Konstantin Korotkov

2024

AI is a viable alternative to high throughput screening: a 318-target study

Wallach, I., Bernard, D., Nguyen, K., Ho, G., Morrison, A., Stecula, A., Rosnik, A., O’Sullivan, A. M., Davtyan, A., Samudio, B., Thomas, B., Worley, B., Butler, B., Laggner, C., Thayer, D., Moharreri, E., Friedland, G., Truong, H., van den Bedem, H., Ng, H. L., & 668 othersStafford, K., Sarangapani, K., Giesler, K., Ngo, L., Mysinger, M., Ahmed, M., Anthis, N. J., Henriksen, N., Gniewek, P., Eckert, S., de Oliveira, S., Suterwala, S., PrasadPrasad, S. V. K., Shek, S., Contreras, S., Hare, S., Palazzo, T., O’Brien, T. E., Van Grack, T., Williams, T., Chern, T. R., Kenyon, V., Lee, A. H., Cann, A. B., Bergman, B., Anderson, B. M., Cox, B. D., Warrington, J. M., Sorenson, J. M., Goldenberg, J. M., Young, M. A., DeHaan, N., Pemberton, R. P., Schroedl, S., Abramyan, T. M., Gupta, T., Mysore, V., Presser, A. G., Ferrando, A. A., Andricopulo, A. D., Ghosh, A., Ayachi, A. G., Mushtaq, A., Shaqra, A. M., Toh, A. K. L., Smrcka, A. V., Ciccia, A., de Oliveira, A. S., Sverzhinsky, A., de Sousa, A. M., Agoulnik, A. I., Kushnir, A., Freiberg, A. N., Statsyuk, A. V., Gingras, A. R., Degterev, A., Tomilov, A., Vrielink, A., Garaeva, A. A., Bryant-Friedrich, A., Caflisch, A., Patel, A. K., Rangarajan, A. V., Matheeussen, A., Battistoni, A., Caporali, A., Chini, A., Ilari, A., Mattevi, A., Foote, A. T., Trabocchi, A., Stahl, A., Herr, A. B., Berti, A., Freywald, A., Reidenbach, A. G., Lam, A., Cuddihy, A. R., White, A., Taglialatela, A., Ojha, A. K., Cathcart, A. M., Motyl, A. A. L., Borowska, A., D’Antuono, A., Hirsch, A. K. H., Porcelli, A. M., Minakova, A., Montanaro, A., Müller, A., Fiorillo, A., Virtanen, A., O’Donoghue, A. J., Del Rio Flores, A., Garmendia, A. E., Pineda-Lucena, A., Panganiban, A. T., Samantha, A., Chatterjee, A. K., Haas, A. L., Paparella, A. S., John, A. L. S., Prince, A., ElSheikh, A., Apfel, A. M., Colomba, A., O’Dea, A., Diallo, B. N., Ribeiro, B. M. R. M., Bailey-Elkin, B. A., Edelman, B. L., Liou, B., Perry, B., Chua, B. S. K., Kováts, B., Englinger, B., Balakrishnan, B., Gong, B., Agianian, B., Pressly, B., Salas, B. P. M., Duggan, B. M., Geisbrecht, B. V., Dymock, B. W., Morten, B. C., Hammock, B. D., Mota, B. E. F., Dickinson, B. C., Fraser, C., Lempicki, C., Novina, C. D., Torner, C., Ballatore, C., Bon, C., Chapman, C. J., Partch, C. L., Chaton, C. T., Huang, C., Yang, C. Y., Kahler, C. M., Karan, C., Keller, C., Dieck, C. L., Huimei, C., Liu, C., Peltier, C., Mantri, C. K., Kemet, C. M., Müller, C. E., Weber, C., Zeina, C. M., Muli, C. S., Morisseau, C., Alkan, C., Reglero, C., Loy, C. A., Wilson, C. M., Myhr, C., Arrigoni, C., Paulino, C., Santiago, C., Luo, D., Tumes, D. J., Keedy, D. A., Lawrence, D. A., Chen, D., Manor, D., Trader, D. J., Hildeman, D. A., Drewry, D. H., Dowling, D. J., Hosfield, D. J., Smith, D. M., Moreira, D., Siderovski, D. P., Shum, D., Krist, D. T., Riches, D. W. H., Ferraris, D. M., Anderson, D. H., Coombe, D. R., Welsbie, D. S., Hu, D., Ortiz, D., Alramadhani, D., Zhang, D., Chaudhuri, D., Slotboom, D. J., Ronning, D. R., Lee, D., Dirksen, D., Shoue, D. A., Zochodne, D. W., Krishnamurthy, D., Duncan, D., Glubb, D. M., Gelardi, E. L. M., Hsiao, E. C., Lynn, E. G., Silva, E. B., Aguilera, E., Lenci, E., Abraham, E. T., Lama, E., Mameli, E., Leung, E., Christensen, E. M., Mason, E. R., Petretto, E., Trakhtenberg, E. F., Rubin, E. J., Strauss, E., Thompson, E. W., Cione, E., Lisabeth, E. M., Fan, E., Kroon, E. G., Jo, E., García-Cuesta, E. M., Glukhov, E., Gavathiotis, E., Yu, F., Xiang, F., Leng, F., Wang, F., Ingoglia, F., van den Akker, F., Borriello, F., Vizeacoumar, F. J., Luh, F., Buckner, F. S., Vizeacoumar, F. S., Bdira, F. B., Svensson, F., Rodriguez, G. M., Bognár, G., Lembo, G., Zhang, G., Dempsey, G., Eitzen, G., Mayer, G., Greene, G. L., Garcia, G. A., Lukacs, G. L., Prikler, G., Parico, G. C. G., Colotti, G., De Keulenaer, G., Cortopassi, G., Roti, G., Girolimetti, G., Fiermonte, G., Gasparre, G., Leuzzi, G., Dahal, G., Michlewski, G., Conn, G. L., Stuchbury, G. D., Bowman, G. R., Popowicz, G. M., Veit, G., de Souza, G. E., Akk, G., Caljon, G., Alvarez, G., Rucinski, G., Lee, G., Cildir, G., Li, H., Breton, H. E., Jafar-Nejad, H., Zhou, H., Moore, H. P., Tilford, H., Yuan, H., Shim, H., Wulff, H., Hoppe, H., Chaytow, H., Tam, H. K., Van Remmen, H., Xu, H., Debonsi, H. M., Lieberman, H. B., Jung, H., Fan, H. Y., Feng, H., Zhou, H., Kim, H. J., Greig, I. R., Caliandro, I., Corvo, I., Arozarena, I., Mungrue, I. N., Verhamme, I. M., Qureshi, I. A., Lotsaris, I., Cakir, I., Perry, J. J. P., Kwiatkowski, J., Boorman, J., Ferreira, J., Fries, J., Kratz, J. M., Miner, J., Siqueira-Neto, J. L., Granneman, J. G., Ng, J., Shorter, J., Voss, J. H., Gebauer, J. M., Chuah, J., Mousa, J. J., Maynes, J. T., Evans, J. D., Dickhout, J., MacKeigan, J. P., Jossart, J. N., Zhou, J., Lin, J., Xu, J., Wang, J., Zhu, J., Liao, J., Xu, J., Zhao, J., Lin, J., Lee, J., Reis, J., Stetefeld, J., Bruning, J. B., Bruning, J. B., Coles, J. G., Tanner, J. J., Pascal, J. M., So, J., Pederick, J. L., Costoya, J. A., Rayman, J. B., Maciag, J. J., Nasburg, J. A., Gruber, J. J., Finkelstein, J. M., Watkins, J., Rodríguez-Frade, J. M., Arias, J. A. S., Lasarte, J. J., Oyarzabal, J., Milosavljevic, J., Cools, J., Lescar, J., Bogomolovas, J., Wang, J., Kee, J. M., Kee, J. M., Liao, J., Sistla, J. C., Abrahão, J. S., Sishtla, K., Francisco, K. R., Hansen, K. B., Molyneaux, K. A., Cunningham, K. A., Martin, K. R., Gadar, K., Ojo, K. K., Wong, K. S., Wentworth, K. L., Lai, K., Lobb, K. A., Hopkins, K. M., Parang, K., Machaca, K., Pham, K., Ghilarducci, K., Sugamori, K. S., McManus, K. J., Musta, K., Faller, K. M. E., Nagamori, K., Mostert, K. J., Korotkov, K. V., Liu, K., Smith, K. S., Sarosiek, K., Rohde, K. H., Kim, K. K., Lee, K. H., Pusztai, L., Lehtiö, L., Haupt, L. M., Cowen, L. E., Byrne, L. J., Su, L., Wert-Lamas, L., Puchades-Carrasco, L., Chen, L., Malkas, L. H., Zhuo, L., Hedstrom, L., Hedstrom, L., Walensky, L. D., Antonelli, L., Iommarini, L., Whitesell, L., Randall, L. M., Fathallah, M. D., Nagai, M. H., Kilkenny, M. L., Ben-Johny, M., Lussier, M. P., Windisch, M. P., Lolicato, M., Lolli, M. L., Vleminckx, M., Caroleo, M. C., Macias, M. J., Valli, M., Barghash, M. M., Mellado, M., Tye, M. A., Wilson, M. A., Hannink, M., Ashton, M. R., Cerna, M. V. C. D., Giorgis, M., Safo, M. K., Maurice, M. S., McDowell, M. A., Pasquali, M., Mehedi, M., Serafim, M. S. M., Soellner, M. B., Alteen, M. G., Champion, M. M., Skorodinsky, M., O’Mara, M. L., Bedi, M., Rizzi, M., Levin, M., Mowat, M., Jackson, M. R., Paige, M., Al-Yozbaki, M., Giardini, M. A., Maksimainen, M. M., De Luise, M., Hussain, M. S., Christodoulides, M., Stec, N., Zelinskaya, N., Van Pelt, N., Merrill, N. M., Singh, N., Kootstra, N. A., Singh, N., Gandhi, N. S., Chan, N. L., Trinh, N. M., Schneider, N. O., Matovic, N., Horstmann, N., Longo, N., Bharambe, N., Rouzbeh, N., Mahmoodi, N., Gumede, N. J., Anastasio, N. C., Khalaf, N. B., Rabal, O., Kandror, O., Escaffre, O., Silvennoinen, O., Bishop, O. T., Iglesias, P., Sobrado, P., Chuong, P., O’Connell, P., Martin-Malpartida, P., Mellor, P., Fish, P. V., Moreira, P. O. L., Zhou, P., Liu, P., Liu, P., Wu, P., Agogo-Mawuli, P., Jones, P. L., Ngoi, P., Toogood, P., Ip, P., von Hundelshausen, P., Lee, P. H., Rowswell-Turner, R. B., Balaña-Fouce, R., Rocha, R. E. O., Guido, R. V. C., Ferreira, R. S., Agrawal, R. K., Harijan, R. K., Ramachandran, R., Verma, R., Singh, R. K., Tiwari, R. K., Mazitschek, R., Koppisetti, R. K., Dame, R. T., Douville, R. N., Austin, R. C., Taylor, R. E., Moore, R. G., Ebright, R. H., Angell, R. M., Yan, R., Kejriwal, R., Batey, R. A., Blelloch, R., Vandenberg, R. J., Hickey, R. J., Kelm, R. J., Lake, R. J., Bradley, R. K., Blumenthal, R. M., Solano, R., Gierse, R. M., Viola, R. E., McCarthy, R. R., Reguera, R. M., Uribe, R. V., do Monte-Neto, R. L., Gorgoglione, R., Cullinane, R. T., Katyal, S., Hossain, S., Phadke, S., Shelburne, S. A., Geden, S. E., Johannsen, S., Wazir, S., Legare, S., Landfear, S. M., Radhakrishnan, S. K., Ammendola, S., Dzhumaev, S., Seo, S. Y., Li, S., Zhou, S., Chu, S., Chauhan, S., Maruta, S., Ashkar, S. R., Shyng, S. L., Conticello, S. G., Buroni, S., Garavaglia, S., White, S. J., Zhu, S., Tsimbalyuk, S., Chadni, S. H., Byun, S. Y., Park, S., Xu, S. Q., Banerjee, S., Zahler, S., Espinoza, S., Gustincich, S., Sainas, S., Celano, S. L., Capuzzi, S. J., Waggoner, S. N., Poirier, S., Olson, S. H., Marx, S. O., Van Doren, S. R., Sarilla, S., Brady-Kalnay, S. M., Dallman, S., Azeem, S. M., Teramoto, T., Mehlman, T., Swart, T., Abaffy, T., Akopian, T., Haikarainen, T., Moreda, T. L., Ikegami, T., Teixeira, T. R., Jayasinghe, T. D., Gillingwater, T. H., Kampourakis, T., Richardson, T. I., Herdendorf, T. J., Kotzé, T. J., O’Meara, T. R., Corson, T. W., Hermle, T., Ogunwa, T. H., Lan, T., Su, T., Banjo, T., O’Mara, T. A., Chou, T., Chou, T. F., Baumann, U., Desai, U. R., Pai, V. P., Thai, V. C., Tandon, V., Banerji, V., Robinson, V. L., Gunasekharan, V., Namasivayam, V., Segers, V. F. M., Maranda, V., Dolce, V., Maltarollo, V. G., Scoffone, V. C., Woods, V. A., Ronchi, V. P., Van Hung Le, V., Clayton, W. B., Lowther, W. T., Houry, W. A., Li, W., Tang, W., Zhang, W., Van Voorhis, W. C., Donaldson, W. A., Hahn, W. C., Kerr, W. G., Gerwick, W. H., Bradshaw, W. J., Foong, W. E., Blanchet, X., Wu, X., Lu, X., Qi, X., Xu, X., Yu, X., Qin, X., Wang, X., Yuan, X., Zhang, X., Zhang, Y. J., Hu, Y., Aldhamen, Y. A., Chen, Y., Li, Y., Sun, Y., Zhu, Y., Gupta, Y. K., Pérez-Pertejo, Y., Li, Y., Tang, Y., He, Y., Tse-Dinh, Y. C., Sidorova, Y. A., Yen, Y., Li, Y., Frangos, Z. J., Chung, Z., Su, Z., Wang, Z., Zhang, Z., Liu, Z., Inde, Z., Artía, Z. & Heifets, A., Dec 2024, In: Scientific Reports. 14, 1, 7526.

Research output: Contribution to journal › Article › peer-review

Open Access

20 Scopus citations

Atypical Mycobacterium abscessus BlaRI Ortholog Mediates Regulation of Energy Metabolism but Not β-Lactam Resistance

Bonefont, L. E., Davenport, H. C., Chaton, C. T., Korotkov, K. V. & Rohde, K. H., Sep 22 2024, (E-pub ahead of print) In: Molecular Microbiology.

Research output: Contribution to journal › Article › peer-review

Differential processing of VesB by two rhomboid proteases in Vibrio cholerae.

Roberts, C. S., Shannon, A. B., Korotkov, K. V. & Sandkvist, M., Sep 11 2024, In: mBio. 15, 9, p. e0127024

Research output: Contribution to journal › Article › peer-review

Disorder regulates homeostasis of extracytoplasmic proteins in streptococci

Rahman, M. M., Zamakhaeva, S., Rush, J. S., Chaton, C. T., Kenner, C. W., Hla, Y. M., Tsui, H-C. T., Winkler, M. E., Korotkov, K. V. & Korotkova, N., May 8 2024, In: bioRxiv.

Research output: Contribution to journal › Article

Structure and mechanism of biosynthesis of Streptococcus mutans cell wall polysaccharide.

Rush, J. S., Zamakhaeva, S., Murner, N. R., Deng, P., Morris, A. J., Kenner, C. W., Black, I., Heiss, C., Azadi, P., Korotkov, K. V., Widmalm, G. & Korotkova, N., May 9 2024, In: bioRxiv.

Research output: Contribution to journal › Article

The regulatory functions of ESX-1 substrates, EspE and EspF, are separable from secretion

Prest, R. J., Korotkov, K. V. & Champion, P. A., Aug 13 2024, (E-pub ahead of print) In: Journal of Bacteriology. p. e0027124

Research output: Contribution to journal › Article › peer-review

2023

Development and characterization of nanobodies that specifically target the oncogenic Phosphatase of Regenerating Liver-3 (PRL-3) and impact its interaction with a known binding partner, CNNM3

Smith, C. N., Kihn, K., Williamson, Z. A., Chow, K. M., Hersh, L. B., Korotkov, K. V., Deredge, D. & Blackburn, J. S., May 2023, In: PLoS ONE. 18, 5 May, e0285964.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Heterogeneity of the group B streptococcal type VII secretion system and influence on colonization of the female genital tract

Spencer, B. L., Job, A. M., Robertson, C. M., Hameed, Z. A., Serchejian, C., Wiafe-Kwakye, C. S., Mendonça, J. C., Apolonio, M. A., Nagao, P. E., Neely, M. N., Korotkova, N., Korotkov, K. V., Patras, K. A. & Doran, K. S., Aug 2023, In: Molecular Microbiology. 120, 2, p. 258-275 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

2022

Functional Analysis of EspM, an ESX-1-Associated Transcription Factor in Mycobacterium marinum

Sanchez, K. G., Prest, R. J., Nicholson, K. R., Korotkov, K. V. & Champion, P. A., Dec 2022, In: Journal of Bacteriology. 204, 12

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

PplD is a de-N-acetylase of the cell wall linkage unit of streptococcal rhamnopolysaccharides

Rush, J. S., Parajuli, P., Ruda, A., Li, J., Pohane, A. A., Zamakhaeva, S., Rahman, M. M., Chang, J. C., Gogos, A., Kenner, C. W., Lambeau, G., Federle, M. J., Korotkov, K. V., Widmalm, G. & Korotkova, N., Feb 1 2022, In: Nature Communications. 13, 1, p. 590

Research output: Contribution to journal › Article › peer-review

PplD is a de-N-acetylase of the cell wall linkage unit of streptococcal rhamnopolysaccharides

Rush, J. S., Parajuli, P., Ruda, A., Li, J., Pohane, A. A., Zamakhaeva, S., Rahman, M. M., Chang, J. C., Gogos, A., Kenner, C. W., Lambeau, G., Federle, M. J., Korotkov, K. V., Widmalm, G. & Korotkova, N., Dec 2022, In: Nature Communications. 13, 1, 590.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

2021

Modification of cell wall polysaccharide guides cell division in Streptococcus mutans

Zamakhaeva, S., Chaton, C. T., Rush, J. S., Ajay Castro, S., Kenner, C. W., Yarawsky, A. E., Herr, A. B., van Sorge, N. M., Dorfmueller, H. C., Frolenkov, G. I., Korotkov, K. V. & Korotkova, N., Aug 2021, In: Nature Chemical Biology. 17, 8, p. 878-887 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

20 Scopus citations

2020

Characterization of recombinant glutelin type-B 5-like protein from proso millet

Akharume, F., Korotkov, K. K. & Adedeji, A., 2020.

Research output: Contribution to conference › Paper

PE5–PPE4–EspG₃ heterotrimer structure from mycobacterial ESX-3 secretion system gives insight into cognate substrate recognition by ESX systems

Williamson, Z. A., Chaton, C. T., Ciocca, W. A., Korotkova, N. & Korotkov, K. V., Sep 4 2020, In: Journal of Biological Chemistry. 295, 36, p. 12706-12715 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

18 Scopus citations

Suppressor Mutations in Type II Secretion Mutants of Vibrio cholerae: Inactivation of the VesC Protease

Rule, C. S., Park, Y. J., Delarosa, J. R., Turley, S., Hol, W. G. J., McColm, S., Gura, C., DiMaio, F., Korotkov, K. V. & Sandkvist, M., 2020, In: mSphere. 5, 6, p. 1-18 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

2019

Architecture, function, and substrates of the type II secretion system

Korotkov, K. V. & Sandkvist, M., 2019, In: EcoSal Plus. 8, 2, p. 1-14 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

52 Scopus citations

Architecture, function, and substrates of the type II secretion system

Korotkov, K. V. & Sandkvist, M., Jan 1 2019, Protein Secretion in Bacteria. p. 227-244 18 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

2 Scopus citations

Discovery of glycerol phosphate modification on streptococcal rhamnose polysaccharides

Edgar, R. J., van Hensbergen, V. P., Ruda, A., Turner, A. G., Deng, P., Le Breton, Y., El-Sayed, N. M., Belew, A. T., McIver, K. S., McEwan, A. G., Morris, A., Lambeau, G., Walker, M. J., Rush, J. S., Korotkov, K. V., Widmalm, G., van Sorge, N. M. & Korotkova, N., May 1 2019, In: Nature Chemical Biology. 15, 5, p. 463-471 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

45 Scopus citations

Novel Antimycobacterial Compounds Suppress NAD Biogenesis by Targeting a Unique Pocket of NaMN Adenylyltransferase

Osterman, A. L., Rodionova, I., Li, X., Sergienko, E., Ma, C. T., Catanzaro, A., Pettigrove, M. E., Reed, R. W., Gupta, R., Rohde, K. H., Korotkov, K. V. & Sorci, L., May 17 2019, In: ACS Chemical Biology. 14, 5, p. 949-958 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

Structural analysis of mycobacterial homoserine transacetylases central to methionine biosynthesis reveals druggable active site

Chaton, C. T., Rodriguez, E. S., Reed, R. W., Li, J., Kenner, C. W. & Korotkov, K. V., Dec 1 2019, In: Scientific Reports. 9, 1, 20267.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

Structural Variability of EspG Chaperones from Mycobacterial ESX-1, ESX-3, and ESX-5 Type VII Secretion Systems

Tuukkanen, A. T., Freire, D., Chan, S., Arbing, M. A., Reed, R. W., Evans, T. J., Zenkeviciutė, G., Kim, J., Kahng, S., Sawaya, M. R., Chaton, C. T., Wilmanns, M., Eisenberg, D., Parret, A. H. A. & Korotkov, K. V., Jan 18 2019, In: Journal of Molecular Biology. 431, 2, p. 289-307 19 p.

Research output: Contribution to journal › Article › peer-review

Open Access

20 Scopus citations

The Mycobacterium tuberculosis Pup-proteasome system regulates nitrate metabolism through an essential protein quality control pathway

Becker, S. H., Jastrab, J. B., Dhabaria, A., Chaton, C. T., Rush, J. S., Korotkov, K. V., Ueberheide, B. & Heran Darwin, K., Feb 19 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 8, p. 3202-3210 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

20 Scopus citations

Type VII secretion substrates of pathogenic mycobacteria are processed by a surface protease

Burggraaf, M. J., Speer, A., Meijers, A. S., Ummels, R., Van Der Sar, A. M., Korotkov, K. V., Bitter, W. & Kuijl, C., 2019, In: mBio. 10, 5, e01951-19.

Research output: Contribution to journal › Article › peer-review

Open Access

23 Scopus citations

2018

Structural and functional insights into the role of BamD and BamE within the β-barrel assembly machinery in Neisseria gonorrhoeae

Sikora, A. E., Wierzbicki, I. H., Zielke, R. A., Ryner, R. F., Korotkov, K. V., Buchanan, S. K. & Noinaj, N., Jan 26 2018, In: Journal of Biological Chemistry. 293, 4, p. 1106-1119 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

31 Scopus citations

Targeting phosphatases of regenerating liver (PRLs) in cancer

Wei, M., Korotkov, K. V. & Blackburn, J. S., Oct 2018, In: Pharmacology and Therapeutics. 190, p. 128-138 11 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

31 Scopus citations

2017

Functional and structural studies on the Neisseria gonorrhoeae GmhA, the first enzyme in the glycero-manno-heptose biosynthesis pathways, demonstrate a critical role in lipooligosaccharide synthesis and gonococcal viability

Wierzbicki, I. H., Zielke, R. A., Korotkov, K. V. & Sikora, A. E., Apr 1 2017, In: MicrobiologyOpen. 6, 2, e00432.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

Peptide inhibitors targeting the Neisseria gonorrhoeae pivotal anaerobic respiration factor AniA

Sikora, A. E., Mills, R. H., Weber, J. V., Hamza, A., Passow, B. W., Romaine, A., Williamson, Z. A., Reed, R. W., Zielke, R. A. & Korotkov, K. V., Aug 2017, In: Antimicrobial Agents and Chemotherapy. 61, 8, e00186.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

The molecular mechanism of N-acetylglucosamine side-chain attachment to the Lancefield group A carbohydrate in Streptococcus pyogenes

Rush, J. S., Edgar, R. J., Deng, P., Chen, J., Zhu, H., Van Sorge, N. M., Morris, A. J., Korotkov, K. V. & Natalia Korotkova, X., Nov 24 2017, In: Journal of Biological Chemistry. 292, 47, p. 19441-19457 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

28 Scopus citations

2016

ALS mutant SOD1 interacts with G3BP1 and affects stress granule dynamics

Gal, J., Kuang, L., Barnett, K. R., Zhu, B. Z., Shissler, S. C., Korotkov, K. V., Hayward, L. J., Kasarskis, E. J. & Zhu, H., Oct 1 2016, In: Acta Neuropathologica. 132, 4, p. 563-576 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

82 Scopus citations

Dual function of C/D box small nucleolar RNAs in rRNA modification and alternative pre-mRNA splicing

Falaleeva, M., Pages, A., Matuszek, Z., Hidmi, S., Agranat-Tamir, L., Korotkov, K., Nevo, Y., Eyras, E., Sperling, R. & Stamm, S., Mar 22 2016, In: Proceedings of the National Academy of Sciences of the United States of America. 113, 12, p. E1625-E1634

Research output: Contribution to journal › Article › peer-review

Open Access

146 Scopus citations

Mycosins are required for the stabilization of the ESX-1 and ESX-5 type VII secretion membrane complexes

Van Winden, V. J. C., Ummels, R., Piersma, S. R., Jiménez, C. R., Korotkov, K. V., Bitter, W. & Houben, E. N. G., Sep 1 2016, In: mBio. 7, 5, e01471-16.

Research output: Contribution to journal › Article › peer-review

Open Access

49 Scopus citations

SpyB, a small heme-binding protein, affects the composition of the cell wall in Streptococcus pyogenes

Edgar, R. J., Chen, J., Kant, S., Rechkina, E., Rush, J. S., Forsberg, L. S., Jaehrig, B., Azadi, P., Tchesnokova, V., Sokurenko, E. V., Zhu, H., Korotkov, K. V., Pancholi, V. & Korotkova, N., Oct 13 2016, In: Frontiers in Cellular and Infection Microbiology. 6, OCT, 126.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

Structures of EccB₁ and EccD₁ from the core complex of the mycobacterial ESX-1 type VII secretion system

Wagner, J. M., Chan, S., Evans, T. J., Kahng, S., Kim, J., Arbing, M. A., Eisenberg, D. & Korotkov, K. V., Feb 27 2016, In: BMC Structural Biology. 16, 1, 5.

Research output: Contribution to journal › Article › peer-review

Open Access

26 Scopus citations

Targeting an essential GTPase obg for the development of broad-spectrum antibiotics

Bonventre, J. A., Zielke, R. A., Korotkov, K. V. & Sikora, A. E., Feb 1 2016, In: PLoS ONE. 11, 2, e0148222.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

2015

Structure of EspB, a secreted substrate of the ESX-1 secretion system of Mycobacterium tuberculosis

Korotkova, N., Piton, J., Wagner, J. M., Boy-Röttger, S., Japaridze, A., Evans, T. J., Cole, S. T., Pojer, F. & Korotkov, K. V., Aug 1 2015, In: Journal of Structural Biology. 191, 2, p. 236-244 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

42 Scopus citations

2014

Application of the 4D fingerprint method with a robust scoring function for scaffold-hopping and drug repurposing strategies

Hamza, A., Wagner, J. M., Wei, N. N., Kwiatkowski, S., Zhan, C. G., Watt, D. S. & Korotkov, K. V., Oct 27 2014, In: Journal of Chemical Information and Modeling. 54, 10, p. 2834-2845 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

Crystal structure of the full-length ATPase GspE from the Vibrio vulnificus type II secretion system in complex with the cytoplasmic domain of GspL

Lu, C., Korotkov, K. V. & Hol, W. G. J., Sep 2014, In: Journal of Structural Biology. 187, 3, p. 223-235 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

32 Scopus citations

Crystal structure of the N-terminal domain of EccA₁ ATPase from the ESX-1 secretion system of Mycobacterium tuberculosis

Wagner, J. M., Evans, T. J. & Korotkov, K. V., Jan 2014, In: Proteins: Structure, Function and Bioinformatics. 82, 1, p. 159-163 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

28 Scopus citations

Functional and structural characterization of vibrio cholerae extracellular serine protease B, VesB

Gadwal, S., Korotkov, K. V., Delarosa, J. R., Hol, W. G. J. & Sandkvist, M., Mar 21 2014, In: Journal of Biological Chemistry. 289, 12, p. 8288-8298 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

25 Scopus citations

Novel mycosin protease MycP₁ inhibitors identified by virtual screening and 4D fingerprints

Hamza, A., Wagner, J. M., Evans, T. J., Frasinyuk, M. S., Kwiatkowski, S., Zhan, C. G., Watt, D. S. & Korotkov, K. V., Apr 28 2014, In: Journal of Chemical Information and Modeling. 54, 4, p. 1166-1173 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

Pentapeptide boronic acid inhibitors of Mycobacterium tuberculosis MycP₁ protease

Frasinyuk, M. S., Kwiatkowski, S., Wagner, J. M., Evans, T. J., Reed, R. W., Korotkov, K. V. & Watt, D. S., Aug 1 2014, In: Bioorganic and Medicinal Chemistry Letters. 24, 15, p. 3546-3548 3 p.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

Structure of the Mycobacterium tuberculosis type VII secretion system chaperone EspG₅ in complex with PE25-PPE41 dimer

Korotkova, N., Freire, D., Phan, T. H., Ummels, R., Creekmore, C. C., Evans, T. J., Wilmanns, M., Bitter, W., Parret, A. H. A., Houben, E. N. G. & Korotkov, K. V., Oct 1 2014, In: Molecular Microbiology. 94, 2, p. 367-382 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

72 Scopus citations

Take five - Type VII secretion systems of Mycobacteria

Houben, E. N. G., Korotkov, K. V. & Bitter, W., Aug 2014, In: Biochimica et Biophysica Acta - Molecular Cell Research. 1843, 8, p. 1707-1716 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

161 Scopus citations

2013

A dodecameric ring-like structure of the N0 domain of the type II secretin from enterotoxigenic Escherichia coli

Korotkov, K. V., Delarosa, J. R. & Hol, W. G. J., Sep 2013, In: Journal of Structural Biology. 183, 3, p. 354-362 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

17 Scopus citations

Assembly of the Type II Secretion System such as Found in Vibrio cholerae Depends on the Novel Pilotin AspS

Dunstan, R. A., Heinz, E., Wijeyewickrema, L. C., Pike, R. N., Purcell, A. W., Evans, T. J., Praszkier, J., Robins-Browne, R. M., Strugnell, R. A., Korotkov, K. V. & Lithgow, T., Jan 2013, In: PLoS Pathogens. 9, 1, e1003117.

Research output: Contribution to journal › Article › peer-review

Open Access

56 Scopus citations

Crystal structure of the pilotin from the enterohemorrhagic Escherichia coli type II secretion system

Korotkov, K. V. & Hol, W. G. J., May 2013, In: Journal of Structural Biology. 182, 2, p. 186-191 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

Understanding specificity of the mycosin proteases in ESX/type VII secretion by structural and functional analysis

Wagner, J. M., Evans, T. J., Chen, J., Zhu, H., Houben, E. N. G., Bitter, W. & Korotkov, K. V., Nov 2013, In: Journal of Structural Biology. 184, 2, p. 115-128 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

33 Scopus citations

2012

The type II secretion system: Biogenesis, molecular architecture and mechanism

Korotkov, K. V., Sandkvist, M. & Hol, W. G. J., May 2012, In: Nature Reviews Microbiology. 10, 5, p. 336-351 16 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

379 Scopus citations

2011

Oligomerization of EpsE coordinates residues from multiple subunits to facilitate ATPase activity

Patrick, M., Korotkov, K. V., Hol, W. G. J. & Sandkvist, M., Mar 25 2011, In: Journal of Biological Chemistry. 286, 12, p. 10378-10386 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

24 Scopus citations

Screening a fragment cocktail library using ultrafiltration

Shibata, S., Zhang, Z., Korotkov, K. V., Delarosa, J., Napuli, A., Kelley, A. M., Mueller, N., Ross, J., Zucker, F. H., Buckner, F. S., Merritt, E. A., Verlinde, C. L. M. J., Van Voorhis, W. C., Hol, W. G. J. & Fan, E., Sep 2011, In: Analytical and Bioanalytical Chemistry. 401, 5, p. 1589-1595 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

Konstantin Korotkov

Research output

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