Projects and Grants per year
Personal profile
Research Interests
Stable isotope resolved metabolomics.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Doctor of Philosophy, University Of California - Davis
1987
Bachelor of Science, University Of Hawaii
1977
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Dive into the research topics where Richard Higashi is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years
Recent external collaboration from the last 5 years on country level. Dive into details by clicking on the dots.
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Targeting the Immunosuppressive Tumor Microenvironment for Colorectal Cancer Treatment
Wang, Q. (PI), Bondada, S. (CoI), Higashi, R. (CoI), Lee, E. (CoI), Wang, C. (CoI), Weiss, H. (CoI) & Evers, B. M. (CoPI)
9/1/23 → 8/31/28
Project: Research project
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Phase II Clinical Trial Evaluating Cabozantinib and Pembrolizumab in Second-Line Therapy for Metastatic Pancreatic Adenocarcinoma
Kim, J. (PI), Fan, W.-M. (CoI), Gao, M. (CoI), Higashi, R. (CoI), Rueckert, J. (CoI) & Qasem, S. (Former CoI)
12/15/21 → 4/29/26
Project: Research project
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Understanding Mechanisms and Consequences of T Cell Co-Receptor Regulated RNA Maturation
Lane, A. (PI), Fan, W.-M. (CoI) & Higashi, R. (CoI)
4/5/21 → 3/31/26
Project: Research project
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Targeting Mitochondrial Redox Capacity to Overcome Cancer Subtype that Regrowth After Radiation
Chaiswing, L. (PI), Higashi, R. (CoI), Luo, W. (CoI), St Clair, W. (CoI) & Weiss, H. (CoI)
4/1/21 → 3/31/26
Project: Research project
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University of Kentucky Center for Cancer Metabolism (Metabolism Core)
Lane, A. (PI), Fan, W.-M. (CoI) & Higashi, R. (CoI)
National Institute of General Medical Sciences
3/1/17 → 12/31/26
Project: Research project
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CD8+ T cell metabolic flexibility elicited by CD28-ARS2 axis-driven alternative splicing of PKM supports antitumor immunity
Holling, G. A., Chavel, C. A., Sharda, A. P., Lieberman, M. M., James, C. M., Lightman, S. M., Tong, J. H., Qiao, G., Emmons, T. R., Giridharan, T., Hou, S., Intlekofer, A. M., Higashi, R. M., Fan, T. W. M., Lane, A. N., Eng, K. H., Segal, B. H., Repasky, E. A., Lee, K. P. & Olejniczak, S. H., Mar 2024, In: Cellular and Molecular Immunology. 21, 3, p. 260-274 15 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Challenges of Spatially Resolved Metabolism in Cancer Research
Lane, A. N., Higashi, R. M. & Fan, T. W. M., Jul 2024, In: Metabolites. 14, 7, 383.Research output: Contribution to journal › Review article › peer-review
Open Access1 Scopus citations -
Metabolic reprogramming driven by EZH2 inhibition depends on cell–matrix interactions
W-M Fan, T., Islam, J. M. M., Higashi, R. M., Lin, P., Brainson, C. F. & Lane, A. N., Jan 2024, In: Journal of Biological Chemistry. 300, 1, 105485.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Myeloid-derived suppressor cell mitochondrial fitness governs chemotherapeutic efficacy in hematologic malignancies
Daneshmandi, S., Choi, J. E., Yan, Q., MacDonald, C. R., Pandey, M., Goruganthu, M., Roberts, N., Singh, P. K., Higashi, R. M., Lane, A. N., Fan, T. W. M., Wang, J., McCarthy, P. L., Repasky, E. A. & Mohammadpour, H., Dec 2024, In: Nature Communications. 15, 1, 2803.Research output: Contribution to journal › Article › peer-review
Open Access18 Scopus citations -
Stable isotope-resolved metabolomics analyses of metabolic phenotypes reveal variable glutamine metabolism in different patient-derived models of non-small cell lung cancer from a single patient
Kinslow, C. J., ll, M. B., Cai, Y., Yan, J., Lorkiewicz, P. K., Al-Attar, A., Tan, J., Higashi, R. M., Lane, A. N. & Fan, T. W. M., Aug 2024, In: Metabolomics. 20, 4, 87.Research output: Contribution to journal › Article › peer-review
1 Scopus citations