Projects and Grants per year
Personal profile
Research Interests
The Gordon lab studies metabolism and atherosclerotic cardiovascular disease in two primary lines of investigation:
Mechanisms regulating dietary fat absorption by the intestine.
- Genes that control chylomicron secretion.
- The influence of fat absorption on body weight, metabolism, and atherosclerosis.
Inflammatory protease activity in the artery wall and suppression by lipoproteins.
- Natural mechanisms of inflammatory regulation involving lipoproteins.
- Development of lipoprotein-targeting protease inhibitors.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Doctor of Philosophy, University Of Cincinnati
2012
Bachelor of Science, State University Of New York
2008
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Collaborations and top research areas from the last five years
Recent external collaboration from the last 5 years on country level. Dive into details by clicking on the dots.
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Fellowship for Clairity Voy: The Impact of Proteolytic Modification of Lipoprotein Metabolism and Atherosclerosis
Gordon, S. (PI)
1/1/25 → 12/31/26
Project: Research project
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Functional Interactions Between Lipoproteins and Protease Inhibitors in Atherosclerosis
Gordon, S. (PI) & Daugherty, A. (CoI)
National Heart Lung and Blood Institute
7/1/24 → 4/30/28
Project: Research project
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Fellowship for Olivia Hage: The role of Dennd5b in Triglyceride-Rich Lipoprotein Secretion from the Liver and Intestine
Gordon, S. (PI) & Hage, O. (CoI)
1/1/24 → 12/31/25
Project: Research project
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Identification of Carnitine Palmitoyltransferase 1a (CPT1a) as a Novel Regulator of Lipoprotein Metabolism
Helsley, R. (PI), Daugherty, A. (CoI), Gordon, S. (CoI) & Graf, G. (CoI)
4/1/23 → 3/31/26
Project: Research project
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The Role of DENND5B in Dietary Lipid Absorption
Gordon, S. (PI) & Graf, G. (CoI)
National Institute Diabetes & Digestive & Kidney
7/15/22 → 5/31/27
Project: Research project
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APOE4 reshapes the lipid droplet proteome and modulates microglial inflammatory responses
Friday, C. M., Stephens, I. O., Smith, C. T., Lee, S., Satish, D., Devanney, N. A., Cohen, S., Morganti, J. M., Gordon, S. M. & Johnson, L. A., Aug 2025, In: Neurobiology of Disease. 212, 106983.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
APOE4 to APOE2 allelic switching in mice improves Alzheimer’s disease-related metabolic signatures, neuropathology and cognition
Golden, L. R., Siano, D. S., Stephens, I. O., MacLean, S. M., Saito, K., Nolt, G. L., Funnell, J. L., Pallerla, A. V., Lee, S., Smith, C., Chen, J., Zhu, H., Voy, C., Whitus, C. M., Hernandez, G., Farmer, B. C., Pandya, K., Cowley, D. O., Macauley, S. L. & Gordon, S. & 2 others, , 2025, (Accepted/In press) In: Nature Neuroscience.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
HDL-associated vitamin D binding protein levels are inversely associated with necrotic plaque burden in psoriasis
Playford, M. P., Li, H., Dey, A. K., Florida, E. M., Teague, H. L., Gordon, S. M. & Mehta, N. N., Mar 2025, In: Atherosclerosis Plus. 59, p. 32-38 7 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Hepatic Inactivation of Carnitine Palmitoyltransferase 1a Lowers ApoB-Containing Lipoproteins in Mice
Helsley, R. N., Zelows, M. M., Noffsinger, V. P., Anspach, G. B., Dharanipragada, N., Mead, A. E., Cobo, I., Carter, A., Wu, Q., Shalaurova, I., Saito, K., Morganti, J. M., Gordon, S. & Graf, G. A., Aug 2025, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 45, 8, p. 1368-1388 21 p.Research output: Contribution to journal › Article › peer-review
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APOA2 increases cholesterol efflux capacity to plasma HDL by displacing the C-terminus of resident APOA1
Sarkar, S., Morris, J., You, Y., Sexmith, H., Street, S. E., Thibert, S. M., Attah, I. K., Hutchinson Bunch, C. M., Novikova, I. V., Evans, J. E., Shah, A. S., Gordon, S. M., Segrest, J. P., Bornfeldt, K. E., Vaisar, T., Heinecke, J. W., Davidson, W. S. & Melchior, J. T., Dec 2024, In: Journal of Lipid Research. 65, 12, 100686.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations