Personal profile
Education/Academic qualification
Doctor of Philosophy, Washington University School of Medicine
2009
Bachelor of Arts, Middlebury College
1999
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
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SCR: Microglial Immunometabolism as a Mechanism for Sleep loss in Alzheimer's Disease
Macauley-Rambach, S. (PI), Johnson, L. (CoI) & Morganti, J. (CoI)
4/1/26 → 3/31/27
Project: Research project
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Metabolic Reprogramming of Microglia in Alzheimer's Disease: The Role of Lactate in Tau Pathology and Neuroinflammation
Macauley-Rambach, S. (PI), Johnson, L. (CoI), Morganti, J. (CoI) & Sullivan, P. (CoI)
Coins for Alzheimers Research Trust
7/1/25 → 6/30/27
Project: Research project
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Lactate as a Regulator of Alzheimer's Pathology
Macauley-Rambach, S. (PI), Johnson, L. (CoI), Morganti, J. (CoI) & Sullivan, P. (CoI)
5/15/25 → 3/31/30
Project: Research project
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Center of Biomedical Research Excellence in CNS Metabolism - Administrative Core
Sullivan, P. (PI), Bachstetter, A. (CoI), Bauer, B. (CoI), Dutch, R. (CoI), Feygin, Y. (CoI), Geisler, C. (CoI), Hubbard, W. (CoI), Johnson, L. (CoI), Macauley-Rambach, S. (CoI), McLouth, C. (CoI), Nikolajczyk, B. (CoI), Patel, S. (CoI), Pinto, A. (CoI), Schmitt, F. (CoI), Selenica, M.-L. (CoI), Slevin, J. (CoI), Yamasaki, T. (CoI), Norris, C. (Former CoI) & Wilcock, D. (Former CoI)
National Institute of General Medical Sciences
5/15/23 → 2/29/28
Project: Research project
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The Metabolic Interplay of Sleep and Alzheimer's Disease
Macauley-Rambach, S. (PI)
8/1/20 → 4/30/26
Project: Research project
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A pathogenic Tau mutation drives autophagy-lysosome dysfunction that limits Tau degradation in a model of frontotemporal dementia
Mirfakhar, F. S., Marsh, J. A., Sato, C., Schache, K. J., Minaya, M. A., Dolle, R. E., Pak, S. C., Silverman, G. A., Perlmutter, D. H., Macauley, S. L. & Karch, C. M., Dec 2026, In: Nature Communications. 17, 1, 2699.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
APOE4 drives maladaptive heterogeneity and immunometabolic responses of astrocytes
Goulding, D. S., Williams, H. C., Gorman, A. A., Devanney, N. A., Harrison, D. A., Walsh, A. E., Tuck, T., Zajac, D. J., Macauley, S. L., Estus, S., TCW, J., A. Johnson, L. & Morganti, J. M., Dec 2026, In: Journal of Neuroinflammation. 23, 1, 89.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
APOE4 to APOE2 allelic switching in mice improves Alzheimer’s disease-related metabolic signatures, neuropathology and cognition
Golden, L. R., Siano, D. S., Stephens, I. O., MacLean, S. M., Saito, K., Nolt, G. L., Funnell, J. L., Pallerla, A. V., Lee, S., Smith, C., Chen, J., Zhu, H., Voy, C., Whitus, C. M., Hernandez, G., Farmer, B. C., Pandya, K., Cowley, D. O., Macauley, S. L. & Gordon, S. M. & 2 others, , Dec 2025, In: Nature Neuroscience. 28, 12, p. 2461-2475 15 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
ATP-sensitive potassium channels alter glycolytic flux to modulate cortical activity and sleep
Constantino, N. J., Carroll, C. M., Williams, H. C., Vekaria, H. J., Yuede, C. M., Saito, K., Sheehan, P. W., Snipes, J. A., Raichle, M. E., Musiek, E. S., Sullivan, P. G., Morganti, J. M., Johnson, L. A. & Macauley, S. L., Feb 25 2025, In: Proceedings of the National Academy of Sciences of the United States of America. 122, 8, e2416578122.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Insulin resistance, cognition, and functional brain network topology in older adults with obesity
McIntyre, C. C., Lyday, R. G., Su, Y., Nicklas, B., Simpson, S. L., Deep, G., Macauley, S. L. & Hugenschmidt, C. E., Dec 2025, In: Scientific Reports. 15, 1, 22612.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations