Toxicology and Cancer Biology

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Developing New Therapeutic Approaches for BRAFV600E Colorectal Cancer
Zaytseva, Y. (PI), Lee, E. (CoI) & Wang, C. (CoI)
Colorectal Cancer Alliance
9/1/24 → 8/31/26
Project: Research project
Targeting Lung Fibrosis Using Epigenetic Therapy
Brainson, C. (PI), Allison, D. (CoI), Beswick, E. (CoI), Liu, J. (CoI), Sturgill, J. (CoI), Weiss, H. (CoI) & Waters, C. (Former CoI)
National Heart Lung and Blood Institute
8/15/24 → 7/31/28
Project: Research project
IPA: Modulation of Mitochondrial Respiration to Treat Colitis
Chaiswing, L. (PI)
Veterans Affairs
8/1/24 → 12/31/25
Project: Research project
CCSG Pilot: The Role of Calpain-5 in Endometrial Cancer
Yang, E. (PI), Goellner, E. (CoI), Piecoro, D. (CoI) & Wang, C. (CoI)
National Cancer Institute
7/1/24 → 6/30/25
Project: Research project
Extracellular vesicle-mediated Nrf2 protein secretion and its therapeutic application in cardiogenic dementia
Tian, C. (PI)
7/1/24 → 6/30/27
Project: Research project
Extracellular Vesicle-Mediated Nrf2 Protein Secretion and its Therapeutic Application in Cardiogenic Dementia
Tian, C. (PI) & Sompol, P. (CoI)
American Heart Association
7/1/24 → 6/30/27
Project: Research project
Plk1 in Prostate Cancer Lineage Plasticity
Liu, X. (PI) & Liu, J. (CoI)
Department of Defense
6/1/24 → 5/31/27
Project: Research project
Integrative Targeted Therapy for Melanoma
Yang, J. (PI), Evers, B. M. (CoI), Ren, X. (CoI) & Yan, D. (CoI)
National Cancer Institute
4/1/24 → 3/31/29
Project: Research project
A Pro-Metastatic Secretory Program Activated By Epithelial-To-Mesenchymal Transition
Xiao, G.-Y. (PI)
National Cancer Institute
3/12/24 → 2/28/27
Project: Research project
Novel Strategy to Augmenting Immunotherapy Against Melanoma
Yang, J. (PI), Ren, X. (CoI) & Yan, D. (CoI)
National Cancer Institute
3/1/24 → 2/28/26
Project: Research project
Fatty Acid Synthase as a Novel Molecular Target for Colon Cancer Treatment
Gao, T. (PI), Lee, E. (CoI), Messaoudi Powers, I. (CoI), St Clair, D. (CoI), Wang, C. (CoI), Zaytseva, Y. (CoI) & Evers, B. M. (CoPI)
National Cancer Institute
3/1/24 → 2/28/29
Project: Research project
Pilot: PLK1 Phosphorylation of NEUROD1 in Prostate Cancer Lineage Plasticity
Zhang, Y. (PI)
American Cancer Society
2/1/24 → 1/31/25
Project: Research project
Mechanistic and structural insights into a new pro-metastatic collagen glucosyltransferase
Guo, H. (PI), Brainson, C. (CoI) & Chen, L. (CoI)
National Cancer Institute
1/16/24 → 12/31/28
Project: Research project
Pdcd4-Rictor Interaction in Suppression of Lung Tumorigenesis
Yang, H.-S. (PI), Chen, L. (CoI), Fan, W.-M. (CoI), Hao, Z. (CoI), Lee, E. (CoI), Liu, X. (CoI) & Zhan, C.-G. (CoI)
National Cancer Institute
9/20/23 → 8/31/28
Project: Research project
Targeting RSK-TRIM28-E2F1 Axis Overcomes CDK4/6 Inhibitor Resistance in Lethal RB1 Deficient Prostate Cancer
Fong, K. W. (PI), Allison, D. (CoI), Liu, J. (CoI) & Liu, X. (CoI)
V Foundation
9/1/23 → 9/1/26
Project: Research project
Targeting the Immunosuppressive Tumor Microenvironment for Colorectal Cancer Treatment
Wang, Q. (PI), Bondada, S. (CoI), Higashi, R. (CoI), Lee, E. (CoI), Wang, C. (CoI), Weiss, H. (CoI) & Evers, B. M. (CoPI)
National Cancer Institute
9/1/23 → 8/31/28
Project: Research project
Targeting NNMT to Inhibit Obesity-Associated Breast Cancer Development and Progression
Zhou, B. (PI), Lane, A. (CoI), St Clair, D. (CoI) & Wang, C. (CoI)
Department of Defense
9/1/23 → 8/31/26
Project: Research project
CCSG Pilot: Determining Mechanisms of Immunotherapy Resistance in KEAP1 and LKB1 Mutant Lung Cancers
Brainson, C. (PI), Durbin, E. B. (CoI), Hao, Z. (CoI), Jeong, J. C. (CoI) & Liu, J. (CoI)
National Cancer Institute
9/1/23 → 12/31/24
Project: Research project
Diversity Supplement for Kahleel Guerrier: Targeting Mitochondrial Redox Capacity to Overcome Cancer Subtype that Regrowth After Radiation
Chaiswing, L. (PI) & St Clair, D. (CoI)
National Cancer Institute
8/1/23 → 3/31/26
Project: Research project
Point-of-care Optical Spectroscopy Platform and Novel Ratio-metric Algorithms for Rapid and Systematic Functional Characterization of Biological Models in Vivo
Zhu, C. (PI), Arnold, S. (CoI), Fan, W.-M. (CoI), Tong, S. (CoI) & Wang, C. (CoI)
National Institute of Dental and Craniofacial Research
8/1/23 → 7/31/28
Project: Research project
Targeting the Plk1/Pdcd4/mTORC2 Signaling to Treat Castration-Resistant Prostate Cancer
Liu, X. (PI), Allison, D. (CoI), Chen, L. (CoI) & Yang, H.-S. (CoPI)
National Cancer Institute
7/1/23 → 6/30/28
Project: Research project
Targeting the Plk1/Pdcd4/mTORC2 Signaling to Treat Castration-Resistant Prostate Cancer
Yang, H.-S. (PI), Allison, D. (CoI), Chen, L. (CoI) & Liu, X. (CoPI)
National Cancer Institute
7/1/23 → 6/30/28
Project: Research project
Roles of mRNA Transfer in Cancer Cell-Platelet Communication
Xu, R. (PI), Liu, X. (CoI) & Trinkle, C. (CoI)
National Cancer Institute
7/1/23 → 6/30/28
Project: Research project
Developing New Therapies for Metatsic Melanoma
Plattner, R. (PI), Goellner, E. (CoI), Liu, J. (CoI) & Richards, D. (CoI)
Markey Cancer Center Foundation
7/1/23 → 7/31/25
Project: Research project
Overcoming Therapeutic Resistance in Lung Cancer Using Novel Combination Therapies
Brainson, C. (PI) & Liu, J. (CoI)
Markey Cancer Center Foundation
7/1/23 → 7/31/25
Project: Research project
Diversity Supplement for Dave-Preston Esoe: Targeting Epigenetic Heterogeneity to Improve Lung Cancer Immunotherapy Response
Brainson, C. (PI)
National Cancer Institute
7/1/23 → 6/30/25
Project: Research project
Center for Appalachian Research in Environmental Sciences: Pilot Project Program
Curry, T. (PI), Bloomer, E. (CoI), Fan, W.-M. (CoI), Haynes, E. (CoI), Hahn, E. (Former CoI), Richardson, K. (Former CoI) & Swanson, H. (Former CoI)
6/3/23 → 4/30/28
Project: Research project
Inflammatory Injury Caused by Silica Exposure
Fu, J. (PI)
National Heart Lung and Blood Institute
5/1/23 → 4/30/27
Project: Research project
Diversity in Cancer Research Supplement: University of Kentucky
O'Connor, K. (PI), Adegboyega, A. (CoI), Awuah, S. (CoI), Blackburn, J. (CoI), Brainson, C. (CoI), Gao, T. (CoI), Hull, P. (CoI), Lee, Y.-S. (CoI), Williams, L. (CoI) & Hahn, E. (Former CoI)
American Cancer Society
1/1/23 → 12/31/25
Project: Research project
Markey STRONG Post-baccalaureate Program
O'Connor, K. (PI), Adegboyega, A. (CoI), Awuah, S. (CoI), Blackburn, J. (CoI), Brainson, C. (CoI), Gao, T. (CoI) & Williams, L. (CoI)
American Cancer Society
1/1/23 → 12/31/25
Project: Research project
Gold Complexes that Regulate Metabolism and Microbiome to Accelerate Mucosal Healing in IBD
Barrett, T. (PI), Alam, M. (CoI), Awuah, S. (CoI), Chaiswing, L. (CoI), Kapur, N. (CoI), Sullivan, P. (CoI) & Wang, C. (CoI)
Crohns and Colitis Foundation of America
1/1/23 → 12/31/24
Project: Research project
Aberrant Glycogen in Lung Adenocarcinoma Tumorigenesis
Allison, D. (PI) & Brainson, C. (CoI)
University of Florida
11/1/22 → 6/30/27
Project: Research project
Non-Destructive Optical Spectroscopic Assay for High-Throughput Metabolic Characterization of in Vitro Cell Models and Patient-Derived Organoids
Zhu, C. (PI), Fan, W.-M. (CoI), Wang, X. (CoI), Wang, C. (CoI) & Wang, P. (CoI)
National Institute of Biomedical Imaging & Bioengineer
8/1/22 → 4/30/25
Project: Research project
Targeting Polo-Like Kinase 1 in Prostate Cancer to Enhance Therapeutic Efficacy
Li, Z. (PI), Allison, D. (CoI), Liu, J. (CoI), Lutz, C. (CoI) & Wang, C. (Former CoI)
National Cancer Institute
7/1/22 → 6/30/27
Project: Research project
Elucidating Molecular Mechanisms Linking Fructose to Cholesterol Metabolism
Helsley, R. (PI), Graf, G. (CoI), Lane, A. (CoI) & Softic, S. (Former CoI)
National Institute Diabetes & Digestive & Kidney
1/1/22 → 12/31/26
Project: Research project
Phase II Clinical Trial Evaluating Cabozantinib and Pembrolizumab in Second-Line Therapy for Metastatic Pancreatic Adenocarcinoma
Kim, J. (PI), Fan, W.-M. (CoI), Gao, M. (CoI), Higashi, R. (CoI), Rueckert, J. (CoI) & Qasem, S. (Former CoI)
Exelixis Inc.
12/15/21 → 6/7/25
Project: Research project
HDAC6 Regulation of Myeloid Cell Responses in Sepsis
Fu, J. (PI)
National Institute of Allergy and Infectious Diseases
9/17/21 → 8/31/26
Project: Research project
Enhancing the Efficacy of Androgen Signaling Inhibitors in Prostate Cancer
Liu, X. (PI), Allison, D. (CoI), Wang, C. (CoI) & Wang, P. (Former CoI)
National Cancer Institute
7/1/21 → 6/30/26
Project: Research project
Plk1 as a Prognostic Biomarker for Prostate Cancer
Liu, X. (PI), Allison, D. (CoI), Berry, S. (CoI), Li, Z. (CoI), Wang, C. (CoI) & Wang, P. (Former CoI)
National Cancer Institute
7/1/21 → 6/30/26
Project: Research project
Nrf2 Regulation of Oxidative Stress in Heart Failure and Extra Vesicular Communication
Tian, C. (PI)
University of Nebraska
7/1/21 → 3/31/25
Project: Research project
Understanding Mechanisms and Consequences of T Cell Co-Receptor Regulated RNA Maturation
Lane, A. (PI), Fan, W.-M. (CoI) & Higashi, R. (CoI)
Health Research Incorporated
4/5/21 → 3/31/25
Project: Research project
Targeting Mitochondrial Redox Capacity to Overcome Cancer Subtype that Regrowth After Radiation
Chaiswing, L. (PI), Higashi, R. (CoI), Luo, W. (CoI), St Clair, W. (CoI) & Weiss, H. (CoI)
National Cancer Institute
4/1/21 → 3/31/26
Project: Research project
Targeting Lipid Metabolism in Colorectal Cancer
Zaytseva, Y. (PI), Evers, B. M. (CoI), Lee, E. (CoI), Moseley, H. (CoI), Nikolova-Karakashian, M. (CoI), Rychahou, P. (CoI) & Weiss, H. (CoI)
National Cancer Institute
4/1/21 → 3/31/26
Project: Research project
Defining the Critical Function and Regulation of NNMT in Breast Cancer Progression and Metastasis
Zhou, B. (PI), Lane, A. (CoI), St Clair, D. (CoI), Wang, C. (CoI) & Zhu, H. (Former CoI)
National Cancer Institute
4/1/21 → 3/31/26
Project: Research project
The Role of Crypt Fissioning in IBD Ulcer Healing
Barrett, T. (PI), Beyer, R. (CoI), Chaiswing, L. (CoI), Flomenhoft, D. (CoI), Gao, T. (CoI), Goretsky, T. (CoI), Harrison, D. (CoI), Kapur, N. (CoI), Lohr, K. (CoI), Sullivan, P. (CoI), Grigorian, A. (Former CoI), Holt, E. (Former CoI), Liu, J. (Former CoI) & Stromberg, A. (Former CoI)
National Institute Diabetes & Digestive & Kidney
2/24/21 → 1/31/25
Project: Research project
Defining Genetic and Metabolic Requirements of Aggressive Breast Cancer (KY SOW)
Lane, A. (PI) & Fan, W.-M. (CoI)
University of Cincinnati
4/1/20 → 3/31/25
Project: Research project
Diversity Supplement for Christian Gosser Targeting Epigenetic Heterogeneity to Improve Lung Cancer Immunotherapy Response
Brainson, C. (PI)
National Cancer Institute
7/1/19 → 6/30/25
Project: Research project
Targeting Epigenetic Heterogeneity to Improve Lung Cancer Immunotherapy Response
Brainson, C. (PI), Liu, J. (CoI) & Wang, C. (CoI)
National Cancer Institute
7/1/19 → 6/30/25
Project: Research project
Improving Chemotherapy of Castration-Resistant Prostate Cancer
Liu, X. (PI), Allison, D. (CoI), Chen, L. (CoI), Wang, C. (CoI) & Wang, P. (Former CoI)
National Cancer Institute
1/15/19 → 6/30/26
Project: Research project
Integrin alpha6beta4 Regulation of Cancer Epigenetics
O'Connor, K. (PI), Chen, M. (CoI), Liu, J. (CoI), Wang, C. (CoI), Fondufe-Mittendorf, Y. (Former CoI) & Hodges, K. (Former CoI)
National Cancer Institute
1/1/19 → 12/31/24
Project: Research project