Projects and Grants per year
Personal profile
Research Interests
Our laboratory is focused on identifying the underlying pathophysiological mechanisms linking dietary nutrient metabolism to the development of obesity and associated metabolic disorders. In particular, we are interested in understanding how fructose consumption and long chain fatty acid oxidation disorders contribute to obesity and associated NAFLD.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Doctor of Philosophy, University Of Kentucky
2016
Bachelor of Science, Miami University
2011
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Dive into the research topics where Robert Helsley is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years
Recent external collaboration from the last 5 years on country level. Dive into details by clicking on the dots.
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Identification of Carnitine Palmitoyltransferase 1a (CPT1a) as a Novel Regulator of Lipoprotein Metabolism
Helsley, R. (PI), Daugherty, A. (CoI), Gordon, S. (CoI) & Graf, G. (CoI)
4/1/23 → 3/31/26
Project: Research project
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Elucidating Molecular Mechanisms Linking Fructose to Cholesterol Metabolism
Helsley, R. (PI), Graf, G. (CoI), Lane, A. (CoI) & Softic, S. (Former CoI)
National Institute Diabetes & Digestive & Kidney
1/1/22 → 12/31/26
Project: Research project
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Pilot: Identification of Mechanisms Controlling Fatty Acid Metabolism in Sexually Dimorphic Obesity-Driven Liver Cancer
Helsley, R. (PI)
6/1/23 → 8/31/24
Project: Research project
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Identification of Carnitine Palmitoyltransferase 1a (CPT1a) as a Novel Regulator of Lipoprotein Metabolism
Helsley, R. (PI), Daugherty, A. (CoI), Gordon, S. (CoI) & Graf, G. (CoI)
4/1/23 → 3/31/24
Project: Research project
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Elucidating Molecular Mechanisms Linking Fructose to Cholesterol Metabolism
Helsley, R. (PI), Graf, G. (CoI), Lane, A. (CoI) & Softic, S. (CoI)
National Institute Diabetes & Digestive & Kidney
1/1/22 → 12/31/23
Project: Research project
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FOXS1 is increased in liver fibrosis and regulates TGFβ responsiveness and proliferation pathways in human hepatic stellate cells
Bates, E. A., Kipp, Z. A., Lee, W. H., Martinez, G. J., Weaver, L., Becker, K. N., Pauss, S. N., Creeden, J. F., Anspach, G. B., Helsley, R. N., Xu, M., Bruno, M. E. C., Starr, M. E. & Hinds, T. D., Mar 2024, In: Journal of Biological Chemistry. 300, 3, 105691.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
The nonvesicular sterol transporter Aster-C plays a minor role in whole body cholesterol balance
Banerjee, R., Hohe, R. C., Cao, S., Jung, B. M., Horak, A. J., Ramachandiran, I., Massey, W. J., Varadharajan, V., Zajczenko, N. I., Burrows, A. C., Dutta, S., Goudarzi, M., Mahen, K., Carter, A., Helsley, R. N., Gordon, S. M., Morton, R. E., Strauch, C., Willard, B. & Gogonea, C. B. & 4 others, , 2024, In: Frontiers in Physiology. 15, 1371096.Research output: Contribution to journal › Article › peer-review
Open Access -
Fructose induced KHK-C can increase ER stress independent of its effect on lipogenesis to drive liver disease in diet-induced and genetic models of NAFLD
Park, S. H., Helsley, R. N., Fadhul, T., Willoughby, J. L. S., Noetzli, L., Tu, H. C., Solheim, M. H., Fujisaka, S., Pan, H., Dreyfuss, J. M., Bons, J., Rose, J., King, C. D., Schilling, B., Lusis, A. J., Pan, C., Gupta, M., Kulkarni, R. N., Fitzgerald, K. & Kern, P. A. & 3 others, , Aug 2023, In: Metabolism: Clinical and Experimental. 145, 155591.Research output: Contribution to journal › Article › peer-review
Open Access17 Scopus citations -
Ketohexokinase-C regulates global protein acetylation to decrease carnitine palmitoyltransferase 1a-mediated fatty acid oxidation
Helsley, R. N., Park, S. H., Vekaria, H. J., Sullivan, P. G., Conroy, L. R., Sun, R. C., Romero, M. D. M., Herrero, L., Bons, J., King, C. D., Rose, J., Meyer, J. G., Schilling, B., Kahn, C. R. & Softic, S., Jul 2023, In: Journal of Hepatology. 79, 1, p. 25-42 18 p.Research output: Contribution to journal › Article › peer-review
Open Access19 Scopus citations -
Loss of carnitine palmitoyltransferase 1a reduces docosahexaenoic acid-containing phospholipids and drives sexually dimorphic liver disease in mice
Zelows, M. M., Cady, C., Dharanipragada, N., Mead, A. E., Kipp, Z. A., Bates, E. A., Varadharajan, V., Banerjee, R., Park, S. H., Shelman, N. R., Clarke, H. A., Hawkinson, T. R., Medina, T., Sun, R. C., Lydic, T. A., Hinds, T. D., Brown, J. M., Softic, S., Graf, G. A. & Helsley, R. N., Dec 2023, In: Molecular Metabolism. 78, 101815.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations