Projects and Grants per year
Personal profile
Research Interests
The overall goal of the research program in Dr. Woodward's lab is to understand the mechanisms of immunological tolerance toward self-antigens.
It is clear that clones of T-lymphocytes with specificity toward self-peptides exist in normal individuals, but that these clones are normally held in check by poorly understood mechanisms, operationally termed peripheral tolerance. Clonal deletion, clonal anergy, and active suppression have all been shown to participate in the generation of peripheral tolerance. A breakdown in peripheral tolerance results in autoimmune disease. One of the key goals of this research is to determine the behavior of the antigen-specific T cell under conditions invoking immunity or tolerance and to understand the signals controlling each process. The Woodward lab is using a model system in which T cells from an ovalbumin-specific, T cell receptor (OVA-TCR) transgenic mouse are adoptively transferred into normal BALB/c mice. Since these OVA-TCR T cells can be visualized with the use of a monoclonal antibody, it is possible to determine the behavior of these T cells following immunization or tolerance induction. Following removal from the mouse, these T cells are analyzed by two and three color immunofluorescent staining and flow cytometry, immunohistochemistry, intracellular cytokine staining, and in vitro culture.
Ongoing projects in the lab concern the role of different tissues in peripheral tolerance induction using the eye as a model system, the role of the antigen-presenting cell in tolerance induction, the ability of tumor cells to escape immune recognition by inducing a state of tolerance and, the production of transgenic mice as models of autoimmune disease to study the role of tolerance in regulating autoimmunity.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Post Doctoral Fellow, University Of Southern California
1983
Doctor of Philosophy, University Of Utah
1979
Bachelor of Science, University Of California - Irvine
1975
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Collaborations and top research areas from the last five years
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SBIR: Increasing Availability of Emulsion Adjuvants Via Synthetic Biolog
Chappell, J. (PI), Chambers, T. (CoI) & Woodward, J. (CoI)
10/11/22 → 8/29/25
Project: Research project
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Validated Vaccine Candidates Product Development Support
Woodward, J. (PI)
11/1/15 → 6/30/25
Project: Research project
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University of Kentucky Markey Cancer Center - Cancer Center Support Grant (Clinical Protocol and Data Management (CPMD))
Evers, B. M. (PI), Adams, V. (CoI), Allison, D. (CoI), Anthony, L. (CoI), Arnold, S. (CoI), Bocklage, T. (CoI), Burris, J. (CoI), Butterfield, D. A. (CoI), Chen, L. (CoI), COHEN, D. (CoI), Durbin, E. B. (CoI), Ellingson, S. (CoI), Gao, T. (CoI), Hands, I. (CoI), Higashi, R. (CoI), Huang, B. (CoI), Hull, P. (CoI), Jeong, J. C. (CoI), Kavuluru, R. (CoI), Kuhs, K. (CoI), Kunos, C. (CoI), Lee, E. (CoI), Liu, J. (CoI), McGarry, R. (CoI), Moseley, H. (CoI), Mullett, T. (CoI), O'Connor, K. (CoI), Patel, R. (CoI), Plattner, R. (CoI), Rogers, J. (CoI), Shelton, B. (CoI), St Clair, D. (CoI), Stanley, S. (CoI), Stapleton, J. (CoI), Sturgill, J. (CoI), Vanderford, N. (CoI), Villano, PhD, J. (CoI), Wang, C. (CoI), Wei, S. (CoI), Weiss, H. (CoI), Williams, L. (CoI), Woodward, J. (CoI), Yan, D. (CoI), Zhang, S. (CoI), Zhou, B. (CoI) & Kolesar, J. (Former CoI)
7/8/13 → 6/30/28
Project: Research project
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University of Kentucky Markey Cancer Center - Cancer Center Support Grant (Prime)
Evers, B. M. (PI), Adams, V. (CoI), Allison, D. (CoI), Anthony, L. (CoI), Arnold, S. (CoI), Bocklage, T. (CoI), Brainson, C. (CoI), Burris, J. (CoI), Burrows Franco, A. (CoI), Butterfield, D. A. (CoI), Chen, L. (CoI), Durbin, E. B. (CoI), Ellingson, S. (CoI), Gandhapudi, S. (CoI), Gao, T. (CoI), Hands, I. (CoI), Hao, Z. (CoI), Higashi, R. (CoI), Huang, B. (CoI), Hull, P. (CoI), Jeong, J. C. (CoI), Kavuluru, R. (CoI), Kuhs, K. (CoI), Lee, E. (CoI), Liu, J. (CoI), McGarry, R. (CoI), McLouth, L. (CoI), Moseley, H. (CoI), Mullett, T. (CoI), O'Connor, K. (CoI), Patel, R. (CoI), Plattner, R. (CoI), Rogers, J. (CoI), Shelton, B. (CoI), St Clair, D. (CoI), Sturgill, J. (CoI), Vanderford, N. (CoI), Villano, PhD, J. (CoI), Wang, C. (CoI), Wei, S. (CoI), Weiss, H. (CoI), Williams, L. (CoI), Yan, D. (CoI), Zhang, S. (CoI), Zhou, B. (CoI), COHEN, D. (Former CoI), Kolesar, J. (Former CoI), Kunos, C. (Former CoI), Stanley, S. (Former CoI), Stapleton, J. (Former CoI) & Woodward, J. (Former CoI)
7/8/13 → 6/30/28
Project: Research project
Research output
- 72 Article
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R-DOTAP Cationic Lipid Nanoparticles Outperform Squalene-Based Adjuvant Systems in Elicitation of CD4 T Cells after Recombinant Influenza Hemagglutinin Vaccination
Henson, T. R., Richards, K. A., Gandhapudi, S. K., Woodward, J. G. & Sant, A. J., Feb 2023, In: Viruses. 15, 2, 538.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
Recombinant Protein Vaccines Formulated with Enantio-Specific Cationic Lipid R-DOTAP Induce Protective Cellular and Antibody-Mediated Immune Responses in Mice
Gandhapudi, S. K., Shi, H., Ward, M. R., Bush, J. P., Avdiushko, M., Sundarapandiyan, K., Wood, L. V., Dorrani, M., Fatima, A., Dervan, J., Bedu-Addo, F., Conn, G., Ross, T. M. & Woodward, J. G., Feb 2023, In: Viruses. 15, 2, 432.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
Priming immunotherapy with radiotherapy (RT) in advanced non-small cell lung cancer (NSCLC) and head and neck squamous cell cancer (HNSCC): Interim analysis of phase II clinical trial.
Jacob, A., Kreimer, A., Wei, J., Wu, J., Corum, L., Reusch, E., Woodward, J., Cohen, D., Bondada, S., Adams, V. R., Morgan, R., McGarry, R. C., St Clair, W. H., Kudrimoti, M. R., Myint, Z., Arnold, S. M. & Villano, J. L., May 20 2021, In: Journal of Clinical Oncology.Research output: Contribution to journal › Article
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Synthetic Biology-derived triterpenes as efficacious immunomodulating adjuvants
Tateno, M., Stone, B. J., Srodulski, S. J., Reedy, S., Gawriluk, T. R., Chambers, T. M., Woodward, J., Chappell, J. & Kempinski, C. F., Dec 1 2020, In: Scientific Reports. 10, 1, 17090.Research output: Contribution to journal › Article › peer-review
Open Access14 Scopus citations -
Antigen priming with enantiospecific cationic lipid nanoparticles induces potent antitumor CTL responses through novel induction of a type I IFN response
Gandhapudi, S. K., Ward, M., Bush, J. P. C., Bedu-Addo, F., Conn, G. & Woodward, J. G., Jun 15 2019, In: Journal of Immunology. 202, 12, p. 3524-3536 13 p.Research output: Contribution to journal › Article › peer-review
Open Access41 Scopus citations