Personal profile
Research Interests
Clinical Trials involved in Neuro-Oncology and in lung cancer. I am also involved in collaborating with the investigators at Kentucky Cancer Registry (KCR) and at Central Brain Tumor Registry of the United States (CBTRUS) to perform descriptive epidemiology studies. We have worked on topics that are less known or investigated, where the application of clinical knowledge assists in the interpretation of epidemiology data.
Education/Academic qualification
Doctor of Philosophy, University of Texas Southwestern
1997
Doctor of Medicine, University of Texas Southwestern
1997
Bachelor of Science, Texas A & M University
1989
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being -
SDG 16 Peace, Justice and Strong Institutions
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Collaborations and top research areas from the last five years
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25-LUN-145-BMS CA240-0029 A Randomized Phase 2/3 Study of BMS-986504 in Combination with Pembrolizumab and Chemotherapy Versus Placebo Plus Pembrolizumab and Chemotherapy in First-line Metastatic Non-small Cell Lung Cancer Participants with Homozygous MTA
Villano, PhD, J. (PI)
11/19/25 → 11/19/27
Project: Research project
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24-MULTI-65-TB-PMC (TORL123-001): A Phase 1, First in Human, Dose-Escalation Study of TORL-1-23 in Participants With Advanced Cancer
Villano, PhD, J. (PI)
Translational Research in Oncology
2/19/25 → 2/19/27
Project: Research project
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24-GBM-16-NL (EF-41): A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of Optune (TTFields, 200 kHz) Concomitant with Maintenance Temozolomide and Pembrolizumab Versus Optune Concomitant with Maintenance Temozolomide and Placebo for the Tre
Villano, PhD, J. (PI)
12/4/24 → 12/4/26
Project: Research project
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Statistical Methods for Identification and Evaluation of Predictive Biomarkers in Cancer
Chen, L. (PI), Villano, PhD, J. (CoI), Wang, C. (CoI) & Kolesar, J. (Former CoI)
7/4/24 → 6/30/26
Project: Research project
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FY26 Spatial Transcriptomic Characterization of Pediatric Brain Tumors in Kentucky
Wang, C. (PI), Durbin, E. B. (CoI), Harrison, D. (CoI), Jeong, J. C. (CoI), Liu, J. (CoI), Neltner, J. (CoI), Villano, PhD, J. (CoI), Zhang, S. (CoI) & Tucker, T. (Former CoI)
KY Cabinet for Health and Family Services
7/1/24 → 6/30/26
Project: Research project
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Phase 1 open-label study of ASP9801, an oncolytic virus, in patients with advanced or metastatic solid tumors
Villano, J. L., Luke, J. J., Julian, R., Fountzilas, C., Patel, M. R., Chisamore, M. J., Bhattacharya, P., Takeshita, S., Soukharev, S., Yamada, S., Zhang, L. & Wentzel, K. P., Feb 11 2026, In: Journal for ImmunoTherapy of Cancer. 14, 2, e012377.Research output: Contribution to journal › Article › peer-review
Open Access -
Prevalence and characteristics for mental health disorder before and after childhood cancer diagnosis—a statewide population-based study among Medicaid beneficiaries
Lei, F., McLouth, L. E., Durbin, E. B., Tucker, T. T., Villano, J. L. & Huang, B., 2026, In: Frontiers in Psychology. 16, 1680382.Research output: Contribution to journal › Article › peer-review
Open Access -
Case Report: Advanced grade 2 meningioma with PBRM1 inactivation with prolonged response to immunotherapy
Reusch, E., Peh, K. H., Morgan, R., Momo, H., Orren, D., Rock, S., Pittman, T., Neltner, J., Kolesar, J. & Villano, J., 2025, In: Frontiers in Oncology. 15, 1587752.Research output: Contribution to journal › Article › peer-review
Open Access -
Case Report: Advanced grade 2 meningioma with PBRM1 inactivation with prolonged response to immunotherapy.
Reusch, E., Peh, K. H., Morgan, R., Momo, H., Orren, D., Rock, S., Pittman, T., Neltner, J., Kolesar, J. & Villano, J., 2025, In: Frontiers in Oncology. 15, p. 1587752Research output: Contribution to journal › Article › peer-review
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Dihydropyrimidine enzyme activity and its effect on chemotherapy toxicity: importance of genetic testing
Shamaei Zadeh, A., Roberts, D., Williams, A., Pandey, D. & Villano, J. L., Dec 2025, In: Cancer Chemotherapy and Pharmacology. 95, 1, 26.Research output: Contribution to journal › Letter › peer-review
Open Access