Projects and Grants per year
Personal profile
Research Interests
Our laboratory focuses on malignant melanoma of the skin, a cancer that kills more than 10,000 Americans every year. Melanoma incidence has increased so much over the last century that whereas a US citizen in the 1930's had only a 1 in 1,500 chance of developing it, now almost 1 in 50 of us will be diagnosed with the disease. We are interested in the genetic and environmental factors that cause melanomas to develop so that we can design ways to reduce melanoma incidence.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Post Doctoral Fellow, Other Institution
2003
Residency, Massachusetts General Hospital
2000
Internship, Other Institution
1997
Doctor of Medicine, University Of Miami
1996
Doctor of Philosophy, University Of Miami
1994
Bachelor of Science, Florida Atlantic University
1987
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- 1 Similar Profiles
Collaborations and top research areas from the last five years
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FY25 Defining TP53 Mutations in the Li-Fraumeni Spectrum - Elucidating Specific Effects of TP53 Mutations
D'Orazio, J. (PI), Ellingson, S. (CoI), Shao, Q. (CoI) & Shelton, B. (CoI)
KY Cabinet for Health and Family Services
7/1/24 → 6/30/26
Project: Research project
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FY26 UK/UL Joint Program Inherited Cancer Risk Program
D'Orazio, J. (PI), Allison, D. (CoI), Durbin, E. B. (CoI), Harrington, A. (CoI), Jeong, J. C. (CoI), Shelman, N. (CoI), Weiss, H. (CoI) & Zhang, S. (CoI)
KY Cabinet for Health and Family Services
7/1/24 → 6/30/26
Project: Research project
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FY26 Defining TP53 Mutations in the Li-Fraumeni Spectrum - Elucidating Specific Effects of TP53 Mutations
D'Orazio, J. (PI), Ellingson, S. (CoI), Shao, Q. (CoI) & Shelton, B. (CoI)
KY Cabinet for Health and Family Services
7/1/24 → 6/30/26
Project: Research project
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FY25 Role of Obesity in Regulation of Cell Surface GRP78
Rangnekar, V. (PI), D'Orazio, J. (CoI), Jiang, J. (CoI) & Kesler, M. (CoI)
KY Cabinet for Health and Family Services
7/1/24 → 6/30/25
Project: Research project
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FY25 UK/UL Joint Program Inherited Cancer Risk Program
D'Orazio, J. (PI), Allison, D. (CoI), Durbin, E. B. (CoI), Harrington, A. (CoI), Jeong, J. C. (CoI), Shelman, N. (CoI), Weiss, H. (CoI) & Zhang, S. (CoI)
KY Cabinet for Health and Family Services
7/1/24 → 6/30/26
Project: Research project
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Congenital Malignant Ectomesenchymoma Presenting as a Neck Mass in a Newborn
Blanchard, I. S. C., Bhavsar, R. C., Olszewski, A. M., Shelman, N. R., D’Orazio, J. A., Bhandary, P. & Sithisarn, T., Apr 2025, In: Children. 12, 4, 480.Research output: Contribution to journal › Article › peer-review
Open Access -
Engaging Nurses in Effective Cost of Care Conversations to Address Cancer-Related Financial Toxicity: Results from an Exploratory Survey
Edward, J. S., Wiggins, A. T., Baser, L. G., Fariduddin, H., Doran, J. F., Bryant, M. F., D’Orazio, J. A. & Northrip, K. D., Jan 2025, In: Current Oncology. 32, 1, 33.Research output: Contribution to journal › Article › peer-review
Open Access -
Extracellular vesicles released by ALL patients contain HNE-adducted proteins: Implications of collateral damage
Ho, J., Sukati, S., Taylor, T., Carter, S., Fuller, B., Marmo, A., Sorge, C., D'Orazio, J., Butterfield, D. A., Bondada, S., Weiss, H., St Clair, D. K. & Chaiswing, L., Feb 1 2025, In: Free Radical Biology and Medicine. 227, p. 312-321 10 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Racial and Rural Disparities in Financial Toxicity and Healthcare Transitions Among Adolescent and Young Adult Cancer Survivors in Kentucky: A Cross-Sectional Study
Edward, J. S., Shelton, B. J., Corum, L., Fariduddin, H., Brown, K., D’Orazio, J. A. & Northrip, K. D., Jan 1 2025, In: Cancer Control. 32, 10732748251339251.Research output: Contribution to journal › Article › peer-review
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S6K1 is a Targetable Vulnerability in Tumors Exhibiting Plasticity and Therapy Resistance
Ganguly, S., Burikhanov, R., Sviripa, V. M., Ellingson, S., Jiang, J., Gosser, C. M., Orren, D., Goellner, E. M., Shenoy, G. G., Rao, M., D’orazio, J., Brainson, C. F., Zhan, C. G., Spielmann, P. H., Watt, D. S. & Rangnekar, V. M., 2025, In: International Journal of Biological Sciences. 21, 2, p. 454-472 19 p.Research output: Contribution to journal › Article › peer-review