Grants and Contracts per year
Personal profile
Research Interests
Fetal programming is likely playing a role in the alarming increase in childhood obesity and will result in increased diabetes, cardiovascular disease, and cancer during adulthood. However, the majority of research in this field has focused on negative outcomes associated with unhealthy or stressful pregnancies.
Instead, we hope to provide evidence that the reverse can also be true. Our goal is to provide new information on the positive impact that maternal exercise or other interventions can have on offspring health. Such an intervention provides a realistic mechanism to improve insulin sensitivity in the next generation and positively impact insulin-resistant states that are associated with a plethora of age-related diseases, including cardiovascular disease, cancer, and Alzheimer’s disease. If translatable to humans, healthcare costs would be significantly reduced by a short-term intervention like maternal exercise positively influencing long-term health in offspring. Education and public health campaigns were successful for the majority of women when the scientific community provided data that alcohol and drug use during pregnancy negatively impact the developing fetus, and we predict that women will exercise or try other safe interventions for the short-term duration of pregnancy if it translates into long-term beneficial effects for their children.
Education/Academic qualification
Doctor of Philosophy, Univ Of Cincinnati
2005
Bachelor of Science, Univ Of Pittsburgh
1999
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Growth and Metabolic Programming from Prenatal PFAS Exposure: Examining the Roles of Placental Functional Genomics and Protection by Maternal Exercise
Pearson, K. & Morris, A.
National Institute of Environmental Health Sciences
9/6/21 → 8/31/24
Project: Research project
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Interactive Mentoring to Enhance Research Skills (IMERS)
Frazier, D., D'Orazio, S., Davidshofer, E., Duncan, B., Estus, G., Glueck, A., Grzech, K., Herron, S., Lee, L., Loria Kinsey, A., McCullers, M., Murphy, M., Nickell, M., Park-Sarge, O., Scott, S., Selwitz, A., Stratton, T., Spear, B., Bradley, L., DeRouchey, J., Fondufe-Mittendorf, Y., McConnell, M., Pearson, K., Peterson, M. & Stevens-Watkins, D.
National Institute of General Medical Sciences
9/1/18 → 8/31/23
Project: Research project
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COBRE: Center of Research on Obesity and Cardiovascular Disease Pilot Projects
National Institute of General Medical Sciences
8/1/18 → 7/31/23
Project: Research project
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COBRE: Center of Research on Obesity and Cardiovascular Disease
Cassis, L., Finlin, B., Katz, W., Pearson, K., Stanley, S., Thompson, K., Wang, S., Morris, A. & Zhou, C.
National Institute of General Medical Sciences
8/1/18 → 7/31/23
Project: Research project
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Summer Research in Environmental Health Sciences
Swanson, H., Bradley, L., McWhorter, K., Osterhage, J., Rice, B., Xiang, L. & Pearson, K.
National Institute of Environmental Health Sciences
5/1/17 → 10/31/27
Project: Research project
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Exposure to PCB126 during the nursing period reversibly impacts early-life glucose tolerance
Rice, B. B., Sammons, K. W., Ngo Tenlep, S. Y., Weltzer, M. T., Reynolds, L. J., Rashid, C. S., Swanson, H. I. & Pearson, K. J., 2023, In: Frontiers in Endocrinology. 14, 1085958.Research output: Contribution to journal › Article › peer-review
Open Access -
PCB126 exposure during pregnancy alters maternal and fetal gene expression
Rashid, C. S., Preston, J. D., Ngo Tenlep, S. Y., Cook, M. K., Blalock, E. M., Zhou, C., Swanson, H. I. & Pearson, K. J., Aug 2023, In: Reproductive Toxicology. 119, 108385.Research output: Contribution to journal › Article › peer-review
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Effects of maternal controlled exercise on offspring adiposity and glucose tolerance
Platt, K. M., Przybylowski, J., Charnigo, R. J., Tenlep, S. Y. N., Reynolds, L. J. & Pearson, K. J., Aug 10 2022, In: Journal of Developmental Origins of Health and Disease. 13, 4, p. 455-462 8 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Chronic exposure to cadmium induces differential methylation in mice spermatozoa
Saintilnord, W. N., Tenlep, S. Y. N., Preston, J. D., Duregon, E., DeRouchey, J. E., Unrine, J. M., de Cabo, R., Pearson, K. J. & Fondufe-Mittendorf, Y. N., Apr 1 2021, In: Toxicological Sciences. 180, 2, p. 262-276 15 p.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
Elevated lipid oxidation is associated with exceeding gestational weight gain recommendations and increased neonatal anthropometrics: a cross-sectional analysis
Maples, J. M., Ehrlich, S. F., Zite, N. B., Pearson, K. J., Cade, W. T., Riedinger, C. J., Blankenship, M. M. & Tinius, R. A., Dec 2021, In: BMC Pregnancy and Childbirth. 21, 1, 575.Research output: Contribution to journal › Article › peer-review
Open Access