Projects and Grants per year
Personal profile
Research Interests
Gene regulation at transcriptional and post-transcriptional levels has been the central focus of my research program. While transcription initiation begins the process of gene expression, the post-transcriptional steps of RNA splicing, cleavage polyadenylation, transport and stability all contribute to the type and final levels of a protein that will be produced. In addition, these steps are coupled to each other, which can contribute to overall regulation.
My lab has been studying several different model systems that allow us to address aspects of gene regulation including immunoglobulin gene expression during B lymphocyte development and, in collaboration with the lab of Brett Spear, liver development and disease. In the liver, we have identified Zhx2 as a regulator of genes involved in lipid metabolism and genes that are misregulated during liver cancer.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Doctor of Philosophy, University Of Wisconsin-Madison
1984
Bachelor of Arts, Augustana College
1979
Fingerprint
- 1 Similar Profiles
Collaborations and top research areas from the last five years
-
University of Kentucky SuRE Resource Center
Spear, B. (PI), D'Orazio, S. (CoI), Dupont-Versteegden, E. (CoI), Fardo, D. (CoI), Loria Kinsey, A. (CoI), Murphy, M. (CoI), Nickell, M. (CoI), Peterson, M. (CoI), Rice, B. (CoI), Smalls, B. (CoI), Stevens-Watkins, D. (CoI), Stratton, T. (CoI) & Wolf, B. G. (CoI)
National Institute of General Medical Sciences
9/5/22 → 8/31/27
Project: Research project
-
National Science Foundation Graduate Research Fellowship Program
Kenney, P. (PI) & Peterson, M. (Former PI)
9/1/22 → 8/31/27
Project: Research project
-
LSAMP BD: University of Kentucky, KY-WV LSAMP
DiPaola, R. (PI), Kenney, P. (CoI), Parker, J. (CoI), Spear, B. (CoI), Wright, G. (CoI), Blackwell, D. (Former PI), Feist-Price, S. (Former CoI), Jackson, B. (Former CoI), Peterson, M. (Former CoI), Pittman, M. (Former CoI), Williams, F. (Former CoI) & Wright, G. (Former CoI)
6/1/20 → 5/31/25
Project: Research project
-
Participant Support: LSAMP BD: University of Kentucky, KY-WV LSAMP
DiPaola, R. (PI), Kenney, P. (CoI), Parker, J. (CoI), Spear, B. (CoI), Blackwell, D. (Former PI), Feist-Price, S. (Former CoI), Jackson, B. (Former CoI), Peterson, M. (Former CoI), Pittman, M. (Former CoI), Williams, F. (Former CoI) & Wright, G. (Former CoI)
6/1/20 → 5/31/25
Project: Research project
-
Interactive Mentoring to Enhance Research Skills (IMERS)
Spear, B. (PI), D'Orazio, S. (CoI), Davidshofer, E. (CoI), Duncan, B. (CoI), Estus, G. (CoI), Frazier, D. (CoI), Glueck, A. (CoI), Grzech, K. (CoI), Herron, S. (CoI), Lee, L. (CoI), Loria Kinsey, A. (CoI), Murphy, M. (CoI), Nickell, M. (CoI), Park-Sarge, O.-K. (CoI), Selwitz, A. (CoI), Stratton, T. (CoI), Bradley, L. (Former CoI), DeRouchey, J. (Former CoI), Fondufe-Mittendorf, Y. (Former CoI), McConnell, M. (Former CoI), McCullers, M. (Former CoI), Pearson, K. (Former CoI), Peterson, M. (Former CoI), Scott, S. (Former CoI) & Stevens-Watkins, D. (Former CoI)
National Institute of General Medical Sciences
9/1/18 → 8/31/25
Project: Research project
-
Elongation of very long chain fatty acids-3 (Elovl3) is activated by ZHX2 and is a regulator of cell cycle progression
Creasy, K. T., Ren, H., Jiang, J., Peterson, M. L. & Spear, B. T., Dec 2023, In: American Journal of Physiology - Gastrointestinal and Liver Physiology. 325, 6, p. G582-G592Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Zinc fingers and homeoboxes 2 is required for diethylnitrosamine-induced liver tumor formation in C57BL/6 mice
Jiang, J., Turpin, C., Qiu, G., Xu, M., Lee, E., Hinds, T. D., Peterson, M. L. & Spear, B. T., Dec 2022, In: Hepatology Communications. 6, 12, p. 3550-3562 13 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Highly homologous mouse Cyp2a4 and Cyp2a5 genes are differentially expressed in the liver and both express long non-coding antisense RNAs
Nail, A. N., Spear, B. T. & Peterson, M. L., Jan 30 2021, In: Gene. 767, 145162.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Evolutionary Analysis of the Zinc Finger and Homeoboxes Family of Proteins Identifies Multiple Conserved Domains and a Common Early Chordate Ancestor
Nail, A. N., Smith, J. J., Peterson, M. L., Spear, B. T. & Das, S., Mar 17 2020, In: Genome Biology and Evolution. 12, 3, p. 174-184 11 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Liver size and lipid content differences between BALB/c and BALB/cJ mice on a high-fat diet are due, in part, to Zhx2
Clinkenbeard, E. L., Turpin, C., Jiang, J., Peterson, M. L. & Spear, B. T., Aug 1 2019, In: Mammalian Genome. 30, 7-8, p. 226-236 11 p.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations