Projects and Grants per year
Personal profile
Research Interests
Dr. Gregory Graf holds a PhD in Physiology from the College of Medicine at the University of Kentucky. Following postdoctoral training in Molecular Genetics in the laboratory of Dr. Helen Hobbs at the UT Southwestern Medical Center in Dallas, he returned to the University of Kentucky and joined the faculty in the Division of Pharmacology and Experimental Therapeutics in the Department of Pharmaceutical Sciences. Dr. Graf returned to the Department of Physiology in 2022 and serves as the Associate Director of the Saha Cardiovascular Research Center.
The goal of Dr. Graf’s research program is to identify novel proteins and pathways that directly influence risk factors for metabolic diseases that include dyslipidemia, hyperglycemia, insulin resistance, and inflammation. Cholesterol has long been known to increase risk for cardiovascular disease. It is now clear that disturbances in cholesterol metabolism also contribute to obesity-related phenotypes such as insulin resistance, inflammation, and nonalcoholic fatty liver disease. Our present focus is to understand the mechanism by which disruptions in sterol homeostasis influence these risk factors and to determine if accelerating cholesterol elimination will improve obesity-related metabolic dysfunction.
Education/Academic qualification
Doctor of Philosophy, University Of Kentucky
2000
Master of Science, University Of Kentucky
1997
Bachelor of Science, Texas A & M University
1994
External positions
Chair of Board, Don S Fredrickson Research Conference
Jan 1 2018 → …
Keywords
- QP Physiology
- R Medicine (General)
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Collaborations and top research areas from the last five years
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Contributions of Hepatic and Intestinal Pathways to Cholesterol Excretion
Graf, G. (PI)
National Institute Diabetes & Digestive & Kidney
4/1/23 → 3/31/27
Project: Research project
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Elucidating Molecular Mechanisms Linking Fructose to Cholesterol Metabolism
Helsley, R. (PI), Graf, G. (CoI), Lane, A. (CoI) & Softic, S. (Former CoI)
National Institute Diabetes & Digestive & Kidney
1/1/22 → 12/31/26
Project: Research project
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Supplement: Pharmacological Mechanistic Insights into Thoracic Aortic Aneurysm
Sheppard, M. (PI), Cassis, L. (CoI), Daugherty, A. (CoI) & Graf, G. (CoI)
National Heart Lung and Blood Institute
7/15/21 → 6/30/25
Project: Research project
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Pharmacological Mechanistic Insights into Thoracic Aortic Aneurysm
Sheppard, M. (PI), Cassis, L. (CoI), Daugherty, A. (CoI) & Graf, G. (CoI)
National Heart Lung and Blood Institute
12/18/20 → 11/30/25
Project: Research project
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COBRE in Pharmaceutical Research and Innovation
Thorson, J. (PI), Helmy, Y. A. (CoI), Jaramillo, A. (CoI), She, Q.-B. (CoI), Adams, V. (Former CoI), Alam, M. (Former CoI), Awuah, S. (Former CoI), Bardo, M. (Former CoI), Bauer, B. (Former CoI), Burgess, D. (Former CoI), Czuba, L. (Former CoI), Daugherty, A. (Former CoI), Dwoskin, L. (Former CoI), Feola, D. (Former CoI), Garneau-Tsodikova, S. (Former CoI), Gensel, J. (Former CoI), Glazer, E. (Former CoI), Grady, M. (Former CoI), Graf, G. (Former CoI), Kapur, N. (Former CoI), Kolesar, J. (Former CoI), Korotkov, K. (Former CoI), Korotkova, N. (Former CoI), Leggas, M. (Former CoI), Mahmoud, K. A. (Former CoI), McLaurin, K. (Former CoI), Messaoudi Powers, I. (Former CoI), Nikolajczyk, B. (Former CoI), Ortinski, P. (Former CoI), Pack, D. (Former CoI), Park, J. (Former CoI), Prisinzano, T. (Former CoI), Richards, C. (Former CoI), Rohr, J. (Former CoI), Sen, P. (Former CoI), Shaffer, C. (Former CoI), Stevenson, B. (Former CoI), Sturgill, J. (Former CoI), Sviripa, V. (Former CoI), Tidgewell, K. (Former CoI), Tiruvannamalai Annam, R. (Former CoI), Turner, J. (Former CoI), Van Lanen, S. (Former CoI), Venditto, V. (Former CoI), Watt, D. (Former CoI), Webb, N. (Former CoI) & Zhan, C.-G. (Former CoI)
National Institute of General Medical Sciences
3/1/20 → 1/31/26
Project: Research project
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Enhancement of high-density lipoprotein-associated protease inhibitor activity prevents atherosclerosis progression
Mobilia, M., Karakashian, A., Neupane, K. R., Hage, O., Whitus, C., Carter, A., Voy, C., Johnson, L. A., Graf, G. A. & Gordon, S. M., Sep 2024, In: Atherosclerosis. 396, 118544.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Functional Exploration of Conserved Sequences in the Distal Face of Angiotensinogen - Brief Report
Amioka, N., Wu, C. H., Sawada, H., Ito, S., Pettey, A. C., Wu, C., Moorleghen, J. J., Howatt, D. A., Graf, G. A., Vander Kooi, C. W., Daugherty, A. & Lu, H. S., Aug 1 2023, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 43, 8, p. 1524-1532 9 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Loss of carnitine palmitoyltransferase 1a reduces docosahexaenoic acid-containing phospholipids and drives sexually dimorphic liver disease in mice
Zelows, M. M., Cady, C., Dharanipragada, N., Mead, A. E., Kipp, Z. A., Bates, E. A., Varadharajan, V., Banerjee, R., Park, S. H., Shelman, N. R., Clarke, H. A., Hawkinson, T. R., Medina, T., Sun, R. C., Lydic, T. A., Hinds, T. D., Brown, J. M., Softic, S., Graf, G. A. & Helsley, R. N., Dec 2023, In: Molecular Metabolism. 78, 101815.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Rats with high aerobic capacity display enhanced transcriptional adaptability and upregulation of bile acid metabolism in response to an acute high-fat diet
Stierwalt, H. D., Morris, E. M., Maurer, A., Apte, U., Phillips, K., Li, T., Meers, G. M. E., Koch, L. G., Britton, S. L., Graf, G., Rector, R. S., Mercer, K., Shankar, K. & Thyfault, J. P., Aug 2022, In: Physiological Reports. 10, 15, e15405.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Age and sex are associated with the plasma lipidome: findings from the GOLDN study
Slade, E., Irvin, M. R., Xie, K., Arnett, D. K., Claas, S. A., Kind, T., Fardo, D. W. & Graf, G. A., Dec 2021, In: Lipids in Health and Disease. 20, 1, 30.Research output: Contribution to journal › Article › peer-review
Open Access55 Scopus citations
Prizes
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Robert A. Blouin Excellence in Professional Education Teaching Award
Graf, G. (Recipient), 2009
Prize: Honorary award
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SAHA Cardiovascular Research Center Distinguished Alumni Award
Graf, G. (Recipient), 2018
Prize: Honorary award
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