Konstantin Korotkov
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1994 …2024

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  • 2024

    AI is a viable alternative to high throughput screening: a 318-target study

    Wallach, I., Bernard, D., Nguyen, K., Ho, G., Morrison, A., Stecula, A., Rosnik, A., O’Sullivan, A. M., Davtyan, A., Samudio, B., Thomas, B., Worley, B., Butler, B., Laggner, C., Thayer, D., Moharreri, E., Friedland, G., Truong, H., van den Bedem, H. & Ng, H. L. & 668 others, Stafford, K., Sarangapani, K., Giesler, K., Ngo, L., Mysinger, M., Ahmed, M., Anthis, N. J., Henriksen, N., Gniewek, P., Eckert, S., de Oliveira, S., Suterwala, S., PrasadPrasad, S. V. K., Shek, S., Contreras, S., Hare, S., Palazzo, T., O’Brien, T. E., Van Grack, T., Williams, T., Chern, T. R., Kenyon, V., Lee, A. H., Cann, A. B., Bergman, B., Anderson, B. M., Cox, B. D., Warrington, J. M., Sorenson, J. M., Goldenberg, J. M., Young, M. A., DeHaan, N., Pemberton, R. P., Schroedl, S., Abramyan, T. M., Gupta, T., Mysore, V., Presser, A. G., Ferrando, A. A., Andricopulo, A. D., Ghosh, A., Ayachi, A. G., Mushtaq, A., Shaqra, A. M., Toh, A. K. L., Smrcka, A. V., Ciccia, A., de Oliveira, A. S., Sverzhinsky, A., de Sousa, A. M., Agoulnik, A. I., Kushnir, A., Freiberg, A. N., Statsyuk, A. V., Gingras, A. R., Degterev, A., Tomilov, A., Vrielink, A., Garaeva, A. A., Bryant-Friedrich, A., Caflisch, A., Patel, A. K., Rangarajan, A. V., Matheeussen, A., Battistoni, A., Caporali, A., Chini, A., Ilari, A., Mattevi, A., Foote, A. T., Trabocchi, A., Stahl, A., Herr, A. B., Berti, A., Freywald, A., Reidenbach, A. G., Lam, A., Cuddihy, A. R., White, A., Taglialatela, A., Ojha, A. K., Cathcart, A. M., Motyl, A. A. L., Borowska, A., D’Antuono, A., Hirsch, A. K. H., Porcelli, A. M., Minakova, A., Montanaro, A., Müller, A., Fiorillo, A., Virtanen, A., O’Donoghue, A. J., Del Rio Flores, A., Garmendia, A. E., Pineda-Lucena, A., Panganiban, A. T., Samantha, A., Chatterjee, A. K., Haas, A. L., Paparella, A. S., John, A. L. S., Prince, A., ElSheikh, A., Apfel, A. M., Colomba, A., O’Dea, A., Diallo, B. N., Ribeiro, B. M. R. M., Bailey-Elkin, B. A., Edelman, B. L., Liou, B., Perry, B., Chua, B. S. K., Kováts, B., Englinger, B., Balakrishnan, B., Gong, B., Agianian, B., Pressly, B., Salas, B. P. M., Duggan, B. M., Geisbrecht, B. V., Dymock, B. W., Morten, B. C., Hammock, B. D., Mota, B. E. F., Dickinson, B. C., Fraser, C., Lempicki, C., Novina, C. D., Torner, C., Ballatore, C., Bon, C., Chapman, C. J., Partch, C. L., Chaton, C. T., Huang, C., Yang, C. Y., Kahler, C. M., Karan, C., Keller, C., Dieck, C. L., Huimei, C., Liu, C., Peltier, C., Mantri, C. K., Kemet, C. M., Müller, C. E., Weber, C., Zeina, C. M., Muli, C. S., Morisseau, C., Alkan, C., Reglero, C., Loy, C. A., Wilson, C. M., Myhr, C., Arrigoni, C., Paulino, C., Santiago, C., Luo, D., Tumes, D. J., Keedy, D. A., Lawrence, D. A., Chen, D., Manor, D., Trader, D. J., Hildeman, D. A., Drewry, D. H., Dowling, D. J., Hosfield, D. J., Smith, D. M., Moreira, D., Siderovski, D. P., Shum, D., Krist, D. T., Riches, D. W. H., Ferraris, D. M., Anderson, D. H., Coombe, D. R., Welsbie, D. S., Hu, D., Ortiz, D., Alramadhani, D., Zhang, D., Chaudhuri, D., Slotboom, D. J., Ronning, D. R., Lee, D., Dirksen, D., Shoue, D. A., Zochodne, D. W., Krishnamurthy, D., Duncan, D., Glubb, D. M., Gelardi, E. L. M., Hsiao, E. C., Lynn, E. G., Silva, E. B., Aguilera, E., Lenci, E., Abraham, E. T., Lama, E., Mameli, E., Leung, E., Christensen, E. M., Mason, E. R., Petretto, E., Trakhtenberg, E. F., Rubin, E. J., Strauss, E., Thompson, E. W., Cione, E., Lisabeth, E. M., Fan, E., Kroon, E. G., Jo, E., García-Cuesta, E. M., Glukhov, E., Gavathiotis, E., Yu, F., Xiang, F., Leng, F., Wang, F., Ingoglia, F., van den Akker, F., Borriello, F., Vizeacoumar, F. J., Luh, F., Buckner, F. S., Vizeacoumar, F. S., Bdira, F. B., Svensson, F., Rodriguez, G. M., Bognár, G., Lembo, G., Zhang, G., Dempsey, G., Eitzen, G., Mayer, G., Greene, G. L., Garcia, G. A., Lukacs, G. L., Prikler, G., Parico, G. C. G., Colotti, G., De Keulenaer, G., Cortopassi, G., Roti, G., Girolimetti, G., Fiermonte, G., Gasparre, G., Leuzzi, G., Dahal, G., Michlewski, G., Conn, G. L., Stuchbury, G. D., Bowman, G. R., Popowicz, G. M., Veit, G., de Souza, G. E., Akk, G., Caljon, G., Alvarez, G., Rucinski, G., Lee, G., Cildir, G., Li, H., Breton, H. E., Jafar-Nejad, H., Zhou, H., Moore, H. P., Tilford, H., Yuan, H., Shim, H., Wulff, H., Hoppe, H., Chaytow, H., Tam, H. K., Van Remmen, H., Xu, H., Debonsi, H. M., Lieberman, H. B., Jung, H., Fan, H. Y., Feng, H., Zhou, H., Kim, H. J., Greig, I. R., Caliandro, I., Corvo, I., Arozarena, I., Mungrue, I. N., Verhamme, I. M., Qureshi, I. A., Lotsaris, I., Cakir, I., Perry, J. J. P., Kwiatkowski, J., Boorman, J., Ferreira, J., Fries, J., Kratz, J. M., Miner, J., Siqueira-Neto, J. L., Granneman, J. G., Ng, J., Shorter, J., Voss, J. H., Gebauer, J. M., Chuah, J., Mousa, J. J., Maynes, J. T., Evans, J. D., Dickhout, J., MacKeigan, J. P., Jossart, J. N., Zhou, J., Lin, J., Xu, J., Wang, J., Zhu, J., Liao, J., Xu, J., Zhao, J., Lin, J., Lee, J., Reis, J., Stetefeld, J., Bruning, J. B., Bruning, J. B., Coles, J. G., Tanner, J. J., Pascal, J. M., So, J., Pederick, J. L., Costoya, J. A., Rayman, J. B., Maciag, J. J., Nasburg, J. A., Gruber, J. J., Finkelstein, J. M., Watkins, J., Rodríguez-Frade, J. M., Arias, J. A. S., Lasarte, J. J., Oyarzabal, J., Milosavljevic, J., Cools, J., Lescar, J., Bogomolovas, J., Wang, J., Kee, J. M., Kee, J. M., Liao, J., Sistla, J. C., Abrahão, J. S., Sishtla, K., Francisco, K. R., Hansen, K. B., Molyneaux, K. A., Cunningham, K. A., Martin, K. R., Gadar, K., Ojo, K. K., Wong, K. S., Wentworth, K. L., Lai, K., Lobb, K. A., Hopkins, K. M., Parang, K., Machaca, K., Pham, K., Ghilarducci, K., Sugamori, K. S., McManus, K. J., Musta, K., Faller, K. M. E., Nagamori, K., Mostert, K. J., Korotkov, K. V., Liu, K., Smith, K. S., Sarosiek, K., Rohde, K. H., Kim, K. K., Lee, K. H., Pusztai, L., Lehtiö, L., Haupt, L. M., Cowen, L. E., Byrne, L. J., Su, L., Wert-Lamas, L., Puchades-Carrasco, L., Chen, L., Malkas, L. H., Zhuo, L., Hedstrom, L., Hedstrom, L., Walensky, L. D., Antonelli, L., Iommarini, L., Whitesell, L., Randall, L. M., Fathallah, M. D., Nagai, M. H., Kilkenny, M. L., Ben-Johny, M., Lussier, M. P., Windisch, M. P., Lolicato, M., Lolli, M. L., Vleminckx, M., Caroleo, M. C., Macias, M. J., Valli, M., Barghash, M. M., Mellado, M., Tye, M. A., Wilson, M. A., Hannink, M., Ashton, M. R., Cerna, M. V. C. D., Giorgis, M., Safo, M. K., Maurice, M. S., McDowell, M. A., Pasquali, M., Mehedi, M., Serafim, M. S. M., Soellner, M. B., Alteen, M. G., Champion, M. M., Skorodinsky, M., O’Mara, M. L., Bedi, M., Rizzi, M., Levin, M., Mowat, M., Jackson, M. R., Paige, M., Al-Yozbaki, M., Giardini, M. A., Maksimainen, M. M., De Luise, M., Hussain, M. S., Christodoulides, M., Stec, N., Zelinskaya, N., Van Pelt, N., Merrill, N. M., Singh, N., Kootstra, N. A., Singh, N., Gandhi, N. S., Chan, N. L., Trinh, N. M., Schneider, N. O., Matovic, N., Horstmann, N., Longo, N., Bharambe, N., Rouzbeh, N., Mahmoodi, N., Gumede, N. J., Anastasio, N. C., Khalaf, N. B., Rabal, O., Kandror, O., Escaffre, O., Silvennoinen, O., Bishop, O. T., Iglesias, P., Sobrado, P., Chuong, P., O’Connell, P., Martin-Malpartida, P., Mellor, P., Fish, P. V., Moreira, P. O. L., Zhou, P., Liu, P., Liu, P., Wu, P., Agogo-Mawuli, P., Jones, P. L., Ngoi, P., Toogood, P., Ip, P., von Hundelshausen, P., Lee, P. H., Rowswell-Turner, R. B., Balaña-Fouce, R., Rocha, R. E. O., Guido, R. V. C., Ferreira, R. S., Agrawal, R. K., Harijan, R. K., Ramachandran, R., Verma, R., Singh, R. K., Tiwari, R. K., Mazitschek, R., Koppisetti, R. K., Dame, R. T., Douville, R. N., Austin, R. C., Taylor, R. E., Moore, R. G., Ebright, R. H., Angell, R. M., Yan, R., Kejriwal, R., Batey, R. A., Blelloch, R., Vandenberg, R. J., Hickey, R. J., Kelm, R. J., Lake, R. J., Bradley, R. K., Blumenthal, R. M., Solano, R., Gierse, R. M., Viola, R. E., McCarthy, R. R., Reguera, R. M., Uribe, R. V., do Monte-Neto, R. L., Gorgoglione, R., Cullinane, R. T., Katyal, S., Hossain, S., Phadke, S., Shelburne, S. A., Geden, S. E., Johannsen, S., Wazir, S., Legare, S., Landfear, S. M., Radhakrishnan, S. K., Ammendola, S., Dzhumaev, S., Seo, S. Y., Li, S., Zhou, S., Chu, S., Chauhan, S., Maruta, S., Ashkar, S. R., Shyng, S. L., Conticello, S. G., Buroni, S., Garavaglia, S., White, S. J., Zhu, S., Tsimbalyuk, S., Chadni, S. H., Byun, S. Y., Park, S., Xu, S. Q., Banerjee, S., Zahler, S., Espinoza, S., Gustincich, S., Sainas, S., Celano, S. L., Capuzzi, S. J., Waggoner, S. N., Poirier, S., Olson, S. H., Marx, S. O., Van Doren, S. R., Sarilla, S., Brady-Kalnay, S. M., Dallman, S., Azeem, S. M., Teramoto, T., Mehlman, T., Swart, T., Abaffy, T., Akopian, T., Haikarainen, T., Moreda, T. L., Ikegami, T., Teixeira, T. R., Jayasinghe, T. D., Gillingwater, T. H., Kampourakis, T., Richardson, T. I., Herdendorf, T. J., Kotzé, T. J., O’Meara, T. R., Corson, T. W., Hermle, T., Ogunwa, T. H., Lan, T., Su, T., Banjo, T., O’Mara, T. A., Chou, T., Chou, T. F., Baumann, U., Desai, U. R., Pai, V. P., Thai, V. C., Tandon, V., Banerji, V., Robinson, V. L., Gunasekharan, V., Namasivayam, V., Segers, V. F. M., Maranda, V., Dolce, V., Maltarollo, V. G., Scoffone, V. C., Woods, V. A., Ronchi, V. P., Van Hung Le, V., Clayton, W. B., Lowther, W. T., Houry, W. A., Li, W., Tang, W., Zhang, W., Van Voorhis, W. C., Donaldson, W. A., Hahn, W. C., Kerr, W. G., Gerwick, W. H., Bradshaw, W. J., Foong, W. E., Blanchet, X., Wu, X., Lu, X., Qi, X., Xu, X., Yu, X., Qin, X., Wang, X., Yuan, X., Zhang, X., Zhang, Y. J., Hu, Y., Aldhamen, Y. A., Chen, Y., Li, Y., Sun, Y., Zhu, Y., Gupta, Y. K., Pérez-Pertejo, Y., Li, Y., Tang, Y., He, Y., Tse-Dinh, Y. C., Sidorova, Y. A., Yen, Y., Li, Y., Frangos, Z. J., Chung, Z., Su, Z., Wang, Z., Zhang, Z., Liu, Z., Inde, Z., Artía, Z. & Heifets, A., Dec 2024, In: Scientific Reports. 14, 1, 7526.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    21 Citations (SciVal)
  • Atypical Mycobacterium abscessus BlaRI Ortholog Mediates Regulation of Energy Metabolism but Not β-Lactam Resistance

    Bonefont, L. E., Davenport, H. C., Chaton, C. T., Korotkov, K. V. & Rohde, K. H., Sep 22 2024, (E-pub ahead of print) In: Molecular Microbiology.

    Research output: Contribution to journalArticlepeer-review

  • Differential processing of VesB by two rhomboid proteases in Vibrio cholerae.

    Roberts, C. S., Shannon, A. B., Korotkov, K. V. & Sandkvist, M., Sep 11 2024, In: mBio. 15, 9, p. e0127024

    Research output: Contribution to journalArticlepeer-review

  • Disorder regulates homeostasis of extracytoplasmic proteins in streptococci

    Rahman, M. M., Zamakhaeva, S., Rush, J. S., Chaton, C. T., Kenner, C. W., Hla, Y. M., Tsui, H.-C. T., Winkler, M. E., Korotkov, K. V. & Korotkova, N., May 8 2024, In: bioRxiv.

    Research output: Contribution to journalArticle

  • Structure and mechanism of biosynthesis of Streptococcus mutans cell wall polysaccharide.

    Rush, J. S., Zamakhaeva, S., Murner, N. R., Deng, P., Morris, A. J., Kenner, C. W., Black, I., Heiss, C., Azadi, P., Korotkov, K. V., Widmalm, G. & Korotkova, N., May 9 2024, In: bioRxiv.

    Research output: Contribution to journalArticle

  • The regulatory functions of ESX-1 substrates, EspE and EspF, are separable from secretion

    Prest, R. J., Korotkov, K. V. & Champion, P. A., Aug 13 2024, (E-pub ahead of print) In: Journal of Bacteriology. p. e0027124

    Research output: Contribution to journalArticlepeer-review

  • 2023

    Development and characterization of nanobodies that specifically target the oncogenic Phosphatase of Regenerating Liver-3 (PRL-3) and impact its interaction with a known binding partner, CNNM3

    Smith, C. N., Kihn, K., Williamson, Z. A., Chow, K. M., Hersh, L. B., Korotkov, K. V., Deredge, D. & Blackburn, J. S., May 2023, In: PLoS ONE. 18, 5 May, e0285964.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    3 Scopus citations
  • Heterogeneity of the group B streptococcal type VII secretion system and influence on colonization of the female genital tract

    Spencer, B. L., Job, A. M., Robertson, C. M., Hameed, Z. A., Serchejian, C., Wiafe-Kwakye, C. S., Mendonça, J. C., Apolonio, M. A., Nagao, P. E., Neely, M. N., Korotkova, N., Korotkov, K. V., Patras, K. A. & Doran, K. S., Aug 2023, In: Molecular Microbiology. 120, 2, p. 258-275 18 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    5 Scopus citations
  • 2022

    Functional Analysis of EspM, an ESX-1-Associated Transcription Factor in Mycobacterium marinum

    Sanchez, K. G., Prest, R. J., Nicholson, K. R., Korotkov, K. V. & Champion, P. A., Dec 2022, In: Journal of Bacteriology. 204, 12

    Research output: Contribution to journalArticlepeer-review

    Open Access
    3 Scopus citations
  • PplD is a de-N-acetylase of the cell wall linkage unit of streptococcal rhamnopolysaccharides

    Rush, J. S., Parajuli, P., Ruda, A., Li, J., Pohane, A. A., Zamakhaeva, S., Rahman, M. M., Chang, J. C., Gogos, A., Kenner, C. W., Lambeau, G., Federle, M. J., Korotkov, K. V., Widmalm, G. & Korotkova, N., Dec 2022, In: Nature Communications. 13, 1, 590.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    9 Scopus citations
  • PplD is a de-N-acetylase of the cell wall linkage unit of streptococcal rhamnopolysaccharides

    Rush, J. S., Parajuli, P., Ruda, A., Li, J., Pohane, A. A., Zamakhaeva, S., Rahman, M. M., Chang, J. C., Gogos, A., Kenner, C. W., Lambeau, G., Federle, M. J., Korotkov, K. V., Widmalm, G. & Korotkova, N., Feb 1 2022, In: Nature Communications. 13, 1, p. 590

    Research output: Contribution to journalArticlepeer-review

  • 2021

    Modification of cell wall polysaccharide guides cell division in Streptococcus mutans

    Zamakhaeva, S., Chaton, C. T., Rush, J. S., Ajay Castro, S., Kenner, C. W., Yarawsky, A. E., Herr, A. B., van Sorge, N. M., Dorfmueller, H. C., Frolenkov, G. I., Korotkov, K. V. & Korotkova, N., Aug 2021, In: Nature Chemical Biology. 17, 8, p. 878-887 10 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    20 Scopus citations
  • 2020

    PE5–PPE4–EspG3 heterotrimer structure from mycobacterial ESX-3 secretion system gives insight into cognate substrate recognition by ESX systems

    Williamson, Z. A., Chaton, C. T., Ciocca, W. A., Korotkova, N. & Korotkov, K. V., Sep 4 2020, In: Journal of Biological Chemistry. 295, 36, p. 12706-12715 10 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    18 Scopus citations
  • Suppressor Mutations in Type II Secretion Mutants of Vibrio cholerae: Inactivation of the VesC Protease

    Rule, C. S., Park, Y. J., Delarosa, J. R., Turley, S., Hol, W. G. J., McColm, S., Gura, C., DiMaio, F., Korotkov, K. V. & Sandkvist, M., 2020, In: mSphere. 5, 6, p. 1-18 18 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    3 Scopus citations
  • 2019

    Architecture, function, and substrates of the type II secretion system

    Korotkov, K. V. & Sandkvist, M., 2019, In: EcoSal Plus. 8, 2, p. 1-14 14 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    52 Scopus citations
  • Discovery of glycerol phosphate modification on streptococcal rhamnose polysaccharides

    Edgar, R. J., van Hensbergen, V. P., Ruda, A., Turner, A. G., Deng, P., Le Breton, Y., El-Sayed, N. M., Belew, A. T., McIver, K. S., McEwan, A. G., Morris, A., Lambeau, G., Walker, M. J., Rush, J. S., Korotkov, K. V., Widmalm, G., van Sorge, N. M. & Korotkova, N., May 1 2019, In: Nature Chemical Biology. 15, 5, p. 463-471 9 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    45 Scopus citations
  • Novel Antimycobacterial Compounds Suppress NAD Biogenesis by Targeting a Unique Pocket of NaMN Adenylyltransferase

    Osterman, A. L., Rodionova, I., Li, X., Sergienko, E., Ma, C. T., Catanzaro, A., Pettigrove, M. E., Reed, R. W., Gupta, R., Rohde, K. H., Korotkov, K. V. & Sorci, L., May 17 2019, In: ACS Chemical Biology. 14, 5, p. 949-958 10 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    14 Scopus citations
  • Structural analysis of mycobacterial homoserine transacetylases central to methionine biosynthesis reveals druggable active site

    Chaton, C. T., Rodriguez, E. S., Reed, R. W., Li, J., Kenner, C. W. & Korotkov, K. V., Dec 1 2019, In: Scientific Reports. 9, 1, 20267.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    10 Scopus citations
  • Structural Variability of EspG Chaperones from Mycobacterial ESX-1, ESX-3, and ESX-5 Type VII Secretion Systems

    Tuukkanen, A. T., Freire, D., Chan, S., Arbing, M. A., Reed, R. W., Evans, T. J., Zenkeviciutė, G., Kim, J., Kahng, S., Sawaya, M. R., Chaton, C. T., Wilmanns, M., Eisenberg, D., Parret, A. H. A. & Korotkov, K. V., Jan 18 2019, In: Journal of Molecular Biology. 431, 2, p. 289-307 19 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    20 Scopus citations
  • The Mycobacterium tuberculosis Pup-proteasome system regulates nitrate metabolism through an essential protein quality control pathway

    Becker, S. H., Jastrab, J. B., Dhabaria, A., Chaton, C. T., Rush, J. S., Korotkov, K. V., Ueberheide, B. & Heran Darwin, K., Feb 19 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 8, p. 3202-3210 9 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    20 Scopus citations
  • Type VII secretion substrates of pathogenic mycobacteria are processed by a surface protease

    Burggraaf, M. J., Speer, A., Meijers, A. S., Ummels, R., Van Der Sar, A. M., Korotkov, K. V., Bitter, W. & Kuijl, C., 2019, In: mBio. 10, 5, e01951-19.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    23 Scopus citations
  • 2018

    Structural and functional insights into the role of BamD and BamE within the β-barrel assembly machinery in Neisseria gonorrhoeae

    Sikora, A. E., Wierzbicki, I. H., Zielke, R. A., Ryner, R. F., Korotkov, K. V., Buchanan, S. K. & Noinaj, N., Jan 26 2018, In: Journal of Biological Chemistry. 293, 4, p. 1106-1119 14 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    31 Scopus citations
  • 2017

    Functional and structural studies on the Neisseria gonorrhoeae GmhA, the first enzyme in the glycero-manno-heptose biosynthesis pathways, demonstrate a critical role in lipooligosaccharide synthesis and gonococcal viability

    Wierzbicki, I. H., Zielke, R. A., Korotkov, K. V. & Sikora, A. E., Apr 1 2017, In: MicrobiologyOpen. 6, 2, e00432.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    19 Scopus citations
  • Peptide inhibitors targeting the Neisseria gonorrhoeae pivotal anaerobic respiration factor AniA

    Sikora, A. E., Mills, R. H., Weber, J. V., Hamza, A., Passow, B. W., Romaine, A., Williamson, Z. A., Reed, R. W., Zielke, R. A. & Korotkov, K. V., Aug 2017, In: Antimicrobial Agents and Chemotherapy. 61, 8, e00186.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    16 Scopus citations
  • The molecular mechanism of N-acetylglucosamine side-chain attachment to the Lancefield group A carbohydrate in Streptococcus pyogenes

    Rush, J. S., Edgar, R. J., Deng, P., Chen, J., Zhu, H., Van Sorge, N. M., Morris, A. J., Korotkov, K. V. & Natalia Korotkova, X., Nov 24 2017, In: Journal of Biological Chemistry. 292, 47, p. 19441-19457 17 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    28 Scopus citations
  • 2016

    ALS mutant SOD1 interacts with G3BP1 and affects stress granule dynamics

    Gal, J., Kuang, L., Barnett, K. R., Zhu, B. Z., Shissler, S. C., Korotkov, K. V., Hayward, L. J., Kasarskis, E. J. & Zhu, H., Oct 1 2016, In: Acta Neuropathologica. 132, 4, p. 563-576 14 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    82 Scopus citations
  • Dual function of C/D box small nucleolar RNAs in rRNA modification and alternative pre-mRNA splicing

    Falaleeva, M., Pages, A., Matuszek, Z., Hidmi, S., Agranat-Tamir, L., Korotkov, K., Nevo, Y., Eyras, E., Sperling, R. & Stamm, S., Mar 22 2016, In: Proceedings of the National Academy of Sciences of the United States of America. 113, 12, p. E1625-E1634

    Research output: Contribution to journalArticlepeer-review

    Open Access
    146 Scopus citations
  • Mycosins are required for the stabilization of the ESX-1 and ESX-5 type VII secretion membrane complexes

    Van Winden, V. J. C., Ummels, R., Piersma, S. R., Jiménez, C. R., Korotkov, K. V., Bitter, W. & Houben, E. N. G., Sep 1 2016, In: mBio. 7, 5, e01471-16.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    49 Scopus citations
  • SpyB, a small heme-binding protein, affects the composition of the cell wall in Streptococcus pyogenes

    Edgar, R. J., Chen, J., Kant, S., Rechkina, E., Rush, J. S., Forsberg, L. S., Jaehrig, B., Azadi, P., Tchesnokova, V., Sokurenko, E. V., Zhu, H., Korotkov, K. V., Pancholi, V. & Korotkova, N., Oct 13 2016, In: Frontiers in Cellular and Infection Microbiology. 6, OCT, 126.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    6 Scopus citations
  • Structures of EccB1 and EccD1 from the core complex of the mycobacterial ESX-1 type VII secretion system

    Wagner, J. M., Chan, S., Evans, T. J., Kahng, S., Kim, J., Arbing, M. A., Eisenberg, D. & Korotkov, K. V., Feb 27 2016, In: BMC Structural Biology. 16, 1, 5.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    26 Scopus citations
  • Targeting an essential GTPase obg for the development of broad-spectrum antibiotics

    Bonventre, J. A., Zielke, R. A., Korotkov, K. V. & Sikora, A. E., Feb 1 2016, In: PLoS ONE. 11, 2, e0148222.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    10 Scopus citations
  • 2015

    Structure of EspB, a secreted substrate of the ESX-1 secretion system of Mycobacterium tuberculosis

    Korotkova, N., Piton, J., Wagner, J. M., Boy-Röttger, S., Japaridze, A., Evans, T. J., Cole, S. T., Pojer, F. & Korotkov, K. V., Aug 1 2015, In: Journal of Structural Biology. 191, 2, p. 236-244 9 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    42 Scopus citations
  • 2014

    Application of the 4D fingerprint method with a robust scoring function for scaffold-hopping and drug repurposing strategies

    Hamza, A., Wagner, J. M., Wei, N. N., Kwiatkowski, S., Zhan, C. G., Watt, D. S. & Korotkov, K. V., Oct 27 2014, In: Journal of Chemical Information and Modeling. 54, 10, p. 2834-2845 12 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    14 Scopus citations
  • Crystal structure of the full-length ATPase GspE from the Vibrio vulnificus type II secretion system in complex with the cytoplasmic domain of GspL

    Lu, C., Korotkov, K. V. & Hol, W. G. J., Sep 2014, In: Journal of Structural Biology. 187, 3, p. 223-235 13 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    32 Scopus citations
  • Crystal structure of the N-terminal domain of EccA1 ATPase from the ESX-1 secretion system of Mycobacterium tuberculosis

    Wagner, J. M., Evans, T. J. & Korotkov, K. V., Jan 2014, In: Proteins: Structure, Function and Bioinformatics. 82, 1, p. 159-163 5 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    28 Scopus citations
  • Functional and structural characterization of vibrio cholerae extracellular serine protease B, VesB

    Gadwal, S., Korotkov, K. V., Delarosa, J. R., Hol, W. G. J. & Sandkvist, M., Mar 21 2014, In: Journal of Biological Chemistry. 289, 12, p. 8288-8298 11 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    25 Scopus citations
  • Novel mycosin protease MycP1 inhibitors identified by virtual screening and 4D fingerprints

    Hamza, A., Wagner, J. M., Evans, T. J., Frasinyuk, M. S., Kwiatkowski, S., Zhan, C. G., Watt, D. S. & Korotkov, K. V., Apr 28 2014, In: Journal of Chemical Information and Modeling. 54, 4, p. 1166-1173 8 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    15 Scopus citations
  • Pentapeptide boronic acid inhibitors of Mycobacterium tuberculosis MycP1 protease

    Frasinyuk, M. S., Kwiatkowski, S., Wagner, J. M., Evans, T. J., Reed, R. W., Korotkov, K. V. & Watt, D. S., Aug 1 2014, In: Bioorganic and Medicinal Chemistry Letters. 24, 15, p. 3546-3548 3 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    13 Scopus citations
  • Structure of the Mycobacterium tuberculosis type VII secretion system chaperone EspG5 in complex with PE25-PPE41 dimer

    Korotkova, N., Freire, D., Phan, T. H., Ummels, R., Creekmore, C. C., Evans, T. J., Wilmanns, M., Bitter, W., Parret, A. H. A., Houben, E. N. G. & Korotkov, K. V., Oct 1 2014, In: Molecular Microbiology. 94, 2, p. 367-382 16 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    72 Scopus citations
  • Take five - Type VII secretion systems of Mycobacteria

    Houben, E. N. G., Korotkov, K. V. & Bitter, W., Aug 2014, In: Biochimica et Biophysica Acta - Molecular Cell Research. 1843, 8, p. 1707-1716 10 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    161 Scopus citations
  • 2013

    A dodecameric ring-like structure of the N0 domain of the type II secretin from enterotoxigenic Escherichia coli

    Korotkov, K. V., Delarosa, J. R. & Hol, W. G. J., Sep 2013, In: Journal of Structural Biology. 183, 3, p. 354-362 9 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    17 Scopus citations
  • Assembly of the Type II Secretion System such as Found in Vibrio cholerae Depends on the Novel Pilotin AspS

    Dunstan, R. A., Heinz, E., Wijeyewickrema, L. C., Pike, R. N., Purcell, A. W., Evans, T. J., Praszkier, J., Robins-Browne, R. M., Strugnell, R. A., Korotkov, K. V. & Lithgow, T., Jan 2013, In: PLoS Pathogens. 9, 1, e1003117.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    56 Scopus citations
  • Crystal structure of the pilotin from the enterohemorrhagic Escherichia coli type II secretion system

    Korotkov, K. V. & Hol, W. G. J., May 2013, In: Journal of Structural Biology. 182, 2, p. 186-191 6 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    10 Scopus citations
  • Understanding specificity of the mycosin proteases in ESX/type VII secretion by structural and functional analysis

    Wagner, J. M., Evans, T. J., Chen, J., Zhu, H., Houben, E. N. G., Bitter, W. & Korotkov, K. V., Nov 2013, In: Journal of Structural Biology. 184, 2, p. 115-128 14 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    34 Scopus citations
  • 2011

    Oligomerization of EpsE coordinates residues from multiple subunits to facilitate ATPase activity

    Patrick, M., Korotkov, K. V., Hol, W. G. J. & Sandkvist, M., Mar 25 2011, In: Journal of Biological Chemistry. 286, 12, p. 10378-10386 9 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    24 Scopus citations
  • Screening a fragment cocktail library using ultrafiltration

    Shibata, S., Zhang, Z., Korotkov, K. V., Delarosa, J., Napuli, A., Kelley, A. M., Mueller, N., Ross, J., Zucker, F. H., Buckner, F. S., Merritt, E. A., Verlinde, C. L. M. J., Van Voorhis, W. C., Hol, W. G. J. & Fan, E., Sep 2011, In: Analytical and Bioanalytical Chemistry. 401, 5, p. 1589-1595 7 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    8 Scopus citations
  • Structural and functional studies on the interaction of gspc and gspd in the type ii secretion system

    Korotkov, K. V., Johnson, T. L., Jobling, M. G., Pruneda, J., Pardon, E., Héroux, A., Turley, S., Steyaert, J., Holmes, R. K., Sandkvist, M. & Hol, W. G. J., Sep 2011, In: PLoS Pathogens. 7, 9, e1002228.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    78 Scopus citations
  • The binding of cholera toxin to the periplasmic vestibule of the type II secretion channel

    Reichow, S. L., Korotkov, K. V., Gonen, M., Sun, J., Delarosa, J. R., Hol, W. G. J. & Gonen, T., 2011, In: Channels. 5, 3, p. 215-218 4 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    40 Scopus citations
  • 2010

    Structure of the cholera toxin secretion channel in its closed state

    Reichow, S. L., Korotkov, K. V., Hol, W. G. J. & Gonen, T., Oct 2010, In: Nature Structural and Molecular Biology. 17, 10, p. 1226-1232 7 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    118 Scopus citations
  • 2009

    Calcium is essential for the major pseudopilin in the type 2 secretion system

    Korotkov, K. V., Gray, M. D., Kreger, A., Turley, S., Sandkvist, M. & Hol, W. G. J., Sep 18 2009, In: Journal of Biological Chemistry. 284, 38, p. 25466-25470 5 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    39 Scopus citations
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