Personal profile
Research Interests
Research Programs:
- Genomic Instability, Epigenetics and Metabolism
Research Focus:
- Oxidative stress, redox proteomics, chemotherapy-induced cognitive impairment (chemobrain), Alzheimer's disease.
Our laboratory studies these and other aspects of oxidative stress in brain membranes using a variety of techniques, including immunochemical, metabolomic, and proteomics methods.
Area of Study: Free radical chemistry/Alzheimer's disease
Education/Academic qualification
Doctor of Philosophy, Duke University
1974
Bachelor of Arts, University of Maine
1968
Keywords
- QH426 Genetics
- QD Chemistry
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being -
SDG 7 Affordable and Clean Energy
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Collaborations and top research areas from the last five years
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Biomarkers of oxidative stress in neurodegenerative diseases
Sultana, R., Cenini, G. & Butterfield, D. A., Jan 23 2025, Molecular Basis of Oxidative Stress: Chemistry, Toxicology, Disease Pathogenesis, Diagnosis, and Therapeutics: Second Edition. p. 437-454 18 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
1 Scopus citations -
Extracellular vesicles released by ALL patients contain HNE-adducted proteins: Implications of collateral damage
Ho, J., Sukati, S., Taylor, T., Carter, S., Fuller, B., Marmo, A., Sorge, C., D'Orazio, J., Butterfield, D. A., Bondada, S., Weiss, H., St Clair, D. K. & Chaiswing, L., Feb 1 2025, In: Free Radical Biology and Medicine. 227, p. 312-321 10 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Activation of the Neuronal Cell Cycle in Brains in Amnestic Mild Cognitive Impairment: Early Involvement in the Progression of Alzheimer's Disease
Butterfield, D. A., Aug 20 2024, In: Journal of Alzheimer's Disease. 100, s1, p. S277-S281Research output: Contribution to journal › Review article › peer-review
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Biliverdin Reductase-A integrates insulin signaling with mitochondrial metabolism through phosphorylation of GSK3β
Lanzillotta, C., Tramutola, A., Lanzillotta, S., Greco, V., Pagnotta, S., Sanchini, C., Di Angelantonio, S., Forte, E., Rinaldo, S., Paone, A., Cutruzzolà, F., Cimini, F. A., Barchetta, I., Cavallo, M. G., Urbani, A., Butterfield, D. A., Di Domenico, F., Paul, B. D., Perluigi, M. & Duarte, J. M. N. & 1 others, , Jul 2024, In: Redox Biology. 73, 103221.Research output: Contribution to journal › Article › peer-review
Open Access22 Scopus citations -
Correction to: Extraction of redox extracellular vesicles using exclusion-based sample preparation (Analytical and Bioanalytical Chemistry, (2024), 416, 28, (6317-6331), 10.1007/s00216-024-05518-z)
Banadaki, M. D., Rummel, N. G., Backus, S., Butterfield, D. A., St. Clair, D. K., Campbell, J. M., Zhong, W., Mayer, K., Berry, S. M. & Chaiswing, L., Dec 2024, In: Analytical and Bioanalytical Chemistry. 416, 29, p. 7187-7188 2 p.Research output: Contribution to journal › Comment/debate
Open Access
Prizes
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Research Foundation Faculty Research Award, University of Kentucky
Butterfield, D. A. (Recipient), 1979
Prize: Honorary award
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Research Professorship, University of Kentucky
Butterfield, D. A. (Recipient), 1980
Prize: Honorary award
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Biomedical Science Research Award, National Institutes of Health (NIH)
Butterfield, D. A. (Recipient), 1972
Prize: Honorary award
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William B. Sturgill Award for Graduate Education
Butterfield, D. A. (Recipient), 1997
Prize: Honorary award
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Distinguished University Scientist Award, Kentucky Academy of Science
Butterfield, D. A. (Recipient), 1996
Prize: Honorary award