Michael Anstead, MD

7/1/23 → 6/30/24

Project: Research project

A Phase 3, Randomized, Double-blind, Controlled Study Evaluating the Efficacy and Safety of VX-121 Combination Therapy in Subjects With Cystic Fibrosis Who Are Heterozygous for F508del and a Minimal Function Mutation (F/MF)

Wurth, M. (PI), Anstead, M. (CoI) & Danov, Z. (Former PI)

9/2/22 → 5/25/24

Project: Research project

Cystic Fibrosis Center Program 2022-2023 (Adult Portion)

Anstead, M. (PI) & Fuller, W. (CoI)

7/1/22 → 6/30/23

Project: Research project

Therapeutic Development Center FY23

Wurth, M. (PI), Anstead, M. (CoI), Danov, Z. (CoI), Kanga, J. (CoI) & Kuhn, R. (CoI)

4/1/22 → 3/31/23

Project: Research project

Therapeutic Development Center FY24

Wurth, M. (PI), Anstead, M. (CoI), Kanga, J. (CoI), Kuhn, R. (CoI), Ramdial, F. (CoI) & Danov, Z. (Former CoI)

4/1/22 → 6/30/24

Project: Research project

A Phase 3, Randomized, Double-blind, Controlled Study Evaluating the Efficacy and Safety of VX-121 Combination Therapy in Subjects With Cystic Fibrosis Who Are Homozygous for F508del or Heterozygous for F508del and a Gating (F/G) or Residual Function (F/R

Wurth, M. (PI), Anstead, M. (CoI), Garrett, N. (CoI) & Danov, Z. (Former PI)

9/1/21 → 5/25/24

Project: Research project

Cystic Fibrosis Center Program 2021-2022 (Adult Portion)

Anstead, M. (PI) & Fuller, W. (CoI)

7/1/21 → 6/30/22

Project: Research project

Cystic Fibrosis Care Center Program 2020-2021 (Adult Portion)

Anstead, M. (PI) & Fuller, W. (CoI)

7/1/20 → 6/30/21

Project: Research project

A Master Protocol to Test the Impact of Discontinuing Chronic Therapies in People with Cystic Fibrosis on Highly Effective CFTR Modulator Therapy (SIMPLIFY)

Danov, Z. (PI), Anstead, M. (CoI), Garrett, N. (CoI), Wilson, E. (CoI) & Pancham, K. (Former CoI)

1/1/20 → 2/8/23

Project: Research project

VS18-445-113: A Phase 3, Open-label Study Evaluating the Long-term Safety of VX-445 Combination Therapy in Subjects with Cystic Fibrosis

Danov, Z. (PI), Anstead, M. (CoI) & Pancham, K. (Former PI)

7/22/19 → 5/27/23

Project: Research project

VX18-445-104: A Phase 3, Randomized, Double-Blind, Controlled Study Evaluating the Efficacy and Safety of VX-445 Comination Therapy in Subject with Cystic Fibrosis Who Are Heterozygous for the F508del Mutation and a Gating or Residual Function Mutation

Danov, Z. (PI), Anstead, M. (CoI) & Pancham, K. (CoI)

7/8/19 → 6/18/21

Project: Research project

A Phase 2, Randomized, Double-blind Study to Evaluate the Efficacy and Safety of VX-561 in Subjects Aged 18 Years and Older With Cystic Fibrosis

Pancham, K. (PI) & Anstead, M. (CoI)

3/14/19 → 1/29/21

Project: Research project

A Phase 2, Randomized, Double-blind, Controlled Study to Evaluate the Safety and Efficacy of VX-121 Combination Therapy in Subjects Aged 18 Years and Older with Cystic Fibrosis

Pancham, K. (PI) & Anstead, M. (CoI)

1/25/19 → 12/6/20

Project: Research project

A Phase 3, Randomized, Double-blind, Controlled Study Evaluating the Efficacy and Safety of VX-659 Combination Therapy in Subjects with Cystic Fibrosis Who are Heterozygous for the F508del Mutation and a Minimal Function Mutation (F/MF) VX17-659-102

Pancham, K. (PI) & Anstead, M. (CoI)

3/27/18 → 3/20/19

Project: Research project

A Real-World Chart Review Study on ORKAMBI Use in the United States

Anstead, M. (PI)

10/17/16 → 10/31/18

Project: Research project

Cystic Fibrosis Center Program 2016-2017

Kanga, J. (PI), Anstead, M. (CoI), Danov, Z. (CoI) & Pancham, K. (CoI)

7/1/16 → 6/30/17

Project: Research project

A Phase 3, Open-label, Rollover Study to Evaluate the Safety and Efficacy of Long-term Treatment With VX-661 in Combination With Ivacaftor in Subjects Aged 12 Years and Older With Cystic Fibrosis, Homozygous or Heterozygous for the F508del-CFTR Mutation

Anstead, M. (PI)

Nivalis Therapeutics Incorporated

10/28/15 → 8/7/18

Project: Research project

A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study of N91115 to Evaluate Efficacy and Safety in Patients with Cystic Fibrosis who are Homozygous for the F508del-CFTR Mutation and Being Treated with lumacaftor/ivacaftor (ORKAMBI)

Anstead, M. (PI), Danov, Z. (CoI), Kanga, J. (CoI) & Tupayachi Ortiz, M. (CoI)

9/30/15 → 8/30/17

Project: Research project

Cystic Fibrosis Center Program 2014-2015

Kanga, J. (PI) & Anstead, M. (CoI)

7/1/15 → 6/30/16

Project: Research project

A Phase 3, Randomized, Double-Blind, Ivacaftor-Controlled, Parellel-Group Study to Evaluate the Efficacy and Safety of VX-661 in Comibayion with IVacaftor in Subjects Aged 12 years and Older with Cystic Fibrosis, Heterozygous for the F508del-CFTR Mutaton

Anstead, M. (PI)

Cystic Fibrosis Foundation Therapeutics Incorporated

6/16/15 → 5/30/17

Project: Research project

CFFT TDN Spring Meeting

Anstead, M. (PI) & Danov, Z. (CoI)

2/1/15 → 7/31/15

Project: Research project

University of Kentucky ARC Award

Anstead, M. (PI)

Cystic Fibrosis Foundation Therapeutics Incorporated

12/1/14 → 11/30/15

Project: Research project

Additional Research Coordinator (ARC) Award FY 17

Pancham, K. (PI) & Anstead, M. (CoI)

Cystic Fibrosis Foundation Therapeutics Incorporated

12/1/14 → 11/30/17

Project: Research project

Additional Research Coordinator (ARC) Award

Anstead, M. (PI)

Cystic Fibrosis Foundation Therapeutics Incorporated

12/1/14 → 11/30/16

Project: Research project

Cystic Fibrosis Center Program--2014-2015

Kanga, J. (PI) & Anstead, M. (CoI)

7/1/14 → 6/30/15

Project: Research project

Therapeutic Development Center FY 2018

Pancham, K. (PI), Anstead, M. (CoI), Danov, Z. (CoI) & Kuhn, R. (CoI)

1/1/14 → 12/31/18

Project: Research project

Therapeutic Development Center FY2022

Wurth, M. (PI), Anstead, M. (CoI), Danov, Z. (CoI), Kanga, J. (CoI) & Kuhn, R. (CoI)

Cystic Fibrosis Foundation Therapeutics Incorporated

1/1/14 → 3/30/22

Project: Research project

Therapeutics Development Network 2014-2015

Anstead, M. (PI), Danov, Z. (CoI), Kanga, J. (CoI) & Kuhn, R. (CoI)

1/1/14 → 12/31/15

Project: Research project

Therapeutic Development Center FY2020

Pancham, K. (PI), Anstead, M. (CoI), Danov, Z. (CoI), Kanga, J. (CoI) & Kuhn, R. (CoI)

1/1/14 → 3/31/20

Project: Research project

Therapeutic Development Center FY2021

Pancham, K. (PI), Anstead, M. (CoI), Danov, Z. (CoI), Kanga, J. (CoI) & Kuhn, R. (CoI)

Cystic Fibrosis Foundation Therapeutics Incorporated

1/1/14 → 3/31/21

Project: Research project

Therapeutic Development Center

Pancham, K. (PI), Anstead, M. (CoI), Danov, Z. (CoI) & Kuhn, R. (CoI)

1/1/14 → 12/31/17

Project: Research project

Therapeutics Development Center

Anstead, M. (PI), Danov, Z. (CoI), Kuhn, R. (CoI) & Tupayachi Ortiz, M. (CoI)

Cystic Fibrosis Foundation Therapeutics Incorporated

1/1/14 → 12/31/16

Project: Research project

VX12-809-105 A Phase 3, Rollover Study to Evaluate the Safety and Efficacy of Long-term Treatment With Lu,acaftor in Combination With Ivacaftor in

Anstead, M. (PI)

12/4/13 → 1/31/16

Project: Research project

Vertex 770-115 An Ocular Safety Study of Ivacaftor-Treated Pediatric Patients 11 years of Age or Younger With Cystic Fibrosis

Anstead, M. (PI)

11/25/13 → 11/30/15

Project: Research project

Proof of Principal Evaluation of IV Gallium Nitrate (Ganite) in Patients with Cystic Fibrosis

Pancham, K. (PI), Danov, Z. (CoI), Kanga, J. (CoI), Anstead, M. (Former PI) & Tupayachi Ortiz, M. (Former PI)

9/1/13 → 6/30/18

Project: Research project

G551D Observational Study - Expanded to Additional Genotypes and TExtended for Long-term Follow-up

Anstead, M. (PI)

9/1/13 → 12/31/16

Project: Research project

Cystic Fibrosis Center Program 2019-2020 (Adult Portion)

Anstead, M. (PI)

7/1/13 → 6/30/20

Project: Research project

Cystic Fibrosis Center Program 2019-2020 (Adult Portion)

Anstead, M. (PI)

7/1/13 → 6/30/19

Project: Research project

Cystic Fibrosis Center Program 2017-2018

Kanga, J. (PI), Anstead, M. (CoI), Danov, Z. (CoI) & Pancham, K. (CoI)

7/1/13 → 6/30/18

Project: Research project

Cystic Fibrosis Center Program 2013-2014

Kanga, J. (PI) & Anstead, M. (CoI)

7/1/13 → 6/30/14

Project: Research project

A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Efficacy and Safety of Lumacaftor in Combination with Ivacaftor in Subjects Aged 12 Years and Older With Cystic Fibrosis, omozygous for the F508del-CFTR Mutation

Anstead, M. (PI), Danov, Z. (CoI) & Kanga, J. (CoI)

KaloBios Pharmaceuticals Incorporated

6/20/13 → 6/30/15

Project: Research project

A phase 2, randomized, double blind, placebo-controlled study of AeroVanc for the treatment of persistent methicillin-resistant Staphylococcus aureus lung infection in cystic fibrosis patients (SAV005-02)

Danov, Z. (PI), Anstead, M. (CoI) & Kanga, J. (CoI)

Savara Incorporated

3/13/13 → 3/31/15

Project: Research project

KaloBios CF KB001A-05 A Phase 2, Randomized Double-Blind, Placebo-Controlled, Repeat-dose Study of KB001A in Subjects with Cystic Fibrosis Infected withPseudomonas Aeruginosa

Danov, Z. (PI), Anstead, M. (CoI) & Kanga, J. (CoI)

10/30/12 → 10/30/14

Project: Research project

A Long-Term Prospective Observational Safety Study of the Incidence of and Risk Factors for Fibrosing Colonopathy

Anstead, M. (PI), Danov, Z. (CoI) & Kanga, J. (CoI)

Chiltern International Incorporated

10/22/12 → 9/30/20

Project: Research project

KaloBios Asthma Study KB003-04 Safety, Tolerability, and Efficacy

Anstead, M. (PI), Danov, Z. (CoI), Kanga, J. (CoI) & Khosravi, M. (CoI)

10/1/12 → 9/30/14

Project: Research project

VX12-770-112 / A Phase 3, Two-Arm, Rollover Study to Evaluate the Safety of Long-Term Ivacaftor Treatment in Subjects 6 Years of Age and Older

Anstead, M. (PI), Danov, Z. (CoI) & Kanga, J. (CoI)

9/1/12 → 8/30/14

Project: Research project

A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Efficacy and Safety of Ivacaftor in Subjects with Cystic Fibrosis who have the R117H-CFTR Mutation

Anstead, M. (PI), Danov, Z. (CoI) & Kanga, J. (CoI)

KY Cabinet for Health and Family Services

7/2/12 → 6/30/14

Project: Research project

Metabolic Newborn Screening

Wallace, C. (PI), Hong-McAtee, I. (CoI), Kanga, J. (CoI) & Anstead, M. (Former CoI)

7/1/12 → 6/30/13

Project: Research project

Cystic Fibrosis Center Program

Kanga, J. (PI) & Anstead, M. (CoI)