Projects and Grants per year
Personal profile
Research Interests
My research focuses on applying systems biochemical approaches including novel Stable Isotope-Resolved Metabolomic (SIRM), metabolomics-edited transcriptomic (META), and proteomic approaches (METPA) which we have developed 1) to investigate the anticancer mechanism of natural products and novel therapeutic agents; 2) to explore the functional role(s) of tumor microenvironment and extrinsic environmental factors in cancer development, progression, and therapy; 3) to uncover novel therapeutic targets and distinct mechanism-informed biochemical marker patterns for human diseases by interrogating the human metabolome; and 4) to decipher the gene networks that govern cancer metabolism. The central tool that I have used to achieve these goals is the integration of nuclear magnetic resonance (NMR) with mass spectrometry (MS) technologies, which enables a systematic interrogation of human metabolic networks and their perturbations by diseases.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Doctor of Philosophy, University Of California - Davis
1983
Master of Science, University Of Hawaii
1979
Bachelor of Science, National Taiwan University
1977
Fingerprint
- 1 Similar Profiles
Collaborations and top research areas from the last five years
-
Pdcd4-Rictor Interaction in Suppression of Lung Tumorigenesis
Yang, H.-S. (PI), Chen, L. (CoI), Fan, W.-M. (CoI), Hao, Z. (CoI), Lee, E. (CoI), Liu, X. (CoI) & Zhan, C.-G. (CoI)
9/20/23 → 8/31/28
Project: Research project
-
Point-of-care Optical Spectroscopy Platform and Novel Ratio-metric Algorithms for Rapid and Systematic Functional Characterization of Biological Models in Vivo
Zhu, C. (PI), Arnold, S. (CoI), Fan, W.-M. (CoI), Tong, S. (CoI) & Wang, C. (CoI)
National Institute of Dental and Craniofacial Research
8/1/23 → 7/31/28
Project: Research project
-
Center for Appalachian Research in Environmental Sciences: Administrative Core
Haynes, E. (PI), Bauer, J. (CoI), Cassis, L. (CoI), Christian, J. (CoI), Cox, N. (CoI), Curry, T. (CoI), Dignan, M. (CoI), Evers, B. M. (CoI), Fan, W.-M. (CoI), Hoover, A. (CoI), Pearson, K. (CoI), Pennell, K. (CoI), Sanderson, W. (CoI), Schoenberg, N. (CoI), Stanifer, S. (CoI), Stratton, T. (CoI), Swanson, H. (CoI), Talbert, J. (CoI), Unrine, J. (CoI), Hahn, E. (Former PI), Arnett, D. (Former CoI), DiPaola, R. (Former CoI), Heath, E. (Former CoI), Kern, P. (Former CoI), May, B. (Former CoI), Miller, J. (Former CoI), Richardson, K. (Former CoI), Stanley, S. (Former CoI) & Stromberg, A. (Former CoI)
National Institute of Environmental Health Sciences
6/3/23 → 4/30/28
Project: Research project
-
Center for Appalachian Research in Environmental Sciences: Pilot Project Program
Curry, T. (PI), Bloomer, E. (CoI), Fan, W.-M. (CoI), Haynes, E. (CoI), Hahn, E. (Former CoI), Richardson, K. (Former CoI) & Swanson, H. (Former CoI)
National Institute of Environmental Health Sciences
6/3/23 → 4/30/28
Project: Research project
-
Non-Destructive Optical Spectroscopic Assay for High-Throughput Metabolic Characterization of in Vitro Cell Models and Patient-Derived Organoids
Zhu, C. (PI), Fan, W.-M. (CoI), Wang, X. (CoI), Wang, C. (CoI) & Wang, P. (Former CoI)
National Institute of Biomedical Imaging & Bioengineer
8/1/22 → 4/30/26
Project: Research project
-
CD8+ T cell metabolic flexibility elicited by CD28-ARS2 axis-driven alternative splicing of PKM supports antitumor immunity
Holling, G. A., Chavel, C. A., Sharda, A. P., Lieberman, M. M., James, C. M., Lightman, S. M., Tong, J. H., Qiao, G., Emmons, T. R., Giridharan, T., Hou, S., Intlekofer, A. M., Higashi, R. M., Fan, T. W. M., Lane, A. N., Eng, K. H., Segal, B. H., Repasky, E. A., Lee, K. P. & Olejniczak, S. H., Mar 2024, In: Cellular and Molecular Immunology. 21, 3, p. 260-274 15 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Challenges of Spatially Resolved Metabolism in Cancer Research
Lane, A. N., Higashi, R. M. & Fan, T. W. M., Jul 2024, In: Metabolites. 14, 7, 383.Research output: Contribution to journal › Review article › peer-review
Open Access1 Scopus citations -
Correction: Bayesian kinetic modeling for tracer-based metabolomic data (BMC Bioinformatics, (2023), 24, 1, (108), 10.1186/s12859-023-05211-5)
Zhang, X., Su, Y., Lane, A. N., Stromberg, A. J., Fan, T. W. M. & Wang, C., Dec 2024, In: BMC Bioinformatics. 25, 1, 14.Research output: Contribution to journal › Comment/debate
Open Access -
Exercise-induced changes in myocardial glucose utilization during periods of active cardiac growth
Fulghum, K. L., Collins, H. E., Lorkiewicz, P. K., Cassel, T. A., Fan, T. W. M. & Hill, B. G., Jun 2024, In: Journal of Molecular and Cellular Cardiology. 191, p. 50-62 13 p.Research output: Contribution to journal › Article › peer-review
-
Metabolic reprogramming driven by EZH2 inhibition depends on cell–matrix interactions
W-M Fan, T., Islam, J. M. M., Higashi, R. M., Lin, P., Brainson, C. F. & Lane, A. N., Jan 2024, In: Journal of Biological Chemistry. 300, 1, 105485.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations