), Liu, X. (CoI) & St Clair, D. (CoI)

9/1/20 → 3/31/22

Project: Research project

Novel DNA Mismatch Repair Interacting Proteins in Colon and Endometrial Cancers

Goellner, E. (PI)

Phi Beta Psi Sorority

8/15/20 → 8/14/21

Project: Research project

Uncovering Plasma Exosomal Lipid Patterns for Early Detection of Pancreatic Cancer

Fan, W.-M. (PI), Barrett, T. (CoI), Higashi, R. (CoI), Kim, J. (CoI), Mardini, S. (CoI) & Wang, C. (CoI)

Markey Cancer Center Foundation

6/5/20 → 6/30/22

Project: Research project

NRSA Fellowship for Aria Byrd: Bronchiolar Dysplasia in COPD is Governed by Loss of Polycomb Repressive Complex 2

Brainson, C. (PI), Byrd, A. (CoI) & Gao, T. (CoI)

National Heart Lung and Blood Institute

3/15/20 → 10/14/21

Project: Research project

NRSA Fellowship for Aria Byrd: Bronchiolar Dysplasia in COPD is Governed by Loss of Polycomb Repressive Complex 2

Brainson, C. (PI), Byrd, A. (CoI) & Gao, T. (CoI)

National Heart Lung and Blood Institute

3/15/20 → 3/14/21

Project: Research project

University of Kentucky Center for Cancer and Metabolism (Project 1)

Liu, X. (PI), Moseley, H. (CoI), Weiss, H. (CoI) & St Clair, D. (CoPI)

3/4/20 → 12/31/20

Project: Research project

A Genomic Locus Associated with Radiation Resistance of Oral Cancer Cells

Izumi, T. (PI), Smith, M. (CoI) & Smith, M. (Former CoI)

National Institute of Environmental Health Sciences

3/3/20 → 11/30/23

Project: Research project

Career Development Award: Center for Appalachian Research in Environmental Sciences: Targeted Treatment of Arsenic-Induced Lung Cancer by PLK1 Inhibitors

Li, Z. (PI) & Hahn, E. (CoI)

1/1/20 → 3/31/21

Project: Research project

Career Development Award: Center for Appalachian Research in Environmental Sciences: Targeted Treatment of Arsenic-Induced Lung Cancer by PLK1 Inhibitors

Li, Z. (PI) & Hahn, E. (CoI)

National Institute of Environmental Health Sciences

1/1/20 → 3/31/20

Project: Research project

CCSG Pilot: Targeting the Synthetic Lethal Relationship Between Deficiencies in DNA Mismatch Repair and WRN Helicase to Treat MSI-High Tumors

Goellner, E. (PI), Evers, B. M. (CoI), Orren, D. (CoI), Thorson, J. (CoI), Wu, J. (CoI) & Zaytseva, Y. (CoI)