R. Kip Guy

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R. Kip Guy, Ph.D.

 https://orcid.org/0000-0002-9638-2060
Calculated based on number of publications stored in Pure and citations from Scopus
1992 …2023

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  • 2023

    Author Correction: Proteasome inhibition targets the KMT2A transcriptional complex in acute lymphoblastic leukemia

    Kamens, J. L., Nance, S., Koss, C., Xu, B., Cotton, A., Lam, J. W., Garfinkle, E. A. R., Nallagatla, P., Smith, A. M. R., Mitchell, S., Ma, J., Currier, D., Wright, W. C., Kavdia, K., Pagala, V. R., Kim, W., Wallace, L. M., Cho, J-H., Fan, Y., Seth, A., & 13 othersTwarog, N., Choi, J. K., Obeng, E. A., Hatley, M. E., Metzger, M. L., Inaba, H., Jeha, S., Rubnitz, J. E., Peng, J., Chen, T., Shelat, A. A., Guy, R. K. & Gruber, T. A., Mar 9 2023, In: Nature Communications. 14, 1, p. 1297

    Research output: Contribution to journal › Article

  • Optimization of Orally Bioavailable Antileishmanial 2,4,5-Trisubstituted Benzamides

    Kim, H. S., Ortiz, D., Kadayat, T. M., Fargo, C. M., Hammill, J. T., Chen, Y., Rice, A. L., Begley, K. L., Shoeran, G., Pistel, W., Yates, P. A., Sanchez, M. A., Landfear, S. M. & Guy, R. K., Jun 8 2023, In: Journal of Medicinal Chemistry. 66, 11, p. 7374-7386 13 p.

    Research output: Contribution to journal › Article › peer-review

  • Proteasome inhibition targets the KMT2A transcriptional complex in acute lymphoblastic leukemia

    Kamens, J. L., Nance, S., Koss, C., Xu, B., Cotton, A., Lam, J. W., Garfinkle, E. A. R., Nallagatla, P., Smith, A. M. R., Mitchell, S., Ma, J., Currier, D., Wright, W. C., Kavdia, K., Pagala, V. R., Kim, W., Wallace, L. M., Cho, J-H., Fan, Y., Seth, A., & 13 othersTwarog, N., Choi, J. K., Obeng, E. A., Hatley, M. E., Metzger, M. L., Inaba, H., Jeha, S., Rubnitz, J. E., Peng, J., Chen, T., Shelat, A. A., Guy, R. K. & Gruber, T. A., Feb 13 2023, In: Nature Communications. 14, 1, p. 809

    Research output: Contribution to journal › Article › peer-review

    2 Scopus citations
  • 2022

    Combining SJ733, an oral ATP4 inhibitor of Plasmodium falciparum, with the pharmacokinetic enhancer cobicistat: An innovative approach in antimalarial drug development

    Gaur, A. H., Panetta, J. C., Smith, A. M., Dallas, R. H., Freeman, B. B., Stewart, T. B., Tang, L., John, E., Branum, K. C., Patel, N. D., Ost, S., Heine, R. N., Richardson, J. L., Hammill, J. T., Bebrevska, L., Gusovsky, F., Maki, N., Yanagi, T., Flynn, P. M., McCarthy, J. S., & 2 othersChalon, S. & Guy, R. K., Jun 2022, In: EBioMedicine. 80, p. 104065

    Research output: Contribution to journal › Article › peer-review

    2 Scopus citations

  • Similarly efficacious anti-malarial drugs SJ733 and pyronaridine differ in their ability to remove circulating parasites in mice

    SheelaNair, A., Romanczuk, A. S., Aogo, R. A., Haldar, R. N., Lansink, L. I. M., Cromer, D., Salinas, Y. G., Guy, R. K., McCarthy, J. S., Davenport, M. P., Haque, A. & Khoury, D. S., Dec 2022, In: Malaria Journal. 21, 1, 49.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    2 Scopus citations
  • 2021

    Amino-Substituted 3-Aryl- And 3-Heteroarylquinolines as Potential Antileishmanial Agents

    Hammill, J. T., Sviripa, V. M., Kril, L. M., Ortiz, D., Fargo, C. M., Kim, H. S., Chen, Y., Rector, J., Rice, A. L., Domagalska, M. A., Begley, K. L., Liu, C., Rangnekar, V. M., Dujardin, J. C., Watt, D. S., Landfear, S. M. & Guy, R. K., Aug 26 2021, In: Journal of Medicinal Chemistry. 64, 16, p. 12152-12162 11 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    3 Scopus citations

  • Antimalarial activity of 2,6-dibenzylidenecyclohexanone derivatives

    Eagon, S., Hammill, J. T., Fitzsimmons, K., Sienko, N., Nguyen, B., Law, J., Manjunath, A., Wilkinson, S. P., Thompson, K., Glidden, J. E., Rice, A. L., Falade, M. O., Kimball, J. J., DiBernardo, C. & Guy, R. K., Sep 1 2021, In: Bioorganic and Medicinal Chemistry Letters. 47, 128216.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    1 Scopus citations

  • Identification of Plasmodium falciparum heat shock 90 inhibitors via molecular docking

    Everson, N., Bach, J., Hammill, J. T., Falade, M. O., Rice, A. L., Guy, R. K. & Eagon, S., Mar 1 2021, In: Bioorganic and Medicinal Chemistry Letters. 35, 127818.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    2 Scopus citations

  • Improvement of Oral Bioavailability of Pyrazolo-Pyridone Inhibitors of the Interaction of DCN1/2 and UBE2M

    Kim, H. S., Hammill, J. T., Scott, D. C., Chen, Y., Rice, A. L., Pistel, W., Singh, B., Schulman, B. A. & Guy, R. K., May 13 2021, In: Journal of Medicinal Chemistry. 64, 9, p. 5850-5862 13 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    6 Scopus citations

  • Selecting an anti-malarial clinical candidate from two potent dihydroisoquinolones

    Chen, Y., Zhu, F., Hammill, J., Holbrook, G., Yang, L., Freeman, B., White, K. L., Shackleford, D. M., O’Loughlin, K. G., Charman, S. A., Mirsalis, J. C. & Guy, R. K., Dec 2021, In: Malaria Journal. 20, 1, 107.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    6 Scopus citations
  • 2020

    Antimalarial activity of tetrahydro-β-carbolines targeting the ATP binding pocket of the Plasmodium falciparum heat shock 90 protein

    Eagon, S., Hammill, J. T., Bach, J., Everson, N., Sisley, T. A., Walls, M. J., Durham, S., Pillai, D. R., Falade, M. O., Rice, A. L., Kimball, J. J., Lazaro, H., DiBernardo, C. & Kiplin Guy, R., Nov 1 2020, In: Bioorganic and Medicinal Chemistry Letters. 30, 21, 127502.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    8 Scopus citations

  • Bromodomain-selective BET inhibitors are potent antitumor agents against MYC-driven pediatric cancer

    Jake Slavish, P., Chi, L., Yun, M. K., Tsurkan, L., Martinez, N. E., Jonchere, B., Chai, S. C., Connelly, M., Brett Waddell, M., Das, S., Neale, G., Li, Z., Shadrick, W. R., Olsen, R. R., Freeman, K. W., Low, J. A., Price, J. E., Young, B. M., Bharatham, N., Boyd, V. A., & 10 othersYang, J., Lee, R. E., Morfouace, M., Roussel, M. F., Chen, T., Savic, D., Kiplin Guy, R., White, S. W., Shelat, A. A. & Potter, P. M., Sep 1 2020, In: Cancer Research. 80, 17, p. 3507-3518 12 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    24 Scopus citations

  • Evaluation of 1,1-cyclopropylidene as a thioether isostere in the 4-thio-thienopyrimidine (TTP) series of antimalarials

    Barrows, R. D., Hammill, J. T., Tran, M. C., Falade, M. O., Rice, A. L., Davis, C. W., Emge, T. J., Rablen, P. R., Kiplin Guy, R. & Knapp, S., Nov 15 2020, In: Bioorganic and Medicinal Chemistry. 28, 22, 115758.

    Research output: Contribution to journal › Article › peer-review

    7 Scopus citations

  • Safety, tolerability, pharmacokinetics, and antimalarial efficacy of a novel Plasmodium falciparum ATP4 inhibitor SJ733: a first-in-human and induced blood-stage malaria phase 1a/b trial

    Gaur, A. H., McCarthy, J. S., Panetta, J. C., Dallas, R. H., Woodford, J., Tang, L., Smith, A. M., Stewart, T. B., Branum, K. C., Freeman, B. B., Patel, N. D., John, E., Chalon, S., Ost, S., Heine, R. N., Richardson, J. L., Christensen, R., Flynn, P. M., Van Gessel, Y., Mitasev, B., & 4 othersMöhrle, J. J., Gusovsky, F., Bebrevska, L. & Guy, R. K., Aug 2020, In: The Lancet Infectious Diseases. 20, 8, p. 964-975 12 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    36 Scopus citations

  • Synthesis and Structure-Activity Relationship of Dual-Stage Antimalarial Pyrazolo[3,4- b]pyridines

    Eagon, S., Hammill, J. T., Sigal, M., Ahn, K. J., Tryhorn, J. E., Koch, G., Belanger, B., Chaplan, C. A., Loop, L., Kashtanova, A. S., Yniguez, K., Lazaro, H., Wilkinson, S. P., Rice, A. L., Falade, M. O., Takahashi, R., Kim, K., Cheung, A., Dibernardo, C., Kimball, J. J., & 11 othersWinzeler, E. A., Eribez, K., Mittal, N., Gamo, F. J., Crespo, B., Churchyard, A., García-Barbazán, I., Baum, J., Anderson, M. O., Laleu, B. & Guy, R. K., Oct 22 2020, In: Journal of Medicinal Chemistry. 63, 20, p. 11902-11919 18 p.

    Research output: Contribution to journal › Article › peer-review

    14 Scopus citations
  • 2019

    A high-throughput screen indicates gemcitabine and JAK inhibitors may be useful for treating pediatric AML

    Drenberg, C. D., Shelat, A., Dang, J., Cotton, A., Orwick, S. J., Li, M., Jeon, J. Y., Fu, Q., Buelow, D. R., Pioso, M., Hu, S., Inaba, H., Ribeiro, R. C., Rubnitz, J. E., Gruber, T. A., Guy, R. K. & Baker, S. D., Dec 1 2019, In: Nature Communications. 10, 1, 2189.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    17 Scopus citations

  • Discovery of Novel Pyrazolo-pyridone DCN1 Inhibitors Controlling Cullin Neddylation

    Kim, H. S., Hammill, J. T., Scott, D. C., Chen, Y., Min, J., Rector, J., Singh, B., Schulman, B. A. & Guy, R. K., Sep 26 2019, In: Journal of Medicinal Chemistry. 62, 18, p. 8429-8442 14 p.

    Research output: Contribution to journal › Article › peer-review

    20 Scopus citations

  • Phenotypic screens reveal posaconazole as a rapidly acting amebicidal combination partner for treatment of primary amoebic meningoencephalitis

    Colon, B. L., Rice, C. A., Guy, R. K. & Kyle, D. E., Mar 15 2019, In: Journal of Infectious Diseases. 219, 7, p. 1095-1103 9 p.

    Research output: Contribution to journal › Article › peer-review

    23 Scopus citations

  • Report of the 2018-2019 research and graduate affairs committee

    O’donnell, J. M., Anand, S., Brown, S. D., Fuji, K. T., Guy, R. K., Kawaguchi-Suzuki, M., Meier, K. E., Nelson, C. E., Vyas, A., Block, K. F. & Farrell, D. F., Dec 2019, In: American Journal of Pharmaceutical Education. 83, 10, p. 2233-2247 15 p., 7595.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    1 Scopus citations
  • 2018

    Amine containing analogs of sulindac for cancer prevention

    Mathew, B., Hobrath, J. V., Connelly, M. C., Guy, R. K. & Reynolds, R. C., Jan 31 2018, In: Open Medicinal Chemistry Journal. 12, p. 1-12 12 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    1 Scopus citations

  • A small diversity library of α-methyl amide analogs of sulindac for probing anticancer structure-activity relationships

    Mathew, B., Snowden, T. S., Connelly, M. C., Guy, R. K. & Reynolds, R. C., Jul 1 2018, In: Bioorganic and Medicinal Chemistry Letters. 28, 12, p. 2136-2142 7 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    6 Scopus citations

  • CDK2 inhibitors as candidate therapeutics for cisplatin- and noise-induced hearing loss

    Teitz, T., Fang, J., Goktug, A. N., Bonga, J. D., Diao, S., Hazlitt, R. A., Iconaru, L., Morfouace, M., Currier, D., Zhou, Y., Umans, R. A., Taylor, M. R., Cheng, C., Min, J., Freeman, B., Peng, J., Roussel, M. F., Kriwacki, R., Kiplin Guy, R., Chen, T., & 1 othersZuo, J., Apr 1 2018, In: Journal of Experimental Medicine. 215, 4, p. 1187-1203 17 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    59 Scopus citations

  • Cysteine modifiers suggest an allosteric inhibitory site on the CAL PDZ domain

    Zhao, Y., Cushing, P. R., Smithson, D. C., Pellegrini, M., Pletnev, A. A., Al-Ayyoubi, S., Grassetti, A. V., Gerber, S. A., Kiplin Guy, R. & Madden, D. R., Jul 6 2018, In: Bioscience Reports. 38, 4, BSR20180231.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    4 Scopus citations

  • Discovery of an Orally Bioavailable Inhibitor of Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation

    Hammill, J. T., Bhasin, D., Scott, D. C., Min, J., Chen, Y., Lu, Y., Yang, L., Kim, H. S., Connelly, M. C., Hammill, C., Holbrook, G., Jeffries, C., Singh, B., Schulman, B. A. & Guy, R. K., Apr 12 2018, In: Journal of Medicinal Chemistry. 61, 7, p. 2694-2706 13 p.

    Research output: Contribution to journal › Article › peer-review

    38 Scopus citations

  • Establishing a Preclinical Multidisciplinary Board for Brain Tumors

    Nimmervoll, B. V., Boulos, N., Bianski, B., Dapper, J., DeCuypere, M., Shelat, A., Terranova, S., Terhune, H. E., Gajjar, A., Patel, Y. T., Freeman, B. B., Onar-Thomas, A., Stewart, C. F., Roussel, M. F., Guy, R. K., Merchant, T. E., Calabrese, C., Wright, K. D. & Gilbertson, R. J., Apr 1 2018, In: Clinical Cancer Research. 24, 7, p. 1654-1666 13 p.

    Research output: Contribution to journal › Article › peer-review

    11 Scopus citations

  • Exploiting a water network to achieve enthalpy-driven, bromodomain-selective BET inhibitors

    Shadrick, W. R., Slavish, P. J., Chai, S. C., Waddell, B., Connelly, M., Low, J. A., Tallant, C., Young, B. M., Bharatham, N., Knapp, S., Boyd, V. A., Morfouace, M., Roussel, M. F., Chen, T., Lee, R. E., Kiplin Guy, R., Shelat, A. A. & Potter, P. M., Jan 1 2018, In: Bioorganic and Medicinal Chemistry. 26, 1, p. 25-36 12 p.

    Research output: Contribution to journal › Article › peer-review

    19 Scopus citations

  • Identification of Toll-like receptor signaling inhibitors based on selective activation of hierarchically acting signaling proteins

    Ippagunta, S. K., Pollock, J. A., Sharma, N., Lin, W., Chen, T., Tawaratsumida, K., High, A. A., Min, J., Chen, Y., Guy, R. K., Redecke, V., Katzenellenbogen, J. A. & Häcker, H., Aug 14 2018, In: Science Signaling. 11, 543, eaaq1077.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    13 Scopus citations

  • Oxazole and thiazole analogs of sulindac for cancer prevention

    Mathew, B., Hobrath, J. V., Connelly, M. C., Guy, R. K. & Reynolds, R. C., Apr 2018, In: Future Medicinal Chemistry. 10, 7, p. 743-753 11 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    6 Scopus citations

  • Piperidinyl Ureas Chemically Control Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation

    Hammill, J. T., Scott, D. C., Min, J., Connelly, M. C., Holbrook, G., Zhu, F., Matheny, A., Yang, L., Singh, B., Schulman, B. A. & Guy, R. K., Apr 12 2018, In: Journal of Medicinal Chemistry. 61, 7, p. 2680-2693 14 p.

    Research output: Contribution to journal › Article › peer-review

    32 Scopus citations
  • 2017

    Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase

    Scott, D. C., Hammill, J. T., Min, J., Rhee, D. Y., Connelly, M., Sviderskiy, V. O., Bhasin, D., Chen, Y., Ong, S. S., Chai, S. C., Goktug, A. N., Huang, G., Monda, J. K., Low, J., Kim, H. S., Paulo, J. A., Cannon, J. R., Shelat, A. A., Chen, T., Kelsall, I. R., & 8 othersAlpi, A. F., Pagala, V., Wang, X., Peng, J., Singh, B., Harper, J. W., Schulman, B. A. & Guy, R. K., Aug 1 2017, In: Nature Chemical Biology. 13, 8, p. 850-857 8 p.

    Research output: Contribution to journal › Article › peer-review

    68 Scopus citations

  • Discovery of a Diaminopyrimidine FLT3 Inhibitor Active against Acute Myeloid Leukemia

    Jarusiewicz, J. A., Jeon, J. Y., Connelly, M. C., Chen, Y., Yang, L., Baker, S. D. & Guy, R. K., May 31 2017, In: ACS Omega. 2, 5, p. 1985-2009 25 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    10 Scopus citations

  • Discovery of novel, orally bioavailable, antileishmanial compounds using phenotypic screening

    Ortiz, D., Armand Guiguemde, W., Hammill, J. T., Carrillo, A. K., Chen, Y., Connelly, M., Stalheim, K., Elya, C., Johnson, A., Min, J., Shelat, A., Smithson, D. C., Yang, L., Zhu, F., Kiplin Guy, R. & Landfear, S. M., 2017, In: PLoS Neglected Tropical Diseases. 11, 12, e0006157.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    19 Scopus citations

  • Diverse amide analogs of sulindac for cancer treatment and prevention

    Mathew, B., Hobrath, J. V., Connelly, M. C., Kiplin Guy, R. & Reynolds, R. C., 2017, In: Bioorganic and Medicinal Chemistry Letters. 27, 20, p. 4614-4621 8 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    19 Scopus citations

  • Performance of a docking/molecular dynamics protocol for virtual screening of nutlin-class inhibitors of Mdmx

    Bharatham, N., Finch, K. E., Min, J., Mayasundari, A., Dyer, M. A., Guy, R. K. & Bashford, D., Jun 1 2017, In: Journal of Molecular Graphics and Modelling. 74, p. 54-60 7 p.

    Research output: Contribution to journal › Article › peer-review

    11 Scopus citations

  • Shared Consensus Machine Learning Models for Predicting Blood Stage Malaria Inhibition

    Verras, A., Waller, C. L., Gedeck, P., Green, D. V. S., Kogej, T., Raichurkar, A., Panda, M., Shelat, A. A., Clark, J., Guy, R. K., Papadatos, G. & Burrows, J., Mar 27 2017, In: Journal of Chemical Information and Modeling. 57, 3, p. 445-453 9 p.

    Research output: Contribution to journal › Article › peer-review

    12 Scopus citations

  • Targeting histone demethylases in MYC-driven neuroblastomas with ciclopirox

    Yang, J., Milasta, S., Hu, D., AlTahan, A. M., Interiano, R. B., Zhou, J., Davidson, J., Low, J., Lin, W., Bao, J., Goh, P., Nathwani, A. C., Wang, R., Wang, Y., Ong, S. S., Boyd, V. A., Young, B., Das, S., Shelat, A., Wu, Y., & 11 othersLi, Z., Zheng, J. J., Mishra, A., Cheng, Y., Qu, C., Peng, J., Green, D. R., White, S., Guy, R. K., Chen, T. & Davidoff, A. M., Sep 1 2017, In: Cancer Research. 77, 17, p. 4626-4638 13 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    32 Scopus citations

  • Ventromorphins: A New Class of Small Molecule Activators of the Canonical BMP Signaling Pathway

    Genthe, J. R., Min, J., Farmer, D. M., Shelat, A. A., Grenet, J. A., Lin, W., Finkelstein, D., Vrijens, K., Chen, T., Guy, R. K., Clements, W. K. & Roussel, M. F., Sep 15 2017, In: ACS Chemical Biology. 12, 9, p. 2436-2447 12 p.

    Research output: Contribution to journal › Article › peer-review

    18 Scopus citations
  • 2016

    Diversity-oriented natural product platform identifies plant constituents targeting Plasmodium falciparum

    Zhang, J., Bowling, J. J., Smithson, D., Clark, J., Jacob, M. R., Khan, S. I., Tekwani, B. L., Connelly, M., Samoylenko, V., Ibrahim, M. A., Zaki, M. A., Wang, M., Hester, J. P., Tu, Y., Jeffries, C., Twarog, N., Shelat, A. A., Walker, L. A., Muhammad, I. & Guy, R. K., May 10 2016, In: Malaria Journal. 15, 1, 270.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    4 Scopus citations

  • Evaluation of artemisinins for the treatment of acute myeloid leukemia

    Drenberg, C. D., Buaboonnam, J., Orwick, S. J., Hu, S., Li, L., Fan, Y., Shelat, A. A., Guy, R. K., Rubnitz, J. & Baker, S. D., Jun 1 2016, In: Cancer Chemotherapy and Pharmacology. 77, 6, p. 1231-1243 13 p.

    Research output: Contribution to journal › Article › peer-review

    33 Scopus citations

  • Flexibility is important for inhibition of the MDM2/p53 protein-protein interaction by cyclic β-hairpins

    Danelius, E., Pettersson, M., Bred, M., Min, J., Waddell, M. B., Guy, R. K., Grøtli, M. & Erdelyi, M., 2016, In: Organic and Biomolecular Chemistry. 14, 44, p. 10386-10393 8 p.

    Research output: Contribution to journal › Article › peer-review

    19 Scopus citations

  • Hit-to-Lead Studies for the Antimalarial Tetrahydroisoquinolone Carboxanilides

    Floyd, D. M., Stein, P., Wang, Z., Liu, J., Castro, S., Clark, J. A., Connelly, M., Zhu, F., Holbrook, G., Matheny, A., Sigal, M. S., Min, J., Dhinakaran, R., Krishnan, S., Bashyum, S., Knapp, S. & Guy, R. K., Sep 8 2016, In: Journal of Medicinal Chemistry. 59, 17, p. 7950-7962 13 p.

    Research output: Contribution to journal › Article › peer-review

    38 Scopus citations

  • Monitoring Ligand-Induced Protein Ordering in Drug Discovery

    Grace, C. R., Ban, D., Min, J., Mayasundari, A., Min, L., Finch, K. E., Griffiths, L., Bharatham, N., Bashford, D., Kiplin Guy, R., Dyer, M. A. & Kriwacki, R. W., Mar 27 2016, In: Journal of Molecular Biology. 428, 6, p. 1290-1303 14 p.

    Research output: Contribution to journal › Article › peer-review

    23 Scopus citations

  • Open source drug discovery: Highly potent antimalarial compounds derived from the tres cantos arylpyrroles

    Williamson, A. E., Ylioja, P. M., Robertson, M. N., Avery, V., Baell, J. B., Batchu, H., Batra, S., Burrows, J. N., Bhattacharyya, S., Calderon, F., Charman, S. A., Clark, J., Crespo, B., Dean, M., Debbert, S. L., Delves, M., Dennis, A. S. M., Deroose, F., Duffy, S., Fletcher, S., & 33 othersGiaever, G., Hallyburton, I., Gamo, F. J., Gebbia, M., Guy, R. K., Hungerford, Z., Kirk, K., Lafuente-Monasterio, M. J., Lee, A., Meister, S., Nislow, C., Overington, J. P., Papadatos, G., Patiny, L., Pham, J., Ralph, S. A., Ruecker, A., Ryan, E., Southan, C., Srivastava, K., Swain, C., Tarnowski, M. J., Thomson, P., Turner, P., Wallace, I. M., Wells, T. N. C., White, K., White, L., Willis, P., Winzeler, E. A., Wittlin, S., Todd, M. H. & Antonova-Koch, Y., Oct 26 2016, In: ACS Central Science. 2, 10, p. 687-701 15 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    54 Scopus citations

  • Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond

    Van Voorhis, W. C., Adams, J. H., Adelfio, R., Ahyong, V., Akabas, M. H., Alano, P., Alday, A., Alemán Resto, Y., Alsibaee, A., Alzualde, A., Andrews, K. T., Avery, S. V., Avery, V. M., Ayong, L., Baker, M., Baker, S., Ben Mamoun, C., Bhatia, S., Bickle, Q., Bounaadja, L., & 167 othersBowling, T., Bosch, J., Boucher, L. E., Boyom, F. F., Brea, J., Brennan, M., Burton, A., Caffrey, C. R., Camarda, G., Carrasquilla, M., Carter, D., Belen Cassera, M., Chih-Chien Cheng, K., Chindaudomsate, W., Chubb, A., Colon, B. L., Colón-López, D. D., Corbett, Y., Crowther, G. J., Cowan, N., D’Alessandro, S., Le Dang, N., Delves, M., DeRisi, J. L., Du, A. Y., Duffy, S., Abd El-Salam El-Sayed, S., Ferdig, M. T., Fernández Robledo, J. A., Fidock, D. A., Florent, I., Fokou, P. V. T., Galstian, A., Gamo, F. J., Gokool, S., Gold, B., Golub, T., Goldgof, G. M., Guha, R., Guiguemde, W. A., Gural, N., Guy, R. K., Hansen, M. A. E., Hanson, K. K., Hemphill, A., Hooft van Huijsduijnen, R., Horii, T., Horrocks, P., Hughes, T. B., Huston, C., Igarashi, I., Ingram-Sieber, K., Itoe, M. A., Jadhav, A., Naranuntarat Jensen, A., Jensen, L. T., Jiang, R. H. Y., Kaiser, A., Keiser, J., Ketas, T., Kicka, S., Kim, S., Kirk, K., Kumar, V. P., Kyle, D. E., Lafuente, M. J., Landfear, S., Lee, N., Lee, S., Lehane, A. M., Li, F., Little, D., Liu, L., Llinás, M., Loza, M. I., Lubar, A., Lucantoni, L., Lucet, I., Maes, L., Mancama, D., Mansour, N. R., March, S., McGowan, S., Medina Vera, I., Meister, S., Mercer, L., Mestres, J., Mfopa, A. N., Misra, R. N., Moon, S., Moore, J. P., Morais Rodrigues da Costa, F., Müller, J., Muriana, A., Nakazawa Hewitt, S., Nare, B., Nathan, C., Narraidoo, N., Nawaratna, S., Ojo, K. K., Ortiz, D., Panic, G., Papadatos, G., Parapini, S., Patra, K., Pham, N., Prats, S., Plouffe, D. M., Poulsen, S. A., Pradhan, A., Quevedo, C., Quinn, R. J., Rice, C. A., Rizk, M. A., Ruecker, A., St. Onge, R., Salgado Ferreira, R., Samra, J., Robinett, N. G., Schlecht, U., Schmitt, M., Silva Villela, F., Silvestrini, F., Sinden, R., Smith, D. A., Soldati, T., Spitzmüller, A., Stamm, S. M., Sullivan, D. J., Sullivan, W., Suresh, S., Suzuki, B. M., Suzuki, Y., Swamidass, S. J., Taramelli, D., Tchokouaha, L. R. Y., Theron, A., Thomas, D., Tonissen, K. F., Townson, S., Tripathi, A. K., Trofimov, V., Udenze, K. O., Ullah, I., Vallieres, C., Vigil, E., Vinetz, J. M., Voong Vinh, P., Vu, H., Watanabe, N. A., Weatherby, K., White, P. M., Wilks, A. F., Winzeler, E. A., Wojcik, E., Wree, M., Wu, W., Yokoyama, N., Zollo, P. H. A., Abla, N., Blasco, B., Burrows, J., Laleu, B., Leroy, D., Spangenberg, T., Wells, T. & Willis, P. A., Jul 2016, In: PLoS Pathogens. 12, 7, e1005763.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    195 Scopus citations

  • Optimization of a Novel Series of Ataxia-Telangiectasia Mutated Kinase Inhibitors as Potential Radiosensitizing Agents

    Min, J., Guo, K., Suryadevara, P. K., Zhu, F., Holbrook, G., Chen, Y., Feau, C., Young, B. M., Lemoff, A., Connelly, M. C., Kastan, M. B. & Guy, R. K., Jan 28 2016, In: Journal of Medicinal Chemistry. 59, 2, p. 559-577 19 p.

    Research output: Contribution to journal › Article › peer-review

    28 Scopus citations

  • PCM-22A NEW APPROACH OF PRECLINICAL TESTING OF CHEMOTHERAPIES - AN EXAMPLE OF BRAIN TUMOUR THERAPY

    Nimmervoll, B., Patel, Y., Bianski, B., DeCuypere, M., Shelat, A., Stewart, C. F., Merchant, T., Guy, R. K. & Gilbertson, R., Jun 2016, In: Neuro-Oncology. 18, suppl 3, p. iii144-iii144

    Research output: Contribution to journal › Article

  • Pentacyclic nitrofurans that rapidly kill nifurtimox-resistant trypanosomes

    Bruhn, D. F., Wyllie, S., Rodríguez-Cortés, A., Carrillo, A. K., Rakesh, Guy, R. K., Fairlamb, A. H. & Lee, R. E., Apr 1 2016, In: Journal of Antimicrobial Chemotherapy. 71, 4, p. 956-963 8 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    5 Scopus citations

  • Progress in small molecule therapeutics for the treatment of retinoblastoma

    Pritchard, E. M., Pritchard, E. M., Dyer, M. A., Dyer, M. A., Dyer, M. A. & Guy, R. K., Apr 1 2016, In: Mini-Reviews in Medicinal Chemistry. 16, 6, p. 430-454 25 p.

    Research output: Contribution to journal › Article › peer-review

    41 Scopus citations

  • Screening and development of new inhibitors of FtsZ from M. tuberculosis

    Mathew, B., Hobrath, J. V., Ross, L., Connelly, M. C., Lofton, H., Rajagopalan, M., Guy, R. K. & Reynolds, R. C., Oct 2016, In: PLoS ONE. 11, 10, e0164100.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    21 Scopus citations
  • 2015

    8-Triazolylpurines: Towards fluorescent inhibitors of the MDM2/p53 interaction

    Pettersson, M., Bliman, D., Jacobsson, J., Nilsson, J. R., Min, J., Iconaru, L., Guy, R. K., Kriwacki, R. W., Andréasson, J. & Grøtli, M., May 5 2015, In: PLoS ONE. 10, 5, e0124423.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    9 Scopus citations
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