Projects and Grants per year
Personal profile
Biography
Dr. Brainson joined the faculty of the UK College of Medicine Department of Toxicology and Cancer Biology in 2016. Previously she worked as a post-doctoral fellow at Boston Children's Hospital, where she was part of the Harvard Medical School Department of Genetics, the Boston Children's Hospital Stem Cell Program, and the Harvard Stem Cell Institute. Dr. Brainson completed her Bachelor of Arts at Middlebury College and earned her PhD from Tufts University. Recently, Dr. Brainson was named a Markey Women Strong Distinguished Researcher and grant recipient.
Her research focuses on defining precision medicine opportunities for lung cancer by leveraging ideas and techniques from stem cell biology and epigenetics. Her research is currently funded through the National Cancer Institute, Markey Women Strong, the American Lung Association, the American Institute for Cancer Research, and the American Cancer Society.
Research Interests
Epigenetic control of lung stem cells and lung cancer.
For more information on Dr. Brainson's lab, visit the homepage online.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Post Doctoral Fellow, Harvard University
2016
Doctor of Philosophy, Tufts University
2009
Bachelor of Arts, Middlebury College
2002
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Collaborations and top research areas from the last five years
Recent external collaboration from the last 5 years on country level. Dive into details by clicking on the dots.
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Targeting Lung Fibrosis Using Epigenetic Therapy
Brainson, C. (PI), Allison, D. (CoI), Beswick, E. (CoI), Liu, J. (CoI), Sturgill, J. (CoI), Weiss, H. (CoI) & Waters, C. (Former CoI)
National Heart Lung and Blood Institute
8/15/24 → 7/31/28
Project: Research project
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Mechanistic and structural insights into a new pro-metastatic collagen glucosyltransferase
Guo, H. (PI), Brainson, C. (CoI) & Chen, L. (CoI)
1/16/24 → 12/31/28
Project: Research project
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CCSG Pilot: Determining Mechanisms of Immunotherapy Resistance in KEAP1 and LKB1 Mutant Lung Cancers
Brainson, C. (PI), Durbin, E. B. (CoI), Hao, Z. (CoI), Jeong, J. C. (CoI) & Liu, J. (CoI)
9/1/23 → 12/31/24
Project: Research project
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Overcoming Therapeutic Resistance in Lung Cancer Using Novel Combination Therapies
Brainson, C. (PI) & Liu, J. (CoI)
Markey Cancer Center Foundation
7/1/23 → 7/31/25
Project: Research project
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Diversity Supplement for Dave-Preston Esoe: Targeting Epigenetic Heterogeneity to Improve Lung Cancer Immunotherapy Response
Brainson, C. (PI)
7/1/23 → 6/30/25
Project: Research project
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Isolation, Culture, and Phenotypic Analysis of Murine Lung Organoids
Evans, K., Dabrowska, C., Ng, M. E., Brainson, C. F. & Lee, J. H., 2024, In: Methods in Molecular Biology. 2805, p. 3-18 16 p.Research output: Contribution to journal › Article › peer-review
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Metabolic reprogramming driven by EZH2 inhibition depends on cell–matrix interactions
W-M Fan, T., Islam, J. M. M., Higashi, R. M., Lin, P., Brainson, C. F. & Lane, A. N., Jan 2024, In: Journal of Biological Chemistry. 300, 1, 105485.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Using 3-Dimensional Cultures to Propagate Genetically Modified Lung Organoids
Chen, F., Naughton, K. J., Lee, J. H. & Brainson, C. F., 2024, Methods in Molecular Biology. p. 19-30 12 p. (Methods in Molecular Biology; vol. 2805).Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
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Dysregulated Polycomb Repressive Complex 2 contributes to chronic obstructive pulmonary disease by rewiring stem cell fate
Byrd, A. L., Qu, X., Lukyanchuk, A., Liu, J., Chen, F., Naughton, K. J., DuCote, T. J., Song, X., Bowman, H. C., Zhao, Y., Edgin, A. R., Wang, C., Liu, J. & Brainson, C. F., Jan 10 2023, In: Stem Cell Reports. 18, 1, p. 289-304 16 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Polycomb deficiency drives a FOXP2-high aggressive state targetable by epigenetic inhibitors
Chen, F., Byrd, A. L., Liu, J., Flight, R. M., DuCote, T. J., Naughton, K. J., Song, X., Edgin, A. R., Lukyanchuk, A., Dixon, D. T., Gosser, C. M., Esoe, D. P., Jayswal, R. D., Orkin, S. H., Moseley, H. N. B., Wang, C. & Brainson, C. F., Dec 2023, In: Nature Communications. 14, 1, 336.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations
Prizes
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William Rippe Award for Distinguished Research in Lung Cancer
Brainson, C. (Recipient), 2015
Prize: Honorary award
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