Toxicology and Cancer Biology

Grants and Contracts

Grants and Contracts per year 1979 2013 2017 2027

• 61 Active
• 344 Finished

Grants and Contracts per year

Search results

• Finished

  The Role of MRP1 in Protection of Cardiac Injury

  Vore, M. & Piascik, M.

  9/25/08 → 7/31/14

  Project: Research project

  • Oxidative Stress 100%
  • Tumor Necrosis Factor 83%
  • Tumor Necrosis Factors 83%
  • Doxorubicin 66%
  • Injury 66%

• Telomeric Dysfunction and the Premature Aging and Cancer-Prone Disease Werner Syndrome

  Orren, D. & Machwe, A.

  National Institute on Aging

  8/1/08 → 12/31/13

  Project: Research project

  • Aging 100%
  • Werner Syndrome 87%
  • Telomere 87%
  • Protein 37%
  • Development 37%

• Telomeric Dysfunction and the Premature Aging and Cancer-Prone Disease Werner Syndrome

  Orren, D.

  National Cancer Institute

  8/1/08 → 6/30/11

  Project: Research project

  • Aging 100%
  • Werner Syndrome 87%
  • Telomere 87%
  • Protein 37%
  • Development 37%

• The Role of PHLPP in Colon Cancer

  Gao, T., Al-Attar, A., Evers, B. M., Fan, W., Weiss, H., Wen, Y. A. & Xiong, X.

  National Cancer Institute

  4/1/08 → 7/31/20

  Project: Research project

  • Protein Phosphatase 100%
  • Leucine-Rich Repeat 94%
  • Pleckstrin Homology Domain 94%
  • Lipogenesis 52%
  • Cancer Cell 26%

• Reactive Oxygen Species in Ni(II) Carcinogenesis

  Shi, X.

  3/1/08 → 2/28/15

  Project: Research project

  • Species 100%
  • Reactive Oxygen Metabolite 100%
  • NFAT 61%
  • Nickel 61%
  • Carcinogenesis 53%

• Regulation WRN Deacetylation by SIRT1 After DNA Damage

  Orren, D.

  University of Massachusetts

  2/15/08 → 4/30/10

  Project: Research project

  • Regulatory Mechanism 100%
  • DNA Damage 100%
  • Deacetylation 100%
  • Sirtuin1 100%

• Roche Real-Time Polymerase Chain Reaction Workflow System

  Vore, M.

  2/1/08 → 1/31/09

  Project: Research project

  • Real Time Polymerase Chain Reaction 100%
  • Malignant Neoplasm 100%
  • Real-Time Polymerase Chain Reaction 100%
  • Student 66%
  • Tenidap 66%

• Summer Educational Experience for Research in Toxicology

  Vore, M.

  1/1/08 → 11/30/14

  Project: Research project

  • Students 100%
  • Research 73%
  • Academic Teaching Personnel 60%
  • Universities 40%
  • Experience 40%

• A Transgenic Mouse Model for Understanding Rev1 and Lung Cancer

  Wang, Z.

  9/1/07 → 8/31/10

  Project: Research project

  • Mutagenesis 100%
  • Malignant Neoplasm 85%
  • DNA Damage 57%
  • DNA 57%
  • Nested Gene 42%

• Lung cancer survival in Kentucky: a multifactorial approach

  Hopenhayn, C. & Mellon, I.

  KY Lung Cancer Research Fund

  9/1/07 → 6/30/12

  Project: Research project

  • Lung Cancer 100%
  • Survival 100%
  • Patient 60%
  • Lung Cancer Survival 60%
  • Cancer Registry 60%

• Redox Modulation Of Prostate Cancer

  St Clair, W. & St Clair, D.

  National Cancer Institute

  8/1/07 → 11/30/12

  Project: Research project

  • Nuclear Factor 100%
  • Prostate Cancer 80%
  • Cancer Cell 50%
  • Androgen 30%
  • Radiosensitivity 30%

• Diversity Supplement: DNA Mismatch Repair Deficiency and Leukemia Relapse

  Gu, L.

  8/1/07 → 2/28/12

  Project: Research project

  • Relapse 100%
  • Leukemia Relapse 100%
  • Leukemia 75%
  • Polymerase Chain Reaction 50%
  • Phenotype 50%

• Redox Modulation Of Prostate Cancer

  St Clair, D.

  National Cancer Institute

  8/1/07 → 11/30/12

  Project: Research project

  • Nuclear Factor 100%
  • Prostate Cancer 80%
  • Cancer Cell 50%
  • Androgen 30%
  • Radiosensitivity 30%

• Oxidative Stress in Cr(VI)-Induced Carcinogenesis

  Shi, X.

  2/7/07 → 12/31/11

  Project: Research project

  • Cell Transformation 100%
  • Mutant 100%
  • Reactive Oxygen Metabolite 100%
  • Carcinogenesis 80%
  • Transcription Factor 60%

• IRG Yang Scope

  Yang, H.

  American Cancer Society

  1/1/07 → 12/31/07

  Project: Research project

• Apple Peel Extract Protects UV-induced Carcinogenesis

  Shi, X.

  9/28/06 → 7/31/11

  Project: Research project

  • Apple 100%
  • Antioxidant 57%
  • Carcinogenesis 42%
  • Animal 28%
  • Ultraviolet Radiation 28%

• Mechnism of PCNA-Dependant 5' -3' Mismatch Excisiion

  Li, G. M.

  7/1/06 → 11/30/12

  Project: Research project

  • DNA Mismatch Repair 100%
  • Nuclease 50%
  • Protein 33%
  • HMGB1 16%
  • Escherichia coli 16%

• Mechanisms of As-induced Carcinogenesis

  Shi, X.

  2/1/06 → 12/31/07

  Project: Research project

  • Arsenic 100%
  • Carcinogenesis 50%
  • Reactive Oxygen Metabolite 25%
  • Protein 16%
  • Nude Mouse 16%

• Mechanisms of As-induced Carcinogenesis

  Shi, X.

  2/1/06 → 12/31/10

  Project: Research project

  • Arsenic 100%
  • Carcinogenesis 50%
  • Reactive Oxygen Metabolite 25%
  • Protein 16%
  • Nude Mouse 16%

• ARRA: Mechanisms of As-Induced Carcinogenesis

  Shi, X.

  2/1/06 → 12/31/11

  Project: Research project

  • Arsenite 100%
  • Arsenic 75%
  • Carcinogenicity 62%
  • Chronic Inflammation 50%
  • Lung Cancer 37%

• Dissection and Reconstitution of Mismatch Repair

  Li, G. M.

  1/1/06 → 12/31/11

  Project: Research project

  • DNA Mismatch Repair 100%
  • Mutant Protein 20%
  • Protein 20%
  • Protein MutS 10%
  • Heteroduplex 10%

• Role of Endothelial ATla receptors on sidestream Cigarette Smoke Induced Atherosclerosis and Vascular

  Gairola, C.

  9/1/05 → 8/31/08

  Project: Research project

• Molecular Mechanicanisms of Toxicity Training Grant

  Vore, M.

  7/1/05 → 6/30/06

  Project: Research project

  • Toxicology 100%
  • Toxicity 66%
  • Rose 16%
  • DNA 16%
  • Neurotoxicology 16%

• Molecular Mechanisms of Toxicity Training Grant

  Vore, M.

  7/1/05 → 6/30/08

  Project: Research project

  • Toxicology 100%
  • Toxicity 66%
  • Rose 16%
  • DNA 16%
  • Neurotoxicology 16%

• Carryforward: Molecular Mechanisms of Toxicity Training Grant

  Vore, M.

  7/1/05 → 6/30/07

  Project: Research project

  • Toxicology 100%
  • Toxicity 66%
  • Rose 16%
  • DNA 16%
  • Neurotoxicology 16%

• Molecular Mechanisms of Toxicity Training Grant

  Vore, M.

  7/1/05 → 6/30/07

  Project: Research project

  • Toxicology 100%
  • Toxicity 66%
  • Rose 16%
  • DNA 16%
  • Neurotoxicology 16%

• Carryforward: Molecular Mechanisms of Toxicity Training Grant

  Vore, M.

  7/1/05 → 6/30/08

  Project: Research project

  • Toxicology 100%
  • Toxicity 66%
  • Rose 16%
  • DNA 16%
  • Neurotoxicology 16%

• Calcium Regulation in Brain Aging and Alzheimer's Disease - Project 2

  Butterfield, D. A. & St Clair, D.

  National Institute on Aging

  9/30/04 → 8/31/10

  Project: Research project

  • Calcium Ion 100%
  • Brain 100%
  • Alzheimer's Disease 87%
  • Aging 87%
  • Gene 25%

• The Role of Radicals in Space Radiation-Induced Maliganant Transformations

  St Clair, D.

  University of Pennsylvania

  9/1/04 → 8/31/08

  Project: Research project

  • Extraterrestrial Radiation 100%
  • Radiation 100%

• Biochemical Basis of WRN and RecQ Helicase Function

  Orren, D.

  National Cancer Institute

  8/10/04 → 10/31/09

  Project: Research project

  • RecQ Helicase 100%

• Identifying Proteins Involved in DNA Damage Response

  Li, G. M.

  7/5/04 → 6/30/06

  Project: Research project

  • DNA Mismatch Repair 100%
  • Protein 54%
  • Apoptosis 45%
  • DNA 36%
  • Genome Instability 27%

• Novel Mechanisms of Carcinoma Cell Migration

  O'Connor, K., Chen, M., Weiss, H. & Samayoa, L.

  National Cancer Institute

  7/1/04 → 7/31/17

  Project: Research project

  • Integrin 100%
  • Polarization 28%
  • Cell Migration 14%
  • Motivation 14%
  • Sample 7%

• Novel Mechanisms of Carcinoma Cell Migration

  O'Connor, K., Chen, M., Weiss, H. & Samayoa, L.

  National Cancer Institute

  7/1/04 → 3/31/16

  Project: Research project

  • Integrin 100%
  • Polarization 28%
  • Cell Migration 14%
  • Motivation 14%
  • Sample 7%

• KSEF R&D Excellence: Search for Novel Inhibitors of Neuronal Nitric Oxide Synthase in Tobacco Leaves

  MILLER, R. & Gairola, C.

  6/1/04 → 8/31/05

  Project: Research project

• Prolactin and Bile Secretory Function

  Vore, M.

  5/1/04 → 6/30/10

  Project: Research project

  • Functions 100%
  • Prolactin 100%

• The 6th Annual Midwest DNA Repair Symposium

  Mellon, I.

  National Institute of Environmental Health Sciences

  4/1/04 → 3/31/05

  Project: Research project

  • Genes 100%
  • Conferences 69%
  • DNA 50%
  • Maintenance 50%
  • Students 20%

• In vitro mechanisms of action of ursodeoxycholic acid

  GERK, P.

  1/15/04 → 1/31/05

  Project: Research project

• Ang II Upregulates Macrophage MMP-2 Activity to Facilitate Entry of this Cell Type into Arterial Tissue

  Huang, J.

  7/1/03 → 6/30/05

  Project: Research project

  • Macrophage 100%
  • MMP2 85%
  • Gelatinase A 78%
  • Cell Type 21%
  • Low Density Lipoprotein Receptor Related Protein 14%

• Genetic Polymorphism and Lung Cancer: Animal Models of Tobacco Carcinogenesis

  Gairola, C.

  7/1/03 → 12/31/08

  Project: Research project

  • Malignant Neoplasm 100%
  • Animal 80%
  • Carcinogenesis 80%
  • Lung Cancer 60%
  • Smoke 40%

• Chemoprevention of Experimental Tobacco Carciniogenesis

  Gairola, C.

  7/1/03 → 4/30/08

  Project: Research project

• Repair of oxidative DNA damage in mammalian cells

  Izumi, T.

  National Cancer Institute

  3/10/03 → 5/31/16

  Project: Research project

  • P53 100%
  • Base Excision Repair 80%
  • DNA Damage 60%
  • Ubiquitination 60%
  • Cancer Cell 40%

• Responses of Replication, Recombination and Checkpoint Signalling Pathways to Unrepaired PAH Adducts in DNA

  Orren, D.

  KY Lung Cancer Research Fund

  2/1/03 → 7/31/06

  Project: Research project

  • Mutation 100%
  • DNA 88%
  • Cells 77%
  • Carcinogen 66%
  • Lung 55%

• Alterations of DNA Mismatch Repair Genes in Lung Cancer

  Li, G. M. & Gu, L.

  7/1/02 → 6/30/05

  Project: Research project

  • MLH1 100%
  • DNA Mismatch Repair 66%
  • MSH2 33%
  • Gene Repair 33%
  • Recombinant Protein 16%

• Scope account: Mechanisms of Sidestream Cigarette-Induced Atherogenesis

  Gairola, C.

  5/1/02 → 1/31/06

  Project: Research project

• Mechanisms of DNA Lesion Bypass in Eukaryotes

  Wang, Z.

  4/1/02 → 3/31/07

  Project: Research project

  • DNA Damage 100%
  • Mutagenesis 44%
  • Eukaryote 33%
  • Polymerase 33%
  • Experiment 33%

• Mechanism of Redox Mediated Cardioprotection

  St Clair, D.

  National Cancer Institute

  4/1/02 → 3/31/09

  Project: Research project

  • Tumor Necrosis Factor 100%
  • Tamoxifen 80%
  • Tumor Necrosis Factor Alpha 69%
  • Tumor Necrosis Factor Receptor 40%
  • Heart Protection 40%

• Environmental Toxicology/Short Term Research

  Vore, M.

  4/1/01 → 3/31/06

  Project: Research project

  • Toxicology 100%
  • Toxicity 100%
  • Environmental Toxicology 100%
  • Animal 50%
  • DNA 50%

• Environmental Toxicology/Short-Term Research

  Vore, M.

  4/1/01 → 3/31/05

  Project: Research project

  • Toxicology 100%
  • Toxicity 100%
  • Environmental Toxicology 100%
  • Animal 50%
  • DNA 50%

• The Role of Mismatch Repair in Sporadic Tumor Supression

  Li, G. M.

  2/14/01 → 1/31/06

  Project: Research project

  • DNA Mismatch Repair 100%
  • Microsatellite Instability 30%
  • Protein 23%
  • DNA 15%
  • Cell Mutant 15%

• Unliquidated Obligations: Training Program in Oxidative Stress and Nutrition

  Webb, N. & St Clair, D.

  National Institute Diabetes & Digestive & Kidney

  8/15/00 → 7/31/15

  Project: Research project

  • Training 100%
  • Athletic Training 100%
  • Program 76%
  • Science 61%
  • Oxidative Stress 53%