Personal profile
Research Interests
Research in the Cassis laboratory focuses on the renin-angiotensin system in cardiovascular and metabolic diseases. This includes studies focused on hypertension, aortic aneurysmal disease, obesity and associated diseases, and COVID-19 in the context of the renin-angiotensin system. An area of emphasis is on biologic determinants of sex and how they influence the development and treatment of disease.
Education/Academic qualification
Doctor of Philosophy, West Virginia University
1984
Bachelor of Science, West Virginia University
1980
Keywords
- RM Therapeutics. Pharmacology
- QP Physiology
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being -
SDG 13 Climate Action
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Collaborations and top research areas from the last five years
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KY EPSCoR: FY26: Administrative Costs
Messaoudi Powers, I. (PI) & Cassis, L. (Former PI)
7/1/24 → 6/30/26
Project: Research project
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The Serotonergic System in Periaortic Fat Regulates Regional Aortopathy Development
Cassis, L. (PI), Alsiraj, Y. (CoI), Blalock, E. (CoI), Loria Kinsey, A. (CoI) & Nikolajczyk, B. (Former CoI)
National Heart Lung and Blood Institute
8/1/23 → 7/31/27
Project: Research project
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Unliquidated Obligations Year 3: NRSA T32: Training in Translational Research in Alzheimer's and Related Dementias (TRIAD)
Van Eldik, L. (PI), Cassis, L. (CoI), Gerhardt, G. (CoI), Saatman, K. (CoI), Schoenberg, N. (CoI), Spear, B. (CoI), Murphy, M. (CoPI) & Webb, N. (Former CoI)
8/1/22 → 7/31/27
Project: Research project
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NRSA T32: Training in Translational Research in Alzheimer's and Related Dementias (TRIAD)
Van Eldik, L. (PI), Cassis, L. (CoI), Gerhardt, G. (CoI), Saatman, K. (CoI), Schoenberg, N. (CoI), Spear, B. (CoI), Murphy, M. (CoPI) & Webb, N. (Former CoI)
8/1/22 → 7/31/27
Project: Research project
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Center for Appalachian Research in Environmental Sciences: Administrative Core
Haynes, E. (PI), Bauer, J. (CoI), Cassis, L. (CoI), Christian, J. (CoI), Cox, N. (CoI), Curry, T. (CoI), Dignan, M. (CoI), Evers, B. M. (CoI), Fan, W.-M. (CoI), Hannon, P. (CoI), Hoover, A. (CoI), Pearson, K. (CoI), Pennell, K. (CoI), Sanderson, W. (CoI), Schoenberg, N. (CoI), Stanifer, S. (CoI), Stratton, T. (CoI), Swanson, H. (CoI), Talbert, J. (CoI), Unrine, J. (CoI), Hahn, E. (Former PI), Arnett, D. (Former CoI), DiPaola, R. (Former CoI), Heath, E. (Former CoI), Kern, P. (Former CoI), May, B. (Former CoI), Miller, J. (Former CoI), Richardson, K. (Former CoI), Stanley, S. (Former CoI) & Stromberg, A. (Former CoI)
National Institute of Environmental Health Sciences
5/1/17 → 4/30/28
Project: Research project
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Role of adipocyte angiotensinogen or angiotensin type 1a receptors in the development of diet-induced atherosclerosis or angiotensin II-induced abdominal aortic aneurysms
AlSiraj, Y., Putnam, K., Brunner, S. I., English, V. L., Ensor, C. M. & Cassis, L. A., 2026, In: JVS-Vascular Science. 7, 100397.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Institutional requirement and central tracking of RCR training of all researchers and research eligible individuals
Lake-Bullock, H., Smith, J., Matuszak, E., Chun, J., Hill, J., Clark, B., Lodder, L., Wolf, B. & Cassis, L., Jul 2025, In: Research Ethics. 21, 3, p. 425-447 23 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Nicotine promotes AngII-induced abdominal aortic aortopathies in female and male mice: role of sex hormones
Ensor, M., Thatcher, S. E., McQuerry, K., Heier, K., Ali, H. M., English, V., Cassis, L. A. & Alsiraj, Y., Apr 2025, In: Clinical Science. 139, 8, p. 411-429 19 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Serotonin 3 receptor antagonism reduces angiotensin II–induced abdominal aortic aneurysms: Contribution of periaortic fat–derived serotonin
AlSiraj, Y., Ensor, C. M., English, V., Loria, A., Ali, H. & Cassis, L. A., Feb 2025, In: Journal of Pharmacology and Experimental Therapeutics. 392, 2, 100533.Research output: Contribution to journal › Article › peer-review
Open Access -
Obese Male Mice Exposed to Early Life Stress Display Sympathetic Activation and Hypertension Independent of Circulating Angiotensin II
Dalmasso, C., Ahmed, N. S., Ghuneim, S., Cincinelli, C., Leachman, J. R., Giani, J. F., Cassis, L. & Loria, A. S., Jan 2 2024, In: Journal of the American Heart Association. 13, 1, e029511.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations