Luksana Chaiswing, Ph.D.

Calculated based on number of publications stored in Pure and citations from Scopus
20022022

Research activity per year

If you made any changes in Pure these will be visible here soon.

Personal profile

Research Interests

My research interests are centered on the role(s) of redox state and cancer progression, particularly, subcellular redox states. Elucidating the molecular mechanisms underlying redox state-regulated gene/protein expression is critical for understanding the behavior of cancer cells.

Previously, we discovered that both intra- and extracellular redox states were significantly different between prostate cancer cells and normal prostate epithelial cells; the intracellular redox state becomes more oxidized while the extracellular redox state becomes more reduced in prostate cancer cell lines. These differences correlated with prostate cancer cell growth and invasion.

Additionally, alteration of extracellular redox state by overexpression of extracellular superoxide dismutase (ECSOD) or decreasing of extracellular spaces redox potential values through varying cysteine/cystine ratio significantly inhibited prostate cancer invasion, whereas alteration of intracellular redox state by overexpression of manganese superoxide dismutase (MnSOD) or treatment with glutathione-depleting compounds significantly inhibited cell growth.

Currently, we investigate the expression levels of selected antioxidant proteins (e.g. MnSOD, thioredoxin 1, or ECSOD) at specific subcellular organelle in epithelial vs. stromal cells of benign vs. cancer tissues of prostate cancer patients using immunohistochemistry staining with specific antibodies and Aperio Image analysis system. The study is the first to focus on site-specific intra- and extracellular redox imbalances as new therapeutic target proteins for prostate cancer treatment. Another important and exciting aspect of my current work is using the cutting-edge tool, nitroxides-enhanced MRI to measure tissue redox activity in prostate cancer of living mice. The assay is based on nitroxides redox cycling coupled with the appearance/disappearance of an enhanced MRI signal, which makes them useful molecular sensors for changing redox state. This method may be used as a tool for diagnosis and therapy guidance since it has low toxicity, minimal side effects, and has a short half-life for imaging.

In summary, differences in tissue redox activities and antioxidant protein levels may serve as biomarkers to identify cancer from non-cancer in prostate biopsies and identify patients with low-grade cancers who will progress to high-grade cancers, providing possible new information to guide therapeutic decisions.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Education/Academic qualification

Post Doctoral Scholar, Univ Of Wisconsin-Madison

2009

Doctor of Philosophy, Mahidol University

2004

Bachelor of Science, Mahidol University

1999

Fingerprint

Dive into the research topics where Luksana Chaiswing is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
  • 1 Similar Profiles

Network

Recent external collaboration from the last 5 years on country level. Dive into details by clicking on the dots.