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Personal profile

Research Interests

Our research program is focused on identifying new therapeutic targets for pediatric cancers using zebrafish models. Approximately 70% of human genes have a direct zebrafish ortholog, and cancers made in transgenic zebrafish develop in much the same way as human cancers. 

My laboratory uses zebrafish models primarily as a screening tool to identify oncogenic drivers of pediatric cancers using transgenic and transplantation approaches where genes of interest are over-expressed or knocked out to assess their contribution to tumor progression. We also use zebrafish for in vivo drug screens so that we can better understand how tumors respond to therapy and why they develop resistance to ultimately relapse. A major benefit of zebrafish in this setting is the scale at which these experiments can be done. We can use hundreds to thousands of animals to develop statistically significant results, making us more confident in the relevance of our findings as we move to pre-clinical models and human samples.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Education/Academic qualification

Doctor of Philosophy, Dartmouth College


Bachelor of Science, Centre College



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