Projects and Grants per year
Personal profile
Research Interests
Research Expertise. I am an expert on the biology of the olfactory sensory neurons and the odorant receptors (ORs) they express. My passion for investigating olfaction began as a graduate student working on motivation of adaptive behaviors in natural environments when I chose to investigate a behavior triggered by odor cues. I became intrigued by questions of how animals detect and discriminate odors. These questions continue to motivate my research efforts. I enjoy benchwork and continue to perform experiments, in part because it is a wonderfully creative endeavor. I have a long history of technological innovation, the latest being the invention of the Kentucky assay to simultaneously measure the in vivo function of all 1,100 ORs and 14 trace amine-associated receptors in freely behaving mice. To investigate such a large family of genes and the molecular biology of the neurons that express them I developed expertise in genomics that has led to collaborations on projects investigating the physiology of several organ systems and diseases, including Alzheimer’s Disease. They are welcome opportunities to take new translational directions, which are rare in the field of olfactory biology.
Courses Taught
Education and Service. In addition to my research efforts, I have been an innovator in education and training, developing 5 new courses and implementing active learning approaches. Current teaching assignments include:
IBS 603 Cell Biology & Signaling (3 credits)
IBS 608 Genomics & Bioinformatics Tools (Course Director; 2 credits)
PGY 502 Systems, Cellular, and Molecular Physiology
PGY 602 Readings in Systems, Cellular, and Molecular Physiology
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Post Doctoral Fellow, Yale University
1992
Doctor of Philosophy, University Of Florida
1989
Master of Science, Florida State University
1984
Bachelor of Science, Michigan State University
1982
External positions
President, International Society of Neurogastronomy
2020 → …
President, Association for Chemoreception Sciences (AChemS)
2011 → 2012
Executive Editor, Chemical Senses
2008 → …
Chairman, Society for Neuroscience
2006 → 2008
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- 1 Similar Profiles
Collaborations and top research areas from the last five years
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The Role of Macrophage Metabolism and Age in Recovery from Spinal Cord Injury
Gensel, J. (PI), Johnson, L. (CoI), McClintock, T. (CoI), Sullivan, P. (CoI), Venditto, V. (CoI), Wilson, M. (CoI) & Patel, S. (CoPI)
National Institute of Neurological Disorders & Stroke
6/1/23 → 5/31/28
Project: Research project
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Olfactory Epithelium Vulnerability to Human Apoe Alleles
McClintock, T. (PI) & Johnson, L. (CoI)
4/1/23 → 3/31/26
Project: Research project
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Function of Ceramide in Extracellular Vesicle-Mediated Neurodegenerative Disease
Bieberich, E. (PI), McClintock, T. (CoI), Spassieva, S. (CoI) & Rabchevsky, A. (Former CoI)
9/1/22 → 8/31/25
Project: Research project
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Regulation of Microglial Activation State by a Lipid Transporter
Bieberich, E. (PI), Bachstetter, A. (CoI), Estus, G. (CoI), McClintock, T. (CoI), Wang, G. (Former PI) & Stromberg, A. (Former CoI)
3/1/20 → 12/31/25
Project: Research project
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International Society for Neurogastronomy Symposium
McClintock, T. (PI) & Han, D. (CoI)
National Institute on Deafness & Other Communications
9/26/17 → 2/28/30
Project: Research project
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Androgen aggravates aortic aneurysms via suppressing PD-1 in mice
Mu, X., Liu, S., Wang, Z., Jiang, K., McClintock, T., Stromberg, A. J., Tezanos, A. V., Lee, E. S., Curci, J. A., Gong, M. C. & Guo, Z., Jun 17 2024, In: Journal of Clinical Investigation. 134, 12, 169085.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Transcriptomics analysis reveals potential regulatory role of nSMase2 (Smpd3) in nervous system development and function of middle-aged mouse brains
Zhu, Z., McClintock, T. & Bieberich, E., Aug 2024, In: Genes, Brain and Behavior. 23, 4, e12911.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Dissociation of Mouse Olfactory Mucosae for Fluorescence-Activated Cell Sorting of Olfactory Sensory Neurons
Wang, Q., Sengoku, T., Titlow, W. B., Strange, J. L. & McClintock, T. S., 2023, Methods in Molecular Biology. p. 111-120 10 p. (Methods in Molecular Biology; vol. 2710).Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
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Human APOE ϵ3 and APOE ϵ4 Alleles Have Differential Effects on Mouse Olfactory Epithelium
Khan, N., Alimova, Y., Clark, S. J., Vekaria, H. J., Walsh, A. E., Williams, H. C., Hawk, G. S., Sullivan, P. G., Johnson, L. A. & McClintock, T. S., 2022, In: Journal of Alzheimer's Disease. 85, 4, p. 1481-1494 14 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Neutral Sphingomyelinase 2 Mediates Oxidative Stress Effects on Astrocyte Senescence and Synaptic Plasticity Transcripts
Zhu, Z., Quadri, Z., Crivelli, S. M., Elsherbini, A., Zhang, L., Tripathi, P., Qin, H., Roush, E., Spassieva, S. D., Nikolova-Karakashian, M., McClintock, T. S. & Bieberich, E., May 2022, In: Molecular Neurobiology. 59, 5, p. 3233-3253 21 p.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations