Projects and Grants per year
Personal profile
Research Interests
My research is focused on cellular mechanisms driving organ-specific cancer metastasis and therapeutic strategies to target cancer metastases in parenchymal organs. I have an expertise background in translational research with a focus on evaluation of drug delivery into metastatic tumors with nanocarrier products, development of in vitro and in vivo translational models of cancer metastasis and non-invasive imaging of cancer metastasis.
To determine therapeutic efficiency of radiation therapy and radiopharmaceuticals, I have developed models of neuroendocrine and colorectal cancer lung or liver metastasis and techniques, which allow us to address translational and clinically relevant questions in preclinical models. In addition, I continue to examine role of DNA repairs pathways and role of nucleotide synthesis in neuroendocrine cancer sensitivity to radiation therapy. These qualifications in developing animal models of metastasis and a long track record of collaborating together with multidisciplinary teams to address translational problems laid the groundwork for answering questions in the proposed research.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Post Doctoral Fellow, University Of Texas Medical
2008
Master of Science, University Of Texas Medical
2007
Doctor of Medicine, Byelorussian State Medical University
2002
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Collaborations and top research areas from the last five years
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FY25 DNA-PK Inhibition in Neuroblastoma
Rellinger, E. (PI), Weiss, H. (CoI) & Rychahou, P. (CoPI)
KY Cabinet for Health and Family Services
7/1/24 → 6/30/26
Project: Research project
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Targeting Lipid Metabolism in Colorectal Cancer
Zaytseva, Y. (PI), Evers, B. M. (CoI), Lee, E. (CoI), Moseley, H. (CoI), Nikolova-Karakashian, M. (CoI), Rychahou, P. (CoI) & Weiss, H. (CoI)
4/1/21 → 3/31/26
Project: Research project
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Pilot: Targeting De Novo and Salvage Nucleotide Synthesis with FASN/ATR Inhibition to Enhance Radiation Therapy Reponses
Rychahou, P. (PI), Weiss, H. (CoI) & Zaytseva, Y. (CoI)
National Institute of General Medical Sciences
1/1/23 → 12/31/23
Project: Research project
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Evaluation of Deoxynucleosides as a Novel Resistance Mechanism for Radiotherapy
Kolesar, J. (PI), Evers, B. M. (CoI) & Rychahou, P. (CoI)
5/5/20 → 2/28/23
Project: Research project
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Inhibition of ribonucleotide reductase subunit M2 enhances the radiosensitivity of metastatic pancreatic neuroendocrine tumor
Chow, Z., Johnson, J., Chauhan, A., Jeong, J. C., Castle, J. T., Izumi, T., Weiss, H., Townsend, C. M., Schrader, J., Anthony, L., Yang, E. S., Evers, B. M. & Rychahou, P., Aug 1 2024, In: Cancer Letters. 596, 216993.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Delivery of RNA nanoparticles into colorectal cancer metastases following systemic administration
Rychahou, P., Haque, F., Shu, Y., Zaytseva, Y., Weiss, H. L., Lee, E. Y., Mustain, W., Valentino, J., Guo, P. & Evers, B. M., Feb 24 2015, In: ACS Nano. 9, 2, p. 1108-1116 9 p.Research output: Contribution to journal › Article › peer-review
Open Access83 Scopus citations -
Akt2 overexpression plays a critical role in the establishment of colorectal cancer metastasis
Rychahou, P. G., Kang, J., Gulhati, P., Doan, H. Q., Chen, L. A., Xiao, S. Y., Chung, D. H. & Evers, B. M., Dec 23 2008, In: Proceedings of the National Academy of Sciences of the United States of America. 105, 51, p. 20315-20320 6 p.Research output: Contribution to journal › Article › peer-review
Open Access154 Scopus citations -
A Novel Protozoa Parasite-Derived Protein Adjuvant Is Effective in Immunization with Cancer Cells to Activate the Cancer-Specific Protective Immunity and Inhibit the Cancer Growth in a Murine Model of Colorectal Cancer
Mani, R., Martin, C. G., Balu, K. E., Wang, Q., Rychahou, P., Izumi, T., Evers, B. M. & Suzuki, Y., Jan 2024, In: Cells. 13, 2, 111.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Carfilzomib-Loaded Ternary Polypeptide Nanoparticles Stabilized by Polycationic Complexation
Agbana, P., Park, J. E., Rychahou, P., Kim, K. B. & Bae, Y., Mar 2024, In: Journal of Pharmaceutical Sciences. 113, 3, p. 711-717 7 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations