Kathryn Saatman

1999

Differential acute and chronic responses of tumor necrosis factor-deficient mice to experimental brain injury

Scherbel, U., Raghupathi, R., Nakamura, M., Saatman, K. E., Trojanowski, J. Q., Neugebauer, E., Marino, M. W. & McIntosh, T. K., Jul 20 1999, In: Proceedings of the National Academy of Sciences of the United States of America. 96, 15, p. 8721-8726 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

345 Scopus citations

Evolution of neurofilament subtype accumulation in axons following diffuse brain injury in the pig

Chen, X. H., Meaney, D. F., Xu, B. N., Nonaka, M., McIntosh, T. K., Wolf, J. A., Saatman, K. E. & Smith, D. H., Jun 1999, In: Journal of Neuropathology and Experimental Neurology. 58, 6, p. 588-596 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

88 Scopus citations

Genetic approaches to neurotrauma research: Opportunities and potential pitfalls of murine models

Steward, O., Schauwecker, P. E., Guth, L., Zhang, Z., Fujiki, M., Inman, D., Wrathall, J., Kempermann, G., Gage, F. H., Saatman, K. E., Raghupathi, R. & McIntosh, T., May 1999, In: Experimental Neurology. 157, 1, p. 19-42 24 p.

Research output: Contribution to journal › Review article › peer-review

140 Scopus citations

Increased vulnerability of NFH-LacZ transgenic mouse to traumatic brain injury-induced behavioral deficits and cortical damage

Nakamura, M., Saatman, K. E., Galvin, J. E., Scherbel, U., Raghupathi, R., Trojanowski, J. Q. & McIntosh, T. K., 1999, In: Journal of Cerebral Blood Flow and Metabolism. 19, 7, p. 762-770 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

41 Scopus citations

Interleukin-1 receptor antagonist attenuates regional neuronal cell death and cognitive dysfunction after experimental brain injury

Sanderson, K. L., Raghupathi, R., Saatman, K. E., Martin, D., Miller, G. & McIntosh, T. K., 1999, In: Journal of Cerebral Blood Flow and Metabolism. 19, 10, p. 1118-1125 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

84 Scopus citations

Overexpression of Bcl-2 is neuroprotective after experimental brain injury in transgenic mice

Nakamura, M., Raghupathi, R., Merry, D. E., Scherbel, U., Saatman, K. E. & McIntosh, T. K., Oct 4 1999, In: Journal of Comparative Neurology. 412, 4, p. 681-692 12 p.

Research output: Contribution to journal › Article › peer-review

75 Scopus citations

Regional and temporal alterations in DNA fragmentation factor (DFF)-like proteins following experimental brain trauma in the rat

Zhang, C., Raghupathi, R., Saatman, K. E., LaPlaca, M. C. & McIntosh, T. K., 1999, In: Journal of Neurochemistry. 73, 4, p. 1650-1659 10 p.

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Sequential pharmacotherapy with magnesium chloride and basic fibroblast growth factor after fluid percussion brain injury results in less neuromotor efficacy than that achieved with magnesium alone

Guluma, K. Z., Saatman, K. E., Brown, A., Raghupathi, R. & McIntosh, T. K., Apr 1999, In: Journal of Neurotrauma. 16, 4, p. 311-321 11 p.

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Survival and integration of transplanted postmitotic human neurons following experimental brain injury in immunocompetent rats

Philips, M. F., Muir, J. K., Saatman, K. E., Raghupathi, R., Lee, V. M. Y., Trojanowski, J. Q. & McIntosh, T. K., Jan 1999, In: Journal of Neurosurgery. 90, 1, p. 116-124 9 p.

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Temporal patterns of poly(ADP-ribose) polymerase activation in the cortex following experimental brain injury in the rat

LaPlaca, M. C., Raghupathi, R., Verma, A., Pieper, A. A., Saatman, K. E., Snyder, S. H. & McIntosh, T. K., 1999, In: Journal of Neurochemistry. 73, 1, p. 205-213 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

82 Scopus citations

Terminally differentiated human neurons survive and integrate following transplantation into the traumatically injured rat brain

Muir, J. K., Raghupathi, R., Saatman, K. E., Wilson, C. A., Lee, V. M. Y., Trojanowski, J. Q., Philips, M. F. & McIntosh, T. K., May 1999, In: Journal of Neurotrauma. 16, 5, p. 403-414 12 p.

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Traumatic brain injury in young, amyloid-β peptide overexpressing transgenic mice induces marked ipsilateral hippocampal atrophy and diminished deposition during aging

Nakagawa, Y., Nakamura, M., McIntosh, T. K., Rodriguez, A., Berlin, J. A., Smith, D. H., Saatman, K. E., Raghupathi, R., Clemens, J., Saido, T. C., Schmidt, M. L., Lee, V. M. Y. & Trojanowski, J. Q., 1999, In: Journal of Comparative Neurology. 411, 3, p. 390-398 9 p.

Research output: Contribution to journal › Article › peer-review

84 Scopus citations

1998

Brain trauma induces massive hippocampal neuron death linked to a surge in β-amyloid levels in mice overexpressing mutant amyloid precursor protein

Smith, D. H., Nakamura, M., McIntosh, T. K., Wang, J., Rodríguez, A., Chen, X. H., Raghupathi, R., Saatman, K. E., Clemens, J., Schmidt, M. L., Lee, V. M. Y. & Trojanowski, J. Q., Sep 1998, In: American Journal of Pathology. 153, 3, p. 1005-1010 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

124 Scopus citations

In vitro central nervous system models of mechanically induced trauma: A review

Morrison, B., Saatman, K. E., Meaney, D. F. & McIntosh, T. K., Nov 1998, In: Journal of Neurotrauma. 15, 11, p. 911-928 18 p.

Research output: Contribution to journal › Review article › peer-review

174 Scopus citations

Riluzole attenuates cortical lesion size, but not hippocampal neuronal loss, following traumatic brain injury in the rat

Zhang, C., Raghupathi, R., Saatman, K. E., Smith, D. H., Stutzmann, J. M., Wahl, F. & McIntosh, T. K., May 1 1998, In: Journal of Neuroscience Research. 52, 3, p. 342-349 8 p.

Research output: Contribution to journal › Article › peer-review

75 Scopus citations

The neuronal cytoskeleton is at risk after mild and moderate brain injury

Saatman, K. E., Graham, D. I. & Mcintosh, T. K., Dec 1998, In: Journal of Neurotrauma. 15, 12, p. 1047-1058 12 p.

Research output: Contribution to journal › Article › peer-review

110 Scopus citations

Twofold overexpression of human β-amyloid precursor proteins in transgenic mice does not affect the neuromotor, cognitive, or neurodegenerative sequelae following experimental brain injury

Murai, H., Pierce, J. E. S., Raghupathi, R., Smith, D. H., Saatman, K. E., Trojanowski, J. Q., Lee, V. M. Y., Loring, J. F., Eckman, C., Younkin, S. & Mcintosh, T. K., Mar 23 1998, In: Journal of Comparative Neurology. 392, 4, p. 428-438 11 p.

Research output: Contribution to journal › Article › peer-review

76 Scopus citations

1997

Calcium and the pathogenesis of traumatic CNS injury: Cellular and molecular mechanisms

Mcintosh, T. K., Saatman, K. E. & Raghupathi, R., May 1997, In: Neuroscientist. 3, 3, p. 169-175 7 p.

Research output: Contribution to journal › Review article › peer-review

42 Scopus citations

Central nervous system resuscitation

McIntosh, T. K., Garde, E., Saatman, K. E. & Smith, D. H., 1997, In: Emergency Medicine Clinics of North America. 15, 3, p. 527-550 24 p.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Delayed administration of basic fibroblast growth factor (bFGF) attenuates cognitive dysfunction following parasagittal fluid percussion brain injury in the rat

Mcdermott, K. L., Raghupathi, R., Fernandez, S. C., Saatman, K. E., Protter, A. A., Finklestein, S. P., Sinson, G., Smith, D. H. & Mcintosh, T. K., Apr 1997, In: Journal of Neurotrauma. 14, 4, p. 191-200 10 p.

Research output: Contribution to journal › Article › peer-review

64 Scopus citations

Insulin-like growth factor-1 (IGF-1) improves both neurological motor and cognitive outcome following experimental brain injury

Saatman, K. E., Contreras, P. C., Smith, D. H., Raghupathi, R., McDermott, K. L., Fernandez, S. C., Sanderson, K. L., Voddi, M. & McIntosh, T. K., Oct 1997, In: Experimental Neurology. 147, 2, p. 418-427 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

166 Scopus citations

Metabolic quantification of lesion volume following experimental traumatic brain injury in the rat

Perri, B. R., Smith, D. H., Murai, H., Sinson, G., Saatman, K. E., Raghupathi, R., Bartus, R. T. & McIntosh, T. K., Jan 1997, In: Journal of Neurotrauma. 14, 1, p. 15-22 8 p.

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Remacemide hydrochloride reduces cortical lesion volume following brain trauma in the rat

Smith, D. H., Perri, B. R., Raghupathi, R., Saatman, K. E. & McIntosh, T. K., Aug 15 1997, In: Neuroscience Letters. 231, 3, p. 135-138 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

23 Scopus citations

1996

Calpain inhibitor AK295 attenuates motor and cognitive deficits following experimental brain injury in the rat

Saatman, K. E., Murai, H., Bartus, R. T., Smith, D. H., Hayward, N. J., Perri, B. R. & McIntosh, T. K., Apr 16 1996, In: Proceedings of the National Academy of Sciences of the United States of America. 93, 8, p. 3428-3433 6 p.

Research output: Contribution to journal › Article › peer-review

216 Scopus citations

Prolonged calpain-mediated spectrin breakdown occurs regionally following experimental brain injury in the rat

Saatman, K. E., Bozyczko-Coyne, D., Marcy, V., Siman, R. & Mcintosh, T. K., Jul 1996, In: Journal of Neuropathology and Experimental Neurology. 55, 7, p. 850-860 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

210 Scopus citations

1995

A Model of Parasagittal Controlled Cortical Impact in the Mouse: Cognitive and Histopathologic Effects

Smith, D. H., Soares, H. D., Pierce, J. S., Perlman, K. G., Saatman, K. E., Meaney, D. F., Dixon, C. E. & Mcintosh, T. K., Apr 1995, In: Journal of Neurotrauma. 12, 2, p. 169-178 10 p.

Research output: Contribution to journal › Article › peer-review

377 Scopus citations

1992

Biomechanics of isolated myelinated nerve as related to brain injury

Saatman, K. E., Thibault, L. E. & Meaney, D. F., 1992, 1992 Advances in Bioengineering. p. 549-552 4 p. (American Society of Mechanical Engineers, Bioengineering Division (Publication) BED; vol. 22).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

1989

Rapid elongation of a myelinated nerve fiber: A model for neural injury

Saatman, K. E. & Thibault, L. E., Nov 1989, In: Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. 11 pt 5, p. 1663-1664 2 p.

Research output: Contribution to journal › Conference article › peer-review

1 Scopus citations

Kathryn Saatman, Ph.D.

Research output

Search results