Projects and Grants per year
Personal profile
Research Interests
My lab studies oncogenic factors and pathways that drive disease progression and therapeutic resistance in colorectal cancer (CRC). We particularly focus on understanding the mechanistic basis of redundancy and crosstalk among oncoprotein-activated signaling pathways and how the functional crosstalk among these pathways promotes cancer progression and alters the therapeutic response to CRC. Through molecular analysis of mRNA translation states, our work establishes dysregulation of cap-dependent translation downstream of mTOR at the level of 4E-BP1/eIF4E, as a key to tumor formation, metastasis and resistance to upstream kinase-targeted therapies. Specifically, we identify 4E-BP1 as a critical node that integrates the oncogenic effects of the PI3K/AKT and RAS/RAF/MEK/ERK pathways in CRC progression.
We employ a combination of molecular, cellular, biochemical, genetic, pharmacologic, imaging, bioinformatic, animal and clinical association approaches to decipher the transcriptional and post-transcriptional mechanisms controlling gene expression and pathways important for the malignant transformation and metastatic progression of CRC, with the ultimate goal of developing novel biomarkers and therapies for improving the diagnosis and treatment of this disease. In addition, we are interested in developing natural product-based small molecular inhibitors for targeting translational control of CRC and potentially other major cancers.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Doctor of Philosophy, Gifu University
1995
Master of Science, Gifu University
1992
Bachelor of Science, Fuzhou University
1984
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- 1 Similar Profiles
Collaborations and top research areas from the last five years
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CCSG Pilot: Targeting Merkel Cell Carcinoma by Natural Product-Based Degraders of MCV Small T Antigen
She, Q.-B. (PI), Thorson, J. (CoI) & Wang, C. (CoI)
7/1/24 → 6/30/25
Project: Research project
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COBRE in Pharmaceutical Research and Innovation
Thorson, J. (PI), Helmy, Y. A. (CoI), Jaramillo, A. (CoI), She, Q.-B. (CoI), Adams, V. (Former CoI), Alam, M. (Former CoI), Awuah, S. (Former CoI), Bardo, M. (Former CoI), Bauer, B. (Former CoI), Burgess, D. (Former CoI), Czuba, L. (Former CoI), Daugherty, A. (Former CoI), Dwoskin, L. (Former CoI), Feola, D. (Former CoI), Garneau-Tsodikova, S. (Former CoI), Gensel, J. (Former CoI), Glazer, E. (Former CoI), Grady, M. (Former CoI), Graf, G. (Former CoI), Kapur, N. (Former CoI), Kolesar, J. (Former CoI), Korotkov, K. (Former CoI), Korotkova, N. (Former CoI), Leggas, M. (Former CoI), Mahmoud, K. A. (Former CoI), McLaurin, K. (Former CoI), Messaoudi Powers, I. (Former CoI), Nikolajczyk, B. (Former CoI), Ortinski, P. (Former CoI), Pack, D. (Former CoI), Park, J. (Former CoI), Prisinzano, T. (Former CoI), Richards, C. (Former CoI), Rohr, J. (Former CoI), Sen, P. (Former CoI), Shaffer, C. (Former CoI), Stevenson, B. (Former CoI), Sturgill, J. (Former CoI), Sviripa, V. (Former CoI), Tidgewell, K. (Former CoI), Tiruvannamalai Annam, R. (Former CoI), Turner, J. (Former CoI), Van Lanen, S. (Former CoI), Venditto, V. (Former CoI), Watt, D. (Former CoI), Webb, N. (Former CoI) & Zhan, C.-G. (Former CoI)
National Institute of General Medical Sciences
3/1/20 → 1/31/25
Project: Research project
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Targeting Translation Dependence in Colorectal Cancer Progression
She, Q.-B. (PI), Evers, B. M. (CoI), Lee, E. (CoI), Wang, C. (CoI), Woodward, J. (CoI), Zaytseva, Y. (CoI), Zhou, B. (Former CoI) & Zhu, H. (Former CoI)
4/1/13 → 11/30/25
Project: Research project
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Pilot: Lipid Metabolism Reprograming upon Spermine Synthase Inhibition in Colorectal Cancer
She, Q.-B. (PI), Fan, W.-M. (CoI) & Wang, C. (CoI)
National Institute of General Medical Sciences
6/15/22 → 12/31/22
Project: Research project
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RNA Surveillance and Protein Translation in FTD
Zhu, H. (PI), Murphy, M. (CoI), Nelson, P. (CoI), She, Q.-B. (CoI) & Wang, C. (CoI)
National Institute of Neurological Disorders & Stroke
8/15/20 → 6/30/21
Project: Research project
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Enhanced bypass of PD-L1 translation reduces the therapeutic response to mTOR kinase inhibitors
Cao, Y., Ye, Q., Ma, M. & She, Q. B., Jul 25 2023, In: Cell Reports. 42, 7, 112764.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Targeting Squalene Epoxidase Interrupts Homologous Recombination via the ER Stress Response and Promotes Radiotherapy Efficacy
Hong, Z., Liu, T., Wan, L., Fa, P., Kumar, P., Cao, Y., Prasad, C. B., Qiu, Z., Liu, J., Wang, H., Li, Z., Wang, Q. E., Guo, P., Guo, D., Yilmaz, A. S., Lu, L., Papandreou, I., Jacob, N. K., Yan, C. & Zhang, X. & 3 others, , Apr 1 2022, In: Cancer Research. 82, 7, p. 1298-1312 15 p.Research output: Contribution to journal › Article › peer-review
Open Access29 Scopus citations -
Himalaquinones A-G, Angucyclinone-Derived Metabolites Produced by the Himalayan Isolate Streptomycessp. PU-MM59
Zhang, Y., Cheema, M. T., Ponomareva, L. V., Ye, Q., Liu, T., Sajid, I., Rohr, J., She, Q. B., Voss, S. R., Thorson, J. S. & Shaaban, K. A., Jul 23 2021, In: Journal of Natural Products. 84, 7, p. 1930-1940 11 p.Research output: Contribution to journal › Review article › peer-review
Open Access10 Scopus citations -
Spermine synthase and MYC cooperate to maintain colorectal cancer cell survival by repressing Bim expression
Guo, Y., Ye, Q., Deng, P., Cao, Y., He, D., Zhou, Z., Wang, C., Zaytseva, Y. Y., Schwartz, C. E., Lee, E. Y., Mark Evers, B., Morris, A. J., Liu, S. & She, Q. B., Dec 1 2020, In: Nature Communications. 11, 1, 3243.Research output: Contribution to journal › Article › peer-review
Open Access58 Scopus citations -
Frenolicin B Targets Peroxiredoxin 1 and Glutaredoxin 3 to Trigger ROS/4E-BP1-Mediated Antitumor Effects
Ye, Q., Zhang, Y., Cao, Y., Wang, X., Guo, Y., Chen, J., Horn, J., Ponomareva, L. V., Chaiswing, L., Shaaban, K. A., Wei, Q., Anderson, B. D., St Clair, D. K., Zhu, H., Leggas, M., Thorson, J. S. & She, Q. B., Mar 21 2019, In: Cell Chemical Biology. 26, 3, p. 366-377.e12Research output: Contribution to journal › Article › peer-review
Open Access33 Scopus citations