Projects and Grants per year
Personal profile
Research Interests
The goal of our research is to understand the molecular mechanisms of Hedgehog (Hh) signal transduction and the roles of Hh signaling components in development and cancer. We focus on the regulation of Smoothened (Smo), a seven-span transmembrane protein required for transduction of the Hh signal in cells exposed to the Hh ligand. We have been investigating novel mechanisms that are critical in mediating the activation of Smo.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Doctor of Philosophy, Chinese Academy of Sciences
2000
Master of Science, Hebei University
1997
Bachelor of Science, Hebei University
1987
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Dive into the research topics where Jianhang Jia is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years
Recent external collaboration from the last 5 years on country level. Dive into details by clicking on the dots.
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Hedgehog Signaling in Development and Metabolism
Jia, J., Wang, C., Vander Kooi, C. & Zhu, H.
National Institute of General Medical Sciences
9/1/19 → 8/31/25
Project: Research project
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Hedgehog Signaling in the Brain Contributes to Alzheimer's Disease in a Drosophila Model
National Institute of General Medical Sciences
9/1/19 → 8/31/25
Project: Research project
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University of Kentucky Center for Cancer Metabolism (Imaging Core)
National Institute of General Medical Sciences
3/1/17 → 12/31/26
Project: Research project
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University of Kentucky Center for Cancer Metabolism (Admin Core)
Zhou, B., Brainson, C., Cassis, L., Chaiswing, L., D'Orazio, J., Evers, B. M., Fan, W., Fong, K. W., Hao, Z., Hersh, L., Higashi, R., Jia, J., Lane, A., Liu, J., Liu, X., Moseley, H., Rellinger, E., Thorson, J., Van Eldik, L., Vanderford, N., Wang, C., Weiss, H., Arnold, S., Gentry, M., Hildebrandt, G., Liu, X., Marcinkowski, E., Stromberg, A., Wang, P., Wu, Y., Xu, R. & Zhu, C.
National Institute of General Medical Sciences
3/1/17 → 12/31/26
Project: Research project
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Plant Fund: University of Kentucky Center for Cancer Metabolism (Imaging Core) - Equipment 1
National Institute of General Medical Sciences
3/1/17 → 12/31/26
Project: Research project
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Phosphatidic acid binding to Patched contributes to the inhibition of Smoothened and Hedgehog signaling in Drosophila wing development
Zhang, J., Liu, Y., Wang, C., Vander Kooi, C. W. & Jia, J., Oct 17 2023, In: Science Signaling. 16, 807, eadd6834.Research output: Contribution to journal › Article › peer-review
Open Access -
Characterization of Smoothened Phosphorylation and Activation
Jia, J., Han, Y., Cho, Y. S. & Jiang, J., 2022, Methods in Molecular Biology. p. 121-137 17 p. (Methods in Molecular Biology; vol. 2374).Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
Open Access1 Scopus citations -
Neurotensin Regulates Proliferation and Stem Cell Function in the Small Intestine in a Nutrient-Dependent Manner
Rock, S. A., Jiang, K., Wu, Y., Liu, Y., Li, J., Weiss, H. L., Wang, C., Jia, J., Gao, T. & Evers, B. M., Jan 2022, In: CMGH. 13, 2, p. 501-516 16 p.Research output: Contribution to journal › Article › peer-review
Open Access14 Scopus citations -
Regulation of Smoothened Trafficking and Abundance in Hedgehog Signaling
Jia, J. & Jiang, J., Mar 7 2022, In: Frontiers in Cell and Developmental Biology. 10, 847844.Research output: Contribution to journal › Review article › peer-review
Open Access1 Scopus citations -
Mechanisms of smoothened regulation in hedgehog signaling
Zhang, J., Liu, Z. & Jia, J., Aug 2021, In: Cells. 10, 8, 2138.Research output: Contribution to journal › Article › peer-review
Open Access21 Scopus citations