Grants and Contracts per year
Personal profile
Research Interests
Dr. Gregory Graf holds a PhD in Physiology from the College of Medicine at the University of Kentucky. Following postdoctoral training in Molecular Genetics in the laboratory of Dr. Helen Hobbs at the UT Southwestern Medical Center in Dallas, he returned to the University of Kentucky and joined the faculty in the Division of Pharmacology and Experimental Therapeutics in the Department of Pharmaceutical Sciences. Dr. Graf returned to the Department of Physiology in 2022 and serves as the Associate Director of the Saha Cardiovascular Research Center.
The goal of Dr. Graf’s research program is to identify novel proteins and pathways that directly influence risk factors for metabolic diseases that include dyslipidemia, hyperglycemia, insulin resistance, and inflammation. Cholesterol has long been known to increase risk for cardiovascular disease. It is now clear that disturbances in cholesterol metabolism also contribute to obesity-related phenotypes such as insulin resistance, inflammation, and nonalcoholic fatty liver disease. Our present focus is to understand the mechanism by which disruptions in sterol homeostasis influence these risk factors and to determine if accelerating cholesterol elimination will improve obesity-related metabolic dysfunction.
Education/Academic qualification
Doctor of Philosophy, Univ Of Kentucky
2000
Master of Science, Univ Of Kentucky
1997
Bachelor of Science, Texas A & M University
1994
External positions
Chair of Board, Don S Fredrickson Research Conference
Jan 1 2018 → …
Keywords
- QP Physiology
- R Medicine (General)
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Network
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Identification of Carnitine Palmitoyltransferase 1a (CPT1a) as a Novel Regulator of Lipoprotein Metabolism
Helsley, R., Daugherty, A., Gordon, S. & Graf, G.
4/1/23 → 3/31/26
Project: Research project
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Contributions of Hepatic and Intestinal Pathways to Cholesterol Excretion
National Institute Diabetes & Digestive & Kidney
4/1/23 → 3/31/27
Project: Research project
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The Don S. Fredrickson Lipid Research Conference
National Heart Lung and Blood Institute
8/1/22 → 7/31/23
Project: Research project
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The Role of DENND5B in Dietary Lipid Absorption
National Institute Diabetes & Digestive & Kidney
7/15/22 → 5/31/27
Project: Research project
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Elucidating Molecular Mechanisms Linking Fructose to Cholesterol Metabolism
Helsley, R., Graf, G., Lane, A. & Softic, S.
National Institute Diabetes & Digestive & Kidney
1/1/22 → 12/31/26
Project: Research project
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Rats with high aerobic capacity display enhanced transcriptional adaptability and upregulation of bile acid metabolism in response to an acute high-fat diet
Stierwalt, H. D., Morris, E. M., Maurer, A., Apte, U., Phillips, K., Li, T., Meers, G. M. E., Koch, L. G., Britton, S. L., Graf, G., Rector, R. S., Mercer, K., Shankar, K. & Thyfault, J. P., Aug 2022, In: Physiological Reports. 10, 15, e15405.Research output: Contribution to journal › Article › peer-review
Open Access -
Age and sex are associated with the plasma lipidome: findings from the GOLDN study
Slade, E., Irvin, M. R., Xie, K., Arnett, D. K., Claas, S. A., Kind, T., Fardo, D. W. & Graf, G. A., Dec 2021, In: Lipids in Health and Disease. 20, 1, 30.Research output: Contribution to journal › Article › peer-review
Open Access15 Scopus citations -
Sitosterolemia: Twenty years of discovery of the function of abcg5 abcg8
Williams, K., Segard, A. & Graf, G. A., Mar 1 2021, In: International Journal of Molecular Sciences. 22, 5, p. 1-14 14 p., 2641.Research output: Contribution to journal › Review article › peer-review
Open Access19 Scopus citations -
The prorenin receptor and its soluble form contribute to lipid homeostasis
Gatineau, E., Arthur, G., Poupeau, A., Nichols, K., Spear, B. T., Shelman, N. R., Graf, G. A., Temel, R. E. & Yiannikouris, F. B., Mar 2021, In: American Journal of Physiology - Endocrinology and Metabolism. 320, 3, p. E609-E618Research output: Contribution to journal › Article › peer-review
8 Scopus citations -
Metabolomics, lipid pathways, and blood pressure change
Arnett, D. K. & Graf, G. A., Aug 1 2020, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 40, 8, p. 1801-1803 3 p.Research output: Contribution to journal › Editorial
Open Access1 Scopus citations
Prizes
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SAHA Cardiovascular Research Center Distinguished Alumni Award
Graf, Gregory (Recipient), 2018
Prize: Honorary award
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Robert A. Blouin Excellence in Professional Education Teaching Award
Graf, Gregory (Recipient), 2009
Prize: Honorary award