Projects and Grants per year
Personal profile
Research Interests
Our research program is focused on identifying new therapeutic targets for pediatric cancers using zebrafish models. Approximately 70% of human genes have a direct zebrafish ortholog, and cancers made in transgenic zebrafish develop in much the same way as human cancers.
My laboratory uses zebrafish models primarily as a screening tool to identify oncogenic drivers of pediatric cancers using transgenic and transplantation approaches where genes of interest are over-expressed or knocked out to assess their contribution to tumor progression. We also use zebrafish for in vivo drug screens so that we can better understand how tumors respond to therapy and why they develop resistance to ultimately relapse. A major benefit of zebrafish in this setting is the scale at which these experiments can be done. We can use hundreds to thousands of animals to develop statistically significant results, making us more confident in the relevance of our findings as we move to pre-clinical models and human samples.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Doctor of Philosophy, Dartmouth College
2009
Bachelor of Science, Centre College
2001
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Collaborations and top research areas from the last five years
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Fellowship for Oza: Harnessing Extracellular Vesicles to Overcome Radiation Resistance in Pediatric Diffuse Midline Glioma
Blackburn, J. (PI)
9/1/24 → 8/31/26
Project: Research project
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A New Personalized Medicine Model for High-Risk Pediatric Sarcomas
Blackburn, J. (PI) & Munnikhuysen, S. (CoI)
Army Medical Research and Materiel Command
8/1/24 → 7/31/26
Project: Research project
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Zebrafish Avatars C4785
Blackburn, J. (PI) & Rellinger, E. (CoI)
KY Cabinet for Health and Family Services
7/1/24 → 6/30/26
Project: Research project
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Analysis and Targeting BRD4 in DIPG C4964
Blackburn, J. (PI) & Bruntz, R. (CoI)
KY Cabinet for Health and Family Services
7/1/24 → 6/30/25
Project: Research project
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The Phosphatase PRL3 as a MYC Target and Pro-Survival Oncogene in Acute Lymphoblastic Leukemia
Blackburn, J. (PI)
4/1/23 → 3/31/25
Project: Research project
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A dynamic model of inorganic arsenic-induced carcinogenesis reveals an epigenetic mechanism for epithelial–mesenchymal plasticity.
Rea, M., Kimmerer, G., Mittendorf, S., Xiong, X., Green, M., Chandler, D., Saintilnord, W., Blackburn, J., Gao, T. & Fondufe-Mittendorf, Y. N., Apr 15 2024, In: Environmental Pollution. 347, 123586.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Examining Phosphatases Through Immunofluorescent Microscopy
Smith, C. N. & Blackburn, J. S., 2024, Methods in Molecular Biology. p. 111-122 12 p. (Methods in Molecular Biology; vol. 2743).Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
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Identification of Quiescent Cells in a Zebrafish T-Cell Acute Lymphoblastic Leukemia Model Using Cell Proliferation Staining
Al-Hamaly, M. A., Chernyavskaya, Y. & Blackburn, J. S., Jul 2024, In: Journal of Visualized Experiments. 2024, 209, e67059.Research output: Contribution to journal › Article › peer-review
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Zebrafish drug screening identifies Erlotinib as an inhibitor of Wnt/β-catenin signaling and self-renewal in T-cell acute lymphoblastic leukemia
Al-Hamaly, M. A., Cox, A. H., Haney, M. G., Zhang, W., Arvin, E. C., Sampathi, S., Wimsett, M., Liu, C. & Blackburn, J. S., Jan 2024, In: Biomedicine and Pharmacotherapy. 170, 116013.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
A monoadduct generating Ru(ii) complex induces ribosome biogenesis stress and is a molecular mimic of phenanthriplatin
Mitchell, R. J., Kriger, S. M., Fenton, A. D., Havrylyuk, D., Pandeya, A., Sun, Y., Smith, T., DeRouchey, J. E., Unrine, J. M., Oza, V., Blackburn, J. S., Wei, Y., Heidary, D. K. & Glazer, E. C., Feb 27 2023, In: RSC Chemical Biology. 4, 5, p. 344-353 10 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations