James Badgett, MD

3/31/17 → 5/2/24

Project: Research project

A Phase 2 Study of the JAK1/JAK2 Inhibitor Ruxolitinib with Chemotherapy in Children with De Novo High-Risk CRLLF2-Rearranged and/or JAK Pathway-Mutant Acute Lymphoblastic Leukemia AALL1521

Badgett, J., Radulescu, V. & Wagner, L.

H Lee Moffitt Cancer Center and Research Institute Hospital

12/1/16 → 1/25/24

Project: Research project

Sunshine Study Protocol MCC 18613 Phase II Study of nab-Paclitaxel in Combination with Gemcitabine for Treatment of Recurrent/Refractory Sarcoma in Teenagers and Young Adults

Badgett, J. & Wagner, L.

10/19/16 → 5/18/24

Project: Research project

NCTN BIQSFP AALL1131

Badgett, J., Radulescu, V. & Wagner, L.

3/1/16 → 1/12/24

Project: Research project

Finished

FY23 Project Inherited Cancer Risk

D'Orazio, J., Allison, D., Badgett, J., Durbin, E. B., Harrington, A., Jeong, J. C., Kolesar, J., Overley, C., Shelman, N., Weiss, H., Zhang, S. & Shaw, A.

7/1/22 → 6/30/23

Project: Research project

FY23 Macrophage Derived Engineered Vesicles for Preventing Metastases in Pediatric Osteosarcoma

Kolesar, J., Badgett, J. & Richards, C.

7/1/22 → 6/30/23

Project: Research project

Analysis and Targeting of the Transcriptional Regulator BRD4 in Diffuse Intrinsic Pontine Glioma (DIPG)

Blackburn, J., Badgett, J., Chernyavskaya, Y., Glazer, E. & Havrylyuk, D.

7/1/22 → 6/30/23

Project: Research project

FY23 Artesunate as Treatment for Childhood Acute Myeloid Leukemia

Kolesar, J., Badgett, J., Ellingson, S., Hill, K., Ji, H. & Yuan, L.

7/1/22 → 6/30/23

Project: Research project

Pediatric Molecular Tumor Board C3358: FY 23

Villano, J., Badgett, J., Durbin, E. B., Kolesar, J., Lightner, D., Lukins, D., Mirza, F., Morgan, R. & Shelton, B.

7/1/22 → 6/30/23

Project: Research project

ARST2031: A Randomized Phase 3 Trial of Vinorelbine, Dactinomycin, and Cyclophosphamide (VINO-AC) Plus Maintenance Chemotherapy with Vinorelbine and Oral Cyclophosphamide (VINO-CPO) vs Vincristine, Dactinomycin and Cyclophosphamide (VAC) plus VINO-CPO Mai

12/16/21 → 7/28/22

Project: Research project

ANHL1131: Intergroup Trial for Children or Adolescents With B-Cell NHL or B-AL: Evaluation of Rituximab Efficacy in High Risk Patients

Badgett, J., Radulescu, V. & Wagner, L.

5/15/21 → 4/15/22

Project: Research project

AGCT1532: Phase 3 Accelerated BEP Trial: A Randomised Phase 3 Trial of Accelerated Versus Standard BEP Chemotherapy for Patients with Intermediate and Poor-Risk Metastatic Germ Cell Tumours

5/1/21 → 1/13/22

Project: Research project

AGCT1532: Phase 3 Accelerated BEP Trial: A Randomised Phase 3 Trial of Accelerated Versus Standard BEP Chemotherapy for Patients with Intermediate and Poor-Risk Metastatic Germ Cell Tumours

5/1/21 → 9/7/23

Project: Research project

AAML18P1: Stopping Tyrosine Kinase Inhibitors (TKI) to Assess Treatment-Free Remission (TFR) in Pediatric Chronic Myeloid Leukemia - Chronic Phase (CML-CP)

4/5/21 → 9/9/21

Project: Research project

APEC1621I: NCI-COG Pediatric MATCH (Molecular Analysis for Therapy Choice) - Phase 2 Subprotocol of Palbociclib in Patients with Tumors Harboring Activating Alterations in Cell Cycle Genes

4/1/21 → 5/5/22

Project: Research project

ANBL1821: A Phase 2 Randomized Study of Irinotecan/Temozolomide/Dinutuximab with or Without Eflornithine (DFMO) (IND# 141913) in Children with Relapsed, Refractory or Progressive Neuroblastoma

4/1/21 → 9/9/21

Project: Research project

A Phase III, Randomized Study of Nivolumab (Opdivo) Plus AVD or Brentuximab Vedotin (Adcetris) Plus AVD in Patients (Age >/= 12 Years) with Newly Diagnosed Advanced Stage Classical Hodgkin Lymphoma

3/18/21 → 3/17/22

Project: Research project

A Phase III, Randomized Study of Nivolumab (Opdivo) Plus AVD or Brentuximab Vedotin (Adcetris) Plus AVD in Patients (Age >/= 12 Years) with Newly Diagnosed Advanced Stage Classical Hodgkin Lymphoma

3/18/21 → 2/2/23

Project: Research project

AAML1831: A Phase 3 Randomized Trial for Patients with De Novo AML Comparing Standard Therapy Including Gemtuzumab Ozogamicin (GO) to CPX-351 with GO, and the Addition of the FLT3 Inhibitor Gilteritinib for Patients with FLT3 Mutations

3/18/21 → 1/13/22

Project: Research project

ACNS1831: A Phase 3 Randomized Study of Selumetinib (IND #77782) Versus Carboplatin/Vincristine in Newly Diagnosed or Previously Untreated Neurofibromatosis Type 1 (NF1) Associated Low-Grade Glioma (LGG)

3/1/21 → 12/9/21

Project: Research project

AALL1821: A Phase 2 Study of Blinatumomab (NSC# 765986, IND# 125462) in Combination with Nivolumab (NSC# 748726, IND# 125462), a Checkpoint Inhibitor of PD-1, in B-ALL Patients Aged #1 to <30 Years Old with First Relapse

12/4/20 → 10/2/21

Project: Research project

Novel Antibody-Enzyme Fusion Therapy Targeting Ewing's Sarcoma

Sun, R., Allison, D., Badgett, J. & Wang, C.

V Foundation

12/1/20 → 10/31/22

Project: Research project

AALL1131: Supplemental PCR

8/1/20 → 7/31/21

Project: Research project

AAML1831: A Phase 3 Randomized Trial for Patients with De Novo AML Comparing Standard Therapy Including Gemtuzumab Ozogamicin (GO) to CPX-351 with GO, and the Addition of the FLT3 Inhibitor Gilteritinib for Patients with FLT3 Mutations

7/20/20 → 1/13/22

Project: Research project

ADVL1823: Larotrectinib For Previously Untreated NTRK-fusion Positive Pediatric Solid Tumors and NTRK-fusion Positive Relapsed Pediatric Acute Leukemias

7/8/20 → 8/11/22

Project: Research project

Larotrectinib For Previously Untreated NTRK-fusion Positive Pediatric Solid Tumors and NTRK-fusion Positive Relapsed Pediatric Acute Leukemias

7/8/20 → 10/7/21

Project: Research project

FY21 Macrophage derived Engineered Vesicles for Preventing Metastases in Pediatric Osteosarcoma

Kolesar, J., Badgett, J., Ellingson, S., Gensel, J. & Richards, C.

7/1/20 → 6/30/21

Project: Research project

Risk-Stratified Therapy for Acute Myeloid Leukemia in Down Syndrome

7/1/20 → 3/10/22

Project: Research project

FY21 Artesunate as Treatment for Childhood Acute Myeloid Leukemia

Kolesar, J., Badgett, J., Hill, K., Ji, H., Plattner, R., Wu, J. & Yuan, L.

7/1/20 → 6/30/21

Project: Research project

Pediatric Molecular Tumor Board C2448: CL 2: FY22 Pediatric Molecular Tumor Board

Villano, J., Badgett, J., Durbin, E. B., Jeong, J. C., Kolesar, J., Lightner, D., Lukins, D., Miller, B., Morgan, R., Morgan, R., Neltner, J., Shelton, B. & Vela, C.

7/1/20 → 6/30/22

Project: Research project

Carryover: Pediatric Brain and Central Nervous System Tumors C2417

Durbin, E. B., Badgett, J., Christian, J., Huang, B., Jeong, J. C., Tucker, T., Wang, C. & He, C.

7/1/20 → 6/30/21

Project: Research project

FY21-Circulating Tumor DNA as a Prognostic Indicator of Minimal Residual Disease and Central Nervous System Relapse in Acute Lymphoblastic Leukemia

Blackburn, J. & Badgett, J.

7/1/20 → 6/30/21

Project: Research project

FY22 Macrophage derived Engineered Vesicles for Preventing Metastases in Pediatric Osteosarcoma

Kolesar, J., Badgett, J., Ellingson, S., Gensel, J. & Richards, C.

7/1/20 → 6/30/22

Project: Research project

FY22 Artesunate as Treatment for Childhood Acute Myeloid Leukemia

Kolesar, J., Badgett, J., Hill, K., Ji, H., Plattner, R., Yuan, L. & Wu, J.

7/1/20 → 6/30/22

Project: Research project

Pediatric Molecular Tumor Board C2448: CL 1: FY21 Pediatric Molecular Tumor Board

Villano, J., Badgett, J., Durbin, E. B., Jeong, J. C., Kolesar, J., Lightner, D., Lukins, D., Miller, B., Morgan, R., Morgan, R., Neltner, J., Shelton, B. & Vela, C.

7/1/20 → 6/30/21

Project: Research project

A Phase 3 Randomized Non-Inferiority Study of Carboplatin and Vincristine versus Selumetinib (NSC# 748727, IND# 77782) in Newly Diagnosed or Previously Untreated Low-Grade Glioma (LGG) not associated with BRAFV600E Mutations or Systemic Neurofibromatosis

1/3/20 → 9/9/21

Project: Research project

Web-based Physical Activity Intervention for Children with ALL

Badgett, J. & Radulescu, V.

12/4/19 → 10/4/21

Project: Research project

An Open-Label, Uncontrolled, Multicenter Phase II Trial of MK-3475 (Pembrolizumab) in Children and Young Adults with Newly Diagnosed Classical Hodgkin Lymphoma with Inadequate (Slow Early) Response to Frontline Chemotherapy (KEYNOTE 667)

Badgett, J., Bayliff, S., D'Orazio, J., Geil, J., Sorge, C., Radulescu, V. & Shaw, A.

12/4/19 → 3/9/22

Project: Research project

AHOD1822: An Open-Label, Uncontrolled, Multicenter Phase II Trial of MK-3475 (Pembrolizumab) in Children and Young Adults with Newly Diagnosed Classical Hodgkin Lymphoma with Inadequate (Slow Early) Response to Frontline Chemotherapy (KEYNOTE 667)

Badgett, J., Bayliff, S., D'Orazio, J., Geil, J., Sorge, C., Radulescu, V. & Shaw, A.

12/4/19 → 2/15/23

Project: Research project

A Phase III Randomized, Open label, Multi-Center Study of the Safety and Efficacy of Apixaban for Thromboembolism Prevention versus No Systemic Anticoagulant Prophylaxis during Induction Chemotherapy in Children with Newly Diagnosed Acute Lymphoblastic

Badgett, J., Sorge, C. & Radulescu, V.

11/20/19 → 11/29/21

Project: Research project

A Phase III Randomized, Open label, Multi-Center Study of the Safety and Efficacy of Apixaban for Thromboembolism Prevention versus No Systemic Anticoagulant Prophylaxis during Induction Chemotherapy in Children with Newly Diagnosed Acute Lymphoblastic

Badgett, J., Sorge, C. & Radulescu, V.

11/20/19 → 11/29/21

Project: Research project

A Phase 3 Randomized Trial of Inotuzumab Ozogamicin (IND#:133494, NSC#: 772518) for Newly Diagnosed High-Risk B-ALL; Risk-Adapted Post-Induction Therapy for High-Risk B-ALL, Mixed Phenotype Acute Leukemia, and Disseminated B-LLy

10/28/19 → 2/10/22

Project: Research project

A Phase 3 Randomized Study of Selumetinib (IND # 77782) versus Carboplatin/Vincristine in Newly Diagnosed or Previously Untreated Neurofibromatosis Type 1 (NF1) Associated Low-Grade Glioma (LGG)

10/4/19 → 12/9/21

Project: Research project

A Phase 2 Study of Dabrafenib (NSC# 763760) with Trametinib (NSC# 763093) after Local Irradiation in Newly-Diagnosed BRAFV600 -Mutant High-Grade Glioma (HGG) (IND# 145355)

10/2/19 → 11/10/23

Project: Research project

A Phase 2 Study of Dabrafenib (NSC# 763760) with Trametinib (NSC# 763093) after Local Irradiation in Newly-Diagnosed BRAFV600 -Mutant High-Grade Glioma (HGG) (IND# 145355)

10/2/19 → 1/13/22

Project: Research project

A Phase 2 Study of Inotuzumab Ozogamicin in Children and Young Adults with Relapsed or Refractory CD22+ B-Acute Lymphoblastic Leukemia (B-ALL)

Badgett, J. & Radulescu, V.

9/17/19 → 1/13/22

Project: Research project

A Phase III Study of 131I Metaiodobenzylguanidine (131I-MIBG) or Crizotinib Added to Intensive Therapy for Children with Newly Diagnosed High-Risk Neuroblastoma (NBL)

Badgett, J. & Radulescu, V.

8/9/19 → 12/9/21

Project: Research project

A Phase 3 Trial Investigating Blinatumomab (IND# 117467, NSC# 765986) in Combination with Chemotherapy in Patients with Newly Diagnosed Standard Risk or Down syndrome B-Lymphoblastic Leukemia (B-ALL) and the Treatment of Patients with Localized B-Lymphobl

Badgett, J., Bayliff, S., D'Orazio, J., Geil, J., Radulescu, V., Shaw, A. & Sorge, C.

6/28/19 → 1/13/22

Project: Research project

Residual Scope: A Phase 3 Trial Investigating Blinatumomab (IND# 117467, NSC# 765986) in Combination with Chemotherapy in Patients with Newly Diagnosed Standard Risk or Down syndrome B-Lymphoblastic Leukemia (B-ALL) and the Treatment of Patients

Badgett, J., Bayliff, S., D'Orazio, J., Geil, J., Radulescu, V., Shaw, A. & Sorge, C.

6/28/19 → 11/10/22

Project: Research project

UK - Pediatric Brain and Central Nervous System Tumors C1632

Durbin, E. B., Badgett, J., Christian, J., He, C., Huang, B., Jeong, J. C. & Tucker, T.