Grants and Contracts per year
Personal profile
Research Interests
My research focuses on applying systems biochemical approaches including novel Stable Isotope-Resolved Metabolomic (SIRM), metabolomics-edited transcriptomic (META), and proteomic approaches (METPA) which we have developed 1) to investigate the anticancer mechanism of natural products and novel therapeutic agents; 2) to explore the functional role(s) of tumor microenvironment and extrinsic environmental factors in cancer development, progression, and therapy; 3) to uncover novel therapeutic targets and distinct mechanism-informed biochemical marker patterns for human diseases by interrogating the human metabolome; and 4) to decipher the gene networks that govern cancer metabolism. The central tool that I have used to achieve these goals is the integration of nuclear magnetic resonance (NMR) with mass spectrometry (MS) technologies, which enables a systematic interrogation of human metabolic networks and their perturbations by diseases.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Doctor of Philosophy, University Of California - Davis
1983
Master of Science, University Of Hawaii
1979
Bachelor of Science, National Taiwan University
1977
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Collaborations and top research areas from the last five years
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Point-of-care Optical Spectroscopy Platform and Novel Ratio-metric Algorithms for Rapid and Systematic Functional Characterization of Biological Models in Vivo
Zhu, C., Arnold, S., Fan, W., Tong, S. & Wang, C.
National Institute of Dental and Craniofacial Research
8/1/23 → 7/31/28
Project: Research project
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Center for Appalachian Research in Environmental Sciences: Administrative Core
Hahn, E., Arnett, D., Bauer, J., Cassis, L., Christian, J., Cox, N., Curry, T., DiPaola, R., Dignan, M., Evers, B. M., Fan, W., Haynes, E., Hoover, A., Kern, P., May, B., Miller, J., Pearson, K., Pennell, K., Richardson, K., Sanderson, W., Schoenberg, N., Stanifer, S., Stratton, T., Swanson, H., Talbert, J., Unrine, J., Heath, E., Stanley, S. & Stromberg, A.
National Institute of Environmental Health Sciences
6/3/23 → 4/30/28
Project: Research project
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Center for Appalachian Research in Environmental Sciences: Pilot Project Program
Curry, T., Fan, W., Hahn, E. & Richardson, K.
National Institute of Environmental Health Sciences
6/3/23 → 4/30/28
Project: Research project
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Asparagine restriction enhances CD8+ T cell metabolic fitness and antitumoral functionality through an NRF2-dependent stress response
Gnanaprakasam, J. N. R., Kushwaha, B., Liu, L., Chen, X., Kang, S., Wang, T., Cassel, T. A., Adams, C. M., Higashi, R. M., Scott, D. A., Xin, G., Li, Z., Yang, J., Lane, A. N., Fan, T. W. M., Zhang, J. & Wang, R., Aug 2023, In: Nature Metabolism. 5, 8, p. 1423-1439 17 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Bayesian kinetic modeling for tracer-based metabolomic data
Zhang, X., Su, Y., Lane, A. N., Stromberg, A. J., Fan, T. W. M. & Wang, C., Dec 2023, In: BMC Bioinformatics. 24, 1, 108.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Differential Inhibition of Anaplerotic Pyruvate Carboxylation and Glutaminolysis-Fueled Anabolism Underlies Distinct Toxicity of Selenium Agents in Human Lung Cancer
Fan, T. W. M., Winnike, J., Al-Attar, A., Belshoff, A. C., Lorkiewicz, P. K., Tan, J. L., Wu, M., Higashi, R. M. & Lane, A. N., Jul 2023, In: Metabolites. 13, 7, 774.Research output: Contribution to journal › Article › peer-review
Open Access -
Portable optical spectroscopic assay for non-destructive measurement of key metabolic parameters on in vitro cancer cells and organotypic fresh tumor slices
Yan, J., Goncalves, C. F. L., Korfhage, M. O., Hasan, M. Z., Fan, T. W. M., Wang, X. & Zhu, C., Aug 1 2023, In: Biomedical Optics Express. 14, 8, p. 4065-4079 15 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Targeting mutant p53-R248W reactivates WT p53 function and alters the onco-metabolic profile
Brown, K., Jenkins, L. M. M., Crooks, D. R., Surman, D. R., Mazur, S. J., Xu, Y., Arimilli, B. S., Yang, Y., Lane, A. N., Fan, T. W. M., Schrump, D. S., Linehan, W. M., Ripley, R. T. & Appella, E., Jan 11 2023, In: Frontiers in Oncology. 12, 1094210.Research output: Contribution to journal › Article › peer-review
Open Access