Calculated based on number of publications stored in Pure and citations from Scopus
1994 …2023

Research activity per year

Personal profile

Research Interests

My lab studies oncogenic factors and pathways that drive disease progression and therapeutic resistance in colorectal cancer (CRC). We particularly focus on understanding the mechanistic basis of redundancy and crosstalk among oncoprotein-activated signaling pathways and how the functional crosstalk among these pathways promotes cancer progression and alters the therapeutic response to CRC. Through molecular analysis of mRNA translation states, our work establishes dysregulation of cap-dependent translation downstream of mTOR at the level of 4E-BP1/eIF4E, as a key to tumor formation, metastasis and resistance to upstream kinase-targeted therapies. Specifically, we identify 4E-BP1 as a critical node that integrates the oncogenic effects of the PI3K/AKT and RAS/RAF/MEK/ERK pathways in CRC progression.

We employ a combination of molecular, cellular, biochemical, genetic, pharmacologic, imaging, bioinformatic, animal and clinical association approaches to decipher the transcriptional and post-transcriptional mechanisms controlling gene expression and pathways important for the malignant transformation and metastatic progression of CRC, with the ultimate goal of developing novel biomarkers and therapies for improving the diagnosis and treatment of this disease. In addition, we are interested in developing natural product-based small molecular inhibitors for targeting translational control of CRC and potentially other major cancers.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Education/Academic qualification

Doctor of Philosophy, Gifu University

1995

Master of Science, Gifu University

1992

Bachelor of Science, Fuzhou University

1984

Fingerprint

Dive into the research topics where Qing-Bai She is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
  • 1 Similar Profiles

Collaborations and top research areas from the last five years

Recent external collaboration from the last 5 years on country level. Dive into details by clicking on the dots.