Grants and Contracts per year
Personal profile
Research Interests
Dr. Evers’s basic research, continuously funded by the NIH for the past 21 years focuses on signaling pathways regulating colorectal cancer proliferation and metastasis and mechanisms contributing to intestinal cell differentiation and aging.
His laboratory has identified key components of the PI3K/Akt/mTOR pathway which play differential roles in colorectal carcinogenesis and differentiation. Activation of phosphatidylinositol 3-kinase (PI3K), a ubiquitous lipid kinase composed of an 85 kDa regulatory subunit (p85) and a 110 kDa catalytic subunit (p110) and its downstream effector protein, Akt, is associated with the growth and progression of a number of cancers, including colorectal cancer. Dr. Evers’s group hypothesizes that colorectal cancer growth and progression are augmented by increased p85α and Akt2 expression and that selective inhibition of PI3K/Akt components can suppress colorectal cancer growth and metastasis and can sensitize resistant colorectal cancers to chemotherapeutic agents.
Dr. Evers is the PI of an NIH MERIT award (R37 AG010885) which is focused on a better understanding of the function of the gut peptide neurotensin (NT) an important regulatory and trophic hormone localized to specialized enteroendocrine cells (N cells) of the adult small bowel.
Using the novel endocrine cell line model, BON, investigators in Dr. Evers’s laboratory have identified the signaling pathways responsible for NT secretion. Current studies are also focused on the effects of NT associated with aging and on the proliferation of various cancers. Dr. Evers is the PI of an R01 from NIDDK (R01 DK048498) which has led to the discovery of new pathways contributing to intestinal cell differentiation.
Current studies are analyzing unique interactions of mTOR on other signaling proteins such as the sirtuin family of proteins. Finally, Dr. Evers is the PI for the UK GI Cancer SPORE planning grant (P20) which represents a multidisciplinary effort to identify better treatment, diagnostic and preventive strategies for GI cancers, a significant problem in Kentucky. One project which is being performed in collaboration with Dr. Tianyan Gao is focused on colorectal cancer cell metabolism and effects of mTOR signaling.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Post Doctoral Fellow, Univ Of Texas Medical
1990
Residency, Univ Of Louisville
1988
Doctor of Medicine, Univ Of Tennessee-Medical
1983
Bachelor of Arts, Univ Of Tennessee-Knoxville
1979
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Network
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Tumor Microbiota-derived Signaling in Colon Carcinogenesis and Cancer Treatment
Alam, M., Evers, B. M., Gao, T. & Suzuki, Y.
6/1/22 → 5/31/23
Project: Research project
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Fellowship for Lyndsay Young: Aberrant Glycogen Modulates Metabolism in Ewing's Sarcoma
9/1/21 → 8/31/23
Project: Research project
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CCSG Supplement: Childhood Cancer Survivors
Evers, B. M., Borders, T., D'Orazio, J., Durbin, E., Stapleton, J. & Vanderford, N.
7/1/21 → 6/30/23
Project: Research project
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CCSG Pilot: Adjunctive Theta Burst Stimulation (TBS) or Attentional Bias Modulation and Smoking Cessation in People Living with HIV/AIDS (PLWHA): A Randomized Clinical Trial
Himelhoch, S., Adams Jr., T., Burris, J., Evers, B. M., Rakesh, G., Rush, C., Shelton, B. & Wesley, M.
7/1/21 → 6/30/23
Project: Research project
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CCSG Pilot: Elucidating How a Truncating ATR Mutation Leads to Genomic Instability
D'Orazio, J., Evers, B. M., Shelton, B. & Zaytseva, Y.
7/1/21 → 6/30/23
Project: Research project
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Glycolytic Regulation of Intestinal Stem Cell Self-Renewal and Differentiation
Li, C., Zhou, Y., Wei, R., Napier, D. L., Sengoku, T., Alstott, M. C., Liu, J., Wang, C., Zaytseva, Y. Y., Weiss, H. L., Wang, Q. & Evers, B. M., Jan 2023, In: CMGH. 15, 4, p. 931-947 17 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Opioid Use After Colorectal Resection: Identifying Preoperative Risk Factors for Postoperative Use
Levy, B. E., Castle, J. T., Ebbitt, L. M., Kennon, C., McAtee, E., Davenport, D. L., Evers, B. M. & Bhakta, A., Mar 2023, In: Journal of Surgical Research. 283, p. 296-304 9 p.Research output: Contribution to journal › Article › peer-review
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Anti-neoplastic sulfonamides alter the metabolic homeostasis and disrupt the suppressor activity of regulatory T cells
Gedaly, R., Cornea, V., Turcios, L., Edmisson, J. S., Harris, D. D., Watt, D. S., Chapelin, F., Khurana, A., Mei, X., Liu, C., Taylor, I., Gonzalez-Valdivieso, J., Mitchel, H., Ruffing, A., Chishti, A., Orozco, G., Zwischenberger, J., Evers, B. M. & Marti, F., Dec 2022, In: Scientific Reports. 12, 1, 19112.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Diaminobutoxy-substituted Isoflavonoid (DBI-1) Enhances the Therapeutic Efficacy of GLUT1 Inhibitor BAY-876 by Modulating Metabolic Pathways in Colon Cancer Cells
Guo, L., Zhang, W., Xie, Y., Chen, X., Olmstead, E. E., Lian, M., Zhang, B., Zaytseva, Y. Y., Mark Evers, B., Peter Spielmann, H., Liu, X., Watt, D. S. & Liu, C., May 2022, In: Molecular Cancer Therapeutics. 21, 5, p. 740-750 11 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
hPG80 (Circulating Progastrin), a Novel Blood-Based Biomarker for Detection of Poorly Differentiated Neuroendocrine Carcinoma and Well Differentiated Neuroendocrine Tumors
Chauhan, A., Prieur, A., Kolesar, J., Arnold, S., Payen, L., Mahi, Y., Vire, B., Sands, M., Evers, B. M., Joubert, D. & Anthony, L., Feb 1 2022, In: Cancers. 14, 4, 863.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations
Prizes
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Member, American Society for Clinical Investigation
Evers, B. Mark (Recipient), 2002
Prize: Honorary award
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Elected Member, Association of American Physicians
Evers, B. Mark (Recipient), 2017
Prize: Honorary award
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