Projects and Grants per year
Personal profile
Research Interests
Dr. Yang's lab studies protein translational control of genes involved in tumor invasion and metastasis. Currently, we focus on investigating how Pdcd4 (Programmed cell death 4), a novel tumor suppressor and a translation inhibitor, impacts on protein translation particularly the genes critical for tumor invasion and metastasis. Therefore, our research interests include:
- Elucidation of the signaling pathways impinged upon tumor invasion and metastasis.
- Identification and characterization of novel factors involved in protein translation initiation.
- Development and identification of novel agents or approaches for cancer therapeutics.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Post Doctoral Fellow, SUNY of Buffalo
1999
Doctor of Philosophy, Arizona State University
1994
Master of Science, Tamkang Col.Of Arts And Sciences
1987
Bachelor of Science, Tamkang Col.Of Arts And Sciences
1985
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Collaborations and top research areas from the last five years
Recent external collaboration from the last 5 years on country level. Dive into details by clicking on the dots.
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Pdcd4-Rictor Interaction in Suppression of Lung Tumorigenesis
Yang, H.-S. (PI), Chen, L. (CoI), Fan, W.-M. (CoI), Hao, Z. (CoI), Lee, E. (CoI), Liu, X. (CoI) & Zhan, C.-G. (CoI)
9/20/23 → 8/31/28
Project: Research project
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Targeting the Plk1/Pdcd4/mTORC2 Signaling to Treat Castration-Resistant Prostate Cancer
Yang, H.-S. (PI), Allison, D. (CoI), Chen, L. (CoI) & Liu, X. (CoPI)
7/1/23 → 6/30/28
Project: Research project
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Targeting the Plk1/Pdcd4/mTORC2 Signaling to Treat Castration-Resistant Prostate Cancer
Liu, X. (PI), Allison, D. (CoI), Chen, L. (CoI) & Yang, H.-S. (CoPI)
7/1/23 → 6/30/28
Project: Research project
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A Novel Peptide Suppresses Invasion and Metastasis in Rictor-amplified Lung Cancer
Yang, H.-S. (PI), Chen, M. (CoI) & Chen, L. (CoI)
Army Medical Research and Materiel Command
7/1/21 → 6/30/23
Project: Research project
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A Novel Peptide to Inhibit Rictor-amplified Lung Tumorigenesis
Yang, H.-S. (PI), Arnold, S. (CoI), Chen, M. (CoI), Piecoro, D. (CoI), Wang, C. (CoI) & Wang, Q. (CoI)
7/1/18 → 6/30/21
Project: Research project
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The kinase PLK1 promotes Hedgehog signaling–dependent resistance to the antiandrogen enzalutamide in metastatic prostate cancer
Zhang, Q., Peng, J., Zhang, Y., Liu, J., He, D., Zhao, Y., Wang, X., Li, C., Kong, Y., Wang, R., Mao, F., Wang, C., Wang, Q., Zhang, M., Wang, J., Yang, H. S. & Liu, X., Mar 18 2025, In: Science Signaling. 18, 878, eadi5174.Research output: Contribution to journal › Article › peer-review
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The Impact of Pdcd4, a Translation Inhibitor, on Drug Resistance
Wang, Q. & Yang, H. S., Oct 2024, In: Pharmaceuticals. 17, 10, 1396.Research output: Contribution to journal › Review article › peer-review
Open Access -
Dissecting the Roles of PDCD4 in Breast Cancer
Cai, Q., Yang, H. S., Li, Y. C. & Zhu, J., Jun 20 2022, In: Frontiers in Oncology. 12, 855807.Research output: Contribution to journal › Review article › peer-review
Open Access25 Scopus citations -
Emodin-8-O-β-D-glucopyranoside, a natural hydroxyanthraquinone glycoside from plant, suppresses cancer cell proliferation via p21-CDKs-Rb axis
Li, Y., Li, K., Zhao, Y., Li, Y., Li, D., Shen, L., Wang, Q., Yang, H. S. & Sun, Z., Mar 1 2022, In: Toxicology and Applied Pharmacology. 438, 115909.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Platycodin D induces apoptosis through JNK1/AP-1/PUMA pathway in non-small cell lung cancer cells: A new mechanism for an old compound
Chen, S., Wang, Q., Ming, S., Zheng, H., Hua, B. & Yang, H. S., Nov 22 2022, In: Frontiers in Pharmacology. 13, 1045375.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations