Research output per year
Research output per year
- 1 - 50 out of 57 results
Search results
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2024
A unique inflammaging profile generated by T cells from people with obesity is metformin resistant
SantaCruz-Calvo, S., Saraswat, S., Kalantar, G. H., Zukowski, E., Marszalkowski, H., Javidan, A., Gholamrezaeinejad, F., Bharath, L. P., Kern, P. A., Zhang, X. D. & Nikolajczyk, B. S., 2024, (Accepted/In press) In: GeroScience.Research output: Contribution to journal › Article › peer-review
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Everolimus alleviates CD4+ T cell inflammation by regulating autophagy and cellular redox homeostasis
Rockhold, J. D., Marszalkowski, H., Sannella, M., Gibney, K., Murphy, L., Zukowski, E., Kalantar, G. H., SantaCruz-Calvo, S., Hart, S. N., Kuhn, M. K., Yu, J., Stefanik, O., Chase, G., Proctor, E. A., Hasturk, H., Nikolajczyk, B. S. & Bharath, L. P., Dec 2024, In: GeroScience. 46, 6, p. 5681-5699 19 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Fasting and Glucose Metabolism Differentially Impact Peripheral Inflammation in Human Type 2 Diabetes
Kalantar, G. H., Saraswat, S., SantaCruz-Calvo, S., Gholamrezaeinejad, F., Javidan, A., Agrawal, M., Liu, R., Kern, P., Zhang, X. & Nikolajczyk, B. S., May 7 2024, In: Nutrients. 16, 10Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Periodontitis and Diabetes Differentially Affect Inflammation in Obesity
SantaCruz-Calvo, S., Saraswat, S., Hasturk, H., Dawson, D., Zhang, X. & Nikolajczyk, B. S., Nov 2024, In: Journal of Dental Research. 103, 12, p. 1313-1322 10 p.Research output: Contribution to journal › Article › peer-review
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Terminally differentiated effector memory T cells associate with cognitive and AD-related biomarkers in an aging-based community cohort
Winford, E., Lutshumba, J., Martin, B. J., Wilcock, D. M., Jicha, G. A., Nikolajczyk, B. S., Stowe, A. M. & Bachstetter, A. D., Dec 2024, In: Immunity and Ageing. 21, 1, 36.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
2023
A blunted TH17 cytokine signature in women with mild cognitive impairment: insights from inflammatory profiling of a community-based cohort of older adults
Bachstetter, A. D., Lutshumba, J., Winford, E., Abner, E. L., Martin, B. J., Harp, J. P., Van Eldik, L. J., Schmitt, F. A., Wilcock, D. M., Stowe, A. M., Jicha, G. A. & Nikolajczyk, B. S., 2023, In: Brain Communications. 5, 5, fcad259.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
STAT3 modulates CD4+ T mitochondrial dynamics and function in aging
Zukowski, E., Sannella, M., Rockhold, J. D., Kalantar, G. H., Yu, J., SantaCruz-Calvo, S., Kuhn, M. K., Hah, N., Ouyang, L., Wang, T. W., Murphy, L., Marszalkowski, H., Gibney, K., Drummond, M. J., Proctor, E. A., Hasturk, H., Nikolajczyk, B. S. & Bharath, L. P., Nov 2023, In: Aging Cell. 22, 11, e13996.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
2022
Early life stress exacerbates obesity in adult female mice via mineralocorticoid receptor-dependent increases in adipocyte triglyceride and glycerol content
Leachman, J. R., Cincinelli, C., Ahmed, N., Dalmasso, C., Xu, M., Gatineau, E., Nikolajczyk, B. S., Yiannikouris, F., Hinds, T. D. & Loria, A. S., Sep 1 2022, In: Life Sciences. 304, 120718.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
Obesity alters pathology and treatment response in inflammatory disease
Bapat, S. P., Whitty, C., Mowery, C. T., Liang, Y., Yoo, A., Jiang, Z., Peters, M. C., Zhang, L. J., Vogel, I., Zhou, C., Nguyen, V. Q., Li, Z., Chang, C., Zhu, W. S., Hastie, A. T., He, H., Ren, X., Qiu, W., Gayer, S. G. & Liu, C. & 23 others, , Apr 14 2022, In: Nature. 604, 7905, p. 337-342 6 p.Research output: Contribution to journal › Article › peer-review
Open Access140 Scopus citations -
Obesity and Fatty Acids Promote Mitochondrial Translocation of STAT3 Through ROS-Dependent Mechanisms
Conway, R., Rockhold, J. D., SantaCruz-Calvo, S., Zukowski, E., Pugh, G. H., Hasturk, H., Kern, P. A., Nikolajczyk, B. S. & Bharath, L. P., 2022, In: Frontiers in Aging. 3, 924003.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Regulatory T Cells Control Effector T Cell Inflammation in Human Prediabetes
Liu, R., Pugh, G. H., Tevonian, E., Thompson, K., Lauffenburger, D. A., Kern, P. A. & Nikolajczyk, B. S., Feb 2022, In: Diabetes. 71, 2, p. 264-274 11 p.Research output: Contribution to journal › Article › peer-review
Open Access16 Scopus citations -
T cells dominate peripheral inflammation in a cross-sectional analysis of obesity-associated diabetes
Pugh, G. H., Fouladvand, S., SantaCruz-Calvo, S., Agrawal, M., Zhang, X. D., Chen, J., Kern, P. A. & Nikolajczyk, B. S., Oct 2022, In: Obesity. 30, 10, p. 1983-1994 12 p.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
2020
Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation
Bharath, L. P., Agrawal, M., McCambridge, G., Nicholas, D. A., Hasturk, H., Liu, J., Jiang, K., Liu, R., Guo, Z., Deeney, J., Apovian, C. M., Snyder-Cappione, J., Hawk, G. S., Fleeman, R. M., Pihl, R. M. F., Thompson, K., Belkina, A. C., Cui, L., Proctor, E. A. & Kern, P. A. & 1 others, , Jul 7 2020, In: Cell Metabolism. 32, 1, p. 44-55.e6Research output: Contribution to journal › Article › peer-review
Open Access433 Scopus citations -
Single-Cell Analysis of the Periodontal Immune Niche in Type 2 Diabetes
Belkina, A. C., Azer, M., Lee, J. J., Elgaali, H. H., Pihl, R., Cleveland, M., Carr, J., Kim, S., Habib, C., Hasturk, H., Snyder-Cappione, J. E. & Nikolajczyk, B. S., Jul 1 2020, In: Journal of Dental Research. 99, 7, p. 855-862 8 p.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
2019
Fatty Acid Metabolites Combine with Reduced β Oxidation to Activate Th17 Inflammation in Human Type 2 Diabetes
Nicholas, D. A., Proctor, E. A., Agrawal, M., Belkina, A. C., Van Nostrand, S. C., Panneerseelan-Bharath, L., Jones, A. R., Raval, F., Ip, B. C., Zhu, M., Cacicedo, J. M., Habib, C., Sainz-Rueda, N., Persky, L., Sullivan, P. G., Corkey, B. E., Apovian, C. M., Kern, P. A., Lauffenburger, D. A. & Nikolajczyk, B. S., Sep 3 2019, In: Cell Metabolism. 30, 3, p. 447-461.e5Research output: Contribution to journal › Article › peer-review
Open Access109 Scopus citations -
Saturated fatty acid activates t cell inflammation through a nicotinamide nucleotide transhydrogenase (Nnt)-dependent mechanism
McCambridge, G., Agrawal, M., Keady, A., Kern, P. A., Hasturk, H., Nikolajczyk, B. S. & Bharath, L. P., Feb 2019, In: Biomolecules. 9, 2, 79.Research output: Contribution to journal › Article › peer-review
Open Access19 Scopus citations -
2018
Metabolic reprogramming of natural killer cells in obesity limits antitumor responses
Michelet, X., Dyck, L., Hogan, A., Loftus, R. M., Duquette, D., Wei, K., Beyaz, S., Tavakkoli, A., Foley, C., Donnelly, R., O’Farrelly, C., Raverdeau, M., Vernon, A., Pettee, W., O’Shea, D., Nikolajczyk, B. S., Mills, K. H. G., Brenner, M. B., Finlay, D. & Lynch, L., Dec 1 2018, In: Nature Immunology. 19, 12, p. 1330-1340 11 p.Research output: Contribution to journal › Article › peer-review
456 Scopus citations -
2017
Adaptive immunity and metabolic health: Harmony becomes dissonant in obesity and aging
Bharath, L. P., Ip, B. C. & Nikolajczyk, B. S., Oct 2017, In: Comprehensive Physiology. 7, 4, p. 1307-1337 31 p.Research output: Contribution to journal › Article › peer-review
18 Scopus citations -
Advances in the quantification of mitochondrial function in primary human immune cells through extracellular flux analysis
Nicholas, D., Proctor, E. A., Raval, F. M., Ip, B. C., Habib, C., Ritou, E., Grammatopoulos, T. N., Steenkamp, D., Dooms, H., Apovian, C. M., Lauffenburger, D. A. & Nikolajczyk, B. S., Feb 2017, In: PLoS ONE. 12, 2, e0170975.Research output: Contribution to journal › Article › peer-review
Open Access56 Scopus citations -
Inhibition of Ubc13-mediated Ubiquitination by GPS2 Regulates Multiple Stages of B Cell Development
Lentucci, C., Belkina, A. C., Cederquist, C. T., Chan, M., Johnson, H. E., Prasad, S., Lopacinski, A., Nikolajczyk, B. S., Monti, S., Snyder-Cappione, J., Tanasa, B., Cardamone, M. D. & Perissi, V., Feb 17 2017, In: Journal of Biological Chemistry. 292, 7, p. 2754-2772 19 p.Research output: Contribution to journal › Article › peer-review
Open Access20 Scopus citations -
Type 1 diabetes alters lipid handling and metabolism in human fibroblasts and peripheral blood mononuclear cells
Jones, A. R., Coleman, E. L., Husni, N. R., Deeney, J. T., Raval, F., Steenkamp, D., Dooms, H., Nikolajczyk, B. S. & Corkey, B. E., Dec 2017, In: PLoS ONE. 12, 12, e0188474.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
2016
Th17 cytokines differentiate obesity from obesity-associated type 2 diabetes and promote TNFα production
Ip, B., Cilfone, N. A., Belkina, A. C., Defuria, J., Jagannathan-Bogdan, M., Zhu, M., Kuchibhatla, R., McDonnell, M. E., Xiao, Q., Kepler, T. B., Apovian, C. M., Lauffenburger, D. A. & Nikolajczyk, B. S., Jan 1 2016, In: Obesity. 24, 1, p. 102-112 11 p.Research output: Contribution to journal › Article › peer-review
Open Access112 Scopus citations -
2014
B cells promote obesity-associated periodontitis and oral pathogen-associated inflammation
Zhu, M., Belkina, A. C., DeFuria, J., Carr, J. D., Van Dyke, T. E., Gyurko, R. & Nikolajczyk, B. S., Aug 2014, In: Journal of Leukocyte Biology. 96, 2, p. 349-357 9 p.Research output: Contribution to journal › Article › peer-review
Open Access35 Scopus citations -
Immune cells link obesity-associated type 2 diabetes and periodontitis
Zhu, M. & Nikolajczyk, B. S., Apr 2014, In: Journal of Dental Research. 93, 4, p. 346-352 7 p.Research output: Contribution to journal › Article › peer-review
Open Access47 Scopus citations -
The double bromodomain protein Brd2 promotes B cell expansion and mitogenesis
Belkina, A. C., Blanton, W. P., Nikolajczyk, B. S. & Denis, G. V., Mar 2014, In: Journal of Leukocyte Biology. 95, 3, p. 451-460 10 p.Research output: Contribution to journal › Article › peer-review
Open Access46 Scopus citations -
2013
B cells promote inflammation in obesity and type 2 diabetes through regulation of T-cell function and an inflammatory cytokine profile
DeFuria, J., Belkina, A. C., Jagannathan-Bogdan, M., Snyder-Cappione, J., Carr, J. D., Nersesova, Y. R., Markham, D., Strissel, K. J., Watkins, A. A., Zhu, M., Allen, J., Bouchard, J., Toraldo, G., Jasuja, R., Obin, M. S., McDonnell, M. E., Apovian, C., Denis, G. V. & Nikolajczyk, B. S., Mar 26 2013, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 13, p. 5133-5138 6 p.Research output: Contribution to journal › Article › peer-review
428 Scopus citations -
BET protein function is required for inflammation: Brd2 genetic disruption and BET inhibitor JQ1 impair mouse macrophage inflammatory responses
Belkina, A. C., Nikolajczyk, B. S. & Denis, G. V., Apr 1 2013, In: Journal of Immunology. 190, 7, p. 3670-3678 9 p.Research output: Contribution to journal › Article › peer-review
Open Access343 Scopus citations -
2012
The outliers become a stampede as immunometabolism reaches a tipping point
Nikolajczyk, B. S., Jagannathan-Bogdan, M. & Denis, G. V., Sep 2012, In: Immunological Reviews. 249, 1, p. 253-275 23 p.Research output: Contribution to journal › Article › peer-review
Open Access46 Scopus citations -
2011
Elevated proinflammatory cytokine production by a skewed T cell compartment requires monocytes and promotes inflammation in type 2 diabetes
Jagannathan-Bogdan, M., McDonnell, M. E., Shin, H., Rehman, Q., Hasturk, H., Apovian, C. M. & Nikolajczyk, B. S., Jan 15 2011, In: Journal of Immunology. 186, 2, p. 1162-1172 11 p.Research output: Contribution to journal › Article › peer-review
Open Access355 Scopus citations -
Short report: Human schistosomiasis is associated with endotoxemia and toll-like receptor 2- and 4-bearing B cells
Onguru, D., Liang, Y. M., Griffith, Q., Nikolajczyk, B., Mwinzi, P. & Ganley-Leal, L., Feb 2011, In: American Journal of Tropical Medicine and Hygiene. 84, 2, p. 321-324 4 p.Research output: Contribution to journal › Article › peer-review
Open Access54 Scopus citations -
2010
Differential regulation of TLR4 expression in human B cells and monocytes
Ganley-Leal, L. M., Liang, Y. M., Jagannathan-Bogdan, M., Farraye, F. A. & Nikolajczyk Barbara S., B. S., Nov 2010, In: Molecular Immunology. 48, 1-3, p. 82-88 7 p.Research output: Contribution to journal › Article › peer-review
Open Access48 Scopus citations -
Toll-like receptors regulate B cell cytokine production in patients with diabetes
Jagannathan, M., McDonnell, M., Liang, Y., Hasturk, H., Hetzel, J., Rubin, D., Kantarci, A., Van Dyke, T. E., Ganley-Leal, L. M. & Nikolajczyk, B. S., Jul 2010, In: Diabetologia. 53, 7, p. 1461-1471 11 p.Research output: Contribution to journal › Article › peer-review
Open Access141 Scopus citations -
2009
B cells from periodontal disease patients express surface Toll-like receptor 4
Shin, H., Zhang, Y., Jagannathan, M., Hasturk, H., Kantarci, A., Liu, H., Van Dyke, T. E., Ganley-Leal, L. M. & Nikolajczyk, B. S., Apr 1 2009, In: Journal of Leukocyte Biology. 85, 4, p. 648-655 8 p.Research output: Contribution to journal › Article › peer-review
Open Access33 Scopus citations -
High levels of tumor necrosis factor-α contribute to accelerated loss of cartilage in diabetic fracture healing
Alblowi, J., Kayal, R. A., Siqueria, M., McKenzie, E., Krothapalli, N., McLean, J., Conn, J., Nikolajczyk, B., Einhorn, T. A., Gerstenfeld, L. & Graves, D. T., 2009, In: American Journal of Pathology. 175, 4, p. 1574-1585 12 p.Research output: Contribution to journal › Article › peer-review
Open Access131 Scopus citations -
Hyperactivated B cells in human inflammatory bowel disease
Noronha, A. M., Liang, Y., Hetzel, J. T., Hasturk, H., Kantarci, A., Stucchi, A., Zhang, Y., Nikolajczyk, B. S., Farraye, F. A. & Ganley-Leal, L. M., Oct 2009, In: Journal of Leukocyte Biology. 86, 4, p. 1007-1016 10 p.Research output: Contribution to journal › Article › peer-review
Open Access67 Scopus citations -
TLR cross-talk specifically regulates cytokine production by B cells from chronic inflammatory disease patients
Jagannathan, M., Hasturk, H., Liang, Y. M., Shin, H., Hetzel, J. T., Kantarci, A., Rubin, D., McDonnell, M. E., Van Dyke, T. E., Ganley-Leal, L. M. & Nikolajczyk, B. S., Dec 1 2009, In: Journal of Immunology. 183, 11, p. 7461-7470 10 p.Research output: Contribution to journal › Article › peer-review
Open Access75 Scopus citations -
2008
Dynamic protein associations define two phases of IL-1β transcriptional activation
Zhang, Y., Saccani, S., Shin, H. & Nikolajczyk, B. S., 2008, In: Journal of Immunology. 181, 1, p. 503-512 10 p.Research output: Contribution to journal › Article › peer-review
Open Access45 Scopus citations -
2007
Immunoglobulin kappa enhancers are differentially regulated at the level of chromatin structure
Nikolajczyk, B. S., Sardi, S. H., Tumang, J. R. & Ganley-Leal, L. M., Jul 2007, In: Molecular Immunology. 44, 13, p. 3407-3415 9 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
2006
Changes in immunoglobulin-nucleoprotein complex structure mapped by chromatin immunoprecipitation
McDevit, D. C. & Nikolajczyk, B. S., Apr 2006, In: Molecular Immunology. 43, 10, p. 1541-1548 8 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
The interleukin-1β gene is transcribed from a poised promoter architecture in monocytes
Liang, M. D., Zhang, Y., McDevit, D., Marecki, S. & Nikolajczyk, B. S., Apr 7 2006, In: Journal of Biological Chemistry. 281, 14, p. 9227-9237 11 p.Research output: Contribution to journal › Article › peer-review
Open Access50 Scopus citations -
2005
The Igκ3′ enhancer is activated by gradients of chromatin accessibility and protein association
McDevit, D. C., Perkins, L., Atchison, M. L. & Nikolajczyk, B. S., Mar 1 2005, In: Journal of Immunology. 174, 5, p. 2834-2842 9 p.Research output: Contribution to journal › Article › peer-review
Open Access23 Scopus citations -
2004
PU.1 as a chromatin accessibility factor for immunoglobulin genes
Marecki, S., McCarthy, K. M. & Nikolajczyk, B. S., Jan 2004, In: Molecular Immunology. 40, 10, p. 723-731 9 p.Research output: Contribution to journal › Article › peer-review
21 Scopus citations -
2003
HMGA1 Co-activates Transcription in B Cells through Indirect Association with DNA
McCarthy, K. M., McDevit, D., Andreucci, A., Reeves, R. & Nikolajczyk, B. S., Oct 24 2003, In: Journal of Biological Chemistry. 278, 43, p. 42106-42114 9 p.Research output: Contribution to journal › Article › peer-review
Open Access19 Scopus citations -
2002
Dominant-negative HMGA1 blocks μ enhancer activation through a novel mechanism
Andreucci, A., Reeves, R., McCarthy, K. M. & Nikolajczyk, B. S., 2002, In: Biochemical and Biophysical Research Communications. 292, 2, p. 427-433 7 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
2001
PU.1-mediated Transcription is Enhanced by HMG-I(Y)-dependent Structural Mechanisms
Lewis, R. T., Andreucci, A. & Nikolajczyk, B. S., Mar 23 2001, In: Journal of Biological Chemistry. 276, 12, p. 9550-9557 8 p.Research output: Contribution to journal › Article › peer-review
Open Access18 Scopus citations -
Splenic and peritoneal B-1 cells differ in terms of transcriptional and proliferative features that separate peritoneal B-1 from splenic B-2 cells
Fischer, G. M., Solt, L. A., Hastings, W. D., Yang, K., Gerstein, R. M., Nikolajczyk, B. S., Clarke, S. H. & Rothstein, T. L., Oct 10 2001, In: Cellular Immunology. 213, 1, p. 62-71 10 p.Research output: Contribution to journal › Article › peer-review
35 Scopus citations -
1999
ETS protein-dependent accessibility changes at the immunoglobulin μ heavy chain enhancer
Nikolajczyk, B. S., Sanchez, J. A. & Sen, R., Jul 1999, In: Immunity. 11, 1, p. 11-20 10 p.Research output: Contribution to journal › Article › peer-review
Open Access47 Scopus citations -
Mechanisms of μ enhancer regulation in B lymphocytes
Nikolajczyk, B. S., Dang, W. & Sen, R., 1999, In: Cold Spring Harbor Symposia on Quantitative Biology. 64, p. 99-107 9 p.Research output: Contribution to journal › Article › peer-review
9 Scopus citations -
1998
ETS-core binding factor: A common composite motif in antigen receptor gene enhancers
Erman, B., Cortes, M., Nikolajczyk, B. S., Speck, N. A. & Sen, R., Mar 1998, In: Molecular and Cellular Biology. 18, 3, p. 1322-1330 9 p.Research output: Contribution to journal › Article › peer-review
Open Access54 Scopus citations -
Exploring functional redundancy in the immunoglobulin μ heavy-chain gene enhancer
Dang, W., Nikolajczyk, B. S. & Sen, R., Nov 1998, In: Molecular and Cellular Biology. 18, 11, p. 6870-6878 9 p.Research output: Contribution to journal › Article › peer-review
Open Access21 Scopus citations