Grants and Contracts per year
Personal profile
Research Interests
Our laboratory is focused on identifying the underlying pathophysiological mechanisms linking dietary nutrient metabolism to the development of obesity and associated metabolic disorders. In particular, we are interested in understanding how fructose consumption and long chain fatty acid oxidation disorders contribute to obesity and associated NAFLD.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Doctor of Philosophy, Univ Of Kentucky
2016
Bachelor of Science, Miami University
2011
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Dive into the research topics where Robert Helsley is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years
Recent external collaboration from the last 5 years on country level. Dive into details by clicking on the dots.
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Pilot: Identification of Mechanisms Controlling Fatty Acid Metabolism in Sexually Dimorphic Obesity-Driven Liver Cancer
6/1/23 → 5/31/24
Project: Research project
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Identification of Carnitine Palmitoyltransferase 1a (CPT1a) as a Novel Regulator of Lipoprotein Metabolism
Helsley, R., Daugherty, A., Gordon, S. & Graf, G.
4/1/23 → 3/31/26
Project: Research project
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Elucidating Molecular Mechanisms Linking Fructose to Cholesterol Metabolism
Helsley, R., Graf, G., Lane, A. & Softic, S.
National Institute Diabetes & Digestive & Kidney
1/1/22 → 12/31/26
Project: Research project
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COBRE Pilot: Fatty Acid Oxidation in Sexual Dimorphic Obesity and Associated NAFLD
National Institute of General Medical Sciences
8/1/18 → 7/31/24
Project: Research project
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Fellowship Robert N Helsley: A novel mechanism for ARV-drug associated dyslipidemia
Zhou, C. & Helsley, R.
7/1/15 → 5/14/16
Project: Research project
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Ketohexokinase-C regulates global protein acetylation to decrease carnitine palmitoyltransferase 1a-mediated fatty acid oxidation
Helsley, R. N., Park, S. H., Vekaria, H. J., Sullivan, P. G., Conroy, L. R., Sun, R. C., Romero, M. D. M., Herrero, L., Bons, J., King, C. D., Rose, J., Meyer, J. G., Schilling, B., Kahn, C. R. & Softic, S., Jul 2023, In: Journal of Hepatology. 79, 1, p. 25-42 18 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Design and rationale for the supermarket and web-based intervention targeting nutrition (SuperWIN) for cardiovascular risk reduction trial
Couch, S. C., Helsley, R. N., Siegel, F. U., Saelens, B. E., Magazine, M., Eckman, M. H., Summer, S., Fenchel, M., King, E. C., Bhatt, D. L. & Steen, D. L., Jun 2022, In: American Heart Journal. 248, p. 21-34Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
A luminescence-based protocol for assessing fructose metabolism via quantification of ketohexokinase enzymatic activity in mouse or human hepatocytes
Park, S-H., Helsley, R. N., Noetzli, L., Tu, H-C., Wallenius, K., O'Mahony, G., Boucher, J., Liu, J. & Softic, S., Sep 17 2021, In: STAR Protocols. 2, 3, p. 100731Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
KHK PROMOTES HEPATIC LIPID DEPOSITION BY REPRESSING CPT1a-MEDIATED FATTY ACID OXIDATION
Helsley, R., Park, S-H., Vekaria, H. J., Sullivan, P. G., Meyer, J. G., Schilling, B., Kahn, C. R. & Softic, S., Oct 2021, In: Hepatology. 74, p. 1074A-1074AResearch output: Contribution to journal › Meeting Abstract › peer-review
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Non-hematopoietic IL-4R alpha expression contributes to fructose-driven obesity and metabolic sequelae
Damen, M. S. M. A., Stankiewicz, T. E., Park, S-H., Helsley, R. N., Chan, C. C., Moreno-Fernandez, M. E., Doll, J. R., Szabo, S., Herbert, DB. R., Softic, S. & Divanovic, S., Nov 2021, In: International Journal of Obesity. 45, 11, p. 2377-2387Research output: Contribution to journal › Article › peer-review
3 Scopus citations