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Gene regulation at transcriptional and post-transcriptional levels has been the central focus of my research program. While transcription initiation begins the process of gene expression, the post-transcriptional steps of RNA splicing, cleavage polyadenylation, transport and stability all contribute to the type and final levels of a protein that will be produced. In addition, these steps are coupled to each other, which can contribute to overall regulation.
My lab has been studying several different model systems that allow us to address aspects of gene regulation including immunoglobulin gene expression during B lymphocyte development and, in collaboration with the lab of Brett Spear, liver development and disease. In the liver, we have identified Zhx2 as a regulator of genes involved in lipid metabolism and genes that are misregulated during liver cancer.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Doctor of Philosophy, University Of Wisconsin-Madison
Bachelor of Arts, Augustana College
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9/1/22 → 8/31/27
Project: Research project
Frazier, D., D'Orazio, S., Davidshofer, E., Duncan, B., Estus, G., Glueck, A., Grzech, K., Herron, S., Lee, L., Loria Kinsey, A., McCullers, M., Murphy, M., Nickell, M., Park-Sarge, O., Scott, S., Selwitz, A., Stratton, T., Spear, B., Bradley, L., DeRouchey, J., Fondufe-Mittendorf, Y., McConnell, M., Pearson, K., Peterson, M. & Stevens-Watkins, D.
9/1/18 → 8/31/24
Project: Research project
Zinc fingers and homeoboxes 2 is required for diethylnitrosamine-induced liver tumor formation in C57BL/6 miceJiang, J., Turpin, C., Qiu, G., Xu, M., Lee, E., Hinds, T. D., Peterson, M. L. & Spear, B. T., Dec 2022, In: Hepatology Communications. 6, 12, p. 3550-3562 13 p.
Research output: Contribution to journal › Article › peer-reviewOpen Access3 Scopus citations
Highly homologous mouse Cyp2a4 and Cyp2a5 genes are differentially expressed in the liver and both express long non-coding antisense RNAsNail, A. N., Spear, B. T. & Peterson, M. L., Jan 30 2021, In: Gene. 767, 145162.
Research output: Contribution to journal › Article › peer-review4 Scopus citations
Evolutionary Analysis of the Zinc Finger and Homeoboxes Family of Proteins Identifies Multiple Conserved Domains and a Common Early Chordate AncestorNail, A. N., Smith, J. J., Peterson, M. L., Spear, B. T. & Das, S., Mar 17 2020, In: Genome Biology and Evolution. 12, 3, p. 174-184 11 p.
Research output: Contribution to journal › Article › peer-reviewOpen Access2 Scopus citations
Liver size and lipid content differences between BALB/c and BALB/cJ mice on a high-fat diet are due, in part, to Zhx2Clinkenbeard, E. L., Turpin, C., Jiang, J., Peterson, M. L. & Spear, B. T., Aug 1 2019, In: Mammalian Genome. 30, 7-8, p. 226-236 11 p.
Research output: Contribution to journal › Article › peer-review9 Scopus citations
Zhx2 (zinc fingers and homeoboxes 2) regulates major urinary protein gene expression in the mouse liverJiang, J., Creasy, K. T., Purnell, J., Peterson, M. L. & Spear, B. T., Apr 21 2017, In: Journal of Biological Chemistry. 292, 16, p. 6765-6774 10 p.
Research output: Contribution to journal › Article › peer-reviewOpen Access18 Scopus citations