Projects and Grants per year
Personal profile
Research Interests
Our research program focuses on understanding the molecular mechanisms through which the fundamental MAPK1/2 pathway is regulated in space and in time.
To that end, we utilize comprehensive and interdisciplinary approaches that incorporate biochemistry, cell biology, state-of-the-art microscopy and vertebrate models. Our current focus is the scaffold protein Shoc2. We investigate how Shoc2 scaffold controls timing and cellular distribution of MAPK1/2 signaling and how Shoc2 itself is regulated by the ubiquitin machinery.
In our studies, we integrate insights from basic research with the study of human cancers and congenital disorders. We believe that a better understanding of the molecular basis of malignant transformation will lead not only to further advances in biology but also novel and effective therapies.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Doctor of Philosophy, Tel-Aviv University
2002
Master of Science, Tel-Aviv University
1997
Bachelor of Science, Tel-Aviv University
1995
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- 1 Similar Profiles
Collaborations and top research areas from the last five years
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Evaluating Causes for Failure to Thrive in a Noonan-like Syndrome with Loose Anagen Hair (NSLH) Patients using NSLH Vertebrate Model
Galperin, E. (PI) & Bruntz, R. (CoI)
National Institute of Child Health and Human Develop
11/6/24 → 10/31/26
Project: Research project
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Mechanisms and Functions of Shoc2-Transduced Cellular Signals
Galperin, E. (PI) & Morris, A. (CoI)
National Institute of General Medical Sciences
5/1/20 → 4/30/25
Project: Research project
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Tampering with ERK1/2 Signals for Cancer Treatment
Galperin, E. (PI)
Markey Cancer Center Foundation
8/1/21 → 8/1/23
Project: Research project
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Equipment Supplement: Mechanisms and Functions of Shoc2-Transduced Cellular Signals
Galperin, E. (PI)
National Institute of General Medical Sciences
5/1/20 → 4/30/22
Project: Research project
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Equipment Supplement: Acquisition of Confocal Scan to Upgrade Existing Fluorescence Microscope
Galperin, E. (PI)
National Institute of General Medical Sciences
5/1/20 → 4/30/24
Project: Research project
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The expression of congenital Shoc2 variants induces AKT-dependent crosstalk activation of the ERK1/2 pathway
Wilson, P. G., Abdelmoti, L., Gao, T. & Galperin, E., Sep 15 2024, In: Human Molecular Genetics. 33, 18, p. 1592-1604 13 p.Research output: Contribution to journal › Article › peer-review
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Shoc2 controls ERK1/2-driven neural crest development by balancing components of the extracellular matrix
Norcross, R. G., Abdelmoti, L., Rouchka, E. C., Andreeva, K., Tussey, O., Landestoy, D. & Galperin, E., Dec 2022, In: Developmental Biology. 492, p. 156-171 16 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
The seventh international RASopathies symposium: Pathways to a cure—expanding knowledge, enhancing research, and therapeutic discovery
Kontaridis, M. I., Roberts, A. E., Schill, L., Schoyer, L., Stronach, B., Andelfinger, G., Aoki, Y., Axelrad, M. E., Bakker, A., Bennett, A. M., Broniscer, A., Castel, P., Chang, C. A., Cyganek, L., Das, T. K., den Hertog, J., Galperin, E., Garg, S., Gelb, B. D. & Gordon, K. & 22 others, , Jun 2022, In: American Journal of Medical Genetics, Part A. 188, 6, p. 1915-1927 13 p.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
The leucine-rich repeat signaling scaffolds Shoc2 and Erbin: cellular mechanism and role in disease
Jang, H. I., Stevens, P., Gao, T. & Galperin, E., Feb 2021, In: FEBS Journal. 288, 3, p. 721-739 19 p.Research output: Contribution to journal › Review article › peer-review
Open Access20 Scopus citations -
The role of USP7 in the Shoc2-ERK1/2 signaling axis and Noonan-like syndrome with loose anagen hair
Wilson, P., Abdelmoti, L., Norcross, R., Jang, E. R., Palayam, M. & Galperin, E., Nov 2021, In: Journal of Cell Science. 134, 21, jcs258922.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations