Grants and Contracts per year
My research focuses on applying systems biochemical approaches including novel Stable Isotope-Resolved Metabolomic (SIRM), metabolomics-edited transcriptomic (META), and proteomic approaches (METPA) which we have developed 1) to investigate the anticancer mechanism of natural products and novel therapeutic agents; 2) to explore the functional role(s) of tumor microenvironment and extrinsic environmental factors in cancer development, progression, and therapy; 3) to uncover novel therapeutic targets and distinct mechanism-informed biochemical marker patterns for human diseases by interrogating the human metabolome; and 4) to decipher the gene networks that govern cancer metabolism. The central tool that I have used to achieve these goals is the integration of nuclear magnetic resonance (NMR) with mass spectrometry (MS) technologies, which enables a systematic interrogation of human metabolic networks and their perturbations by diseases.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Doctor of Philosophy, Univ Of California - Davis
Master of Science, Univ Of Hawaii
Bachelor of Science, National Taiwan University
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6/15/22 → 12/31/22
Project: Research project
4/5/21 → 3/31/23
Project: Research project
In vivo deep network tracing reveals phosphofructokinase-mediated coordination of biosynthetic pathway activity in the myocardiumFulghum, K. L., Audam, T. N., Lorkiewicz, P. K., Zheng, Y., Merchant, M., Cummins, T. D., Dean, W. L., Cassel, T. A., Fan, T. W. M. & Hill, B. G., Jan 2022, In: Journal of Molecular and Cellular Cardiology. 162, p. 32-42 11 p.
Research output: Contribution to journal › Article › peer-reviewOpen Access2 Scopus citations
Mitochondrial superoxide targets energy metabolism to modulate epigenetic regulation of NRF2-mediated transcriptionDhar, S. K., Scott, T., Wang, C., Fan, T. W. M. & St Clair, D. K., Feb 1 2022, In: Free Radical Biology and Medicine. 179, p. 181-189 9 p.
Research output: Contribution to journal › Article › peer-review2 Scopus citations
NMR-based isotope editing, chemoselection and isotopomer distribution analysis in stable isotope resolved metabolomicsLin, P., W-M. Fan, T. & Lane, A. N., Oct 2022, In: Methods. 206, p. 8-17 10 p.
Research output: Contribution to journal › Article › peer-review
Succinate dehydrogenase/complex II is critical for metabolic and epigenetic regulation of T cell proliferation and inflammationChen, X., Sunkel, B., Wang, M., Kang, S., Wang, T., Gnanaprakasam, J. N. R., Liu, L., Cassel, T. A., Scott, D. A., Muñoz-Cabello, A. M., Lopez-Barneo, J., Yang, J., Lane, A. N., Xin, G., Stanton, B. Z., Fan, T. W. M. & Wang, R., Apr 2022, In: Science immunology. 7, 70, abm8161.
Research output: Contribution to journal › Article › peer-review1 Scopus citations
Tissue-Specific Downregulation of Fatty Acid Synthase Suppresses Intestinal Adenoma Formation via Coordinated Reprograming of Transcriptome and Metabolism in the Mouse Model of Apc-Driven Colorectal CancerDrury, J., Young, L. E. A., Scott, T. L., Kelson, C. O., He, D., Liu, J., Wu, Y., Wang, C., Weiss, H. L., Fan, T., Gentry, M. S., Sun, R. & Zaytseva, Y. Y., Jun 1 2022, In: International Journal of Molecular Sciences. 23, 12, 6510.
Research output: Contribution to journal › Article › peer-reviewOpen Access