Personal profile
Research Interests
Shaddox main research interests are aimed at evaluating immunological, microbiological and genetic factors involved with localized aggressive periodontal disease in children and adolescents. Shaddox’s recent NIH R01 grant renewal is aimed at expanding this cohort to tease out possible genetic markers and specific inflammatory mechanisms playing a role in this disease.
She has also led a clinical research project to investigate the relationship between periodontal disease and type II diabetes mellitus and its inflammatory response to bacteria, and how this relationship is associated with diabetics’ clinical response to treatment.
Education/Academic qualification
Doctor of Philosophy, State UniversityOf Campinas
2005
Master of Science, State UniversityOf Campinas
2003
Doctor of Dental Science, State UniversityOf Campinas
2001
External positions
NIDCR Study Section Member
2021 → 2024
AADR Fellow
2021 → …
Task Force for Design and Analysis in Dental and Oral Research Member
2021 → …
AADOCR Member at Large
Keywords
- RK Dentistry
- Periodontitis
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being -
SDG 5 Gender Equality -
SDG 10 Reduced Inequalities
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Collaborations and top research areas from the last five years
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Dental Providers Building Confidence in HPV Vaccination: Reducing Oral Cancer and Increasing HPV Vaccine Uptake: A Community Engaged Approach to Formative Data Insight and Strategic Campaign Design in Appalachian Kentucky
Stein, P. (PI), Helme, D. (CoI), Ivanov, B. (CoI), Parker, K. (CoI) & Shaddox, L. (CoI)
7/25/25 → 1/1/27
Project: Research project
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Understanding the Association Between Sublingual Buprenorphine and Oral Health Outcomes
Rojas Ramirez, M. (PI), Boggero, I. (CoI), Gonzalez Duque, O. (CoI), Lofwall, M. (CoI), Miller, C. (CoI), Moga, D. (CoI), Omami, G. (CoI), Shaddox, L. (CoI), Westgate, P. (CoI), Oyler, D. (CoPI) & Adatorwovor, R. (Former CoI)
National Institute of Dental and Craniofacial Research
9/21/23 → 8/31/28
Project: Research project
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Initial Evidence for a Brief Psychological Telehealth Intervention for Patients with Chronic Masticatory Muscle Pain
Boggero, I. (PI), Adatorwovor, R. (CoI), Bush, M. (CoI), Moreno Hay, I. (CoI) & Shaddox, L. (CoI)
National Institute of Dental and Craniofacial Research
9/1/23 → 8/31/28
Project: Research project
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A Randomized Controlled Trial to Evaluate the Effectiveness of an HPV Vaccination Recommendation Delivered by Dental Providers Versus No Dental Provider HPV Vaccine Recommendation
Shaddox, L. (PI), Adatorwovor, R. (CoI), Stein, P. (CoI) & Stone, D. (Former CoI)
3/1/23 → 3/8/26
Project: Research project
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Susceptibility Patterns for Grade C Periodontitis in Young Individuals
Shaddox, L. (PI), Adatorwovor, R. (CoI), Hartsfield Jr, J. (CoI), Morford, L. (CoI), Moseley, H. (CoI), Santamaria, M. (CoI) & Talbert, J. (CoI)
National Institute of Dental and Craniofacial Research
9/22/22 → 8/31/27
Project: Research project
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Localized Periodontitis in Young Individuals: Aggregatibacter JP2 Clone, Immunological Dysfunctions and Other Stories
Nibali, L., Alamri, M. M., Miguel, M. M. V. & Shaddox, L., 2026, (Accepted/In press) In: Journal of Periodontal Research.Research output: Contribution to journal › Review article › peer-review
Open Access -
Molar–Incisor and Generalized Grade C Periodontitis: Distinct Microbiome–Immune Interactions Suggest Divergent Pathogenesis
Stolf, C. S., Paz, H. E. S., Paraluppi, M. C., Miguel, M. M. V., Santamaria, M. P., Monteiro, M. F., Amgarten, D. E., Franco, R. R. A., Branco-de-Almeida, L. S., Shaddox, L. M. & Casarin, R. C. V., 2026, (Accepted/In press) In: Journal of Periodontal Research.Research output: Contribution to journal › Article › peer-review
Open Access -
The impact of periodontal therapy on clinical and inflammatory parameters in type II diabetics
Tokatlian, J., Al-Sabbagh, M., Dawson, D. R., Pearce, K. A., Andriankaja, M. O., Adatorwovor, R., Miguel, M. M. V. & Shaddox, L. M., 2026, (Accepted/In press) In: Journal of Periodontology.Research output: Contribution to journal › Article › peer-review
Open Access -
Unraveling the Microbial Mosaic and Inflammatory Core of Peri-implantitis
Casarin, R. C. V., Bonilha, G. M., Paz, H., Cerquera, T. B., Stolf, C. S., Pimentel, S. P., Fernandes, W. A. M., Noronha, M. F., Carvalho, L. M., Casati, M. Z., Shaddox, L. M., Santamaria, M. P. & Monteiro, M. F., Feb 2026, In: Journal of Dental Research. 105, 2, p. 267-275 9 p.Research output: Contribution to journal › Article › peer-review
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Antibiotics in the treatment of young patients with molar-incisor pattern periodontitis (C-MIP)
Miguel, M. M. V., Santamaria, M. P., Casarin, R. C. V., Stolf, C. S., Branco-de-Almeida, L. S. & Shaddox, L. M., 2025, (Accepted/In press) In: Periodontology 2000.Research output: Contribution to journal › Review article › peer-review
Open Access